The ER aminopeptidase, ERAP1, trims precursors to lengths of MHC class I peptides by a "molecular ruler" mechanism

Proceedings of the National Academy of Sciences of the United States of America

Volumn 102, Issue 47, 2005, Pages 17107-17112

  Chang, Shih Chung ^a   Momburg, Frank ^b   Bhutani, Nidhi ^a   Goldberg, Alfred L ^a  

^a HARVARD MEDICAL SCHOOL   (United States)

^b GERMAN CANCER RESEARCH CENTER DKFZ   (Germany)

Author keywords

Antigen presentation; Antigen processing; Proteases

Indexed keywords

AMINOPEPTIDASE; ENDOPLASMIC RETICULUM AMINOPEPTIDASE 1; GAMMA INTERFERON; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 1; PEPTIDE; PROTEIN PRECURSOR; TRANSPORTER ASSOCIATED WITH ANTIGEN PROCESSING 1; UNCLASSIFIED DRUG;

AMINO ACID SEQUENCE; AMINO TERMINAL SEQUENCE; ANTIGEN PRESENTATION; ARTICLE; BINDING AFFINITY; CARBOXY TERMINAL SEQUENCE; ENDOPLASMIC RETICULUM; ENZYME ACTIVE SITE; ENZYME SUBSTRATE COMPLEX; HYDROPHOBICITY; MOLECULAR SIZE; PRIORITY JOURNAL; PROTEIN PROCESSING; PROTEIN TRANSPORT;

AMINOPEPTIDASES; ATP-BINDING CASSETTE TRANSPORTERS; ENDOPLASMIC RETICULUM; HISTOCOMPATIBILITY ANTIGENS CLASS I; HUMANS; HYDROLYSIS; HYDROPHOBICITY; PEPTIDE FRAGMENTS; PROTEIN PRECURSORS; PROTEIN PROCESSING, POST-TRANSLATIONAL; SUBSTRATE SPECIFICITY;

EID: 28044456942     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.0500721102     Document Type: Article

References (46)

1. Rock, K. L. & Goldberg, A. L. (1999) Annu. Rev. Immunol. 17, 739-779.
2. Yewdell, J. W. & Bennink, J. R. (2001) Curr. Opin. Immunol. 13, 13-18.
3. Shastri, N., Schwab, S. & Serwold, T. (2002) Annu. Rev. Immunol. 20, 463-493.
4. Rock, K. L., York, I. A., Saric, T. & Goldberg, A. L. (2002) Adv. Immunol. 80, 1-70.
5. Madden, D. R. (1995) Annu. Rev. Immunol. 13, 587-622.
6. Jones, E. Y. (1997) Curr. Opin. Immunol. 9, 75-79.
7. Rammensee, H. G., Friede, T. & Stevanoviic, S. (1995) Immunogenetics 41, 178-228.
8. Rock, K. L., Gramm, C., Rothstein, L., Clark, K., Stein, R., Dick, L., Hwang, D. & Goldberg, A. L. (1994) Cell 78, 761-771.
9. Lehner, P. J. & Cresswell, P. (1996) Curr. Opin. Immunol. 8, 59-67.
10. Goldberg, A. L., Cascio, P., Saric, T. & Rock, K. L. (2002) Mol. Immunol. 39, 147-164.
11. Kisselev, A. F., Akopian, T. N., Woo, K. M. & Goldberg, A. L. (1999) J. Biol. Chem. 274, 3363-3371.
12. Mo, X. Y., Cascio, P., Lemerise, K., Goldberg, A. L. & Rock, K. (1999) J. Immunol. 163, 5851-5859.
13. Saveanu, L., Fruci, D. & van Endert, P. (2002) Mol. Immunol. 39, 203-215.
14. Cascio, P., Hilton, C., Kisselev, A. F., Rock, K. L. & Goldberg, A. L. (2001) EMBO J. 20, 2357-2366.
15. Reits, E., Neijssen, J., Herberts, C., Benckhuijsen, W., Janssen, L., Drijfhout, J. W. & Neefjes, J. (2004) Immunity 20, 495-506.
16. Stoltze, L., Schirle, M., Schwarz, G., Schroter, C., Thompson, M. W., Hersh, L. B., Kalbacher, H., Stevanovic, S., Rammensee, H. G. & Schild, H. (2000) Nat. Immunol. 1, 413-418.
17. Beninga, J., Rock, K. L. & Goldberg, A. L. (1998) J. Biol. Chem. 273, 18734-18742.
18. Androlewicz, M. J., Anderson, K. S. & Cresswell, P. (1993) Proc. Natl. Acad. Sci. USA 90, 9130-9134.
19. Neefjes, J. J., Momburg, F. & Hammerling, G. J. (1993) Science 261, 769-771.
20. Gromme, M. & Neefjes, J. (2002) Mol. Immunol. 39, 181-202.
21. van Endert, P. M., Tampe, R., Meyer, T. H., Tisch, R., Bach, J. F. & McDevitt, H. O. (1994) Immunity 1, 491-500.
22. Lobigs, M., Chelvanayagam, G. & Mullbacher, A. (2000) Eur. J. Immunol. 30, 1496-1506.
23. Komlosh, A., Momburg, F., Weinschenk, T., Emmerich, N., Schild, H., Nadav, E., Shaked, I. & Reiss, Y. (2001) J. Biol. Chem. 276, 30050-30056.
24. Fruci, D., Niedermann, G., Butler, R. H. & van Endert, P. M. (2001) Immunity 15, 467-476.
25. Saric, T., Chang, S. C., Hattori, A., York, I. A., Markant, S., Rock, K. L., Tsujimoto, M. & Goldberg, A. L. (2002) Nat. Immunol. 3, 1169-1176.
26. Serwold, T., Gonzalez, F., Kim, J., Jacob, R. & Shastri, N. (2002) Nature 419, 480-483.
27. York, I. A., Chang, S. C., Saric, T., Keys, J. A., Favreau, J. M., Goldberg, A. L. & Rock, K. L. (2002) Nat. Immunol. 3, 1177-1184.
28. Ma, W., Lehner, P. J., Cresswell, P., Pober, J. S. & Johnson, D. R. (1997) J. Biol. Chem. 272, 16585-16590.
29. Serwold, T., Gaw, S. & Shastri, N. (2001) Nat. Immunol. 2, 644-651.
30. Udenfriend, S., Stein, S., Bohlen, P., Dairman, W., Leimgruber, W. & Weigele, M. (1972) Science 178, 871-872.
31. Hattori, A., Kitatani, K., Matsumoto, H., Miyazawa, S., Rogi, T., Tsuruoka, N., Mizutani, S., Natori, Y. & Tsujimoto, M. (2000) J. Biochem. (Tokyo) 128, 755-762.
32. Koopmann, J. O., Post, M., Neefjes, J. J., Hammerling, G. J. & Momburg, F. (1996) Eur. J. Immunol. 26, 1720-1728.
33. Momburg, F., Roelse, J., Howard, J. C., Butcher, G. W., Hammerling, G. J. & Neefjes, J. J. (1994) Nature 367, 648-651.
34. Saric, T., Graef, C. I. & Goldberg, A. L. (2004) J. Biol. Chem. 279, 46723-46732.
35. Botbol, V. & Scornik, O. A. (1989) J. Biol. Chem. 264, 13504-13509.
36. Tanioka, T., Hattori, A., Masuda, S., Nomura, Y., Nakayama, H., Mizutani, S. & Tsujimoto, M. (2003) J. Biol. Chem. 278, 32275-32283.
37. Saveanu, L., Carroll, O., Lindo, V., Del Val, M., Lopez, D., Lepelletier, Y., Greer, F., Schomburg, L., Fruci, D., Niedermann, G. & van Endert, P. M. (2005) Nat. Immunol. 6, 689-697.
38. Soderling, E. (1983) Arch. Biochem. Biophys. 220, 1-10.
39. Orning, L., Gierse, J. K. & Fitzpatrick, F. A. (1994) J. Biol. Chem. 269, 11269-11273.
40. York, I. A., Mo, A. X., Lemerise, K., Zeng, W., Shen, Y., Abraham, C. R., Saric, T., Goldberg, A. L. & Rock, K. L. (2003) Immunity 18, 429-440.
41. Schumacher, T. N., Kantesaria, D. V., Heemels, M. T., Ashton-Rickardt, P. G., Shepherd, J. C., Fruh, K., Yang, Y., Peterson, P. A., Tonegawa, S. & Ploegh, H. L. (1994) J. Exp. Med. 179, 533-540.
42. Rudberg, P. C., Tholander, F., Andberg, M., Thunnissen, M. M. & Haeggstrom, J. Z. (2004) J. Biol. Chem. 279, 27376-27382.
43. Jaramillo, A., Majumder, K., Manna, P. P., Fleming, T. P., Doherty, G., Dipersio, J. F. & Mohanakumar, T. (2002) Int. J. Cancer. 102, 499-506.
44. Guo, H. C., Jardetzky, T. S., Garrett, T. P., Lane, W. S., Strominger, J. L. & Wiley, D. C. (1992) Nature 360, 364-366.
45. Jardetzky, T. S., Lane, W. S., Robinson, R. A., Madden, D. R. & Wiley, D. C. (1991) Nature 353, 326-329.
46. Yamamoto, N., Nakayama, J., Yamakawa-Kobayashi, K., Hamaguchi, H., Miyazaki, R. & Arinami, T. (2002) Hum. Mutat. 19, 251-257.