Prediabetes in obese youth: A syndrome of impaired glucose tolerance, severe insulin resistance, and altered myocellular and abdominal fat partitioning

Lancet

Volumn 362, Issue 9388, 2003, Pages 951-957

  Weiss, Ram ^a   Dufour, Sylvie ^b   Taksali, Sara E ^a   Tamborlane, William V ^a   Petersen, Kitt F ^b   Bonadonna, Riccardo C ^c   Boselli, Linda ^c   Barbetta, Gina ^a   Allen, Karin ^a   Rife, Francis ^a   Savoye, Mary ^a   Dziura, James ^a   Sherwin, Robert ^b   Shulman, Gerald I ^b   Caprio, Sonia ^a,c  

^a YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b HOWARD HUGHES MEDICAL INSTITUTE   (United States)

^c UNIVERSITY HOSPITAL OF VERONA   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

GLUCOSE;

ADOLESCENT; ARTICLE; BODY MASS; CHILD; CLINICAL ARTICLE; DISEASE SEVERITY; FEMALE; GLUCOSE HOMEOSTASIS; GLUCOSE METABOLISM; HUMAN; HYPERINSULINEMIA; IMPAIRED GLUCOSE TOLERANCE; INSULIN RESISTANCE; INSULIN SENSITIVITY; MALE; MEDICAL ASSESSMENT; NUCLEAR MAGNETIC RESONANCE IMAGING; OBESITY; PRIORITY JOURNAL; PROTON NUCLEAR MAGNETIC RESONANCE; REDUCTION; SEX RATIO;

EID: 0141763847     PISSN: 01406736     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0140-6736(03)14364-4     Document Type: Article

References (32)

1. Rosenbloom A.L., Joe J.R., Young R.S., Winter W.E. Emerging epidemic of type 2 diabetes in youth. Diabetes Care. 22:1999;345-354.
2. Dabelea D., Pettitt D.J., Jones K.L., Arslanian S.A. Type 2 diabetes mellitus in minority children and adolescents: an emerging problem. Endocrinol Metab Clin North Am. 28:1999;709-729.
3. Kitagawa T., Owada M., Urakami T., Yamauchi K. Increased incidence of non-insulin dependent diabetes mellitus among Japanese schoolchildren correlates with an increased intake of animal protein and fat. Clin Pediatr. 37:1998;111-115.
4. Edelstein S.L., Knowler W.C., Bain R.P., et al. Predictors of progression from impaired glucose tolerance to NIDDM: an analysis of six prospective studies. Diabetes. 46:1997;701-710.
5. Sinha R., Fisch G., Teague B., et al. Prevalence of impaired glucose tolerance among children and adolescents with marked obesity. N Engl J Med. 346:2002;802-810.
6. Montague C.T., O'Rahilly S. The perils of portliness: causes and consequences of visceral adiposity. Diabetes. 49:2000;883-888.
7. McGarry D.J. Dysregulation of fatty acid metabolism in the etiology of type 2 diabetes. Diabetes. 51:2002;7-18.
8. Kelley D.E., Mandarino L.J. Fuel selection in human skeletal muscle in insulin resistance: a reexamination. Diabetes. 49:2000;677-683.
9. Perseghin G., Ghosh S., Gerow K., Shulman G.I. Metabolic defects in lean nondiabetic offspring of NIDDM parents: a cross-sectional study. Diabetes. 46:1997;1001-1009.
10. 1H-NMR spectroscopy study. Diabetologia. 42:1999;113-116.
11. Itani S.I., Ruderman N.B., Schmieder F., Boden G. Lipid-induced insulin resistance in human muscle is associated with changes in diacylglycerol, protein kinase C, and IkappaB-alpha. Diabetes. 51:2002;2005-2011.
12. Dresner A., Laurent D., Marcucci M., et al. Effects of free fatty acids on glucose transport and IRS-1-associated phosphatidylinositol 3-kinase activity. J Clin Invest. 103:1999;253-259.
13. Griffin M.E., Marcucci M.J., Cline G.W., et al. Free fatty acid induced insulin resistance is associated with activation of protein kinase C theta and alterations in the insulin signaling cascade. Diabetes. 48:1999;1270-1274.
14. Yu C., Chen Y., Cline G.W., et al. Mechanism by which fatty acids inhibit insulin activation of insulin receptor substrate-1 (IRS-1)-associated phosphatidylinositol 3-kinase activity in muscle. J Biol Chem. 277:2002;50230-50236.
15. Schick F., Eismann B., Jung W.I., Bongers H., Bunse M., Lutz O. Comparison of localized proton NMR signals of skeletal muscle and fat tissue in vivo: two lipid compartments in muscle tissue. Magn Reson Med. 29:1993;158-167.
16. 1H spectroscopy: validation in vivo. Am J Physiol. 276:1999;E977-E989.
17. 1H nuclear magnetic resonance spectroscopy in lean and obese adolescents: relationships to insulin sensitivity, total body fat, and central adiposity. Diabetes. 51:2002;1022-1027.
18. Kuczmarski R.J., Ogden C.L., Guo S.S., et al. 2000 CDC growth charts for the United States: methods and development. Vital Health Stat. 246:2002;1-190.
19. DeFronzo R.A., Tobin J.D., Andres R. Glucose clamp technique: a method for quantifying insulin secretion and resistance. Am J Physiol. 237:1979;E214-E223.
20. Finegood D.T., Bergman R.N., Vranic M. Estimation of endogenous glucose production during hyperinsulinemic-euglycemic glucose clamps: comparison of unlabeled and labeled exogenous glucose infusates. Diabetes. 36:1987;914-924.
21. Frayn K.N. Calculation of substrate oxidation rates in vivo from gaseous exchange. J Appl Physiol. 55:1983;628-634.
22. Caprio S., Hyman L.D., Limb C., et al. Central adiposity and its metabolic correlates in obese adolescent girls. Am J Physiol. 269:1995;E118-E126.
23. Mayerson A.B., Hundal R.S., Dufour S., et al. The effects of rosiglitazone on insulin sensitivity, lipolysis, and hepatic and skeletal muscle triglyceride content in patients with type 2 diabetes. Diabetes. 51:2002;797-802.
24. Robinson C., Tamborlane W.V., Maggs D.G., et al. Effect of insulin on glycerol production in obese adolescents. Am J Physiol. 274:1998;E737-E743.
25. DeFronzo R.A., Ferrannini E., Simonson D.C. Fasting hyperglycemia in non-insulin-dependent diabetes mellitus: contributions of excessive hepatic glucose production and impaired tissue glucose uptake. Metabolism. 38:1989;387-395.
26. Toffolo G., DeGrandi F., Cobelli C. Estimation of beta-cell sensitivity from intravenous glucose tolerance test C-peptide data: knowledge of the kinetics avoids errors in modeling the secretion. Diabetes. 44:1995;845-854.
27. Bonadonna R.C., Stumvoll M., Fritsche A., et al. Altered homeostatic adaptation of first- and second-phase beta-cell secretion in the offspring of patients with type 2 diabetes: studies with a minimal model to assess beta-cell function. Diabetes. 52:2003;470-480.
28. Shulman G.I., Rothman D.L., Jue T., Stein P., DeFronzo R.A., Shulman R.G. Quantitation of muscle glycogen synthesis in normal subjects and subjects with non-insulin-dependent diabetes by 13C nuclear magnetic resonance spectroscopy. N Engl J Med. 322:1990;223-228.
29. Greco A., Mingione G., Giancaterini A., et al. Insulin resistance in morbid obesity: reversal with intramyocellular fat depletion. Diabetes. 51:2002;144-151.
30. Boesch C., Kreis R. Observation of intramyocellular lipids by 1H-magnetic resonance spectroscopy. Ann NY Acad Sci. 904:2000;25-31.
31. Yamauchi T., Kamon J., Minokoshi Y., et al. Adiponectin stimulates glucose utilization and fatty-acid oxidation by activating AMP-activated protein kinase. Nat Med. 8:2002;1288-1295.
32. Weyer C., Bogardus C., Mott D.M., Pratley R.E. The natural history of insulin secretory dysfunction and insulin resistance in the pathogenesis of type 2 diabetes mellitus. J Clin Invest. 104:1999;787-794.