Dairy products and inflammation: A review of the clinical evidence

Critical Reviews in Food Science and Nutrition

Volumn 57, Issue 12, 2017, Pages 2497-2525

  Bordoni, Alessandra ^a   Danesi, Francesca ^a   Dardevet, Dominique ^b,c   Dupont, Didier ^d   Fernandez, Aida S ^e   Gille, Doreen ^f   Nunes dos Santos, Claudia ^g,h   Pinto, Paula ^g,i   Re, Roberta ^e   Rémond, Didier ^b,c   Shahar, Danit R ^j   Vergères, Guy ^f  

^a UNIVERSITY OF BOLOGNA   (Italy)

^b CRNH AUVERGNE   (France)

^c UNIVERSITÉ CLERMONT AUVERGNE   (France)

^d UMR1253   (France)

^e LEATHERHEAD FOOD RESEARCH   (United Kingdom)

^f AGROSCOPE   (Switzerland)

^g INSTITUTO DE TECNOLOGIA QUÍMICA E BIOLÓGICA   (Portugal)

^h Inst de Biol Exp Tecnologica   (Portugal)

ⁱ POLYTECHNIC INSTITUTE OF SANTARÉM   (Portugal)

^j BEN GURION UNIVERSITY OF THE NEGEV   (Israel)

more..

Author keywords

cheese; chronic diseases; health; immune system; Milk; obesity; yoghurt

Indexed keywords

BIOCHEMISTRY; CHEESES; DAIRY PRODUCTS; DISEASES; HEALTH; IMMUNE SYSTEM; MEDICAL APPLICATIONS; METABOLISM; NUTRIENTS; NUTRITION; PATHOLOGY;

ANTI-INFLAMMATORY ACTIVITY; CHRONIC DISEASE; CHRONIC INFLAMMATORY DISEASE; INFLAMMATORY ACTIVITY; MILK; OBESITY; REGULATORY PROPERTIES; YOGHURT;

DAIRIES;

AUTACOID; BIOLOGICAL MARKER;

ANIMAL; BLOOD; BOVINE; DAIRY PRODUCT; DIET; FEEDING BEHAVIOR; HUMAN; INFLAMMATION; METABOLISM; MILK;

ANIMALS; BIOMARKERS; CATTLE; DAIRY PRODUCTS; DIET; FEEDING BEHAVIOR; HUMANS; INFLAMMATION; INFLAMMATION MEDIATORS; MILK;

EID: 85018422789     PISSN: 10408398     EISSN: 15497852     Source Type: Journal    
DOI: 10.1080/10408398.2014.967385     Document Type: Review

References (97)

1. Aggett, P. J., Hathcock, J., Jukes, D., Richardson, D. P., Calder, P. C., Bischoff-Ferrari, H., Nicklas, T., Muhlebach, S., Kwon, O., Lewis, J., Lugard, M. J., and Prock, P., (2012). Nutrition issues in Codex:health claims, nutrient reference values and WTO agreements:a conference report. Eur. J. Nutr. 51(Suppl 1):S1–S7.
2. Arvola, T., Ruuska, T., Keranen, J., Hyoty, H., Salminen, S., and Isolauri, E., (2006). Rectal bleeding in infancy:clinical, allergological, and microbiological examination. Pediatrics 117:e760–e768.
3. Asemi, Z., Samimi, M., Tabassi, Z., Sabihi, S. S., and Esmaillzadeh, A., (2013). A randomized controlled clinical trial investigating the effect of DASH diet on insulin resistance, inflammation, and oxidative stress in gestational diabetes. Nutrition 29:619–624.
4. Augustin, M. A., and Udabage, P., (2007). Influence of processing on functionality of milk and dairy proteins. Adv. Food Nutr. Res. 53:1–38.
5. Ballard, O., and Morrow, A. L., (2013). Human milk composition:nutrients and bioactive factors. Pediatr. Clin. North Am. 60:49–74.
6. Beavers, K. M., Serra, M. C., Beavers, D. P., Cooke, M. B., and Willoughby, D. S., (2009). Soymilk supplementation does not alter plasma markers of inflammation and oxidative stress in postmenopausal women. Nutr Res 29:616–622.
7. Bland, J. M., and Altman, D. G., (2011). Comparisons against baseline within randomised groups are often used and can be highly misleading. Trials 12:264.
8. Bordoni, A., Picone, G., Babini, E., Vignali, M., Danesi, F., Valli, V., Di, N. M., Laghi, L., and Capozzi, F., (2011). NMR comparison of in vitro digestion of Parmigiano Reggiano cheese aged 15 and 30 months. Magn. Reson. Chem. 49(Suppl 1):S61–S70.
9. Breen, E. C., Reynolds, S. M., Cox, C., Jacobson, L. P., Magpantay, L., Mulder, C. B., Dibben, O., Margolick, J. B., Bream, J. H., Sambrano, E., Martinez-Maza, O., Sinclair, E., Borrow, P., Landay, A. L., Rinaldo, C. R., and Norris, P. J., (2011). Multisite comparison of high-sensitivity multiplex cytokine assays. Clin. Vaccine Immunol. 18:1229–1242.
10. Calder, P. C., Ahluwalia, N., Albers, R., Bosco, N., Bourdet-Sicard, R., Haller, D., Holgate, S. T., Jonsson, L. S., Latulippe, M. E., Marcos, A., Moreines, J., M'Rini, C., Muller, M., Pawelec, G., van Neerven, R. J., Watzl, B., and Zhao, J., (2013). A consideration of biomarkers to be used for evaluation of inflammation in human nutritional studies. Br. J. Nutr. 109(Suppl 1):S1–34.
11. Calder, P. C., Ahluwalia, N., Brouns, F., Buetler, T., Clement, K., Cunningham, K., Esposito, K., Jonsson, L. S., Kolb, H., Lansink, M., Marcos, A., Margioris, A., Matusheski, N., Nordmann, H., O'Brien, J., Pugliese, G., Rizkalla, S., Schalkwijk, C., Tuomilehto, J., Warnberg, J., Watzl, B., and Winklhofer-Roob, B. M., (2011). Dietary factors and low-grade inflammation in relation to overweight and obesity. Br. J. Nutr. 106(Suppl 3):S5–78.
12. Candore, G., Caruso, C., Jirillo, E., Magrone, T., and Vasto, S., (2010). Low grade inflammation as a common pathogenetic denominator in age-related diseases:novel drug targets for anti-ageing strategies and successful ageing achievement. Curr. Pharm. Des. 16:584–596.
13. Ceapa, C., Wopereis, H., Rezaiki, L., Kleerebezem, M., Knol, J., and Oozeer, R., (2013). Influence of fermented milk products, prebiotics and probiotics on microbiota composition and health. Best Pract. Res. Clin. Gastroenterol. 27:139–155.
14. Chatterton, D. E., Nguyen, D. N., Bering, S. B., and Sangild, P. T., (2013). Anti-inflammatory mechanisms of bioactive milk proteins in the intestine of newborns. Int. J. Biochem. Cell Biol. 45:1730–1747.
15. Dalbeth, N., Ames, R., Gamble, G. D., Horne, A., Wong, S., Kuhn-Sherlock, B., MacGibbon, A., McQueen, F. M., Reid, I. R., and Palamano, K., (2012). Effects of skim milk powder enriched with glycomacropeptide and G600 milk fat extract on frequency of gout flares:a proof-of-concept randomised controlled trial. Ann Rheum.Dis 71:929–934.
16. Dawczynski, C., Massey, K. A., Ness, C., Kiehntopf, M., Stepanow, S., Platzer, M., Grun, M., Nicolaou, A., and Jahreis, G., (2013). Randomized placebo-controlled intervention with n-3 LC-PUFA-supplemented yoghurt:effects on circulating eicosanoids and cardiovascular risk factors. Clin. Nutr. 32:686–696.
17. Dawczynski, C., Schubert, R., Hein, G., Muller, A., Eidner, T., Vogelsang, H., Basu, S., and Jahreis, G., (2009). Long-term moderate intervention with n-3 long-chain PUFA-supplemented dairy products:effects on pathophysiological biomarkers in patients with rheumatoid arthritis. Br. J Nutr 101:1517–1526.
18. De Aguilar-Nascimento, J. E., Prado Silveira, B. R., and Dock-Nascimento, D. B., (2011). Early enteral nutrition with whey protein or casein in elderly patients with acute ischemic stroke:a double-blind randomized trial. Nutrition 27:440–444.
19. Deopurkar, R., Ghanim, H., Friedman, J., Abuaysheh, S., Sia, C. L., Mohanty, P., Viswanathan, P., Chaudhuri, A., and Dandona, P., (2010). Differential effects of cream, glucose, and orange juice on inflammation, endotoxin, and the expression of Toll-like receptor-4 and suppressor of cytokine signaling-3. Diabetes Care 33:991–997.
20. Dunne, C., O'Mahony, L., Murphy, L., Thornton, G., Morrissey, D., O'Halloran, S., Feeney, M., Flynn, S., Fitzgerald, G., Daly, C., Kiely, B., O'sullivan, G. C., Shanahan, F., and Collins, J. K., (2001). In vitro selection criteria for probiotic bacteria of human origin:correlation with in vivo findings. Am. J. Clin. Nutr. 73:386S–392S.
21. EFSA Panel on Dietetic Products Nutrition and Allergies. (2011). Scientific and technical guidance for the preparation and presentation of an application for authorisation of a health claim (revision 1). 9 edn, p. 2170.
22. EFSA Panel on Dietetic Products, N. a. A. (2011). Guidance on the scientific requirements for health claims related to gut and immune function. EFSA J. 9:1984.
23. Esmaillzadeh, A., Kimiagar, M., Mehrabi, Y., Azadbakht, L., Hu, F. B., and Willett, W. C., (2007). Dietary patterns and markers of systemic inflammation among Iranian women. J. Nutr. 137:992–998.
24. FAO. (2013a). Food outlook - Biannual report on global food markets.
25. FAO. (2013b). Milk and dairy products in human nutrition.
26. FDA Office of Nutrition Labeling and Dietary Supplements. (2009). Guidance for Industry:Evidence-Based Review System for the Scientific Evaluation of Health Claims.
27. German, J. B., and Dillard, C. J., (2006). Composition, structure and absorption of milk lipids:a source of energy, fat-soluble nutrients and bioactive molecules. Crit. Rev. Food Sci. Nutr. 46:57–92.
28. Global Business Intelligence Research. (2011). Anti-Inflammatory Therapeutics Market to 2017 - Respiratory Diseases and Arthritis Continue to Dominate.
29. Gonsalves, N., Yang, G. Y., Doerfler, B., Ritz, S., Ditto, A. M., and Hirano, I., (2012). Elimination diet effectively treats eosinophilic esophagitis in adults; food reintroduction identifies causative factors. Gastroenterology 142:1451–1459.
30. Guri, A. J., and Bassaganya-Riera, J., (2011). Systemic effects of white adipose tissue dysregulation and obesity-related inflammation. Obesity (Silver Spring) 19:689–700.
31. Hakansson, A., and Molin, G., (2011). Gut microbiota and inflammation. Nutrients 3:637–682.
32. Haug, A., Hostmark, A. T., and Harstad, O. M., (2007). Bovine milk in human nutrition—a review. Lipids Health Dis. 6:25.
33. Henderson, C. J., Abonia, J. P., King, E. C., Putnam, P. E., Collins, M. H., Franciosi, J. P., and Rothenberg, M. E., (2012). Comparative dietary therapy effectiveness in remission of pediatric eosinophilic esophagitis. J Allergy Clin Immunol 129:1570–1578.
34. Hernandez-Aguilera, A., Rull, A., Rodriguez-Gallego, E., Riera-Borrull, M., Luciano-Mateo, F., Camps, J., Menendez, J. A., and Joven, J., (2013). Mitochondrial dysfunction:a basic mechanism in inflammation-related non-communicable diseases and therapeutic opportunities. Mediators Inflamm. 2013:135698.
35. Hirai, S., Takahashi, N., Goto, T., Lin, S., Uemura, T., Yu, R., and Kawada, T., (2010). Functional food targeting the regulation of obesity-induced inflammatory responses and pathologies. Mediators Inflamm. 2010:367838.
36. Hlebowicz, J., Persson, M., Gullberg, B., Sonestedt, E., Wallstrom, P., Drake, I., Nilsson, J., Hedblad, B., and Wirfalt, E., (2011). Food patterns, inflammation markers and incidence of cardiovascular disease:the Malmo Diet and Cancer study. J Intern Med 270:365–376.
37. Holmer-Jensen, J., Karhu, T., Mortensen, L. S., Pedersen, S. B., Herzig, K. H., and Hermansen, K., (2011). Differential effects of dietary protein sources on postprandial low-grade inflammation after a single high fat meal in obese non-diabetic subjects. Nutr J 10:115.
38. Hotamisligil, G. S., (2006). Inflammation and metabolic disorders. Nature 444:860–867.
39. Hunter, D. C., Brown, R., Green, T., Thomson, C., Skeaff, M., Williams, S., Todd, J. M., Lister, C. E., McGhie, T., Zhang, J., Martin, H., Rippon, P., Stanley, R., and Skinner, M. A., (2012). Changes in markers of inflammation, antioxidant capacity and oxidative stress in smokers following consumption of milk, and milk supplemented with fruit and vegetable extracts and vitamin C. Int J Food Sci Nutr 63:90–102.
40. Hunter, D. J., and Reddy, K. S., (2013). Noncommunicable diseases. N. Engl. J. Med. 369:1336–1343.
41. Iacono, G., Cavataio, F., Montalto, G., Florena, A., Tumminello, M., Soresi, M., Notarbartolo, A., and Carroccio, A., (1998). Intolerance of cow's milk and chronic constipation in children. N Engl J Med 339:1100–1104.
42. Iwasa, M., Aoi, W., Mune, K., Yamauchi, H., Furuta, K., Sasaki, S., Takeda, K., Harada, K., Wada, S., Nakamura, Y., Sato, K., and Higashi, A., (2013). Fermented milk improves glucose metabolism in exercise-induced muscle damage in young healthy men. Nutr. J. 12:83.
43. Jimenez-Flores, R., Heick, J., Davis, S. C., Hall, K. G., and Schaffner, A., (2012). A comparison of the effects of a high carbohydrate vs. a higher protein milk supplement following simulated mountain skirmishes. Mil. Med 177:723–731.
44. Jones, K. W., Eller, L. K., Parnell, J. A., Doyle-Baker, P. K., Edwards, A. L., and Reimer, R. A., (2013). Effect of a dairy- and calcium-rich diet on weight loss and appetite during energy restriction in overweight and obese adults:a randomized trial. Eur. J. Clin. Nutr. 67:371–376.
45. Jyonouchi, H., Sun, S., and Itokazu, N., (2002). Innate immunity associated with inflammatory responses and cytokine production against common dietary proteins in patients with autism spectrum disorder. Neuropsychobiology 46:76–84.
46. Kagalwalla, A. F., Shah, A., Li, B. U., Sentongo, T. A., Ritz, S., Manuel-Rubio, M., Jacques, K., Wang, D., Melin-Aldana, H., and Nelson, S. P., (2011). Identification of specific foods responsible for inflammation in children with eosinophilic esophagitis successfully treated with empiric elimination diet. J Pediatr. Gastroenterol Nutr 53:145–149.
47. Kagalwalla, A. F., Amsden, K., Shah, A., Ritz, S., Manuel-Rubio, M., Dunne, K., Nelson, S. P., Wershil, B. K., and Melin-Aldana, H., (2012). Cow's milk elimination:a novel dietary approach to treat eosinophilic esophagitis. J. Pediatr. Gastroenterol. Nutr. 55:711–716.
48. Kau, A. L., Ahern, P. P., Griffin, N. W., Goodman, A. L., and Gordon, J. I., (2011). Human nutrition, the gut microbiome and the immune system. Nature 474:327–336.
49. Klop, B., Proctor, S. D., Mamo, J. C., Botham, K. M., and Castro, C. M., (2012). Understanding postprandial inflammation and its relationship to lifestyle behaviour and metabolic diseases. Int. J. Vasc. Med. 2012:947417.
50. Kristjansson, G., Venge, P., and Hallgren, R., (2007). Mucosal reactivity to cow's milk protein in coeliac disease. Clin Exp. Immunol 147:449–455.
51. Labonte, M. E., Couture, P., Richard, C., Desroches, S., and Lamarche, B., (2014). Impact of dairy products on biomarkers of inflammation:a systematic review of randomized controlled nutritional intervention studies in overweight and obese adults. Am. J. Clin. Nutr. 97:706–717.
52. Lawrence, G. D., (2013). Dietary fats and health:dietary recommendations in the context of scientific evidence. Adv. Nutr. 4:294–302.
53. Lee, Y. M., Skurk, T., Hennig, M., and Hauner, H., (2007). Effect of a milk drink supplemented with whey peptides on blood pressure in patients with mild hypertension. Eur J Nutr 46:21–27.
54. Lepage, P., and Van de Perre, P., (2012). The immune system of breast milk:antimicrobial and anti-inflammatory properties. Adv. Exp. Med. Biol. 743:121–137.
55. Liu, M. Y., Xydakis, A. M., Hoogeveen, R. C., Jones, P. H., Smith, E. O., Nelson, K. W., and Ballantyne, C. M., (2005). Multiplexed analysis of biomarkers related to obesity and the metabolic syndrome in human plasma, using the Luminex-100 system. Clin. Chem. 51:1102–1109.
56. Lomax, A. R., and Calder, P. C., (2009). Probiotics, immune function, infection and inflammation:a review of the evidence from studies conducted in humans. Curr. Pharm. Des. 15:1428–1518.
57. Melnik, B. C., (2009). Milk–the promoter of chronic Western diseases. Med. Hypotheses. 72:631–639.
58. Meyer, A. L., Elmadfa, I., Herbacek, I., and Micksche, M., (2007). Probiotic, as well as conventional yogurt, can enhance the stimulated production of proinflammatory cytokines. J Hum Nutr Diet 20:590–598.
59. Meyer, J., Doring, A., Herder, C., Roden, M., Koenig, W., and Thorand, B., (2011). Dietary patterns, subclinical inflammation, incident coronary heart disease and mortality in middle-aged men from the MONICA/KORA Augsburg cohort study. Eur J Clin Nutr 65:800–807.
60. Micha, R., and Mozaffarian, D., (2009). Trans fatty acids:effects on metabolic syndrome, heart disease and diabetes. Nat. Rev. Endocrinol. 5:335–344.
61. Minekus, M., Alminger, M., Alvito, P., Ballance, S., Bohn, T., Bourlieu, C., Carrière, F., Boutrou, R., Corredig, M., Dupont, D., Dufour, C., Egger, L., Golding, M., Karakaya, S., Birkhus, B., Le Feunteun, S., Lesmes, U., Maczierzanka, A., MacKie, A., Marze, S., McClements, D. J., Ménard, O., Recio, I., Santos, C. N., Singh, R. P., Vegarud, G. E., Wickham, M. S. J., Weitschies, W., and Brodkorb, A., (2014). A standardized static in vitro digestion method suitable for food - an international consensus. Food. Funct. Jun;5(6):1113–1124.
62. Moher, D., Liberati, A., Tetzlaff, J., and Altman, D. G., (2009). Reprint–preferred reporting items for systematic reviews and meta-analyses:the PRISMA statement. Phys. Ther. 89:873–880.
63. Monagas, M., Khan, N., Andres-Lacueva, C., Casas, R., Urpi-Sarda, M., Llorach, R., Lamuela-Raventos, R. M., and Estruch, R., (2009). Effect of cocoa powder on the modulation of inflammatory biomarkers in patients at high risk of cardiovascular disease. Am J Clin Nutr 90:1144–1150.
64. Nestel, P. J., Pally, S., MaCintosh, G. L., Greeve, M. A., Middleton, S., Jowett, J., and Meikle, P. J., (2012). Circulating inflammatory and atherogenic biomarkers are not increased following single meals of dairy foods. Eur J Clin Nutr 66:25–31.
65. Nettleton, J. A., Steffen, L. M., Mayer-Davis, E. J., Jenny, N. S., Jiang, R., Herrington, D. M., and Jacobs, JRD. R., (2006). Dietary patterns are associated with biochemical markers of inflammation and endothelial activation in the Multi-Ethnic Study of Atherosclerosis (MESA). Am J Clin Nutr 83:1369–1379.
66. Newburg, D. S., (2013). Glycobiology of human milk. Biochemistry (Mosc) 78:771–785.
67. Oftedal, O. T., (2012). The evolution of milk secretion and its ancient origins. Animal 6:355–368.
68. Pal, S., and Ellis, V., (2011). Acute effects of whey protein isolate on blood pressure, vascular function and inflammatory markers in overweight postmenopausal women. Br.J Nutr 105:1512–1519.
69. Panagiotakos, D. B., Pitsavos, C. H., Zampelas, A. D., Chrysohoou, C. A., and Stefanadis, C. I., (2010). Dairy products consumption is associated with decreased levels of inflammatory markers related to cardiovascular disease in apparently healthy adults:the ATTICA study. J Am Coll. Nutr 29:357–364.
70. Panagiotakos, D. B., Pitsavos, C. H., Zampelas, A. D., Chrysohoou, C. A., and Stefanadis, C. I., (2010). Dairy products consumption is associated with decreased levels of inflammatory markers related to cardiovascular disease in apparently healthy adults:the ATTICA study. J. Am. Coll. Nutr. 29:357–364.
71. Pintus, S., Murru, E., Carta, G., Cordeddu, L., Batetta, B., Accossu, S., Pistis, D., Uda, S., Elena, G. M., Mele, M., Secchiari, P., Almerighi, G., Pintus, P., and Banni, S., (2013). Sheep cheese naturally enriched in alpha-linolenic, conjugated linoleic and vaccenic acids improves the lipid profile and reduces anandamide in the plasma of hypercholesterolaemic subjects. Br. J. Nutr. 109:1453–1462.
72. Raff, M., Tholstrup, T., Basu, S., Nonboe, P., Sorensen, M. T., and Straarup, E. M., (2008). A diet rich in conjugated linoleic acid and butter increases lipid peroxidation but does not affect atherosclerotic, inflammatory, or diabetic risk markers in healthy young men. J Nutr 138:509–514.
73. Rebholz, C. M., Reynolds, K., Wofford, M. R., Chen, J., Kelly, T. N., Mei, H., Whelton, P. K., and He, J., (2013). Effect of soybean protein on novel cardiovascular disease risk factors:A randomized controlled trial. Eur. J. Clin. Nutr. 67:58–63.
74. Romeo, J., Warnberg, J., Garcia-Marmol, E., Rodriguez-Rodriguez, M., Diaz, L. E., Gomez-Martinez, S., Cueto, B., Lopez-Huertaz, E., Cepero, M., Boza, J. J., Fonolla, J., and Marcos, A., (2011). Daily consumption of milk enriched with fish oil, oleic acid, minerals and vitamins reduces cell adhesion molecules in healthy children. Nutr Metab Cardiovasc. Dis 21:113–120.
75. Rosti, L., Braga, M., Fulcieri, C., Sammarco, G., Manenti, B., and Costa, E., (2011). Formula milk feeding does not increase the release of the inflammatory marker calprotectin, compared to human milk. Pediatr.Med Chir 33:178–181.
76. Savilahti, E., and Westerholm-Ormio, M., (2004). Gut inflammation and extraintestinal manifestation of food allergy. J. Pediatr. Gastroenterol. Nutr. 39(Suppl 3):S742–S743.
77. Schwander, F., Kopf-Bolanz, K. A., Buri, C., Portmann, R., Egger, L., Chollet, M., mcTernan, P. G., Piya, M. K., Gijs, M. A. M., Vionnet, N., Pralong, F., Laederach, K., and Vergères, G., (2014). A dose-response strategy reveals differences between normal weight and obese men in their metabolic and inflammatory responses to a high-fat meal. J. Nutr. Oct;144(10):1517–1523.
78. Sofi, F., Buccioni, A., Cesari, F., Gori, A. M., Minieri, S., Mannini, L., Casini, A., Gensini, G. F., Aabbate, R., and Anatongiovanni, M., (2010). Effects of a dairy product (pecorino cheese) naturally rich in cis-9, trans-11 conjugated linoleic acid on lipid, inflammatory and haemorheological variables:a dietary intervention study. Nutr Metab Cardiovasc. Dis 20:117–124.
79. Spegel, J. M., Andrews, T., Brown-Whitehorn, T. F., Beausoleil, J. L., and Liacouras, C. A., (2005). Treatment of eosinophilic esophagitis with specific food elimination diet directed by a combination of skin prick and patch tests. Ann Allergy Asthma Immunol 95:336–343.
80. Stancliffe, R. A., Thorpe, T., and Zemel, M. B., (2011). Dairy attentuates oxidative and inflammatory stress in metabolic syndrome. Am J Clin Nutr 94:422–430.
81. Steinberg, D., (2005). Thematic review series:the pathogenesis of atherosclerosis. An interpretive history of the cholesterol controversy:part II:the early evidence linking hypercholesterolemia to coronary disease in humans. J. Lipid. Res. 46:179–190.
82. Strisciuglio, C., Giannetti, E., Martinelli, M., Sciorio, E., Staiano, A., and Miele, E., (2013). Does cow's milk protein elimination diet have a role on induction and maintenance of remission in children with ulcerative colitis? Acta Paediatr. 102:e273–e278.
83. Sugawara, K., Takahashi, H., Kashiwagura, T., Yamada, K., Yanagida, S., Homma, M., Dairiki, K., Sasaki, H., Kawagoshi, A., Satake, M., and Shioya, T., (2012). Effect of anti-inflammatory supplementation with whey peptide and exercise therapy in patients with COPD. Respir.Med 106:1526–1534.
84. Thompson, D. K., Huffman, K. M., Kraus, W. E., and Kraus, V. B., (2012). Critical appraisal of four IL-6 immunoassays. PLoS One 7:e30659.
85. Topuz, E., Derin, D., Can, G., Kurklu, E., Cinar, S., Aykan, F., Cevikbas, A., Disci, R., Durna, Z., Sakar, B., Saglam, S., Tanyeri, H., Deniz, G., Gurer, U., Tas, F., Guney, N., and Aydiner, A., (2008). Effect of oral administration of kefir on serum proinflammatory cytokines on 5-FU induced oral mucositis in patients with colorectal cancer. Invest New Drugs 26:567–572.
86. Tsai, Y. T., Cheng, P. C., and Pan, T. M., (2012). The immunomodulatory effects of lactic acid bacteria for improving immune functions and benefits. Appl. Microbiol. Biotechnol. 96:853–862.
87. Ulsemer, P., Toutounian, K., Kressel, G., Schmidt, J., Karesten, U., Hahn, A., and Goletz, S., (2012). Safety and tolerance of Bacteroides xylanisolvens DSM 23964 in healthy adults. Benef Microbes 3:99–111.
88. Unknown. (1994). Dietary and other risk factors of ulcerative colitis. A case-control study in Japan. Epidemiology Group of the Research Committee of Inflammatory Bowel Disease in Japan. J Clin Gastroenterol 19:166–171.
89. Van Bussel, B. C., Henry, R. M., Schalkwijk, C. G., Ferreira, I., Feskens, E. J., Streppel, M. T., Smulders, Y. M., Twisk, J. W., and Stehouwer, C. D., (2011). Fish consumption in healthy adults is associated with decreased circulating biomarkers of endothelial dysfunction and inflammation during a 6-year follow-up. J Nutr 141:1719–1725.
90. Van Meijl, L. E., and Mensink, R. P., (2010). Effects of low-fat dairy consumption on markers of low-grade systemic inflammation and endothelial function in overweight and obese subjects:an intervention study. Br.J Nutr 104:1523–1527.
91. Vazquez-Agell, M., Urpi-Sarda, M., Sacanella, E., Camino-Lopez, S., Chiva-Blanch, G., Llorente-Cortes, V., Tobias, E., Roura, E., Andres-Lacueva, C., Lamuela-Raventos, R. M., Badimon, L., and Estruch, R., (2013). Cocoa consumption reduces NF-kappaB activation in peripheral blood mononuclear cells in humans. Nutr.Metab Cardiovasc.Dis. 23:257–263.
92. Vergeres, G., Bogicevic, B., Buri, C., Carrara, S., Chollet, M., Corbino-Giunta, L., Egger, L., Gille, D., Kopf-Bolanz, K., Laederach, K., Portmann, R., Ramadan, Q., Ramsden, J., Schwander, F., Silacci, P., Walther, B., and Gijs, M., (2012). The NutriChip project–translating technology into nutritional knowledge. Br. J. Nutr. 108:762–768.
93. Wang, H., Steffen, L. M., Vessby, B., Basu, S., Steinberger, J., Moran, A., Jacobs, D. R., JR., Hong, C. P., and Sinaiko, A. R., (2011). Obesity modifies the relations between serum markers of dairy fats and inflammation and oxidative stress among adolescents. Obesity (Silver Spring) 19:2404–2410.
94. Wennersberg, M. H., Smedmann, A., Turpeinen, A. M., Retterstol, K., Tengblad, S., Lipre, E., Aro, A., Mutanen, P., Seljeflot, I., Basu, S., Pedersen, J. I., Mutanen, M., and Vessby, B., (2009). Dairy products and metabolic effects in overweight men and women:results from a 6-mo intervention study. Am J Clin Nutr 90:960–968.
95. Wojcik, J. R., Walber-Rankin, J., Smith, L. L., and Gwazdauskas, F. C., (2001). Comparison of carbohydrate and milk-based beverages on muscle damage and glycogen following exercise. Int J Sport Nutr Exerc. Metab 11:406–419.
96. Zemel, M. B., and Sun, X., (2008). Dietary calcium and dairy products modulate oxidative and inflammatory stress in mice and humans. J Nutr 138:1047–1052.
97. Zemel, M. B., Sun, X., Sobhani, T., and Wilson, B., (2010). Effects of dairy compared with soy on oxidative and inflammatory stress in overweight and obese subjects. Am J Clin Nutr 91:16–22.