Alanine aminotransferase levels and fatty liver in childhood obesity: Associations with insulin resistance, adiponectin, and visceral fat

Journal of Clinical Endocrinology and Metabolism

Volumn 91, Issue 11, 2006, Pages 4287-4294

  Burgert, Tania S ^a   Taksali, Sara E ^a   Dziura, James ^a   Goodman, T Robin ^a   Yeckel, Catherine W ^a   Papademetris, Xenophon ^a   Constable, R Todd ^a   Weiss, Ram ^a   Tamborlane, William V ^a   Savoye, Mary ^a   Seyal, Aisha A ^a   Caprio, Sonia ^a  

^a YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADIPOCYTOKINE; ADIPONECTIN; ALANINE AMINOTRANSFERASE; BIOLOGICAL MARKER; FATTY ACID; GLUCOSE; LIPID; TRIACYLGLYCEROL;

ABNORMALLY HIGH SUBSTRATE CONCENTRATION IN BLOOD; ADOLESCENT; ADULT; ALANINE AMINOTRANSFERASE BLOOD LEVEL; ARTICLE; BODY FAT DISTRIBUTION; CONTROLLED STUDY; DEMOGRAPHY; DISEASE ASSOCIATION; FATTY LIVER; FEMALE; GLUCOSE METABOLISM; GLUCOSE TOLERANCE; HUMAN; INFLAMMATION; INSULIN RESISTANCE; INSULIN SENSITIVITY; LIPID METABOLISM; LIPID STORAGE; LIVER INJURY; MAJOR CLINICAL STUDY; MALE; METABOLIC SYNDROME X; NUCLEAR MAGNETIC RESONANCE IMAGING; OBESITY; PRIORITY JOURNAL;

EID: 33751519769     PISSN: 0021972X     EISSN: 0021972X     Source Type: Journal    
DOI: 10.1210/jc.2006-1010     Document Type: Article

References (42)

1. Lavine JE, Schwimmer JB 2004 Nonalcoholic fatty liver disease in the pediatric population. Clin Liver Dis 8:549-558, viii-ix
2. Angulo P 2002 Nonalcoholic fatty liver disease. N Engl J Med 346:1221-1231
3. Day CP, James OF 1998 Hepatic steatosis: innocent bystander or guilty party? Hepatology 27:1463-1466
4. Schwimmer JB, Behling C, Newbury R, Deutsch R, Nievergelt C, Schork NJ, Lavine JE 2005 Histopathology of pediatric nonalcoholic fatty liver disease. Hepatology 42:641-649
5. Vozarova B, Stefan N, Lindsay RS, Saremi A, Pratley RE, Bogardus C, Tataranni PA 2002 High alanine aminotransferase is associated with decreased hepatic insulin sensitivity and predicts the development of type 2 diabetes. Diabetes 51:1889-1895
6. Nadeau KJ, Klingensmith G, Zeitler P 2005 Type 2 diabetes in children is frequently associated with elevated alanine aminotransferase. J Pediatr Gastroenterol Nutr 41:94-98
7. Weiss R, Dziura J, Burgert TS, Tamborlane WV, Taksali SE, Yeckel CW, Allen K, Lopes M, Savoye M, Morrison J, Sherwin RS, Caprio S 2004 Obesity and the metabolic syndrome in children and adolescents. N Engl J Med 350:2362-2374
8. Matsuda M, DeFronzo RA 1999 Insulin sensitivity indices obtained from oral glucose tolerance testing: comparison with the euglycemic insulin clamp. Diabetes Care 22:1462-1470
9. Yeckel CW, Weiss R, Dziura J, Taksali SE, Dufour S, Burgert TS, Tamborlane WV, Caprio S 2004 Validation of insulin sensitivity indices from oral glucose tolerance test parameters in obese children and adolescents. J Clin Endocrinol Metab 89:1096-1101
10. Porte Jr D, Kahn SE 2001 β-Cell dysfunction and failure in type 2 diabetes: potential mechanisms. Diabetes 50(Suppl 1):S160-S163
11. Siest G, Schiele F, Galteau MM, Panek E, Steinmetz J, Fagnani F, Gueguen R 1975 Aspartate aminotransferase and alanine aminotransferase activities in plasma: statistical distributions, individual variations, and reference values. Clin Chem 21:1077-1087
12. Prati D, Taioli E, Zanella A, Della Torre E, Butelli S, Del Vecchio E, Vianello L, Zanuso F, Mozzi F, Milani S, Conte D, Colombo M, Sirchia G 2002 Updated definitions of healthy ranges for serum alanine aminotransferase levels. Ann Intern Med 137:1-10
13. Fishbein MH, Gardner KG, Potter CJ, Schmalbrock P, Smith MA 1997 Introduction of fast MR imaging in the assessment of hepatic steatosis. Magn Reson Imaging 15:287-293
14. Rorden C UoSC. MRIcro. http://www.sph.sc.edu/comd/rorden/mricro.html
15. Szczepaniak LS, Nurenberg P, Leonard D, Browning JD, Reingold JS, Grundy S, Hobbs HH, Dobbins RL 2005 Magnetic resonance spectroscopy to measure hepatic triglyceride content: prevalence of hepatic steatosis in the general population. Am J Physiol Endocrinol Metab 288:E462-E468
16. Papademetris X, Jackowski M, Rajeevan N, Constable R, Staib L Bioimage suite, Yale Department of Diagnostic Imaging. http://www.bioimagesuite.org
17. Ross R, Aru J, Freeman J, Hudson R, Janssen I 2002 Abdominal adiposity and insulin resistance in obese men. Am J Physiol Endocrinol Metab 282:E657-E663
18. Fishbein MH, Miner M, Mogren C, Chalekson J 2003 The spectrum of fatty liver in obese children and the relationship of serum aminotransferases to severity of steatosis. J Pediatr Gastroenterol Nutr 36:54-61
19. Kawasaki T, Hashimoto N, Kikuchi T, Takahashi H, Uchiyama M 1997 The relationship between fatty liver and hyperinsulinemia in obese Japanese children. J Pediatr Gastroenterol Nutr 24:317-321
20. Chan DF, Li AM, Chu WC, Chan MH, Wong EM, Liu EK, Chan IH, Yin J, Lam CW, Fok TF, Nelson EA 2004 Hepatic steatosis in obese Chinese children. Int J Obes Relat Metab Disord 28:1257-1263
21. Schwimmer JB, Deutsch R, Rauch JB, Behling C, Newbury R, Lavine JE 2003 Obesity, insulin resistance, and other clinicopathological correlates of pediatric nonalcoholic fatty liver disease. J Pediatr 143:500-505
22. Sattar N, Scherbakova O, Ford I, O'Reilly DS, Stanley A, Forrest E, Macfarlane PW, Packard CJ, Cobbe SM, Shepherd J; West of Scotland Coronary Prevention Study 2004 Elevated alanine aminotransferase predicts new-onset type 2 diabetes independently of classical risk factors, metabolic syndrome, and C-reactive protein in the west of Scotland coronary prevention study. Diabetes 53:2855-2860
23. Iozzo P, Lautamaki R, Geisler F, Virtanen KA, Oikonen V, Haaparanta M, Yki-Jarvinen H, Ferrannini E, Knuuti J, Nuutila P 2004 Non-esterified fatty acids impair insulin-mediated glucose uptake and disposition in the liver. Diabetologia 47:1149-1156
24. Iozzo P, Turpeinen AK, Takala T, Oikonen V, Bergman J, Gronroos T, Ferrannini E, Nuutila P, Knuuti J 2004 Defective liver disposal of free fatty acids in patients with impaired glucose tolerance. J Clin Endocrinol Metab 89:3496-3502
25. Seppala-Lindroos A, Vehkavaara S, Hakkinen AM, Goto T, Westerbacka J, Sovijarvi A, Halavaara J, Yki-Jarvinen H 2002 Fat accumulation in the liver is associated with defects in insulin suppression of glucose production and serum free fatty acids independent of obesity in normal men. J Clin Endocrinol Metab 87:3023-3028
26. Park SH, Kim BI, Yun JW, Kim JW, Park DI, Cho YK, Sung IK, Park CY, Sohn CI, Jeon WK, Kim H, Rhee EJ, Lee WY, Kim SW 2004 Insulin resistance and C-reactive protein as independent risk factors for non-alcoholic fatty liver disease in non-obese Asian men. J Gastroenterol Hepatol 19:694-698
27. Marchesini G, Bugianesi E, Forlani G, Cerrelli F, Lenzi M, Manini R, Natale S, Vanni E, Villanova N, Melchionda N, Rizzetto M 2003 Nonalcoholic fatty liver, steatohepatitis, and the metabolic syndrome. Hepatology 37:917-923
28. Targher G, Bertolini L, Zenari L 2004 Hypoadiponectinemia is closely associated with nonalcoholic hepatic steatosis in obese subjects. Diabetes Care 27:2085-2086
29. Hui JM, Hodge A, Farrell GC, Kench JG, Kriketos A, George J 2004 Beyond insulin resistance in NASH: TNF-α or adiponectin? Hepatology 40:46-54
30. Xu A, Yin S, Wong L, Chan KW, Lam KS 2004 Adiponectin ameliorates dyslipidemia induced by the human immunodeficiency virus protease inhibitor ritonavir in mice. Endocrinology 145:487-494
31. Bajaj M, Suraamornkul S, Piper P, Hardies LJ, Glass L, Cersosimo E, Pratipanawatr T, Miyazaki Y, DeFronzo RA 2004 Decreased plasma adiponectin concentrations are closely related to hepatic fat content and hepatic insulin resistance in pioglitazone-treated type 2 diabetic patients. J Clin Endocrinol Metab 89:200-206
32. Louthan MV, Barve S, McClain CJ, Joshi-Barve S 2005 Decreased serum adiponectin: an early event in pediatric nonalcoholic fatty liver disease. J Pediatr 147:835-838
33. Sabir N, Sermez Y, Kazil S, Zencir M 2001 Correlation of abdominal fat accumulation and liver steatosis: importance of ultrasonographic and anthropometric measurements. Eur J Ultrasound 14:121-128
34. Busetto L, Tregnaghi A, De Marchi F, Segato G, Foletto M, Sergi G, Favretti F, Lise M, Enzi G 2002 Liver volume and visceral obesity in women with hepatic steatosis undergoing gastric banding. Obes Res 10:408-411
35. Fishbein MH, Mogren C, Gleason T, Stevens WR 2006 Relationship of hepatic steatosis to adipose tissue distribution in pediatric nonalcoholic fatty liver disease. J Pediatr Gastroenterol Nutr 42:83-88
36. Nielsen S, Guo Z, Johnson CM, Hensrud DD, Jensen MD 2004 Splanchnic lipolysis in human obesity. J Clin Invest 113:1582-1588
37. Frayn KN 2000 Visceral fat and insulin resistance - causative or correlative? Br J Nutr 83(Suppl 1):S71-S77
38. Ravussin E, Smith SR 2002 Increased fat intake, impaired fat oxidation, and failure of fat cell proliferation result in ectopic fat storage, insulin resistance, and type 2 diabetes mellitus. Ann NY Acad Sci 967:363-378
39. Kelley DE, Thaete FL, Troost F, Huwe T, Goodpaster BH 2000 Subdivisions of subcutaneous abdominal adipose tissue and insulin resistance. Am J Physiol Endocrinol Metab 278:E941-E948
40. Miyazaki Y, Glass L, Triplitt C, Wajcberg E, Mandarino LJ, DeFronzo RA 2002 Abdominal fat distribution and peripheral and hepatic insulin resistance in type 2 diabetes mellitus. Am J Physiol Endocrinol Metab 283:E1135-E1143
41. Abate N, Garg A, Peshock RM, Stray-Gundersen J, Adams-Huet B, Grundy SM 1996 Relationship of generalized and regional adiposity to insulin sensitivity in men with NIDDM. Diabetes 45:1684-1693
42. Schwimmer JB, McGreal N, Deutsch R, Finegold MJ, Lavine JE 2005 Influence of gender, race, and ethnicity on suspected fatty liver in obese adolescents. Pediatrics 115:e561-e565