Cocoa consumption reduces NF-κB activation in peripheral blood mononuclear cells in humans

Nutrition, Metabolism and Cardiovascular Diseases

Volumn 23, Issue 3, 2013, Pages 257-263

  Vazquez Agell M ^a,b   Urpi Sarda, M ^a,b,c   Sacanella, E ^a,b,c   Camino Lopez S ^d   Chiva Blanch, G ^a,b   Llorente Cortes V ^c,d   Tobias, E ^b   Roura, E ^b   Andres Lacueva, C ^b,e   Lamuela Raventos R M ^b,c   Badimon, L ^c,d   Estruch, R ^a,b,c  

^a HOSPITAL CLÍNIC   (Spain)

^b UNIVERSITY OF BARCELONA   (Spain)

^c Instituto de Salud Carlos III   (Spain)

^d HOSPITAL DE LA SANTA CREU I SANT PAU   (Spain)

^e Ministry of Science and Innovation   (Spain)

Author keywords

Adhesion molecules; Cocoa powder; Inflammation; Matrix effect; NF B; Polyphenols

Indexed keywords

ANTIINFLAMMATORY AGENT; ANTIOXIDANT; CELL ADHESION MOLECULE; ENDOTHELIAL LEUKOCYTE ADHESION MOLECULE 1; ICAM1 PROTEIN, HUMAN; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERCELLULAR ADHESION MOLECULE 1; POLYPHENOL; TRANSCRIPTION FACTOR; VASCULAR CELL ADHESION MOLECULE 1;

ADULT; ANIMAL; ARTICLE; BEVERAGE; BIOAVAILABILITY; CACAO; CHEMISTRY; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CROSSOVER PROCEDURE; DRUG EFFECT; FEMALE; GENETICS; HUMAN; MALE; METABOLISM; MIDDLE AGED; MILK; MONONUCLEAR CELL; PROSPECTIVE STUDY; RANDOMIZED CONTROLLED TRIAL; SIGNAL TRANSDUCTION; WESTERN BLOTTING;

ADULT; ANIMALS; ANTI-INFLAMMATORY AGENTS; ANTIOXIDANTS; BEVERAGES; BIOLOGICAL AVAILABILITY; BLOTTING, WESTERN; CACAO; CELL ADHESION MOLECULES; CROSS-OVER STUDIES; E-SELECTIN; FEMALE; HUMANS; INTERCELLULAR ADHESION MOLECULE-1; LEUKOCYTES, MONONUCLEAR; MALE; MIDDLE AGED; MILK; NF-KAPPA B; POLYPHENOLS; PROSPECTIVE STUDIES; SIGNAL TRANSDUCTION; TRANSCRIPTION FACTORS; VASCULAR CELL ADHESION MOLECULE-1;

THEOBROMA CACAO;

EID: 84875242450     PISSN: 09394753     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.numecd.2011.03.015     Document Type: Article

References (35)

1. Selmi C., Cocchi C.A., Lanfredini M., Keen C.L., Gershwin M.E. Chocolate at heart: the anti-inflammatory impact of cocoa flavanols. Mol Nutr Food Res 2008, 52:1340-1348.
2. Engler M.B., Engler M.M. The emerging role of flavonoid-rich cocoa and chocolate in cardiovascular health and disease. Nutr Rev 2006, 64:109-118.
3. Scalbert A., Manach C., Morand C., Remesy C., Jimenez L. Dietary polyphenols and the prevention of diseases. Crit Rev Food Sci Nutr 2005, 45:287-306.
4. Corti R., Flammer A.J., Hollenberg N.K., Luscher T.F. Cocoa and cardiovascular health. Circulation 2009, 119:1433-1441.
5. Fisher N.D., Hughes M., Gerhard-Herman M., Hollenberg N.K. Flavanol-rich cocoa induces nitric-oxide-dependent vasodilation in healthy humans. J Hypertens 2003, 21:2281-2286.
6. Baba S., Natsume M., Yasuda A., Nakamura Y., Tamura T., Osakabe N., et al. Plasma LDL and HDL cholesterol and oxidized LDL concentrations are altered in normo- and hypercholesterolemic humans after intake of different levels of cocoa powder. J Nutr 2007, 137:1436-1441.
7. Grassi D., Lippi C., Necozione S., Desideri G., Ferri C. Short-term administration of dark chocolate is followed by a significant increase in insulin sensitivity and a decrease in blood pressure in healthy persons. Am J Clin Nutr 2005, 81:611-614.
8. Taubert D., Roesen R., Lehmann C., Jung N., Schomig E. Effects of low habitual cocoa intake on blood pressure and bioactive nitric oxide: a randomized controlled trial. Jama 2007, 298:49-60.
9. Holt R.R., Schramm D.D., Keen C.L., Lazarus S.A., Schmitz H.H. Chocolate consumption and platelet function. Jama 2002, 287:2212-2213.
10. Terra X., Montagut G., Bustos M., Llopiz N., Ardevol A., Blade C., et al. Grape-seed procyanidins prevent low-grade inflammation by modulating cytokine expression in rats fed a high-fat diet. J Nutr Biochem 2009, 20:210-218.
11. Monagas M., Khan N., Andres-Lacueva C., Casas R., Urpi-Sarda M., Llorach R., et al. Effect of cocoa powder on the modulation of inflammatory biomarkers in patients at high risk of cardiovascular disease. Am J Clin Nutr 2009, 90:1144-1150.
12. Mao T.K., Powell J., Van de Water J., Keen C.L., Schmitz H.H., Hammerstone J.F., et al. The effect of cocoa procyanidins on the transcription and secretion of interleukin 1 beta in peripheral blood mononuclear cells. Life Sci 2000, 66:1377-1386.
13. Monagas M., Khan N., Andres-Lacueva C., Urpi-Sarda M., Vazquez-Agell M., Lamuela-Raventos R.M., et al. Dihydroxylated phenolic acids derived from microbial metabolism reduce lipopolysaccharide-stimulated cytokine secretion by human peripheral blood mononuclear cells. Br J Nutr 2009, 102:201-206.
14. Vallabhapurapu S., Karin M. Regulation and function of NF-kappaB transcription factors in the immune system. Annu Rev Immunol 2009, 27:693-733.
15. Miyamoto S., Verma I.M. Rel/NF-kappa B/I kappa B story. Adv Cancer Res 1995, 66:255-292.
16. Carluccio M.A., Siculella L., Ancora M.A., Massaro M., Scoditti E., Storelli C., et al. Olive oil and red wine antioxidant polyphenols inhibit endothelial activation: antiatherogenic properties of Mediterranean diet phytochemicals. Arterioscler Thromb Vasc Biol 2003, 23:622-629.
17. Blanco-Colio L.M., Munoz-Garcia B., Martin-Ventura J.L., Alvarez-Sala L.A., Castilla M., Bustamante A., et al. Ethanol beverages containing polyphenols decrease nuclear factor kappa-B activation in mononuclear cells and circulating MCP-1 concentrations in healthy volunteers during a fat-enriched diet. Atherosclerosis 2007, 192:335-341.
18. Allen R.R., Carson L., Kwik-Uribe C., Evans E.M., Erdman J.W. Daily consumption of a dark chocolate containing flavanols and added sterol esters affects cardiovascular risk factors in a normotensive population with elevated cholesterol. J Nutr 2008, 138:725-731.
19. Kurlandsky S.B., Stote K.S. Cardioprotective effects of chocolate and almond consumption in healthy women. Nutr Res 2006, 26:509-516.
20. Wang-Polagruto J.F., Villablanca A.C., Polagruto J.A., Lee L., Holt R.R., Schrader H.R., et al. Chronic consumption of flavanol-rich cocoa improves endothelial function and decreases vascular cell adhesion molecule in hypercholesterolemic postmenopausal women. J Cardiovasc Pharmacol 2006, 47(Suppl. 2):S177-S186. discussion S206-9.
21. Visioli F., Bernaert H., Corti R., Ferri C., Heptinstall S., Molinari E., et al. Chocolate, lifestyle, and health. Crit Rev Food Sci Nutr 2009, 49:299-312.
22. Mullen W., Borges G., Donovan J.L., Edwards C.A., Serafini M., Lean M.E., et al. Milk decreases urinary excretion but not plasma pharmacokinetics of cocoa flavan-3-ol metabolites in humans. Am J Clin Nutr 2009, 89:1784-1791.
23. Urpi-Sarda M., Llorach R., Khan N., Monagas M., Rotches-Ribalta M., Lamuela-Raventos R., et al. Effect of milk on the urinary excretion of microbial phenolic acids after cocoa powder consumption in humans. J Agric Food Chem 2010, 58:4706-4711.
24. Andres-Lacueva C., Monagas M., Khan N., Izquierdo-Pulido M., Urpi-Sarda M., Permanyer J., et al. Flavanol and flavonol contents of cocoa powder products: influence of the manufacturing process. J Agric Food Chem 2008, 56:3111-3117.
25. Roura E., Andres-Lacueva C., Estruch R., Lourdes Mata Bilbao M., Izquierdo-Pulido M., Lamuela-Raventos R.M. The effects of milk as a food matrix for polyphenols on the excretion profile of cocoa (-)-epicatechin metabolites in healthy human subjects. Br J Nutr 2008, 100:846-851.
26. Sacanella E., Estruch R., Gaya A., Ferrer K., Fernandez-Sola J., Alonso J.R., et al. Upregulated expression of VLA proteins and CD29 in peripheral blood lymphocytes of chronic alcoholics without ethanol-related diseases. Alcohol Clin Exp Res 1999, 23:371-375.
27. Roura E., Andres-Lacueva C., Estruch R., Mata-Bilbao M.L., Izquierdo-Pulido M., Waterhouse A.L., et al. Milk does not affect the bioavailability of cocoa powder flavonoid in healthy human. Ann Nutr Metab 2007, 51:493-498.
28. Li Q., Verma I.M. NF-kappaB regulation in the immune system. Nat Rev Immunol 2002, 2:725-734.
29. Solt L.A., Madge L.A., Orange J.S., May M.J. Interleukin-1-induced NF-kappaB activation is NEMO-dependent but does not require IKKbeta. J Biol Chem 2007, 282:8724-8733.
30. Blanco-Colio L.M., Valderrama M., Alvarez-Sala L.A., Bustos C., Ortego M., Hernandez-Presa M.A., et al. Red wine intake prevents nuclear factor-kappaB activation in peripheral blood mononuclear cells of healthy volunteers during postprandial lipemia. Circulation 2000, 102:1020-1026.
31. Xia Y.F., Liu L.P., Zhong C.P., Geng J.G. NF-kappaB activation for constitutive expression of VCAM-1 and ICAM-1 on B lymphocytes and plasma cells. Biochem Biophys Res Commun 2001, 289:851-856.
32. Mackenzie G.G., Carrasquedo F., Delfino J.M., Keen C.L., Fraga C.G., Oteiza P.I. Epicatechin, catechin, and dimeric procyanidins inhibit PMA-induced NF-kappaB activation at multiple steps in Jurkat T cells. Faseb J 2004, 18:167-169.
33. Moon M.K., Lee Y.J., Kim J.S., Kang D.G., Lee H.S. Effect of caffeic acid on tumor necrosis factor-alpha-induced vascular inflammation in human umbilical vein endothelial cells. Biol Pharm Bull 2009, 32:1371-1377.
34. Farouque H.M., Leung M., Hope S.A., Baldi M., Schechter C., Cameron J.D., et al. Acute and chronic effects of flavanol-rich cocoa on vascular function in subjects with coronary artery disease: a randomized double-blind placebo-controlled study. Clin Sci (Lond) 2006, 111:71-80.
35. Naghavi M., Libby P., Falk E., Casscells S.W., Litovsky S., Rumberger J., et al. From vulnerable plaque to vulnerable patient: a call for new definitions and risk assessment strategies: part I. Circulation 2003, 108:1664-1672.