Measuring Signaling and RNA-Seq in the Same Cell Links Gene Expression to Dynamic Patterns of NF-κB Activation

Cell Systems

Volumn 4, Issue 4, 2017, Pages 458-469.e5

  Lane, Keara ^a   Van Valen, David ^a   DeFelice, Mialy M ^a   Macklin, Derek N ^a   Kudo, Takamasa ^a   Jaimovich, Ariel ^b   Carr, Ambrose ^c   Meyer, Tobias ^b   Pe'er, Dana ^d   Boutet, Stéphane C ^e   Covert, Markus W ^a  

^a Stanford University   (United States)

^b STANFORD UNIVERSITY   (United States)

^c Sloan Kettering Institute ^*  (United States)

^d MEMORIAL SLOAN KETTERING CANCER CENTER   (United States)

^e FLUIDIGM CORPORATION   (United States)

Author keywords

gene expression; live cell imaging; NF B; RNA seq; signaling dynamics; single cell heterogeneity

Indexed keywords

CYTOKINE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; LIPOPOLYSACCHARIDE; TRANSCRIPTOME;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; GENE EXPRESSION; GENE INTERACTION; GENETIC TRANSCRIPTION; MOLECULAR DYNAMICS; NONHUMAN; PRIORITY JOURNAL; RNA SEQUENCE; SIGNAL TRANSDUCTION; ANIMAL; BIOLOGICAL MODEL; GENE EXPRESSION REGULATION; GENETICS; HEK293 CELL LINE; HUMAN; IMMUNOLOGY; INNATE IMMUNITY; METABOLISM; MOUSE; PHYSIOLOGY; RAW 264.7 CELL LINE; SEQUENCE ANALYSIS; SINGLE CELL ANALYSIS; TRANSCRIPTION INITIATION;

ANIMALS; CYTOKINES; GENE EXPRESSION REGULATION; HEK293 CELLS; HUMANS; IMMUNITY, INNATE; LIPOPOLYSACCHARIDES; MICE; MODELS, IMMUNOLOGICAL; NF-KAPPA B; RAW 264.7 CELLS; SEQUENCE ANALYSIS, RNA; SIGNAL TRANSDUCTION; SINGLE-CELL ANALYSIS; TRANSCRIPTIONAL ACTIVATION; TRANSCRIPTOME;

EID: 85017142571     PISSN: 24054712     EISSN: 24054720     Source Type: Journal    
DOI: 10.1016/j.cels.2017.03.010     Document Type: Article

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