메뉴 건너뛰기




Volumn 152, Issue 7, 2017, Pages 1638-1646

Adolescent Obesity and Insulin Resistance: Roles of Ectopic Fat Accumulation and Adipose Inflammation

Author keywords

Adipose Tissue Distribution; Adipose Tissue Inflammation; Childhood and Adolescent Obesity; Fatty Liver; Inflammasome; Resistance

Indexed keywords

ADIPOSE TISSUE; ADOLESCENT; ADOLESCENT OBESITY; ARTICLE; BODY MASS; CARDIOMETABOLIC RISK; DISEASE SEVERITY; DYSLIPIDEMIA; ENDOPHENOTYPE; ETHNIC DIFFERENCE; FATTY LIVER; HUMAN; INFLAMMATION; INSULIN RESISTANCE; INSULIN SENSITIVITY; INTRAPERITONEAL FAT; LIPID STORAGE; PREVALENCE; PRIORITY JOURNAL; RACE DIFFERENCE; ABDOMINAL SUBCUTANEOUS FAT; INTRAABDOMINAL FAT; LIVER; PATHOPHYSIOLOGY; PEDIATRIC OBESITY; PHYSIOLOGY;

EID: 85018661503     PISSN: 00165085     EISSN: 15280012     Source Type: Journal    
DOI: 10.1053/j.gastro.2016.12.051     Document Type: Article
Times cited : (112)

References (64)
  • 1
    • 84902155113 scopus 로고    scopus 로고
    • Prevalence and trends in obesity and severe obesity among children in the United States, 1999-2012
    • 1 Skinner, A., Skelton, J.A., Prevalence and trends in obesity and severe obesity among children in the United States, 1999-2012. JAMA Pediatr 168 (2014), 561–566.
    • (2014) JAMA Pediatr , vol.168 , pp. 561-566
    • Skinner, A.1    Skelton, J.A.2
  • 2
    • 84973390213 scopus 로고    scopus 로고
    • Trends in obesity prevalence among children and adolescents in the United States, 1988–1994 through 2013–2014
    • 2 Ogden, C.L., Carroll, M.D., Lawman, H.G., et al. Trends in obesity prevalence among children and adolescents in the United States, 1988–1994 through 2013–2014. JAMA 315 (2016), 2292–2299.
    • (2016) JAMA , vol.315 , pp. 2292-2299
    • Ogden, C.L.1    Carroll, M.D.2    Lawman, H.G.3
  • 3
    • 0037048695 scopus 로고    scopus 로고
    • Prevalence and trends in overweight among U.S. children and adolescents, 1999-2000
    • 3 Ogden, C.L., Flegal, K.M., Carroll, M.D., et al. Prevalence and trends in overweight among U.S. children and adolescents, 1999-2000. JAMA 288 (2002), 1728–1732.
    • (2002) JAMA , vol.288 , pp. 1728-1732
    • Ogden, C.L.1    Flegal, K.M.2    Carroll, M.D.3
  • 4
    • 0035022880 scopus 로고    scopus 로고
    • Impact of timing of pubertal maturation on growth in black and white female adolescents: The National Heart, Lung, and Blood Institute Growth and Health Study
    • 4 Biro, F.M., McMahon, R.P., Striegel-Moore, R., et al. Impact of timing of pubertal maturation on growth in black and white female adolescents: The National Heart, Lung, and Blood Institute Growth and Health Study. J Pediatr 138 (2001), 636–643.
    • (2001) J Pediatr , vol.138 , pp. 636-643
    • Biro, F.M.1    McMahon, R.P.2    Striegel-Moore, R.3
  • 5
    • 0038305833 scopus 로고    scopus 로고
    • Obesity, regional fat distribution, and syndrome X in obese black versus white adolescents: race differential in diabetogenic and atherogenic risk factors
    • 5 Bacha, F., Saad, R., Gungor, N., et al. Obesity, regional fat distribution, and syndrome X in obese black versus white adolescents: race differential in diabetogenic and atherogenic risk factors. J Clin Endocrinol Metab 88 (2003), 2534–2540.
    • (2003) J Clin Endocrinol Metab , vol.88 , pp. 2534-2540
    • Bacha, F.1    Saad, R.2    Gungor, N.3
  • 6
    • 38449095758 scopus 로고    scopus 로고
    • Expert committee recommendations regarding the prevention, assessment, and treatment of child and adolescent overweight and obesity: summary report
    • 6 Barlow, S.E., Expert Committee. Expert committee recommendations regarding the prevention, assessment, and treatment of child and adolescent overweight and obesity: summary report. Pediatrics 120:suppl 4 (2007), S164–S192.
    • (2007) Pediatrics , vol.120 , pp. S164-S192
    • Barlow, S.E.1
  • 7
    • 33845586264 scopus 로고    scopus 로고
    • Cardiovascular risk factors and excess adiposity among overweight children and adolescents: the Bogalusa Heart Study
    • 7 Freedman, D.S., Mei, Z., Srinivasan, S.R., et al. Cardiovascular risk factors and excess adiposity among overweight children and adolescents: the Bogalusa Heart Study. J Pediatr 150 (2007), 12–17.e2.
    • (2007) J Pediatr , vol.150 , pp. 12-17.e2
    • Freedman, D.S.1    Mei, Z.2    Srinivasan, S.R.3
  • 8
    • 31544461383 scopus 로고    scopus 로고
    • Screening and interventions for childhood overweight: a summary of evidence for the US Preventive Services Task Force
    • 8 Whitlock, E.P., Williams, S.B., Gold, R., et al. Screening and interventions for childhood overweight: a summary of evidence for the US Preventive Services Task Force. Pediatrics 116 (2005), e125–e144.
    • (2005) Pediatrics , vol.116 , pp. e125-e144
    • Whitlock, E.P.1    Williams, S.B.2    Gold, R.3
  • 9
    • 84942857234 scopus 로고    scopus 로고
    • Cardiometabolic risks and severity of obesity in children and young adults
    • 9 Skinner, A.C., Perrin, E.M., Moss, L.A., et al. Cardiometabolic risks and severity of obesity in children and young adults. N Engl J Med 373 (2015), 1307–1317.
    • (2015) N Engl J Med , vol.373 , pp. 1307-1317
    • Skinner, A.C.1    Perrin, E.M.2    Moss, L.A.3
  • 10
    • 2542548063 scopus 로고    scopus 로고
    • Obesity and the metabolic syndrome in children and adolescents
    • 10 Weiss, R., Dziura, J., Burgert, T.S., et al. Obesity and the metabolic syndrome in children and adolescents. N Engl J Med 350 (2004), 2362–2374.
    • (2004) N Engl J Med , vol.350 , pp. 2362-2374
    • Weiss, R.1    Dziura, J.2    Burgert, T.S.3
  • 11
    • 59249093414 scopus 로고    scopus 로고
    • Influence of race, ethnicity, and culture on childhood obesity: implications for prevention and treatment: a consensus statement of Shaping America's Health and the Obesity Society
    • 11 Caprio, S., Daniels, S.R., Drewnowski, A., et al. Influence of race, ethnicity, and culture on childhood obesity: implications for prevention and treatment: a consensus statement of Shaping America's Health and the Obesity Society. Diabetes Care 31 (2008), 2211–2221.
    • (2008) Diabetes Care , vol.31 , pp. 2211-2221
    • Caprio, S.1    Daniels, S.R.2    Drewnowski, A.3
  • 12
    • 0037076025 scopus 로고    scopus 로고
    • Prevalence of impaired glucose tolerance among children and adolescents with marked obesity
    • 12 Sinha, R., Fisch, G., Teague, B., et al. Prevalence of impaired glucose tolerance among children and adolescents with marked obesity. N Engl J Med 346 (2002), 802–810.
    • (2002) N Engl J Med , vol.346 , pp. 802-810
    • Sinha, R.1    Fisch, G.2    Teague, B.3
  • 13
    • 0035046270 scopus 로고    scopus 로고
    • Adiposity in childhood predicts obesity and insulin resistance in young adulthood
    • 13 Steinberger, J., Moran, A., Hong, C.P., et al. Adiposity in childhood predicts obesity and insulin resistance in young adulthood. J Pediatr 138 (2001), 469–473.
    • (2001) J Pediatr , vol.138 , pp. 469-473
    • Steinberger, J.1    Moran, A.2    Hong, C.P.3
  • 14
    • 0029940891 scopus 로고    scopus 로고
    • Adolescent overweight is associated with adult overweight and related multiple cardiovascular risk factors: the Bogalusa Heart Study
    • 14 Srinivasan, S.R., Bao, W., Wattigney, W.A., et al. Adolescent overweight is associated with adult overweight and related multiple cardiovascular risk factors: the Bogalusa Heart Study. Metabolism 45 (1996), 235–240.
    • (1996) Metabolism , vol.45 , pp. 235-240
    • Srinivasan, S.R.1    Bao, W.2    Wattigney, W.A.3
  • 15
    • 0034861648 scopus 로고    scopus 로고
    • Relationship of childhood obesity to coronary heart disease risk factors in adulthood: the Bogalusa Heart Study
    • 15 Freedman, D.S., Khan, L.K., Dietz, W.H., et al. Relationship of childhood obesity to coronary heart disease risk factors in adulthood: the Bogalusa Heart Study. Pediatrics 108 (2001), 712–718.
    • (2001) Pediatrics , vol.108 , pp. 712-718
    • Freedman, D.S.1    Khan, L.K.2    Dietz, W.H.3
  • 16
    • 84908140635 scopus 로고    scopus 로고
    • Childhood obesity and adult cardiovascular disease
    • 16 Litwin, S.E., Childhood obesity and adult cardiovascular disease. J AM Coll Cardio 64 (2014), 1588–1590.
    • (2014) J AM Coll Cardio , vol.64 , pp. 1588-1590
    • Litwin, S.E.1
  • 17
    • 0030792135 scopus 로고    scopus 로고
    • Fasting hyperinsulinemia is a predictor of increased body weight gain and obesity in Pima Indian children
    • 17 Odeleye, O.E., de Courten, M., Pettit, D., et al. Fasting hyperinsulinemia is a predictor of increased body weight gain and obesity in Pima Indian children. Diabetes 46 (1997), 1341–1345.
    • (1997) Diabetes , vol.46 , pp. 1341-1345
    • Odeleye, O.E.1    de Courten, M.2    Pettit, D.3
  • 18
    • 84918819322 scopus 로고    scopus 로고
    • Ectopic fat in insulin resistance, dyslipidemia, and cardiometabolic disease
    • 18 Shulman, G., Ectopic fat in insulin resistance, dyslipidemia, and cardiometabolic disease. N Engl J Med 371 (2014), 2237–2238.
    • (2014) N Engl J Med , vol.371 , pp. 2237-2238
    • Shulman, G.1
  • 19
    • 0141763847 scopus 로고    scopus 로고
    • Pre-type 2 diabetes in obese youth: a syndrome of impaired glucose tolerance, severe insulin resistance and altered myocellular and abdominal fat partitioning
    • 19 Weiss, R., Dufour, S., Taksali, S.E., et al. Pre-type 2 diabetes in obese youth: a syndrome of impaired glucose tolerance, severe insulin resistance and altered myocellular and abdominal fat partitioning. Lancet 362 (2003), 951–957.
    • (2003) Lancet , vol.362 , pp. 951-957
    • Weiss, R.1    Dufour, S.2    Taksali, S.E.3
  • 20
    • 31744443753 scopus 로고    scopus 로고
    • Is visceral obesity the cause of the metabolic syndrome?
    • 20 Despres, J.P., Is visceral obesity the cause of the metabolic syndrome?. Ann Med 38 (2006), 52–63.
    • (2006) Ann Med , vol.38 , pp. 52-63
    • Despres, J.P.1
  • 21
    • 0033927667 scopus 로고    scopus 로고
    • Cellular mechanisms of insulin resistance
    • 21 Shulman, G.I., Cellular mechanisms of insulin resistance. J Clin Invest 106 (2000), 171–176.
    • (2000) J Clin Invest , vol.106 , pp. 171-176
    • Shulman, G.I.1
  • 22
    • 84901944641 scopus 로고    scopus 로고
    • The role of hepatic lipids in hepatic insulin resistance and type 2 diabetes
    • 22 Perry, R.J., Samuel, V.T., Petersen, K.F., et al. The role of hepatic lipids in hepatic insulin resistance and type 2 diabetes. Nature 510 (2014), 84–91.
    • (2014) Nature , vol.510 , pp. 84-91
    • Perry, R.J.1    Samuel, V.T.2    Petersen, K.F.3
  • 23
    • 0036730845 scopus 로고    scopus 로고
    • Unique effect of visceral fat on insulin sensitivity in obese Hispanic children with a family history of type 2 diabetes
    • 23 Cruz, M.L., Bergman, R.N., Goran, M.I., Unique effect of visceral fat on insulin sensitivity in obese Hispanic children with a family history of type 2 diabetes. Diabetes Care 25 (2002), 1631–1636.
    • (2002) Diabetes Care , vol.25 , pp. 1631-1636
    • Cruz, M.L.1    Bergman, R.N.2    Goran, M.I.3
  • 24
    • 40749121780 scopus 로고    scopus 로고
    • High visceral and low abdominal subcutaneous fat stores in the obese adolescent: a determinant of an adverse metabolic syndrome
    • 24 Taksali, S., Caprio, S., Dziura, J., et al. High visceral and low abdominal subcutaneous fat stores in the obese adolescent: a determinant of an adverse metabolic syndrome. Diabetes 57 (2008), 367–371.
    • (2008) Diabetes , vol.57 , pp. 367-371
    • Taksali, S.1    Caprio, S.2    Dziura, J.3
  • 25
    • 68949136755 scopus 로고    scopus 로고
    • Glucose dysregulation and hepatic steatosis in obese adolescents: is there a link?
    • 25 Cali, A.M.G., De Oliveira, A., Kim, H., et al. Glucose dysregulation and hepatic steatosis in obese adolescents: is there a link?. Hepatology 49 (2009), 1896–1903.
    • (2009) Hepatology , vol.49 , pp. 1896-1903
    • Cali, A.M.G.1    De Oliveira, A.2    Kim, H.3
  • 26
    • 77958180000 scopus 로고    scopus 로고
    • Central role of fatty liver in the pathogenesis of insulin resistance in obese adolescents
    • 26 D'Adamo, E., Cali, A.M., Weiss, R., et al. Central role of fatty liver in the pathogenesis of insulin resistance in obese adolescents. Diabetes Care 33 (2010), 1817–1822.
    • (2010) Diabetes Care , vol.33 , pp. 1817-1822
    • D'Adamo, E.1    Cali, A.M.2    Weiss, R.3
  • 27
    • 70349326750 scopus 로고    scopus 로고
    • Intrahepatic fat, not visceral fat, is linked with metabolic complications of obesity
    • 27 Fabbrini, E., Magkos, F., Mohammed, B.S., et al. Intrahepatic fat, not visceral fat, is linked with metabolic complications of obesity. Proc Natl Acad Sci U S A 106 (2009), 15430–15435.
    • (2009) Proc Natl Acad Sci U S A , vol.106 , pp. 15430-15435
    • Fabbrini, E.1    Magkos, F.2    Mohammed, B.S.3
  • 28
    • 75449094816 scopus 로고    scopus 로고
    • Obesity and nonalcoholic fatty liver disease: biochemical, metabolic, and clinical implications
    • 28 Fabbrini, E., Sullivan, S., Klein, S., Obesity and nonalcoholic fatty liver disease: biochemical, metabolic, and clinical implications. Hepatology 51 (2010), 679–689.
    • (2010) Hepatology , vol.51 , pp. 679-689
    • Fabbrini, E.1    Sullivan, S.2    Klein, S.3
  • 29
    • 33751519769 scopus 로고    scopus 로고
    • Alanine aminotransferase levels and fatty liver in childhood obesity: associations with insulin resistance, adiponectin, and visceral fat
    • 29 Burgert, T.S., Taksali, S.E., Dziura, J., et al. Alanine aminotransferase levels and fatty liver in childhood obesity: associations with insulin resistance, adiponectin, and visceral fat. J Clin Endocrinol Metab 91 (2006), 4287–4294.
    • (2006) J Clin Endocrinol Metab , vol.91 , pp. 4287-4294
    • Burgert, T.S.1    Taksali, S.E.2    Dziura, J.3
  • 30
    • 22044438064 scopus 로고    scopus 로고
    • Type 2 diabetes in children is frequently associated with elevated alanine aminotransferase
    • 30 Nadeau, K.J., Klingensmith, G., Zeitler, P., Type 2 diabetes in children is frequently associated with elevated alanine aminotransferase. J Pediatr Gastroenterol Nutr 41 (2005), 94–98.
    • (2005) J Pediatr Gastroenterol Nutr , vol.41 , pp. 94-98
    • Nadeau, K.J.1    Klingensmith, G.2    Zeitler, P.3
  • 31
    • 84996503693 scopus 로고    scopus 로고
    • Prevalence of prediabetes and type 2 diabetes in children with nonalcoholic fatty liver disease
    • 31 Newton, K.P., Hou, J., Crimmins, N., et al. Prevalence of prediabetes and type 2 diabetes in children with nonalcoholic fatty liver disease. JAMA Pediatr, 170, 2016, e161971.
    • (2016) JAMA Pediatr , vol.170 , pp. e161971
    • Newton, K.P.1    Hou, J.2    Crimmins, N.3
  • 32
    • 0030705157 scopus 로고    scopus 로고
    • Obesity and heart disease: a statement for healthcare professionals from the Nutrition Committee, American Heart Association
    • 32 Eckel, R.H., Obesity and heart disease: a statement for healthcare professionals from the Nutrition Committee, American Heart Association. Circulation 96 (1997), 3248–3250.
    • (1997) Circulation , vol.96 , pp. 3248-3250
    • Eckel, R.H.1
  • 33
    • 33845881411 scopus 로고    scopus 로고
    • Mechanisms linking obesity to insulin resistance and type 2 diabetes
    • 33 Kahn, S.E., Hull, R.L., Utzschneider, K.M., Mechanisms linking obesity to insulin resistance and type 2 diabetes. Nature 444 (2006), 840–846.
    • (2006) Nature , vol.444 , pp. 840-846
    • Kahn, S.E.1    Hull, R.L.2    Utzschneider, K.M.3
  • 34
    • 3543072186 scopus 로고    scopus 로고
    • Overweight, obesity and cancer: epidemiological evidence and proposed mechanisms
    • 34 Calle, E.E., Kaaks, R., Overweight, obesity and cancer: epidemiological evidence and proposed mechanisms. Nat Rev Cancer 4 (2004), 579–591.
    • (2004) Nat Rev Cancer , vol.4 , pp. 579-591
    • Calle, E.E.1    Kaaks, R.2
  • 35
    • 0037422846 scopus 로고    scopus 로고
    • Obesity in adulthood and its consequences for life expectancy: a life-table analysis
    • 35 Peeters, A., Barendregt, J.J., Willekens, F., et al. Obesity in adulthood and its consequences for life expectancy: a life-table analysis. Ann Intern Med 138 (2003), 24–32.
    • (2003) Ann Intern Med , vol.138 , pp. 24-32
    • Peeters, A.1    Barendregt, J.J.2    Willekens, F.3
  • 36
    • 0033817811 scopus 로고    scopus 로고
    • Failure of adipocyte differentiation causes type II diabetes mellitus?
    • 36 Danforth, E. Jr., Failure of adipocyte differentiation causes type II diabetes mellitus?. Nat Genet, 26, 2000, 13.
    • (2000) Nat Genet , vol.26 , pp. 13
    • Danforth, E.1
  • 37
    • 0036299262 scopus 로고    scopus 로고
    • Increased fat intake, impaired fat oxidation, and failure of fat cell proliferation result in ectopic fat storage, insulin resistance, and type 2 diabetes mellitus
    • 37 Ravussin, E., Smith, S.R., Increased fat intake, impaired fat oxidation, and failure of fat cell proliferation result in ectopic fat storage, insulin resistance, and type 2 diabetes mellitus. Ann N Y Acad Sci 967 (2002), 363–378.
    • (2002) Ann N Y Acad Sci , vol.967 , pp. 363-378
    • Ravussin, E.1    Smith, S.R.2
  • 38
    • 34547431645 scopus 로고    scopus 로고
    • Adipose tissue expandability in the maintenance of metabolic homeostasis
    • 38 Gray, S.L., Vidal-Puig, A.J., Adipose tissue expandability in the maintenance of metabolic homeostasis. Nutr Rev 65 (2007), S7–S12.
    • (2007) Nutr Rev , vol.65 , pp. S7-S12
    • Gray, S.L.1    Vidal-Puig, A.J.2
  • 39
    • 76049099665 scopus 로고    scopus 로고
    • Adipose tissue expandability, lipotoxicity and the metabolic syndrome–an allostatic perspective
    • 39 Virtue, S., Vidal-Puig, A., Adipose tissue expandability, lipotoxicity and the metabolic syndrome–an allostatic perspective. Biochim Biophys Acta 1801 (2010), 338–349.
    • (2010) Biochim Biophys Acta , vol.1801 , pp. 338-349
    • Virtue, S.1    Vidal-Puig, A.2
  • 40
    • 77956383646 scopus 로고    scopus 로고
    • Cellularity and adipogenic profile of the abdominal subcutaneous adipose tissue from obese adolescents: association with insulin resistance and hepatic steatosis
    • 40 Kursawe, R., Eszlinger, M., Narayan, D., et al. Cellularity and adipogenic profile of the abdominal subcutaneous adipose tissue from obese adolescents: association with insulin resistance and hepatic steatosis. Diabetes 59 (2010), 2288–2296.
    • (2010) Diabetes , vol.59 , pp. 2288-2296
    • Kursawe, R.1    Eszlinger, M.2    Narayan, D.3
  • 41
    • 84874428179 scopus 로고    scopus 로고
    • Decreased transcription of ChREBP-alpha/beta isoforms in abdominal subcutaneous adipose tissue of obese adolescents with prediabetes or early type 2 diabetes: associations with insulin resistance and hyperglycemia
    • 41 Kursawe, R., Caprio, S., Giannini, C., et al. Decreased transcription of ChREBP-alpha/beta isoforms in abdominal subcutaneous adipose tissue of obese adolescents with prediabetes or early type 2 diabetes: associations with insulin resistance and hyperglycemia. Diabetes 62 (2013), 837–844.
    • (2013) Diabetes , vol.62 , pp. 837-844
    • Kursawe, R.1    Caprio, S.2    Giannini, C.3
  • 42
    • 82255164629 scopus 로고    scopus 로고
    • SirT1 regulates adipose tissue inflammation
    • 42 Gillum, M.P., Kotas, M.E., Erion, D.M., et al. SirT1 regulates adipose tissue inflammation. Diabetes 60 (2011), 3235–3245.
    • (2011) Diabetes , vol.60 , pp. 3235-3245
    • Gillum, M.P.1    Kotas, M.E.2    Erion, D.M.3
  • 43
    • 33845866857 scopus 로고    scopus 로고
    • Inflammation and metabolic disorders
    • 43 Hotamisligil, G.S., Inflammation and metabolic disorders. Nature 444 (2006), 860–867.
    • (2006) Nature , vol.444 , pp. 860-867
    • Hotamisligil, G.S.1
  • 44
    • 79957920754 scopus 로고    scopus 로고
    • Inflammatory links between obesity and metabolic disease
    • 44 Lumeng, C.N., Saltiel, A.R., Inflammatory links between obesity and metabolic disease. J Clin Invest 121 (2011), 2111–2117.
    • (2011) J Clin Invest , vol.121 , pp. 2111-2117
    • Lumeng, C.N.1    Saltiel, A.R.2
  • 45
    • 54549096762 scopus 로고    scopus 로고
    • Mechanisms of macrophage activation in obesity-induced insulin resistance
    • 45 Odegaard, J.I., Chawla, A., Mechanisms of macrophage activation in obesity-induced insulin resistance. Nat Clin Pract Endocrinol Metab 4 (2008), 619–626.
    • (2008) Nat Clin Pract Endocrinol Metab , vol.4 , pp. 619-626
    • Odegaard, J.I.1    Chawla, A.2
  • 46
    • 77951918926 scopus 로고    scopus 로고
    • Macrophages, inflammation, and insulin resistance
    • 46 Olefsky, J.M., Glass, C.K., Macrophages, inflammation, and insulin resistance. Annu Rev Physiol 72 (2010), 219–246.
    • (2010) Annu Rev Physiol , vol.72 , pp. 219-246
    • Olefsky, J.M.1    Glass, C.K.2
  • 47
    • 33745861300 scopus 로고    scopus 로고
    • Inflammation and insulin resistance
    • 47 Shoelson, S.E., Lee, J., Goldfine, A.B., Inflammation and insulin resistance. J Clin Invest 116 (2006), 1793–1801.
    • (2006) J Clin Invest , vol.116 , pp. 1793-1801
    • Shoelson, S.E.1    Lee, J.2    Goldfine, A.B.3
  • 48
    • 33644848054 scopus 로고    scopus 로고
    • Obesity and inflammation: evidence for an elementary lesion
    • 48 Sbarbati, A., Osculati, F., Silvagni, D., et al. Obesity and inflammation: evidence for an elementary lesion. Pediatrics 117 (2006), 220–223.
    • (2006) Pediatrics , vol.117 , pp. 220-223
    • Sbarbati, A.1    Osculati, F.2    Silvagni, D.3
  • 49
    • 84859528017 scopus 로고    scopus 로고
    • Adipose tissue remodeling in children: the link between collagen deposition and age-related adipocyte growth
    • 49 Tam, C.S., Tordjman, J., Divoux, A., et al. Adipose tissue remodeling in children: the link between collagen deposition and age-related adipocyte growth. J Clin Endocrinol Metab 97 (2012), 1320–1327.
    • (2012) J Clin Endocrinol Metab , vol.97 , pp. 1320-1327
    • Tam, C.S.1    Tordjman, J.2    Divoux, A.3
  • 50
    • 0028220785 scopus 로고
    • Critical periods in childhood for the development of obesity
    • 50 Dietz, W.H., Critical periods in childhood for the development of obesity. Am J Clin Nutr 59 (1994), 955–959.
    • (1994) Am J Clin Nutr , vol.59 , pp. 955-959
    • Dietz, W.H.1
  • 51
    • 44849132591 scopus 로고    scopus 로고
    • Dynamics of fat cell turnover in humans
    • 51 Spalding, K.L., Arner, E., Westermark, P.O., et al. Dynamics of fat cell turnover in humans. Nature 453 (2008), 783–787.
    • (2008) Nature , vol.453 , pp. 783-787
    • Spalding, K.L.1    Arner, E.2    Westermark, P.O.3
  • 52
    • 0016280526 scopus 로고
    • Effects of age, sex, and clinical conditions on adipose tissue cellularity in man
    • 52 Bjorntorp, P., Effects of age, sex, and clinical conditions on adipose tissue cellularity in man. Metabolism 23 (1974), 1091–1102.
    • (1974) Metabolism , vol.23 , pp. 1091-1102
    • Bjorntorp, P.1
  • 53
    • 0017162520 scopus 로고
    • Adipose tissue cellularity in human obesity
    • 53 Hirsch, J., Batchelor, B., Adipose tissue cellularity in human obesity. Clin Endocrinol Metab 5 (1976), 299–311.
    • (1976) Clin Endocrinol Metab , vol.5 , pp. 299-311
    • Hirsch, J.1    Batchelor, B.2
  • 54
    • 80053087484 scopus 로고    scopus 로고
    • Inflammasome is a central player in the induction of obesity and insulin resistance
    • 54 Stienstra, R., van Diepen, J.A., Tack, C.J., et al. Inflammasome is a central player in the induction of obesity and insulin resistance. Proc Natl Acad Sci U S A 108 (2011), 15324–15329.
    • (2011) Proc Natl Acad Sci U S A , vol.108 , pp. 15324-15329
    • Stienstra, R.1    van Diepen, J.A.2    Tack, C.J.3
  • 55
    • 78649498271 scopus 로고    scopus 로고
    • The inflammasome-mediated caspase-1 activation controls adipocyte differentiation and insulin sensitivity
    • 55 Stienstra, R., Joosten, L.A., Koenen, T., et al. The inflammasome-mediated caspase-1 activation controls adipocyte differentiation and insulin sensitivity. Cell Metab 12 (2010), 593–605.
    • (2010) Cell Metab , vol.12 , pp. 593-605
    • Stienstra, R.1    Joosten, L.A.2    Koenen, T.3
  • 56
    • 80054903245 scopus 로고    scopus 로고
    • Elimination of the NLRP3-ASC inflammasome protects against chronic obesity-induced pancreatic damage
    • 56 Youm, Y.H., Adijiang, A., Vandanmagsar, B., et al. Elimination of the NLRP3-ASC inflammasome protects against chronic obesity-induced pancreatic damage. Endocrinology 152 (2011), 4039–4045.
    • (2011) Endocrinology , vol.152 , pp. 4039-4045
    • Youm, Y.H.1    Adijiang, A.2    Vandanmagsar, B.3
  • 57
    • 79751512463 scopus 로고    scopus 로고
    • The NLRP3 inflammasome instigates obesity-induced inflammation and insulin resistance
    • 57 Vandanmagsar, B., Youm, Y.H., Ravussin, A., et al. The NLRP3 inflammasome instigates obesity-induced inflammation and insulin resistance. Nat Med 17 (2011), 179–188.
    • (2011) Nat Med , vol.17 , pp. 179-188
    • Vandanmagsar, B.1    Youm, Y.H.2    Ravussin, A.3
  • 58
    • 79955038882 scopus 로고    scopus 로고
    • Fatty acid-induced NLRP3-ASC inflammasome activation interferes with insulin signaling
    • 58 Wen, H., Gris, D., Lei, Y., et al. Fatty acid-induced NLRP3-ASC inflammasome activation interferes with insulin signaling. Nat Immunol 12 (2011), 408–415.
    • (2011) Nat Immunol , vol.12 , pp. 408-415
    • Wen, H.1    Gris, D.2    Lei, Y.3
  • 59
    • 74549184092 scopus 로고    scopus 로고
    • The NLRP3 inflammasome: a sensor for metabolic danger?
    • 59 Schroder, K., Zhou, R., Tschopp, J., The NLRP3 inflammasome: a sensor for metabolic danger?. Science 327 (2010), 296–300.
    • (2010) Science , vol.327 , pp. 296-300
    • Schroder, K.1    Zhou, R.2    Tschopp, J.3
  • 60
    • 84962433778 scopus 로고    scopus 로고
    • A role of the inflammasome in the low storage capacity of the abdominal subcutaneous adipose tissue in obese adolescents
    • 60 Kursawe, R., Dixit, V.D., Scherer, P.E., et al. A role of the inflammasome in the low storage capacity of the abdominal subcutaneous adipose tissue in obese adolescents. Diabetes 65 (2016), 610–618.
    • (2016) Diabetes , vol.65 , pp. 610-618
    • Kursawe, R.1    Dixit, V.D.2    Scherer, P.E.3
  • 61
    • 0035344226 scopus 로고    scopus 로고
    • Growth of visceral fat, subcutaneous abdominal fat, and total body fat in children
    • 61 Huang, T.T., Johnson, M.S., Figueroa-Colon, R., et al. Growth of visceral fat, subcutaneous abdominal fat, and total body fat in children. Obes Res 9 (2001), 283–289.
    • (2001) Obes Res , vol.9 , pp. 283-289
    • Huang, T.T.1    Johnson, M.S.2    Figueroa-Colon, R.3
  • 62
    • 84856282020 scopus 로고    scopus 로고
    • Impaired insulin sensitivity and elevated ectopic fat in healthy obese vs. nonobese prepubertal children
    • 62 Bennett, B., Larson-Meyer, D.E., Ravussin, E., et al. Impaired insulin sensitivity and elevated ectopic fat in healthy obese vs. nonobese prepubertal children. Obesity (Silver Spring) 20 (2012), 371–375.
    • (2012) Obesity (Silver Spring) , vol.20 , pp. 371-375
    • Bennett, B.1    Larson-Meyer, D.E.2    Ravussin, E.3
  • 63
    • 0029861999 scopus 로고    scopus 로고
    • Causal linkage between insulin suppression of lipolysis and suppression of liver glucose output in dogs
    • 63 Rebrin, K., Steil, G.M., Mittelman, S.D., et al. Causal linkage between insulin suppression of lipolysis and suppression of liver glucose output in dogs. J Clin Invest 98 (1996), 741–749.
    • (1996) J Clin Invest , vol.98 , pp. 741-749
    • Rebrin, K.1    Steil, G.M.2    Mittelman, S.D.3
  • 64
    • 84922709227 scopus 로고    scopus 로고
    • Hepatic acetyl CoA links adipose tissue inflammation to hepatic insulin resistance and type 2 diabetes
    • 64 Perry, R.J., Camporez, J.P., Kursawe, R., et al. Hepatic acetyl CoA links adipose tissue inflammation to hepatic insulin resistance and type 2 diabetes. Cell 160 (2015), 745–758.
    • (2015) Cell , vol.160 , pp. 745-758
    • Perry, R.J.1    Camporez, J.P.2    Kursawe, R.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.