Transient inhibition of ROR-γt therapeutically limits intestinal inflammation by reducing TH17 cells and preserving group 3 innate lymphoid cells

Nature Medicine

Volumn 22, Issue 3, 2016, Pages 319-323

  Withers, David R ^a   Hepworth, Matthew R ^b   Wang, Xinxin ^b   Mackley, Emma C ^a   Halford, Emily E ^a   Dutton, Emma E ^a   Marriott, Clare L ^a   Brucklacher Waldert, Verena ^c   Veldhoen, Marc ^c   Kelsen, Judith ^d   Baldassano, Robert N ^d   Sonnenberg, Gregory F ^b  

^a MEDICAL RESEARCH COUNCIL   (United Kingdom)

^b WEILL CORNELL MEDICAL COLLEGE   (United States)

^c BABRAHAM INSTITUTE   (United Kingdom)

^d CHILDREN S HOSPITAL OF PHILADELPHIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GSK 2336805; INTERLEUKIN 17; INTERLEUKIN 22; RETINOID RELATED ORPHAN RECEPTOR GAMMA; TAMOXIFEN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BODY WEIGHT; CELL DIFFERENTIATION; CITROBACTER RODENTIUM; CONTROLLED STUDY; CYTOKINE PRODUCTION; CYTOKINE RESPONSE; ENTERITIS; INFLAMMATORY BOWEL DISEASE; INNATE IMMUNITY; INTESTINE INFECTION; LYMPHOID CELL; MOUSE; NONHUMAN; PRIORITY JOURNAL; STEADY STATE; TH17 CELL; ANIMAL; ANTAGONISTS AND INHIBITORS; COLITIS; COLON; CROHN DISEASE; CYTOLOGY; ENTEROBACTERIACEAE INFECTION; FLOW CYTOMETRY; GENETICS; HUMAN; IMMUNOLOGY; LYMPHOCYTE; PATHOLOGY;

ANIMALS; CITROBACTER RODENTIUM; COLITIS; COLON; CROHN DISEASE; ENTEROBACTERIACEAE INFECTIONS; FLOW CYTOMETRY; HUMANS; IMMUNITY, INNATE; INFLAMMATORY BOWEL DISEASES; LYMPHOCYTES; MICE; NUCLEAR RECEPTOR SUBFAMILY 1, GROUP F, MEMBER 3; TH17 CELLS;

EID: 84958087613     PISSN: 10788956     EISSN: 1546170X     Source Type: Journal    
DOI: 10.1038/nm.4046     Document Type: Article

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