-
1
-
-
77951918926
-
Macrophages, inflammation, and insulin resistance
-
Olefsky JM, Glass CK. Macrophages, inflammation, and insulin resistance. Annu Rev Physiol 2010;72:219-246
-
(2010)
Annu Rev Physiol
, vol.72
, pp. 219-246
-
-
Olefsky, J.M.1
Glass, C.K.2
-
2
-
-
0027459878
-
Adipose expression of tumor necrosis factor-alpha: Direct role in obesity-linked insulin resistance
-
Hotamisligil GS, Shargill NS, Spiegelman BM. Adipose expression of tumor necrosis factor-alpha: direct role in obesity-linked insulin resistance. Science 1993;259:87-91
-
(1993)
Science
, vol.259
, pp. 87-91
-
-
Hotamisligil, G.S.1
Shargill, N.S.2
Spiegelman, B.M.3
-
3
-
-
31044456529
-
CCR2 modulates inflammatory and metabolic effects of high-fat feeding
-
Weisberg SP, Hunter D, Huber R, et al. CCR2 modulates inflammatory and metabolic effects of high-fat feeding. J Clin Invest 2006;116:115-124
-
(2006)
J Clin Invest
, vol.116
, pp. 115-124
-
-
Weisberg, S.P.1
Hunter, D.2
Huber, R.3
-
4
-
-
17944365228
-
The fat-derived hormone adiponectin reverses insulin resistance associated with both lipoatrophy and obesity
-
Yamauchi T, Kamon J, Waki H, et al. The fat-derived hormone adiponectin reverses insulin resistance associated with both lipoatrophy and obesity. Nat Med 2001;7:941-946
-
(2001)
Nat Med
, vol.7
, pp. 941-946
-
-
Yamauchi, T.1
Kamon, J.2
Waki, H.3
-
5
-
-
80053087484
-
Inflammasome is a central player in the induction of obesity and insulin resistance
-
Stienstra R, van Diepen JA, Tack CJ, et al. Inflammasome is a central player in the induction of obesity and insulin resistance. Proc Natl Acad Sci USA 2011; 108:15324-15329
-
(2011)
Proc Natl Acad Sci USA
, vol.108
, pp. 15324-15329
-
-
Stienstra, R.1
Van Diepen, J.A.2
Tack, C.J.3
-
6
-
-
78649498271
-
The inflammasome-mediated caspase-1 activation controls adipocyte differentiation and insulin sensitivity
-
Stienstra R, Joosten LA, Koenen T, et al. The inflammasome-mediated caspase-1 activation controls adipocyte differentiation and insulin sensitivity. Cell Metab 2010;12:593-605
-
(2010)
Cell Metab
, vol.12
, pp. 593-605
-
-
Stienstra, R.1
Joosten, L.A.2
Koenen, T.3
-
7
-
-
80054903245
-
Elimination of the NLRP3-ASC inflammasome protects against chronic obesity-induced pancreatic damage
-
Youm YH, Adijiang A, Vandanmagsar B, Burk D, Ravussin A, Dixit VD. Elimination of the NLRP3-ASC inflammasome protects against chronic obesity-induced pancreatic damage. Endocrinology 2011;152:4039-4045
-
(2011)
Endocrinology
, vol.152
, pp. 4039-4045
-
-
Youm, Y.H.1
Adijiang, A.2
Vandanmagsar, B.3
Burk, D.4
Ravussin, A.5
Dixit, V.D.6
-
8
-
-
79751512463
-
The NLRP3 inflammasome instigates obesity-induced inflammation and insulin resistance
-
Vandanmagsar B, Youm YH, Ravussin A, et al. The NLRP3 inflammasome instigates obesity-induced inflammation and insulin resistance. Nat Med 2011; 17:179-188
-
(2011)
Nat Med
, vol.17
, pp. 179-188
-
-
Vandanmagsar, B.1
Youm, Y.H.2
Ravussin, A.3
-
9
-
-
79955038882
-
Fatty acid-induced NLRP3-ASC inflammasome activation interferes with insulin signaling
-
Wen H, Gris D, Lei Y, et al. Fatty acid-induced NLRP3-ASC inflammasome activation interferes with insulin signaling. Nat Immunol 2011;12:408-415
-
(2011)
Nat Immunol
, vol.12
, pp. 408-415
-
-
Wen, H.1
Gris, D.2
Lei, Y.3
-
10
-
-
74549184092
-
The NLRP3 inflammasome: A sensor for metabolic danger?
-
Schroder K, Zhou R, Tschopp J. The NLRP3 inflammasome: a sensor for metabolic danger? Science 2010;327:296-300
-
(2010)
Science
, vol.327
, pp. 296-300
-
-
Schroder, K.1
Zhou, R.2
Tschopp, J.3
-
11
-
-
77956383646
-
Cellularity and adipogenic profile of the abdominal subcutaneous adipose tissue from obese adolescents: Association with insulin resistance and hepatic steatosis
-
Kursawe R, Eszlinger M, Narayan D, et al. Cellularity and adipogenic profile of the abdominal subcutaneous adipose tissue from obese adolescents: association with insulin resistance and hepatic steatosis. Diabetes 2010;59:2288-2296
-
(2010)
Diabetes
, vol.59
, pp. 2288-2296
-
-
Kursawe, R.1
Eszlinger, M.2
Narayan, D.3
-
12
-
-
40749121780
-
High visceral and low abdominal subcutaneous fat stores in the obese adolescent: A determinant of an adverse metabolic phenotype
-
Taksali SE, Caprio S, Dziura J, et al. High visceral and low abdominal subcutaneous fat stores in the obese adolescent: a determinant of an adverse metabolic phenotype. Diabetes 2008;57:367-371
-
(2008)
Diabetes
, vol.57
, pp. 367-371
-
-
Taksali, S.E.1
Caprio, S.2
Dziura, J.3
-
13
-
-
0032821965
-
Insulin sensitivity indices obtained from oral glucose tolerance testing
-
Matsuda M, DeFronzo RA. Insulin sensitivity indices obtained from oral glucose tolerance testing. Diabetes Care. 1999;22:1462-1470
-
(1999)
Diabetes Care
, vol.22
, pp. 1462-1470
-
-
Matsuda, M.1
DeFronzo, R.A.2
-
14
-
-
68949136755
-
Glucose dysregulation and hepatic steatosis in obese adolescents: Is there a link?
-
Cali AM, De Oliveira AM, Kim H, et al. Glucose dysregulation and hepatic steatosis in obese adolescents: is there a link? Hepatology 2009;49:1896-1903
-
(2009)
Hepatology
, vol.49
, pp. 1896-1903
-
-
Cali, A.M.1
De Oliveira, A.M.2
Kim, H.3
-
15
-
-
40449095940
-
Comparative MR study of hepatic fat quantification using single-voxel proton spectroscopy, two-point dixon and three-point IDEAL
-
Kim H, Taksali SE, Dufour S, et al. Comparative MR study of hepatic fat quantification using single-voxel proton spectroscopy, two-point dixon and three-point IDEAL. Magn Reson Med 2008;59:521-527
-
(2008)
Magn Reson Med
, vol.59
, pp. 521-527
-
-
Kim, H.1
Taksali, S.E.2
Dufour, S.3
-
16
-
-
84962345155
-
Sphingolipid profiling of adipose tissue: Specific overexpression of ceramidase improves whole body glucose and lipid metabolism
-
Late-breaking poster presented at the 9-13 June Minneapolis, Minnesota
-
Holland WL, Miyauchi Y, Gordillo R, Scherer PE. Sphingolipid profiling of adipose tissue: specific overexpression of ceramidase improves whole body glucose and lipid metabolism. Late-breaking poster presented at the ASMS 61st Conference on Mass Spectrometry and Allied Topics, 9-13 June 2013, Minneapolis, Minnesota
-
(2013)
ASMS 61st Conference on Mass Spectrometry and Allied Topics
-
-
Holland, W.L.1
Miyauchi, Y.2
Gordillo, R.3
Scherer, P.E.4
-
17
-
-
82255164629
-
SirT1 regulates adipose tissue inflammation
-
Gillum MP, Kotas ME, Erion DM, et al. SirT1 regulates adipose tissue inflammation. Diabetes 2011;60:3235-3245
-
(2011)
Diabetes
, vol.60
, pp. 3235-3245
-
-
Gillum, M.P.1
Kotas, M.E.2
Erion, D.M.3
-
18
-
-
84883825948
-
Mechanisms of disease: Inflammasome activation and the development of type 2 diabetes
-
Grant RW, Dixit VD. Mechanisms of disease: inflammasome activation and the development of type 2 diabetes. Front Immunol 2013;4:50
-
(2013)
Front Immunol
, vol.4
, pp. 50
-
-
Grant, R.W.1
Dixit, V.D.2
-
19
-
-
33746736936
-
Long-term treatment with interleukin-1beta induces insulin resistance in murine and human adipocytes
-
Lagathu C, Yvan-Charvet L, Bastard JP, et al. Long-term treatment with interleukin-1beta induces insulin resistance in murine and human adipocytes. Diabetologia 2006;49:2162-2173
-
(2006)
Diabetologia
, vol.49
, pp. 2162-2173
-
-
Lagathu, C.1
Yvan-Charvet, L.2
Bastard, J.P.3
-
20
-
-
84885863093
-
Obesity phenotype is related to NLRP3 inflammasome activity and immunological profile of visceral adipose tissue
-
Esser N, L'homme L, De Roover A, et al. Obesity phenotype is related to NLRP3 inflammasome activity and immunological profile of visceral adipose tissue. Diabetologia 2013;56:2487-2497
-
(2013)
Diabetologia
, vol.56
, pp. 2487-2497
-
-
Esser, N.1
L'Homme, L.2
De Roover, A.3
-
21
-
-
84857364150
-
Expression of NLRP3 inflammasome and T cell population markers in adipose tissue are associated with insulin resistance and impaired glucose metabolism in humans
-
Goossens GH, Blaak EE, Theunissen R, et al. Expression of NLRP3 inflammasome and T cell population markers in adipose tissue are associated with insulin resistance and impaired glucose metabolism in humans. Mol Immunol 2012;50:142-149
-
(2012)
Mol Immunol
, vol.50
, pp. 142-149
-
-
Goossens, G.H.1
Blaak, E.E.2
Theunissen, R.3
-
22
-
-
84864678390
-
High-fat diet triggers inflammation-induced cleavage of SIRT1 in adipose tissue to promote metabolic dysfunction
-
Chalkiadaki A, Guarente L. High-fat diet triggers inflammation-induced cleavage of SIRT1 in adipose tissue to promote metabolic dysfunction. Cell Metab 2012;16:180-188
-
(2012)
Cell Metab
, vol.16
, pp. 180-188
-
-
Chalkiadaki, A.1
Guarente, L.2
-
23
-
-
0346729968
-
Ceramide content is increased in skeletal muscle from obese insulin-resistant humans
-
Adams JM 2nd, Pratipanawatr T, Berria R, et al. Ceramide content is increased in skeletal muscle from obese insulin-resistant humans. Diabetes 2004;53:25-31
-
(2004)
Diabetes
, vol.53
, pp. 25-31
-
-
Adams, J.M.1
Pratipanawatr, T.2
Berria, R.3
-
24
-
-
33750590489
-
Altered adipose and plasma sphingolipid metabolism in obesity: A potential mechanism for cardiovascular and metabolic risk
-
Samad F, Hester KD, Yang G, Hannun YA, Bielawski J. Altered adipose and plasma sphingolipid metabolism in obesity: a potential mechanism for cardiovascular and metabolic risk. Diabetes 2006;55:2579-2587
-
(2006)
Diabetes
, vol.55
, pp. 2579-2587
-
-
Samad, F.1
Hester, K.D.2
Yang, G.3
Hannun, Y.A.4
Bielawski, J.5
-
25
-
-
0032478314
-
Fatty acid-induced beta cell apoptosis: A link between obesity and diabetes
-
Shimabukuro M, Zhou YT, Levi M, Unger RH. Fatty acid-induced beta cell apoptosis: a link between obesity and diabetes. Proc Natl Acad Sci USA 1998;95: 2498-2502
-
(1998)
Proc Natl Acad Sci USA
, vol.95
, pp. 2498-2502
-
-
Shimabukuro, M.1
Zhou, Y.T.2
Levi, M.3
Unger, R.H.4
-
26
-
-
13444251524
-
TNFalpha-induced insulin resistance in adipocytes as a membrane microdomain disorder: Involvement of ganglioside GM3
-
Kabayama K, Sato T, Kitamura F, et al. TNFalpha-induced insulin resistance in adipocytes as a membrane microdomain disorder: involvement of ganglioside GM3. Glycobiology 2005;15:21-29
-
(2005)
Glycobiology
, vol.15
, pp. 21-29
-
-
Kabayama, K.1
Sato, T.2
Kitamura, F.3
-
27
-
-
79955487247
-
Lipid-induced insulin resistance mediated by the proinflammatory receptor TLR4 requires saturated fatty acid-induced ceramide biosynthesis in mice
-
Holland WL, Bikman BT, Wang LP, et al. Lipid-induced insulin resistance mediated by the proinflammatory receptor TLR4 requires saturated fatty acid-induced ceramide biosynthesis in mice. J Clin Invest 2011;121:1858-1870
-
(2011)
J Clin Invest
, vol.121
, pp. 1858-1870
-
-
Holland, W.L.1
Bikman, B.T.2
Wang, L.P.3
-
28
-
-
84877294515
-
Plasma ceramides are elevated in female children and adolescents with type 2 diabetes
-
Lopez X, Goldfine AB, Holland WL, Gordillo R, Scherer PE. Plasma ceramides are elevated in female children and adolescents with type 2 diabetes. J Pediatr Endocrinol Metab 2013;26:995-998
-
(2013)
J Pediatr Endocrinol Metab
, vol.26
, pp. 995-998
-
-
Lopez, X.1
Goldfine, A.B.2
Holland, W.L.3
Gordillo, R.4
Scherer, P.E.5
-
29
-
-
84862648634
-
Serum sphingolipids and inflammatory mediators in adolescents at risk for metabolic syndrome
-
Majumdar I, Mastrandrea LD. Serum sphingolipids and inflammatory mediators in adolescents at risk for metabolic syndrome. Endocrine 2012;41:442-449
-
(2012)
Endocrine
, vol.41
, pp. 442-449
-
-
Majumdar, I.1
Mastrandrea, L.D.2
-
30
-
-
46649108016
-
Protection from high fat diet-induced increase in ceramide in mice lacking plasminogen activator inhibitor 1
-
Shah C, Yang G, Lee I, Bielawski J, Hannun YA, Samad F. Protection from high fat diet-induced increase in ceramide in mice lacking plasminogen activator inhibitor 1. J Biol Chem 2008;283:13538-13548
-
(2008)
J Biol Chem
, vol.283
, pp. 13538-13548
-
-
Shah, C.1
Yang, G.2
Lee, I.3
Bielawski, J.4
Hannun, Y.A.5
Samad, F.6
-
32
-
-
34547558619
-
Adipose tissue inflammation and increased ceramide content characterize subjects with high liver fat content independent of obesity
-
Kolak M, Westerbacka J, Velagapudi VR, et al. Adipose tissue inflammation and increased ceramide content characterize subjects with high liver fat content independent of obesity. Diabetes 2007;56:1960-1968
-
(2007)
Diabetes
, vol.56
, pp. 1960-1968
-
-
Kolak, M.1
Westerbacka, J.2
Velagapudi, V.R.3
-
33
-
-
77950543816
-
Diacylglycerol-mediated insulin resistance
-
Erion DM, Shulman GI. Diacylglycerol-mediated insulin resistance. Nat Med 2010;16:400-402
-
(2010)
Nat Med
, vol.16
, pp. 400-402
-
-
Erion, D.M.1
Shulman, G.I.2
|