-
1
-
-
84860560358
-
The transition of acute to chronic bowel inflammation in spondyloarthritis
-
Van Praet, L., Jacques, P., Van Den Bosch, F., & Elewaut, D. The transition of acute to chronic bowel inflammation in spondyloarthritis. Nat. Rev. Rheumatol. 8, 288-295 (2012).
-
(2012)
Nat. Rev. Rheumatol
, vol.8
, pp. 288-295
-
-
Van Praet, L.1
Jacques, P.2
Van Den Bosch, F.3
Elewaut, D.4
-
2
-
-
84938709267
-
HLA B27 homodimer-specific antibody modulates the expansion of pro-inflammatory T cells in HLA B27 transgenic rats
-
Marroquin Belaunzaran, O., et al. HLA B27 homodimer-specific antibody modulates the expansion of pro-inflammatory T cells in HLA B27 transgenic rats. PLoS ONE 10, e0130811 (2015).
-
(2015)
PLoS ONE
, vol.10
, pp. e0130811
-
-
Marroquin Belaunzaran, O.1
-
3
-
-
84887992906
-
Anti-interleukin 17A monoclonal antibody secukinumab in treatment of ankylosing spondylitis: A randomised, double-blind, placebo-controlled trial
-
Baeten, D., et al. Anti-interleukin 17A monoclonal antibody secukinumab in treatment of ankylosing spondylitis: a randomised, double-blind, placebo-controlled trial. Lancet 382, 1705-1713 (2013).
-
(2013)
Lancet
, vol.382
, pp. 1705-1713
-
-
Baeten, D.1
-
4
-
-
0015938046
-
Ankylosing spondylitis and HL A 27
-
Brewerton, D. A., et al. Ankylosing spondylitis and HL A 27. Lancet 1, 904-907 (1973).
-
(1973)
Lancet
, vol.1
, pp. 904-907
-
-
Brewerton, D.A.1
-
5
-
-
79960899377
-
Interaction between ERAP1 and HLA B27 in ankylosing spondylitis implicates peptide handling in the mechanism for HLA B27 in disease susceptibility
-
The Australo-Anglo-American Spondyloarthritis Consortium, et al.
-
The Australo-Anglo-American Spondyloarthritis Consortium, et al. Interaction between ERAP1 and HLA B27 in ankylosing spondylitis implicates peptide handling in the mechanism for HLA B27 in disease susceptibility. Nat. Genet. 43, 761-767 (2011).
-
(2011)
Nat. Genet
, vol.43
, pp. 761-767
-
-
-
6
-
-
35748981184
-
Association scan of 14, 500 nonsynonymous SNPs in four diseases identifies autoimmunity variants
-
Wellcome Trust Case Control Consortium et al.
-
Wellcome Trust Case Control Consortium, et al. Association scan of 14, 500 nonsynonymous SNPs in four diseases identifies autoimmunity variants. Nat. Genet. 39, 1329-1337 (2007).
-
(2007)
Nat. Genet
, vol.39
, pp. 1329-1337
-
-
-
7
-
-
84879691837
-
Identification of multiple risk variants for ankylosing spondylitis through high-density genotyping of immune-related loci
-
International Genetics of Ankylosing Spondylitis Consortium, et al.
-
International Genetics of Ankylosing Spondylitis Consortium, et al. Identification of multiple risk variants for ankylosing spondylitis through high-density genotyping of immune-related loci. Nat. Genet. 45, 730-738 (2013).
-
(2013)
Nat. Genet
, vol.45
, pp. 730-738
-
-
-
8
-
-
75749085686
-
Genome-wide association study of ankylosing spondylitis identifies non-MHC susceptibility loci
-
Australo-Anglo-American Spondyloarthritis Consortium et al.
-
Australo-Anglo-American Spondyloarthritis Consortium, et al. Genome-wide association study of ankylosing spondylitis identifies non-MHC susceptibility loci. Nat. Genet. 42, 123-127 (2010).
-
(2010)
Nat. Genet
, vol.42
, pp. 123-127
-
-
-
9
-
-
84964772502
-
Analysis of five chronic inflammatory diseases identifies 27 new associations and highlights disease-specific patterns at shared loci
-
Ellinghaus, D., et al. Analysis of five chronic inflammatory diseases identifies 27 new associations and highlights disease-specific patterns at shared loci. Nat. Genet. 48, 510-518 (2016).
-
(2016)
Nat. Genet
, vol.48
, pp. 510-518
-
-
Ellinghaus, D.1
-
10
-
-
84956807918
-
Genetics of ankylosing spondylitis - Insights into pathogenesis
-
Brown, M. A., Kenna, T., & Wordsworth, B. P. Genetics of ankylosing spondylitis - insights into pathogenesis. Nat. Rev. Rheumatol. 12, 81-91 (2016).
-
(2016)
Nat. Rev. Rheumatol
, vol.12
, pp. 81-91
-
-
Brown, M.A.1
Kenna, T.2
Wordsworth, B.P.3
-
11
-
-
84930216606
-
Major histocompatibility complex associations of ankylosing spondylitis are complex and involve further epistasis with ERAP1
-
Cortes, A., et al. Major histocompatibility complex associations of ankylosing spondylitis are complex and involve further epistasis with ERAP1. Nat. Commun. 6, 7146 (2015).
-
(2015)
Nat. Commun
, vol.6
, pp. 7146
-
-
Cortes, A.1
-
12
-
-
0024462320
-
HLA Bw60 increases susceptibility to ankylosing spondylitis in HLA B27+ patients
-
Robinson, W. P., et al. HLA Bw60 increases susceptibility to ankylosing spondylitis in HLA B27+ patients. Arthritis Rheum. 32, 1135-1141 (1989).
-
(1989)
Arthritis Rheum
, vol.32
, pp. 1135-1141
-
-
Robinson, W.P.1
-
13
-
-
0029879899
-
HLA class i associations of ankylosing spondylitis in the white population in the United Kingdom
-
Brown, M. A., et al. HLA class I associations of ankylosing spondylitis in the white population in the United Kingdom. Ann. Rheum. Dis. 55, 268-270 (1996).
-
(1996)
Ann. Rheum. Dis
, vol.55
, pp. 268-270
-
-
Brown, M.A.1
-
14
-
-
84948777122
-
An HLA C amino-Acid variant in addition to HLA B27 confers risk for ankylosing spondylitis in the Korean population
-
Kim, K., et al. An HLA C amino-Acid variant in addition to HLA B27 confers risk for ankylosing spondylitis in the Korean population. Arthritis Res. Ther. 17, 342 (2015).
-
(2015)
Arthritis Res. Ther
, vol.17
, pp. 342
-
-
Kim, K.1
-
15
-
-
78049347495
-
A genome-wide association study identifies new psoriasis susceptibility loci and an interaction between HLA C and ERAP1
-
Genetic Analysis of Psoriasis Consortium & the Wellcome Trust Case Control Consortium 2, et al.
-
Genetic Analysis of Psoriasis Consortium & the Wellcome Trust Case Control Consortium 2, et al. A genome-wide association study identifies new psoriasis susceptibility loci and an interaction between HLA C and ERAP1. Nat. Genet. 42, 985-990 (2010).
-
(2010)
Nat. Genet
, vol.42
, pp. 985-990
-
-
-
16
-
-
84873091770
-
Genome-wide association analysis identifies new susceptibility loci for Behcet?s disease and epistasis between HLA B51 and ERAP1
-
Kirino, Y., et al. Genome-wide association analysis identifies new susceptibility loci for Behcet?s disease and epistasis between HLA B51 and ERAP1. Nat. Genet. 45, 202-207 (2013).
-
(2013)
Nat. Genet
, vol.45
, pp. 202-207
-
-
Kirino, Y.1
-
17
-
-
84911388736
-
A genome-wide association study identifies a functional ERAP2 haplotype associated with birdshot chorioretinopathy
-
Kuiper, J. J., et al. A genome-wide association study identifies a functional ERAP2 haplotype associated with birdshot chorioretinopathy. Hum. Mol. Genet. 23, 6081-6087 (2014).
-
(2014)
Hum. Mol. Genet
, vol.23
, pp. 6081-6087
-
-
Kuiper, J.J.1
-
18
-
-
84936805563
-
Endoplasmic reticulum aminopeptidase 1 (ERAP1) polymorphism relevant to inflammatory disease shapes the peptidome of the birdshot chorioretinopathy-Associated HLA A29:02 antigen
-
Alvarez-Navarro, C., Martin-Esteban, A., Barnea, E., Admon, A., & Lopez de Castro, J. A. Endoplasmic reticulum aminopeptidase 1 (ERAP1) polymorphism relevant to inflammatory disease shapes the peptidome of the birdshot chorioretinopathy-Associated HLA A 29:02 antigen. Mol. Cell. Proteomics 14, 1770-1780 (2015).
-
(2015)
Mol. Cell. Proteomics
, vol.14
, pp. 1770-1780
-
-
Alvarez-Navarro, C.1
Martin-Esteban, A.2
Barnea, E.3
Admon, A.4
Lopez De Castro, J.A.5
-
19
-
-
82755168804
-
Colonic mucosa-Associated microbiota is influenced by an interaction of Crohn disease and FUT2 (Secretor) genotype
-
Rausch, P., et al. Colonic mucosa-Associated microbiota is influenced by an interaction of crohn disease and FUT2 (Secretor) genotype. Proc. Natl Acad. Sci. USA 108, 19030-19035 (2011).
-
(2011)
Proc. Natl Acad. Sci. USA
, vol.108
, pp. 19030-19035
-
-
Rausch, P.1
-
20
-
-
84923631805
-
Intestinal dysbiosis in ankylosing spondylitis
-
Costello, M. E., et al. Intestinal dysbiosis in ankylosing spondylitis. Arthritis Rheumatol. 67, 686-691 (2014).
-
(2014)
Arthritis Rheumatol
, vol.67
, pp. 686-691
-
-
Costello, M.E.1
-
21
-
-
84930526040
-
Private rare deletions in SEC16A and MAMDC4 may represent novel pathogenic variants in familial axial spondyloarthritis
-
O'Rielly, D. D., et al. Private rare deletions in SEC16A and MAMDC4 may represent novel pathogenic variants in familial axial spondyloarthritis. Ann. Rheum. Dis. 75, 772-779 (2015).
-
(2015)
Ann. Rheum. Dis
, vol.75
, pp. 772-779
-
-
O'Rielly, D.D.1
-
23
-
-
84896414737
-
Polymorphism of HLA B27: 105 subtypes currently known
-
Khan, M. A. Polymorphism of HLA B27: 105 subtypes currently known. Curr. Rheumatol. Rep. 15, 362 (2013).
-
(2013)
Curr. Rheumatol. Rep
, vol.15
, pp. 362
-
-
Khan, M.A.1
-
24
-
-
84928261726
-
Peptide handling by HLA B27 subtypes influences their biological behavior, association with ankylosing spondylitis and susceptibility to endoplasmic reticulum aminopeptidase 1 (ERAP1
-
Garcia-Medel, N., et al. Peptide handling by HLA B27 subtypes influences their biological behavior, association with ankylosing spondylitis and susceptibility to endoplasmic reticulum aminopeptidase 1 (ERAP1). Mol. Cell. Proteomics 13, 3367-3380 (2014).
-
(2014)
Mol Cell. Proteomics
, vol.13
, pp. 3367-3380
-
-
Garcia-Medel, N.1
-
25
-
-
84923611798
-
Revisiting the arthritogenic peptide theory: Quantitative not qualitative changes in the peptide repertoire of HLA B27 allotypes
-
Schittenhelm, R. B., Sian, T. C., Wilmann, P. G., Dudek, N. L., & Purcell, A. W. Revisiting the arthritogenic peptide theory: quantitative not qualitative changes in the peptide repertoire of HLA B27 allotypes. Arthritis Rheumatol. 67, 702-713 (2015).
-
(2015)
Arthritis Rheumatol
, vol.67
, pp. 702-713
-
-
Schittenhelm, R.B.1
Sian, T.C.2
Wilmann, P.G.3
Dudek, N.L.4
Purcell, A.W.5
-
26
-
-
84973293707
-
Human leukocyte antigen (HLA) B27 allotype-specific binding and candidate arthritogenic peptides revealed through heuristic clustering of data-independent acquisition mass spectrometry (DIA MS) data
-
Schittenhelm, R. B., Sivaneswaran, S., Lim Kam Sian, T. C., Croft, N. P., & Purcell, A. W. Human leukocyte antigen (HLA) B27 allotype-specific binding and candidate arthritogenic peptides revealed through heuristic clustering of data-independent acquisition mass spectrometry (DIA MS) data. Mol. Cell. Proteomics 15, 1867-1876 (2016).
-
(2016)
Mol. Cell. Proteomics
, vol.15
, pp. 1867-1876
-
-
Schittenhelm, R.B.1
Sivaneswaran, S.2
Lim Kam Sian, T.C.3
Croft, N.P.4
Purcell, A.W.5
-
27
-
-
0942277249
-
Dual HLA B27 subtype-dependent conformation of a self-peptide
-
Hulsmeyer, M., et al. Dual, HLA B27 subtype-dependent conformation of a self-peptide. J. Exp. Med. 199, 271-281 (2004).
-
(2004)
J. Exp. Med
, vol.199
, pp. 271-281
-
-
Hulsmeyer, M.1
-
28
-
-
84962291460
-
Non-conventional forms of HLA B27 are expressed in spondyloarthritis joints and gut tissue
-
Rysnik, O., et al. Non-conventional forms of HLA B27 are expressed in spondyloarthritis joints and gut tissue. J. Autoimmun. 70, 12-21 (2016).
-
(2016)
J. Autoimmun
, vol.70
, pp. 12-21
-
-
Rysnik, O.1
-
29
-
-
84983142918
-
Endoplasmic reticulum aminopeptidases in the pathogenesis of ankylosing spondylitis
-
Kenna, T. J., Robinson, P. C., & Haroon, N. Endoplasmic reticulum aminopeptidases in the pathogenesis of ankylosing spondylitis. Rheumatology (Oxford) 54, 1549-1556 (2015).
-
(2015)
Rheumatology (Oxford
, vol.54
, pp. 1549-1556
-
-
Kenna, T.J.1
Robinson, P.C.2
Haroon, N.3
-
30
-
-
0033136630
-
Cutting edge: HLA B27 can form a novel β2 microglobulin-free heavy chain homodimer structure
-
Allen, R. L., O'Callaghan, C. A., McMichael, A. J., & Bowness, P. Cutting edge: HLA B27 can form a novel β2 microglobulin-free heavy chain homodimer structure. J. Immunol. 162, 5045-5048 (1999).
-
(1999)
J. Immunol
, vol.162
, pp. 5045-5048
-
-
Allen, R.L.1
O'Callaghan, C.A.2
McMichael, A.J.3
Bowness, P.4
-
31
-
-
73249153202
-
From HLA B27 to spondyloarthritis: A journey through the ER
-
Colbert, R. A., DeLay, M. L., Klenk, E. I., & Layh- Schmitt, G. From HLA B27 to spondyloarthritis: a journey through the ER. Immunol. Rev. 233, 181-202 (2010).
-
(2010)
Immunol. Rev
, vol.233
, pp. 181-202
-
-
Colbert, R.A.1
DeLay, M.L.2
Klenk, E.I.3
Layh-Schmitt, G.4
-
32
-
-
84903907928
-
Evidence that autophagy, but not the unfolded protein response, regulates the expression of IL 23 in the gut of patients with ankylosing spondylitis and subclinical gut inflammation
-
Ciccia, F., et al. Evidence that autophagy, but not the unfolded protein response, regulates the expression of IL 23 in the gut of patients with ankylosing spondylitis and subclinical gut inflammation. Ann. Rheum. Dis. 73, 1566-1574 (2013).
-
(2013)
Ann. Rheum. Dis
, vol.73
, pp. 1566-1574
-
-
Ciccia, F.1
-
33
-
-
84893817150
-
No evidence for a critical role of the unfolded protein response in synovium and blood of patients with ankylosing spondylitis
-
Neerinckx, B., Carter, S., & Lories, R. J. No evidence for a critical role of the unfolded protein response in synovium and blood of patients with ankylosing spondylitis. Ann. Rheum. Dis. 73, 629-630 (2014).
-
(2014)
Ann. Rheum. Dis
, vol.73
, pp. 629-630
-
-
Neerinckx, B.1
Carter, S.2
Lories, R.J.3
-
34
-
-
84963644372
-
Autophagy in the pathogenesis of ankylosing spondylitis
-
Ciccia, F., & Haroon, N. Autophagy in the pathogenesis of ankylosing spondylitis. Clin. Rheumatol. 35, 1433-1436 (2016).
-
(2016)
Clin. Rheumatol
, vol.35
, pp. 1433-1436
-
-
Ciccia, F.1
Haroon, N.2
-
35
-
-
84907684896
-
IL 23 expression and activation of autophagy in synovium and PBMCs of HLA B27 positive patients with ankylosing spondylitis Response to: Evidence that autophagy
-
but not the unfolded protein response, regulates the expression of IL 23 in the gut of patients with ankylosing spondylitis and subclinical gut inflammation? by Ciccia, et al
-
Neerinckx, B., Carter, S., & Lories, R. IL 23 expression and activation of autophagy in synovium and PBMCs of HLA B27 positive patients with ankylosing spondylitis. Response to: ?Evidence that autophagy, but not the unfolded protein response, regulates the expression of IL 23 in the gut of patients with ankylosing spondylitis and subclinical gut inflammation? by Ciccia, et al. Ann. Rheum. Dis. 73, e68 (2014).
-
(2014)
Ann. Rheum. Dis
, vol.73
, pp. e68
-
-
Neerinckx, B.1
Carter, S.2
Lories, R.3
-
36
-
-
84938408657
-
Endoplasmic reticulum degradation-enhancing α-mannosidase-like protein 1 targets misfolded HLA B27 dimers for endoplasmic reticulum-Associated degradation
-
Guiliano, D. B., et al. Endoplasmic reticulum degradation-enhancing α-mannosidase-like protein 1 targets misfolded HLA B27 dimers for endoplasmic reticulum-Associated degradation. Arthritis Rheumatol. 66, 2976-2988 (2014).
-
(2014)
Arthritis Rheumatol
, vol.66
, pp. 2976-2988
-
-
Guiliano, D.B.1
-
37
-
-
79951835541
-
Th17 cells expressing KIR3DL2+ and responsive to HLA B27 homodimers are increased in ankylosing spondylitis
-
Bowness, P., et al. Th17 cells expressing KIR3DL2+ and responsive to HLA B27 homodimers are increased in ankylosing spondylitis. J. Immunol. 186, 2672-2680 (2011).
-
(2011)
J. Immunol
, vol.186
, pp. 2672-2680
-
-
Bowness, P.1
-
38
-
-
84940865827
-
KIR3DL1 interaction with HLA B27 is altered by ankylosing spondylitis associated ERAP1 and enhanced by MHC class i cross-linking
-
Abdullah, H., Zhang, Z., Yee, K., & Haroon, N. KIR3DL1 interaction with HLA B27 is altered by ankylosing spondylitis associated ERAP1 and enhanced by MHC class I cross-linking. Discov. Med. 20, 79-89 (2015).
-
(2015)
Discov. Med
, vol.20
, pp. 79-89
-
-
Abdullah, H.1
Zhang, Z.2
Yee, K.3
Haroon, N.4
-
39
-
-
84962046002
-
Activation-induced killer cell immunoglobulin-like receptor 3DL2 binding to HLA B27 licenses pathogenic T cell differentiation in spondyloarthritis
-
Ridley, A., et al. Activation-induced killer cell immunoglobulin-like receptor 3DL2 binding to HLA B27 licenses pathogenic T cell differentiation in spondyloarthritis. Arthritis Rheumatol. 68, 901-914 (2016).
-
(2016)
Arthritis Rheumatol
, vol.68
, pp. 901-914
-
-
Ridley, A.1
-
40
-
-
22144442460
-
Concerted peptide trimming by human ERAP1 and ERAP2 aminopeptidase complexes in the endoplasmic reticulum
-
Saveanu, L., et al. Concerted peptide trimming by human ERAP1 and ERAP2 aminopeptidase complexes in the endoplasmic reticulum. Nat. Immunol. 6, 689-697 (2005).
-
(2005)
Nat. Immunol
, vol.6
, pp. 689-697
-
-
Saveanu, L.1
-
41
-
-
28044456942
-
The ER aminopeptidase ERAP1 trims precursors to lengths of MHC class i peptides by a "molecular ruler" mechanism
-
Chang, S. C., Momburg, F., Bhutani, N., & Goldberg, A. L. The ER aminopeptidase, ERAP1, trims precursors to lengths of MHC class I peptides by a "molecular ruler" mechanism. Proc. Natl Acad. Sci. USA 102, 17107-17112 (2005).
-
(2005)
Proc. Natl Acad. Sci. USA
, vol.102
, pp. 17107-17112
-
-
Chang, S.C.1
Momburg, F.2
Bhutani, N.3
Goldberg, A.L.4
-
42
-
-
0036902105
-
An IFN-γ-induced aminopeptidase in the ER, ERAP1, trims precursors to MHC class i presented peptides
-
Saric, T., et al. An IFN-γ-induced aminopeptidase in the ER, ERAP1, trims precursors to MHC class I presented peptides. Nat. Immunol. 3, 1169-1176 (2002).
-
(2002)
Nat. Immunol
, vol.3
, pp. 1169-1176
-
-
Saric, T.1
-
43
-
-
79956348710
-
Crystal structures of the endoplasmic reticulum aminopeptidase 1 (ERAP1) reveal the molecular basis for N terminal peptide trimming
-
Kochan, G., et al. Crystal structures of the endoplasmic reticulum aminopeptidase 1 (ERAP1) reveal the molecular basis for N terminal peptide trimming. Proc. Natl Acad. Sci. USA 108, 7745-7750 (2011).
-
(2011)
Proc. Natl Acad. Sci. USA
, vol.108
, pp. 7745-7750
-
-
Kochan, G.1
-
44
-
-
84963591436
-
Silencing or inhibition of endoplasmic reticulum aminopeptidase 1 (ERAP1) suppresses free heavy chain expression and Th17 responses in ankylosing spondylitis
-
Chen, L., et al. Silencing or inhibition of endoplasmic reticulum aminopeptidase 1 (ERAP1) suppresses free heavy chain expression and Th17 responses in ankylosing spondylitis. Ann. Rheum. Dis. 75, 916-923 (2016).
-
(2016)
Ann. Rheum. Dis
, vol.75
, pp. 916-923
-
-
Chen, L.1
-
45
-
-
79951817611
-
Coding single nucleotide polymorphisms of endoplasmic reticulum aminopeptidase 1 can affect antigenic peptide generation in vitro by influencing basic enzymatic properties of the enzyme
-
Evnouchidou, I., et al. Coding single nucleotide polymorphisms of endoplasmic reticulum aminopeptidase 1 can affect antigenic peptide generation in vitro by influencing basic enzymatic properties of the enzyme. J. Immunol. 186, 1909-1913 (2011).
-
(2011)
J. Immunol
, vol.186
, pp. 1909-1913
-
-
Evnouchidou, I.1
-
46
-
-
84916890237
-
Functionally distinct ERAP1 allotype combinations distinguish individuals with ankylosing spondylitis
-
Reeves, E., Colebatch-Bourn, A., Elliott, T., Edwards, C. J., & James, E. Functionally distinct ERAP1 allotype combinations distinguish individuals with ankylosing spondylitis. Proc. Natl Acad. Sci. USA 111, 17594-17599 (2014).
-
(2014)
Proc. Natl Acad. Sci. USA
, vol.111
, pp. 17594-17599
-
-
Reeves, E.1
Colebatch-Bourn, A.2
Elliott, T.3
Edwards, C.J.4
James, E.5
-
47
-
-
84857924158
-
Endoplasmic reticulum aminopeptidase 1 (ERAP1) exhibits functionally significant interaction with HLA B27 and relates to subtype specificity in ankylosing spondylitis
-
Haroon, N., Tsui, F. W., Uchanska-Ziegler, B., Ziegler, A., & Inman, R. D. Endoplasmic reticulum aminopeptidase 1 (ERAP1) exhibits functionally significant interaction with HLA B27 and relates to subtype specificity in ankylosing spondylitis. Ann. Rheum. Dis. 71, 589-595 (2012).
-
(2012)
Ann. Rheum. Dis
, vol.71
, pp. 589-595
-
-
Haroon, N.1
Tsui, F.W.2
Uchanska-Ziegler, B.3
Ziegler, A.4
Inman, R.D.5
-
48
-
-
84869219870
-
Functional interaction of the ankylosing spondylitis-Associated endoplasmic reticulum aminopeptidase 1 polymorphism and HLA B27 in vivo
-
Garcia-Medel, N., et al. Functional interaction of the ankylosing spondylitis-Associated endoplasmic reticulum aminopeptidase 1 polymorphism and HLA B27 in vivo. Mol. Cell. Proteomics 11, 1416-1429 (2012).
-
(2012)
Mol. Cell. Proteomics
, vol.11
, pp. 1416-1429
-
-
Garcia-Medel, N.1
-
49
-
-
84902180272
-
HLA B27, but not HLA B7, immunodominance to influenza is ERAP dependent
-
Akram, A., Lin, A., Gracey, E., Streutker, C. J., & Inman, R. D. HLA B27, but not HLA B7, immunodominance to influenza is ERAP dependent. J. Immunol. 192, 5520-5528 (2014).
-
(2014)
J. Immunol
, vol.192
, pp. 5520-5528
-
-
Akram, A.1
Lin, A.2
Gracey, E.3
Streutker, C.J.4
Inman, R.D.5
-
50
-
-
84963864972
-
ERAP1 reduces accumulation of aberrant and disulfide-linked forms of HLA B27 on the cell surface
-
Tran, T. M., Hong, S., Edwan, J. H., & Colbert, R. A. ERAP1 reduces accumulation of aberrant and disulfide-linked forms of HLA B27 on the cell surface. Mol. Immunol. 74, 10-17 (2016).
-
(2016)
Mol. Immunol
, vol.74
, pp. 10-17
-
-
Tran, T.M.1
Hong, S.2
Edwan, J.H.3
Colbert, R.A.4
-
51
-
-
84921561531
-
Disease-Associated polymorphisms in ERAP1 do not alter endoplasmic reticulum stress in patients with ankylosing spondylitis
-
Kenna, T. J., et al. Disease-Associated polymorphisms in ERAP1 do not alter endoplasmic reticulum stress in patients with ankylosing spondylitis. Genes Immun. 16, 35-42 (2014).
-
(2014)
Genes Immun
, vol.16
, pp. 35-42
-
-
Kenna, T.J.1
-
52
-
-
77950331522
-
Association of an ERAP1 ERAP2 haplotype with familial ankylosing spondylitis
-
Tsui, F. W., et al. Association of an ERAP1 ERAP2 haplotype with familial ankylosing spondylitis. Ann. Rheum. Dis. 69, 733-736 (2010).
-
(2010)
Ann. Rheum. Dis
, vol.69
, pp. 733-736
-
-
Tsui, F.W.1
-
53
-
-
84904256267
-
ERAP1-ERAP2 dimerization increases peptide-Trimming efficiency
-
Evnouchidou, I., Weimershaus, M., Saveanu, L., & van Endert, P. ERAP1-ERAP2 dimerization increases peptide-Trimming efficiency. J. Immunol. 193, 901-908 (2014).
-
(2014)
J. Immunol
, vol.193
, pp. 901-908
-
-
Evnouchidou, I.1
Weimershaus, M.2
Saveanu, L.3
Van Endert, P.4
-
54
-
-
84945189744
-
ERAP2 functional knockout in humans does not alter surface heavy chains or HLA B27, inflammatory cytokines or endoplasmic reticulum stress markers
-
Robinson, P. C., et al. ERAP2 functional knockout in humans does not alter surface heavy chains or HLA B27, inflammatory cytokines or endoplasmic reticulum stress markers. Ann. Rheum. Dis. 74, 2092-2095 (2015).
-
(2015)
Ann. Rheum. Dis
, vol.74
, pp. 2092-2095
-
-
Robinson, P.C.1
-
55
-
-
84981323904
-
Functional interaction of the ankylosing spondylitis associated endoplasmic reticulum aminopeptidase 2 with the HLA B27 peptidome in human cells
-
Martin-Esteban, A., Guasp, P., Barnea, E., Admon, A., & Lopez de Castro, J. A. Functional interaction of the ankylosing spondylitis associated endoplasmic reticulum aminopeptidase 2 with the HLA B27 peptidome in human cells. Arthritis Rheumatol. 68, 2466-2475 (2016).
-
(2016)
Arthritis Rheumatol
, vol.68
, pp. 2466-2475
-
-
Martin-Esteban, A.1
Guasp, P.2
Barnea, E.3
Admon, A.4
Lopez De Castro, J.A.5
-
56
-
-
34248178540
-
Serum IL 17 BMP 7, and bone turnover markers in patients with ankylosing spondylitis
-
Wendling, D., Cedoz, J. P., Racadot, E., & Dumoulin, G. Serum IL 17, BMP 7, and bone turnover markers in patients with ankylosing spondylitis. Joint Bone Spine 74, 304-305 (2007).
-
(2007)
Joint Bone Spine
, vol.74
, pp. 304-305
-
-
Wendling, D.1
Cedoz, J.P.2
Racadot, E.3
Dumoulin, G.4
-
57
-
-
79954450170
-
Increased serum IL 17 and IL 23 in the patient with ankylosing spondylitis
-
Mei, Y., et al. Increased serum IL 17 and IL 23 in the patient with ankylosing spondylitis. Clin. Rheumatol. 30, 269-273 (2011).
-
(2011)
Clin. Rheumatol
, vol.30
, pp. 269-273
-
-
Mei, Y.1
-
58
-
-
66449133523
-
Frequency and phenotype of peripheral blood Th17 cells in ankylosing spondylitis and rheumatoid arthritis
-
Shen, H., Goodall, J. C., & Hill Gaston, J. S. Frequency and phenotype of peripheral blood Th17 cells in ankylosing spondylitis and rheumatoid arthritis. Arthritis Rheum. 60, 1647-1656 (2009).
-
(2009)
Arthritis Rheum
, vol.60
, pp. 1647-1656
-
-
Shen, H.1
Goodall, J.C.2
Hill, G.J.S.3
-
59
-
-
84855254473
-
Proinflammatory Th17 cells are expanded and induced by dendritic cells in spondylarthritis-prone HLA B27 transgenic rats
-
Glatigny, S., et al. Proinflammatory Th17 cells are expanded and induced by dendritic cells in spondylarthritis-prone HLA B27 transgenic rats. Arthritis Rheum. 64, 110-120 (2012).
-
(2012)
Arthritis Rheum
, vol.64
, pp. 110-120
-
-
Glatigny, S.1
-
60
-
-
84903473100
-
Interleukin 23 mediates the intestinal response to microbial β 1, 3 glucan and the development of spondyloarthritis pathology in SKG mice
-
Benham, H., et al. Interleukin 23 mediates the intestinal response to microbial β 1, 3 glucan and the development of spondyloarthritis pathology in SKG mice. Arthritis Rheumatol. 66, 1755-1767 (2014).
-
(2014)
Arthritis Rheumatol
, vol.66
, pp. 1755-1767
-
-
Benham, H.1
-
61
-
-
84963827869
-
Sexual dimorphism in the Th17 signature of ankylosing spondylitis
-
Gracey, E., et al. Sexual dimorphism in the Th17 signature of ankylosing spondylitis. Arthritis Rheumatol. 68, 679-689 (2016).
-
(2016)
Arthritis Rheumatol
, vol.68
, pp. 679-689
-
-
Gracey, E.1
-
62
-
-
84896285523
-
Review: The interleukin 23/interleukin 17 axis in spondyloarthritis pathogenesis: Th17 and beyond
-
Smith, J. A., & Colbert, R. A. Review: the interleukin 23/interleukin 17 axis in spondyloarthritis pathogenesis: Th17 and beyond. Arthritis Rheumatol. 66, 231-241 (2014).
-
(2014)
Arthritis Rheumatol
, vol.66
, pp. 231-241
-
-
Smith, J.A.1
Colbert, R.A.2
-
63
-
-
84966373489
-
Genetic association of ankylosing spondylitis with TBX21 influences T bet and pro-inflammatory cytokine expression in humans and SKG mice as a model of spondyloarthritis
-
Lau, M. C., et al. Genetic association of ankylosing spondylitis with TBX21 influences T bet and pro-inflammatory cytokine expression in humans and SKG mice as a model of spondyloarthritis. Ann. Rheum. Dis. 76, 261-269 (2016).
-
(2016)
Ann. Rheum. Dis
, vol.76
, pp. 261-269
-
-
Lau, M.C.1
-
64
-
-
84969921427
-
T bet is a key modulator of IL 23 driven pathogenic CD4+ T cell responses in the intestine
-
Krausgruber, T., et al. T bet is a key modulator of IL 23 driven pathogenic CD4+ T cell responses in the intestine. Nat. Commun. 7, 11627 (2016).
-
(2016)
Nat. Commun
, vol.7
, pp. 11627
-
-
Krausgruber, T.1
-
65
-
-
84974536519
-
Tissue adaptation of regulatory and intraepithelial CD4+ T cells controls gut inflammation
-
Sujino, T., et al. Tissue adaptation of regulatory and intraepithelial CD4+ T cells controls gut inflammation. Science 352, 1581-1586 (2016).
-
(2016)
Science
, vol.352
, pp. 1581-1586
-
-
Sujino, T.1
-
66
-
-
84973401210
-
IL 7 primes IL 17 in mucosal-Associated invariant T (MAIT) cells, which contribute to the Th17 axis in ankylosing spondylitis
-
Gracey, E., et al. IL 7 primes IL 17 in mucosal-Associated invariant T (MAIT) cells, which contribute to the Th17 axis in ankylosing spondylitis. Ann. Rheum. Dis. 75, 2124-2132 (2016).
-
(2016)
Ann. Rheum. Dis
, vol.75
, pp. 2124-2132
-
-
Gracey, E.1
-
67
-
-
84984941773
-
Involvement of mucosal-Associated invariant T cells in ankylosing spondylitis
-
Hayashi, E., et al. Involvement of mucosal-Associated invariant T cells in ankylosing spondylitis. J. Rheumatol. 43, 1695-1703 (2016).
-
(2016)
J. Rheumatol
, vol.43
, pp. 1695-1703
-
-
Hayashi, E.1
-
68
-
-
84942122568
-
Type 3 innate lymphoid cells producing IL 17 and IL 22 are expanded in the gut, in the peripheral blood, synovial fluid and bone marrow of patients with ankylosing spondylitis
-
Ciccia, F., et al. Type 3 innate lymphoid cells producing IL 17 and IL 22 are expanded in the gut, in the peripheral blood, synovial fluid and bone marrow of patients with ankylosing spondylitis. Ann. Rheum. Dis. 74, 1739-1747 (2015).
-
(2015)
Ann. Rheum. Dis
, vol.74
, pp. 1739-1747
-
-
Ciccia, F.1
-
69
-
-
55849134446
-
Identification of interleukin 7 as a candidate disease mediator in spondylarthritis
-
Rihl, M., et al. Identification of interleukin 7 as a candidate disease mediator in spondylarthritis. Arthritis Rheum. 58, 3430-3435 (2008).
-
(2008)
Arthritis Rheum
, vol.58
, pp. 3430-3435
-
-
Rihl, M.1
-
70
-
-
84858644639
-
Enrichment of circulating interleukin- 17 secreting interleukin 23 receptor-positive γ/d T cells in patients with active ankylosing spondylitis
-
Kenna, T. J., et al. Enrichment of circulating interleukin- 17 secreting interleukin 23 receptor-positive γ/d T cells in patients with active ankylosing spondylitis. Arthritis Rheum. 64, 1420-1429 (2012).
-
(2012)
Arthritis Rheum
, vol.64
, pp. 1420-1429
-
-
Kenna, T.J.1
-
71
-
-
84863697312
-
IL 23 induces spondyloarthropathy by acting on ROR-γt+ CD3+CD4-CD8- entheseal resident T cells
-
Sherlock, J. P., et al. IL 23 induces spondyloarthropathy by acting on ROR-γt+ CD3+CD4-CD8- entheseal resident T cells. Nat. Med. 18, 1069-1076 (2012).
-
(2012)
Nat. Med
, vol.18
, pp. 1069-1076
-
-
Sherlock, J.P.1
-
72
-
-
84988844036
-
IL 23 dependent γ/ T cells produce IL 17 and accumulate in en thesis, aortic valve, and ciliary body
-
Reinhardt, A., et al. IL 23 dependent γ/ T cells produce IL 17 and accumulate in enthesis, aortic valve, and ciliary body. Arthritis Rheumatol. 68, 2476-2486 (2016).
-
(2016)
Arthritis Rheumatol
, vol.68
, pp. 2476-2486
-
-
Reinhardt, A.1
-
73
-
-
84961714917
-
IL 17 producing γ T cells enhance bone regeneration
-
Ono, T., et al. IL 17 producing γ T cells enhance bone regeneration. Nat. Commun. 7, 10928 (2016).
-
(2016)
Nat. Commun
, vol.7
, pp. 10928
-
-
Ono, T.1
-
74
-
-
70349564251
-
The enthesis organ concept and its relevance to the spondyloarthropathies
-
Benjamin, M., & McGonagle, D. The enthesis organ concept and its relevance to the spondyloarthropathies. Adv. Exp. Med. Biol. 649, 57-70 (2009).
-
(2009)
Adv. Exp. Med. Biol
, vol.649
, pp. 57-70
-
-
Benjamin, M.1
McGonagle, D.2
-
75
-
-
34547805510
-
The concept of a "synovio-entheseal complex" and its implications for understanding joint inflammation and damage in psoriatic arthritis and beyond
-
McGonagle, D., Lories, R. J., Tan, A. L., & Benjamin, M. The concept of a "synovio-entheseal complex" and its implications for understanding joint inflammation and damage in psoriatic arthritis and beyond. Arthritis Rheum. 56, 2482-2491 (2007).
-
(2007)
Arthritis Rheum
, vol.56
, pp. 2482-2491
-
-
McGonagle, D.1
Lories, R.J.2
Tan, A.L.3
Benjamin, M.4
-
76
-
-
84891747499
-
Proof of concept: Enthesitis and new bone formation in spondyloarthritis are driven by mechanical strain and stromal cells
-
Jacques, P., et al. Proof of concept: enthesitis and new bone formation in spondyloarthritis are driven by mechanical strain and stromal cells. Ann. Rheum. Dis. 73, 437-445 (2014).
-
(2014)
Ann. Rheum. Dis
, vol.73
, pp. 437-445
-
-
Jacques, P.1
-
77
-
-
84861796578
-
Interleukin 22 and interleukin- 22 producing NKp44+ natural killer cells in subclinical gut inflammation in ankylosing spondylitis
-
Ciccia, F., et al. Interleukin 22 and interleukin- 22 producing NKp44+ natural killer cells in subclinical gut inflammation in ankylosing spondylitis. Arthritis Rheum. 64, 1869-1878 (2012).
-
(2012)
Arthritis Rheum
, vol.64
, pp. 1869-1878
-
-
Ciccia, F.1
-
78
-
-
84930663466
-
Immune tolerance Group 3 innate lymphoid cells mediate intestinal selection of commensal bacteria-specific CD4+ T cells
-
Hepworth, M. R., et al. Immune tolerance. Group 3 innate lymphoid cells mediate intestinal selection of commensal bacteria-specific CD4+ T cells. Science 348, 1031-1035 (2015).
-
(2015)
Science
, vol.348
, pp. 1031-1035
-
-
Hepworth, M.R.1
-
79
-
-
84944675546
-
Interleukin-23 independent IL 17 production regulates intestinal epithelial permeability
-
Lee, J. S., et al. Interleukin-23 independent IL 17 production regulates intestinal epithelial permeability. Immunity 43, 727-738 (2015).
-
(2015)
Immunity
, vol.43
, pp. 727-738
-
-
Lee, J.S.1
-
80
-
-
84866532132
-
Induction and molecular signature of pathogenic TH17 cells
-
Lee, Y., et al. Induction and molecular signature of pathogenic TH17 cells. Nat. Immunol. 13, 991-999 (2012).
-
(2012)
Nat. Immunol
, vol.13
, pp. 991-999
-
-
Lee, Y.1
-
81
-
-
84873635866
-
Th17 cell development: From the cradle to the grave
-
Zuniga, L. A., Jain, R., Haines, C., & Cua, D. J. Th17 cell development: from the cradle to the grave. Immunol. Rev. 252, 78-88 (2013).
-
(2013)
Immunol. Rev
, vol.252
, pp. 78-88
-
-
Zuniga, L.A.1
Jain, R.2
Haines, C.3
Cua, D.J.4
-
82
-
-
33646577466
-
Reciprocal developmental pathways for the generation of pathogenic effector TH17 and regulatory T cells
-
Bettelli, E., et al. Reciprocal developmental pathways for the generation of pathogenic effector TH17 and regulatory T cells. Nature 441, 235-238 (2006).
-
(2006)
Nature
, vol.441
, pp. 235-238
-
-
Bettelli, E.1
-
83
-
-
33646560950
-
Transforming growth factor-β induces development of the TH17 lineage
-
Mangan, P. R., et al. Transforming growth factor-β induces development of the TH17 lineage. Nature 441, 231-234 (2006).
-
(2006)
Nature
, vol.441
, pp. 231-234
-
-
Mangan, P.R.1
-
84
-
-
77958584113
-
Generation of pathogenic TH17 cells in the absence of TGF-β signalling
-
Ghoreschi, K., et al. Generation of pathogenic TH17 cells in the absence of TGF-β signalling. Nature 467, 967-971 (2010).
-
(2010)
Nature
, vol.467
, pp. 967-971
-
-
Ghoreschi, K.1
-
85
-
-
84929955331
-
TH17 cells transdifferentiate into regulatory T cells during resolution of inflammation
-
Gagliani, N., et al. TH17 cells transdifferentiate into regulatory T cells during resolution of inflammation. Nature 523, 221-225 (2015).
-
(2015)
Nature
, vol.523
, pp. 221-225
-
-
Gagliani, N.1
-
86
-
-
84940077758
-
Mucosal immunology Individual intestinal symbionts induce a distinct population of RORγ+ regulatory T cells
-
Sefik, E., et al. Mucosal immunology. Individual intestinal symbionts induce a distinct population of RORγ+ regulatory T cells. Science 349, 993-997 (2015).
-
(2015)
Science
, vol.349
, pp. 993-997
-
-
Sefik, E.1
-
87
-
-
84940547063
-
Mucosal immunology the microbiota regulates type 2 immunity through RORγ+ T cells
-
Ohnmacht, C., et al. Mucosal immunology. The microbiota regulates type 2 immunity through RORγ+ T cells. Science 349, 989-993 (2015).
-
(2015)
Science
, vol.349
, pp. 989-993
-
-
Ohnmacht, C.1
-
88
-
-
84944682316
-
Differential roles for interleukin 23 and interleukin 17 in intestinal immunoregulation
-
Maxwell, J. R., et al. Differential roles for interleukin 23 and interleukin 17 in intestinal immunoregulation. Immunity 43, 739-750 (2015).
-
(2015)
Immunity
, vol.43
, pp. 739-750
-
-
Maxwell, J.R.1
-
89
-
-
84958916856
-
Interleukin-23 induced transcription factor Blimp 1 promotes pathogenicity of T helper 17 cells
-
Jain, R., et al. Interleukin-23 induced transcription factor Blimp 1 promotes pathogenicity of T helper 17 cells. Immunity 44, 131-142 (2016).
-
(2016)
Immunity
, vol.44
, pp. 131-142
-
-
Jain, R.1
-
90
-
-
84880617946
-
Association between variants of PRDM1 and NDP52 and Crohn?s disease, based on exome sequencing and functional studies
-
Ellinghaus, D., et al. Association between variants of PRDM1 and NDP52 and Crohn?s disease, based on exome sequencing and functional studies. Gastroenterology 145, 339-347 (2013).
-
(2013)
Gastroenterology
, vol.145
, pp. 339-347
-
-
Ellinghaus, D.1
-
91
-
-
0035150659
-
Immunomodulatory effects of anti-Tumor necrosis factor alpha therapy on synovium in spondylarthropathy: Histologic findings in eight patients from an open-label pilot study
-
Baeten, D., et al. Immunomodulatory effects of anti-Tumor necrosis factor alpha therapy on synovium in spondylarthropathy: histologic findings in eight patients from an open-label pilot study. Arthritis Rheum. 44, 186-195 (2001).
-
(2001)
Arthritis Rheum
, vol.44
, pp. 186-195
-
-
Baeten, D.1
-
92
-
-
73449131201
-
From gene expression to serum proteins: Biomarker discovery in ankylosing spondylitis
-
Haroon, N., et al. From gene expression to serum proteins: biomarker discovery in ankylosing spondylitis. Ann. Rheum. Dis. 69, 297-300 (2008).
-
(2008)
Ann. Rheum. Dis
, vol.69
, pp. 297-300
-
-
Haroon, N.1
-
93
-
-
84959108673
-
IL 23/Th17 axis is not influenced by TNF-blocking agents in ankylosing spondylitis patients
-
Milanez, F. M., et al. IL 23/Th17 axis is not influenced by TNF-blocking agents in ankylosing spondylitis patients. Arthritis Res. Ther. 18, 52 (2016).
-
(2016)
Arthritis Res. Ther
, vol.18
, pp. 52
-
-
Milanez, F.M.1
-
94
-
-
84893850913
-
TNF-Alpha blockade induces IL 10 expression in human CD4+ T cells
-
Evans, H. G., et al. TNF-Alpha blockade induces IL 10 expression in human CD4+ T cells. Nat. Commun. 5, 3199 (2014).
-
(2014)
Nat. Commun
, vol.5
, pp. 3199
-
-
Evans, H.G.1
-
95
-
-
84889684742
-
Assessment of short-Term symptomatic efficacy of tocilizumab in ankylosing spondylitis: Results of randomised, placebo-controlled trials
-
Sieper, J., Porter-Brown, B., Thompson, L., Harari, O., & Dougados, M. Assessment of short-Term symptomatic efficacy of tocilizumab in ankylosing spondylitis: results of randomised, placebo-controlled trials. Ann. Rheum. Dis. 73, 95-100 (2014).
-
(2014)
Ann. Rheum. Dis
, vol.73
, pp. 95-100
-
-
Sieper, J.1
Porter-Brown, B.2
Thompson, L.3
Harari, O.4
Dougados, M.5
-
96
-
-
84934900296
-
Sarilumab for the treatment of ankylosing spondylitis: Results of a phase II, randomized, double-blind, placebo-controlled, international study (ALIGN
-
Sieper, J., et al. Sarilumab for the treatment of ankylosing spondylitis: results of a phase II, randomized, double-blind, placebo-controlled, international study (ALIGN). Ann. Rheum. Dis. 74, 1051-1057 (2015).
-
(2015)
Ann. Rheum. Dis
, vol.74
, pp. 1051-1057
-
-
Sieper, J.1
-
97
-
-
34548133583
-
Development, cytokine profile and function of human interleukin 17 producing helper T cells
-
Wilson, N. J., et al. Development, cytokine profile and function of human interleukin 17 producing helper T cells. Nat. Immunol. 8, 950-957 (2007).
-
(2007)
Nat. Immunol
, vol.8
, pp. 950-957
-
-
Wilson, N.J.1
-
98
-
-
84897980960
-
Ustekinumab for the treatment of patients with active ankylosing spondylitis: Results of a 28 week, prospective, open-label, proof of concept study (TOPAS
-
Poddubnyy, D., Hermann, K. G., Callhoff, J., Listing, J., & Sieper, J. Ustekinumab for the treatment of patients with active ankylosing spondylitis: results of a 28 week, prospective, open-label, proof of concept study (TOPAS). Ann. Rheum. Dis. 73, 817-823 (2014).
-
(2014)
Ann. Rheum. Dis
, vol.73
, pp. 817-823
-
-
Poddubnyy, D.1
Hermann, K.G.2
Callhoff, J.3
Listing, J.4
Sieper, J.5
-
99
-
-
67349127266
-
Prostaglandin E2-EP4 signaling promotes immune inflammation through TH1 cell differentiation and TH17 cell expansion
-
Yao, C., et al. Prostaglandin E2-EP4 signaling promotes immune inflammation through TH1 cell differentiation and TH17 cell expansion. Nat. Med. 15, 633-640 (2009).
-
(2009)
Nat. Med
, vol.15
, pp. 633-640
-
-
Yao, C.1
-
100
-
-
84958087613
-
Transient inhibition of ROR-γt therapeutically limits intestinal inflammation by reducing TH17 cells and preserving group 3 innate lymphoid cells
-
Withers, D. R., et al. Transient inhibition of ROR-γt therapeutically limits intestinal inflammation by reducing TH17 cells and preserving group 3 innate lymphoid cells. Nat. Med. 22, 319-323 (2016).
-
(2016)
Nat. Med
, vol.22
, pp. 319-323
-
-
Withers, D.R.1
-
101
-
-
84973523411
-
RORγt inhibitors suppress TH17 responses in inflammatory arthritis and inflammatory bowel disease
-
de Wit, J., et al. RORγt inhibitors suppress TH17 responses in inflammatory arthritis and inflammatory bowel disease. J. Allergy Clin. Immunol. 137, 960-963 (2016).
-
(2016)
J. Allergy Clin. Immunol
, vol.137
, pp. 960-963
-
-
De Wit, J.1
-
102
-
-
84868680312
-
Secukinumab, a human anti IL 17A monoclonal antibody, for moderate to severe Crohn?s disease: Unexpected results of a randomised, double-blind placebo-controlled trial
-
Hueber, W., et al. Secukinumab, a human anti IL 17A monoclonal antibody, for moderate to severe Crohn?s disease: unexpected results of a randomised, double-blind placebo-controlled trial. Gut 61, 1693-1700 (2012).
-
(2012)
Gut
, vol.61
, pp. 1693-1700
-
-
Hueber, W.1
-
103
-
-
84996504880
-
OP0113 No increased incidence of inflammatory bowel disease among secukinumab-Treated patients with moderate to severe psoriasis, psoriatic arthritis, or ankylosing spondylitis: Data from 14 phase 2 and phase 3 clinical studies [abstract
-
Suppl
-
Schreiber, S., et al. OP0113 No increased incidence of inflammatory bowel disease among secukinumab-Treated patients with moderate to severe psoriasis, psoriatic arthritis, or ankylosing spondylitis: data from 14 phase 2 and phase 3 clinical studies [abstract]. Ann. Rheum. Dis. 75 (Suppl.), 97-98 (2016).
-
(2016)
Ann Rheum. Dis
, vol.75
, pp. 97-98
-
-
Schreiber, S.1
-
104
-
-
84965050718
-
The interaction between host genetics and the microbiome in the pathogenesis of spondyloarthropathies
-
Asquith, M., & Rosenbaum, J. T. The interaction between host genetics and the microbiome in the pathogenesis of spondyloarthropathies. Curr. Opin. Rheumatol. 28, 405-412 (2016).
-
(2016)
Curr. Opin. Rheumatol
, vol.28
, pp. 405-412
-
-
Asquith, M.1
Rosenbaum, J.T.2
-
105
-
-
84974794919
-
How the microbiota shapes rheumatic diseases
-
Van de Wiele, T., Van Praet, J. T., Marzorati, M., Drennan, M. B., & Elewaut, D. How the microbiota shapes rheumatic diseases. Nat. Rev. Rheumatol. 12, 398-411 (2016).
-
(2016)
Nat. Rev. Rheumatol
, vol.12
, pp. 398-411
-
-
Van De Wiele, T.1
Van Praet, J.T.2
Marzorati, M.3
Drennan, M.B.4
Elewaut, D.5
-
106
-
-
85003546086
-
Dialister as microbial marker of disease activity in spondyloarthritis
-
Tito, R. Y., et al. Dialister as microbial marker of disease activity in spondyloarthritis. Arthritis Rheumatol. 69, 114-121 (2016).
-
(2016)
Arthritis Rheumatol
, vol.69
, pp. 114-121
-
-
Tito, R.Y.1
-
107
-
-
84920951756
-
HLA B27 and human β2 microglobulin affect the gut microbiota of transgenic rats
-
Lin, P., et al. HLA B27 and human β2 microglobulin affect the gut microbiota of transgenic rats. PLoS ONE 9, e105684 (2014).
-
(2014)
PLoS ONE
, vol.9
, pp. e105684
-
-
Lin, P.1
-
108
-
-
84908374585
-
ZAP 70 genotype disrupts the relationship between microbiota and host, leading to spondyloarthritis and ileitis in SKG mice
-
Rehaume, L. M., et al. ZAP 70 genotype disrupts the relationship between microbiota and host, leading to spondyloarthritis and ileitis in SKG mice. Arthritis Rheumatol. 66, 2780-2792 (2014).
-
(2014)
Arthritis Rheumatol
, vol.66
, pp. 2780-2792
-
-
Rehaume, L.M.1
-
109
-
-
0028003794
-
The germfree state prevents development of gut and joint inflammatory disease in HLA B27 transgenic rats
-
Taurog, J. D., et al. The germfree state prevents development of gut and joint inflammatory disease in HLA B27 transgenic rats. J. Exp. Med. 180, 2359-2364 (1994).
-
(1994)
J. Exp. Med
, vol.180
, pp. 2359-2364
-
-
Taurog, J.D.1
-
110
-
-
84929878759
-
High chlamydia burden promotes tumor necrosis factor-dependent reactive arthritis in SKG mice
-
Baillet, A. C., et al. High chlamydia burden promotes tumor necrosis factor-dependent reactive arthritis in SKG mice. Arthritis Rheumatol. 67, 1535-1547 (2015).
-
(2015)
Arthritis Rheumatol
, vol.67
, pp. 1535-1547
-
-
Baillet, A.C.1
-
111
-
-
84858664948
-
Β -glucan triggers spondylarthritis and Crohn?s disease-like ileitis in SKG mice
-
Ruutu, M., et al. β-glucan triggers spondylarthritis and Crohn?s disease-like ileitis in SKG mice. Arthritis Rheum. 64, 2211-2222 (2012).
-
(2012)
Arthritis Rheum
, vol.64
, pp. 2211-2222
-
-
Ruutu, M.1
|