IL-23 expression and activation of autophagy in synovium and PBMCs of HLA-B27 positive patients with ankylosing spondylitis. Response to: 'Evidence that autophagy, but not the unfolded protein response, regulates the expression of IL-23 in the gut of patients with ankylosing spondylitis and subclinical gut inflammation' by Ciccia et al

Annals of the Rheumatic Diseases

Volumn 73, Issue 11, 2014, Pages

  Neerinckx, B ^a,b   Carter, S ^b   Lories, R ^a,b  

^a UNIVERSITY HOSPITALS LEUVEN   (Belgium)

^b UNIVERSITY OF LEUVEN   (Belgium)

Author keywords

[No Author keywords available]

Indexed keywords

AUTOPHAGY PROTEIN 5; HEAT SHOCK COGNATE PROTEIN 70; HEAT SHOCK PROTEIN 90; HLA B27 ANTIGEN; INTERLEUKIN 23; INTERLEUKIN 23P19;

ANKYLOSING SPONDYLITIS; ATG16L1 GENE; ATG5 GENE; AUTOPHAGY; CONTROLLED STUDY; CYTOKINE PRODUCTION; DISEASE ACTIVITY; DISEASE ASSOCIATION; ENTERITIS; EX VIVO STUDY; GENE; GENE EXPRESSION; HSP90AA1 GENE; HSPA8 GENE; HUMAN; HUMAN TISSUE; INTESTINE; IRGM GENE; LETTER; MAP1LC3A GENE; PERIPHERAL BLOOD MONONUCLEAR CELL; PROTEIN EXPRESSION; PROTEIN UNFOLDING; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; RHEUMATOID ARTHRITIS; SPONDYLARTHRITIS; SYNOVIUM; UNFOLDED PROTEIN RESPONSE; FEMALE; ILEITIS; IMMUNOLOGY; MALE;

AUTOPHAGY; FEMALE; HLA-B27 ANTIGEN; HUMANS; ILEITIS; INTERLEUKIN-23 SUBUNIT P19; INTESTINES; MALE; SPONDYLITIS, ANKYLOSING; UNFOLDED PROTEIN RESPONSE;

EID: 84907684896     PISSN: 00034967     EISSN: 14682060     Source Type: Journal    
DOI: 10.1136/annrheumdis-2014-206277     Document Type: Letter

References (7)

1. Mei Y, Pan F, Gao J, et al. Increased serum IL-17 and IL-23 in the patient with ankylosing spondylitis. Clin Rheumatol 2011;30:269-73.
2. Wang X, Lin Z, Wei Q, et al. Expression of IL-23 and IL-17 and effect of IL-23 on IL-17 production in ankylosing spondylitis. Rheumatol Int 2009;29:1343-7.
3. Andersen T, Rasmussen TK, Hvid M, et al. Increased plasma levels of IL-21 and IL-23 in spondyloarthritis are not associated with clinical and MRI findings. Rheumatol Int 2012;32:387-93.
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5. Sherlock J, Joyce-Shaikh B, Turner SP, et al. IL-23 induces spondylarthropathy by acting on ROR-γt+ CD3+CD4-CD8- entheseal resident T cells. Nat Med 2012;18:1069-76.
6. Ciccia F, Accardo-Palumbo A, Rizzo A, et al. Evidence that autophagy, but not the unfolded protein response, regulates the expression of IL-23 in the gut of patients with ankylosing spondylitis and subclinical gut inflammation. Ann Rheum Dis 2014;73:1566-74.
7. Neerinckx B, Carter S, Lories R. No evidence for a critical role of the unfolded protein response in synovium and blood of patients with ankylosing spondylitis. Ann Rheum Dis 2014;73:629-30.