IL-7 primes IL-17 in mucosal-associated invariant T (MAIT) cells, which contribute to the Th17-axis in ankylosing spondylitis

Annals of the Rheumatic Diseases

Volumn 75, Issue 12, 2016, Pages 2124-2132

  Gracey, Eric ^a,b   Qaiyum, Zoya ^a,b   Almaghlouth, Ibrahim ^b   Lawson, Daeria ^b   Karki, Susan ^b   Avvaru, Naga ^b   Zhang, Zhenbo ^b   Yao, Yuchen ^a,b   Ranganathan, Vidya ^b   Baglaenko, Yuriy ^a,b   Inman, Robert D ^a,b  

^a UNIVERSITY OF TORONTO   (Canada)

^b TORONTO WESTERN HOSPITAL   (Canada)

Author keywords

Ankylosing Spondylitis; Cytokines; Gene Polymorphism; T Cells

Indexed keywords

CYTOKINE; GRANZYME; INTERLEUKIN 17; INTERLEUKIN 23; INTERLEUKIN 7; IL17A PROTEIN, HUMAN; IL7 PROTEIN, HUMAN; INTERLEUKIN 7 RECEPTOR;

ANKYLOSING SPONDYLITIS; ANTIGEN SPECIFICITY; ARTICLE; BLOOD CELL; CONTROLLED STUDY; FLOW CYTOMETRY; GENETIC ASSOCIATION; GENETIC RISK; HUMAN; HUMAN CELL; IMMUNOSTIMULATION; MONONUCLEAR CELL; MUCOSAL ASSOCIATED INVARIANT T CELL; PHENOTYPE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; RHEUMATOID ARTHRITIS; SALMONELLA; SINGLE NUCLEOTIDE POLYMORPHISM; SYNOVIAL FLUID; T LYMPHOCYTE; T LYMPHOCYTE ACTIVATION; TH17 CELL; ADULT; AGED; BLOOD; CASE CONTROL STUDY; CYTOLOGY; FEMALE; GENETICS; IMMUNOLOGY; LYMPHOCYTE ACTIVATION; MALE; METABOLISM; MIDDLE AGED; MUCOSAL-ASSOCIATED INVARIANT T CELL;

ADULT; AGED; ARTHRITIS, RHEUMATOID; CASE-CONTROL STUDIES; FEMALE; FLOW CYTOMETRY; HUMANS; INTERLEUKIN-17; INTERLEUKIN-23; INTERLEUKIN-7; LYMPHOCYTE ACTIVATION; MALE; MIDDLE AGED; MUCOSAL-ASSOCIATED INVARIANT T CELLS; POLYMORPHISM, SINGLE NUCLEOTIDE; RECEPTORS, INTERLEUKIN-7; SPONDYLITIS, ANKYLOSING; SYNOVIAL FLUID; TH17 CELLS;

EID: 84973401210     PISSN: 00034967     EISSN: 14682060     Source Type: Journal    
DOI: 10.1136/annrheumdis-2015-208902     Document Type: Article

References (31)

1. Braun J, Sieper J. Ankylosing spondylitis. Lancet 2007;369:1379-90.
2. Smith JA, Colbert RA. Review: the interleukin-23/interleukin-17 axis in spondyloarthritis pathogenesis: Th17 and beyond. Arthritis Rheumatol 2014;66:231-41.
3. Van Praet L, Jacques P, Van den Bosch F, et al. The transition of acute to chronic bowel inflammation in spondyloarthritis. Nat Rev Rheumatol 2012;8:288-95.
4. Farh KK, Marson A, Zhu J, et al. Genetic and epigenetic fine mapping of causal autoimmune disease variants. Nature 2015;518:337-43.
5. Treiner E, Duban L, Bahram S, et al. Selection of evolutionarily conserved mucosal-associated invariant T cells by MR1. Nature 2003;422:164-9.
6. Cho YN, Kee SJ, Kim TJ, et al. Mucosal-associated invariant T cell deficiency in systemic lupus erythematosus. J Immunol 2014;193:3891-901.
7. + MAIT cells infiltrate into the CNS and alterations in their blood frequencies correlate with IL-18 serum levels in multiple sclerosis. Eur J Immunol 2014;44:3119-28.
8. Serriari NE, Eoche M, Lamotte L, et al. Innate mucosal-associated invariant T (MAIT) cells are activated in inflammatory bowel diseases. Clin Exp Immunol 2014;176:266-74.
9. Chiba A, Tajima R, Tomi C, et al. Mucosal-associated invariant T cells promote inflammation and exacerbate disease in murine models of arthritis. Arthritis Rheum 2012;64:153-61.
10. Kjer-Nielsen L, Patel O, Corbett AJ, et al. MR1 presents microbial vitamin B metabolites to MAIT cells. Nature 2012;491:717-23.
11. Le Bourhis L, Mburu YK, Lantz O. MAIT cells, surveyors of a new class of antigen: Development and functions. Curr Opin Immunol 2013;25:174-80.
12. Tang XZ, Jo J, Tan AT, et al. IL-7 licenses activation of human liver intrasinusoidal mucosal-associated invariant T cells. J Immunol 2013;190:3142-52.
13. Tan JT, Dudl E, LeRoy E, et al. IL-7 is critical for homeostatic proliferation and survival of naive T cells. Proc Natl Acad Sci USA 2001;98:8732-7.
14. von Freeden-Jeffry U, Vieira P, Lucian LA, et al. Lymphopenia in interleukin (IL)-7 gene-deleted mice identifies IL-7 as a nonredundant cytokine. J Exp Med 1995;181:1519-26.
15. Ramesh R, Kozhaya L, McKevitt K, et al. Pro-inflammatory human Th17 cells selectively express P-glycoprotein and are refractory to glucocorticoids. J Exp Med 2014;211:89-104.
16. Michel ML, Pang DJ, Haque SF, et al. Interleukin 7 (IL-7) selectively promotes mouse and human IL-17-producing γδ cells. Proc Natl Acad Sci USA 2012;109:17549-54.
17. Palmer MJ, Mahajan VS, Trajman LC, et al. Interleukin-7 receptor signaling network: An integrated systems perspective. Cell Mol Immunol 2008;5:79-89.
18. Cortes A, Hadler J, Pointon JP, et al. Identification of multiple risk variants for ankylosing spondylitis through high-density genotyping of immune-related loci. Nat Genet 2013;45:730-8.
19. Kurioka A, Ussher JE, Cosgrove C, et al. MAIT cells are licensed through granzyme exchange to kill bacterially sensitized targets. Mucosal Immunol 2015;8:429-40.
20. Gracey E, Yao Y, Green B, et al. Sexual Dimorphism in the Th17 Signature of Ankylosing Spondylitis. Arthritis Rheumatol 2016;68:679-89.
21. Lepore M, Kalinichenko A, Colone A, et al. Parallel T-cell cloning and deep sequencing of human MAIT cells reveal stable oligoclonal TCRß 2 repertoire. Nat Commun 2014;5:3866.
22. Lee OJ, Cho YN, Kee SS, et al. Circulating mucosal-associated invariant T cell levels and their cytokine levels in healthy adults. Exp Gerontol 2014;49:47-54.
23. Dusseaux M, Martin E, Serriari N, et al. Human MAIT cells are xenobiotic-resistant, tissue-targeted, CD161hi IL-17-secreting T cells. Blood 2011;117:1250-9.
24. Cosmi L, De Palma R, Santarlasci V, et al. Human interleukin 17-producing cells originate from a CD161+CD4+ T cell precursor. J Exp Med 2008;205:1903-16.
25. Sandborn WJ, Feagan BG, Rutgeerts P, et al. Vedolizumab as induction and maintenance therapy for Crohn's disease. N Engl J Med 2013;369:711-21.
26. Kenna TJ, Davidson SI, Duan R, et al. Enrichment of circulating interleukin-17-secreting interleukin-23 receptor-positive γ/δ T cells in patients with active ankylosing spondylitis. Arthritis Rheum 2012;64:1420-9.
27. Ciccia F, Guggino G, Rizzo A, et al. Type 3 innate lymphoid cells producing IL-17 and IL-22 are expanded in the gut, in the peripheral blood, synovial fluid and bone marrow of patients with ankylosing spondylitis. Ann Rheum Dis 2015;74:1739-47.
28. Sullivan BA, Nagarajan NA, Wingender G, et al. Mechanisms for glycolipid antigen-driven cytokine polarization by Valpha14i NKT cells. J Immunol 2010;184:141-53.
29. Rihl M, Kellner H, Kellner W, et al. Identification of interleukin-7 as a candidate disease mediator in spondylarthritis. Arthritis Rheum 2008;58:3430-5.
30. Zenatti PP, Ribeiro D, Li W, et al. Oncogenic IL7R gain-of-function mutations in childhood T-cell acute lymphoblastic leukemia. Nat Genet 2011;43:932-41.
31. Mazzucchelli RI, Riva A, Durum SK. The human IL-7 receptor gene: Deletions, polymorphisms and mutations. Semin Immunol 2012;24:225-30.