Crystal structures of the endoplasmic reticulum aminopeptidase-1 (ERAP1) reveal the molecular basis for N-terminal peptide trimming

Proceedings of the National Academy of Sciences of the United States of America

Volumn 108, Issue 19, 2011, Pages 7745-7750

  Kochan, Grazyna ^a   Krojer, Tobias ^a   Harvey, David ^a   Fischer, Roman ^b   Chen, Liye ^c   Vollmar, Melanie ^a   Von Delft, Frank ^a   Kavanagh, Kathryn L ^a   Brown, Matthew A ^a,d   Bowness, Paul ^a,c   Wordsworth, Paul ^a   Kessler, Benedikt M ^b   Oppermann, Udo ^a  

^a UNIVERSITY OF OXFORD   (United Kingdom)

^b UNIVERSITY OF OXFORD   (United Kingdom)

^c UNIVERSITY OF OXFORD   (United Kingdom)

^d UNIVERSITY OF QUEENSLAND   (Australia)

Author keywords

Antigen presentation; ERAP1 mechanism; MHC restriction

Indexed keywords

ENDOPLASMIC RETICULUM AMINOPEPTIDASE 1; METALLOPROTEINASE; UNCLASSIFIED DRUG; ZINC BINDING PROTEIN;

AMINO TERMINAL SEQUENCE; ARTICLE; CATALYSIS; CRYSTAL STRUCTURE; ENDOPLASMIC RETICULUM; ENZYME ACTIVE SITE; ENZYME CONFORMATION; ENZYME STRUCTURE; HUMAN; PRIORITY JOURNAL; PROTEIN MOTIF; PROTEIN PROCESSING; STRUCTURE ACTIVITY RELATION;

AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; AMINOPEPTIDASES; ANTIGEN PRESENTATION; CATALYTIC DOMAIN; CRYSTALLOGRAPHY, X-RAY; HLA-B27 ANTIGEN; HUMANS; MODELS, MOLECULAR; MUTAGENESIS, SITE-DIRECTED; POLYMORPHISM, SINGLE NUCLEOTIDE; PROTEIN CONFORMATION; PROTEIN PROCESSING, POST-TRANSLATIONAL; PROTEIN STRUCTURE, TERTIARY; RECOMBINANT PROTEINS; SPONDYLITIS, ANKYLOSING;

EID: 79956348710     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1101262108     Document Type: Article

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