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Volumn 144, Issue 6, 2011, Pages 886-896

Impulse control: Temporal dynamics in gene transcription

Author keywords

[No Author keywords available]

Indexed keywords

CELL FUNCTION; GENE EXPRESSION; GENETIC TRANSCRIPTION; OSCILLATION; PRIORITY JOURNAL; PROMOTER REGION; REVIEW;

EID: 79952672993     PISSN: 00928674     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.cell.2011.02.015     Document Type: Review
Times cited : (210)

References (100)
  • 1
    • 34249079154 scopus 로고    scopus 로고
    • Network motifs: Theory and experimental approaches
    • Alon, U. (2007). Network motifs: theory and experimental approaches. Nat. Rev. Genet. 8, 450-461.
    • (2007) Nat. Rev. Genet. , vol.8 , pp. 450-461
    • Alon, U.1
  • 3
    • 36849068465 scopus 로고    scopus 로고
    • Evolvable signaling networks of receptor tyrosine kinases: Relevance of robustness to malignancy and to cancer therapy
    • Amit, I., Wides, R., and Yarden, Y. (2007b). Evolvable signaling networks of receptor tyrosine kinases: relevance of robustness to malignancy and to cancer therapy. Mol. Syst. Biol. 3, 151.
    • (2007) Mol. Syst. Biol. , vol.3 , pp. 151
    • Amit, I.1    Wides, R.2    Yarden, Y.3
  • 7
    • 68849103521 scopus 로고    scopus 로고
    • Mass cytometry: Technique for real time single cell multitarget immunoassay based on inductively coupled plasma time-of-flight mass spectrometry
    • Bandura, D.R., Baranov, V.I., Ornatsky, O.I., Antonov, A., Kinach, R., Lou, X., Pavlov, S., Vorobiev, S., Dick, J.E., and Tanner, S.D. (2009). Mass cytometry: technique for real time single cell multitarget immunoassay based on inductively coupled plasma time-of-flight mass spectrometry. Anal. Chem. 81, 6813-6822.
    • (2009) Anal. Chem. , vol.81 , pp. 6813-6822
    • Bandura, D.R.1    Baranov, V.I.2    Ornatsky, O.I.3    Antonov, A.4    Kinach, R.5    Lou, X.6    Pavlov, S.7    Vorobiev, S.8    Dick, J.E.9    Tanner, S.D.10
  • 10
    • 2342578714 scopus 로고    scopus 로고
    • Spatiotemporal control of gene expression with pulse-generating networks
    • Basu, S., Mehreja, R., Thiberge, S., Chen, M.T., and Weiss, R. (2004). Spatiotemporal control of gene expression with pulse-generating networks. Proc. Natl. Acad. Sci. USA 101, 6355-6360.
    • (2004) Proc. Natl. Acad. Sci. USA , vol.101 , pp. 6355-6360
    • Basu, S.1    Mehreja, R.2    Thiberge, S.3    Chen, M.T.4    Weiss, R.5
  • 11
    • 0042424655 scopus 로고    scopus 로고
    • Transcriptional regulatory cascades in development: Initial rates, not steady state, determine network kinetics
    • Bolouri, H., and Davidson, E.H. (2003). Transcriptional regulatory cascades in development: initial rates, not steady state, determine network kinetics. Proc. Natl. Acad. Sci. USA 100, 9371-9376.
    • (2003) Proc. Natl. Acad. Sci. USA , vol.100 , pp. 9371-9376
    • Bolouri, H.1    Davidson, E.H.2
  • 12
    • 17144376468 scopus 로고    scopus 로고
    • Transient responses and adaptation to steady state in a eukaryotic gene regulation system
    • Braun, E., and Brenner, N. (2004). Transient responses and adaptation to steady state in a eukaryotic gene regulation system. Phys. Biol. 1, 67-76.
    • (2004) Phys. Biol. , vol.1 , pp. 67-76
    • Braun, E.1    Brenner, N.2
  • 14
    • 52949098296 scopus 로고    scopus 로고
    • Frequency-modulated nuclear localization bursts coordinate gene regulation
    • Cai, L., Dalal, C.K., and Elowitz, M.B. (2008). Frequency-modulated nuclear localization bursts coordinate gene regulation. Nature 455, 485-490.
    • (2008) Nature , vol.455 , pp. 485-490
    • Cai, L.1    Dalal, C.K.2    Elowitz, M.B.3
  • 15
    • 33748028819 scopus 로고    scopus 로고
    • Autogenous and nonautogenous control of response in a genetic network
    • Camas, F.M., Blazquez, J., and Poyatos, J.F. (2006). Autogenous and nonautogenous control of response in a genetic network. Proc. Natl. Acad. Sci. USA 103, 12718-12723.
    • (2006) Proc. Natl. Acad. Sci. USA , vol.103 , pp. 12718-12723
    • Camas, F.M.1    Blazquez, J.2    Poyatos, J.F.3
  • 17
    • 84984933073 scopus 로고    scopus 로고
    • Structure and function of a transcriptional network activated by the MAPK Hog1
    • Capaldi, A.P., Kaplan, T., Liu, Y., Habib, N., Regev, A., Friedman, N., and O'Shea, E.K. (2008). Structure and function of a transcriptional network activated by the MAPK Hog1. Nat. Genet. 40, 1300-1306.
    • (2008) Nat. Genet. , vol.40 , pp. 1300-1306
    • Capaldi, A.P.1    Kaplan, T.2    Liu, Y.3    Habib, N.4    Regev, A.5    Friedman, N.6    O'Shea, E.K.7
  • 18
    • 59649119722 scopus 로고    scopus 로고
    • Timing of gene expression responses to environmental changes
    • Chechik, G., and Koller, D. (2009). Timing of gene expression responses to environmental changes. J. Comput. Biol. 16, 279-290.
    • (2009) J. Comput. Biol. , vol.16 , pp. 279-290
    • Chechik, G.1    Koller, D.2
  • 19
    • 55749116150 scopus 로고    scopus 로고
    • Activity motifs reveal principles of timing in transcriptional control of the yeast metabolic network
    • Chechik, G., Oh, E., Rando, O., Weissman, J., Regev, A., and Koller, D. (2008). Activity motifs reveal principles of timing in transcriptional control of the yeast metabolic network. Nat. Biotechnol. 26, 1251-1259.
    • (2008) Nat. Biotechnol. , vol.26 , pp. 1251-1259
    • Chechik, G.1    Oh, E.2    Rando, O.3    Weissman, J.4    Regev, A.5    Koller, D.6
  • 20
    • 0032561246 scopus 로고    scopus 로고
    • The transcriptional program of sporulation in budding yeast
    • DOI 10.1126/science.282.5389.699
    • Chu, S., DeRisi, J., Eisen, M., Mulholland, J., Botstein, D., Brown, P.O., and Herskowitz, I. (1998). The transcriptional program of sporulation in budding yeast. Science 282, 699-705. (Pubitemid 28489376)
    • (1998) Science , vol.282 , Issue.5389 , pp. 699-705
    • Chu, S.1    DeRisi, J.2    Eisen, M.3    Mulholland, J.4    Botstein, D.5    Brown, P.O.6    Herskowitz, I.7
  • 22
    • 24944586285 scopus 로고    scopus 로고
    • Achieving stability of lipopolysaccharide-induced NF-kappaB activation
    • DOI 10.1126/science.1112304
    • Covert, M.W., Leung, T.H., Gaston, J.E., and Baltimore, D. (2005). Achieving stability of lipopolysaccharide-induced NF-kappaB activation. Science 309, 1854-1857. (Pubitemid 41325095)
    • (2005) Science , vol.309 , Issue.5742 , pp. 1854-1857
    • Covert, M.W.1    Leung, T.H.2    Gaston, J.E.3    Baltimore, D.4
  • 23
    • 71149089027 scopus 로고    scopus 로고
    • Network design principles from the sea urchin embryo
    • Davidson, E.H. (2009). Network design principles from the sea urchin embryo. Curr. Opin. Genet. Dev. 19, 535-540.
    • (2009) Curr. Opin. Genet. Dev. , vol.19 , pp. 535-540
    • Davidson, E.H.1
  • 24
    • 78650362376 scopus 로고    scopus 로고
    • Emerging properties of animal gene regulatory networks
    • Davidson, E.H. (2010). Emerging properties of animal gene regulatory networks. Nature 468, 911-920.
    • (2010) Nature , vol.468 , pp. 911-920
    • Davidson, E.H.1
  • 25
    • 77952996319 scopus 로고    scopus 로고
    • Genome-wide kinetics of nucleosome turnover determined by metabolic labeling of histones
    • Deal, R.B., Henikoff, J.G., and Henikoff, S. (2010). Genome-wide kinetics of nucleosome turnover determined by metabolic labeling of histones. Science 328, 1161-1164.
    • (2010) Science , vol.328 , pp. 1161-1164
    • Deal, R.B.1    Henikoff, J.G.2    Henikoff, S.3
  • 26
    • 77749261483 scopus 로고    scopus 로고
    • Transient genotypeby- environment interactions following environmental shock provide a source of expression variation for essential genes
    • Eng, K.H., Kvitek, D.J., Keles, S., and Gasch, A.P. (2010). Transient genotypeby- environment interactions following environmental shock provide a source of expression variation for essential genes. Genetics 184, 587-593.
    • (2010) Genetics , vol.184 , pp. 587-593
    • Eng, K.H.1    Kvitek, D.J.2    Keles, S.3    Gasch, A.P.4
  • 27
    • 65149083962 scopus 로고    scopus 로고
    • The transcriptional network that controls growth arrest and differentiation in a human myeloid leukemia cell line
    • FANTOM consortium
    • FANTOM consortium, Suzuki, H., Forrest, A.R., van Nimwegen, E., Daub, C.O., Balwierz, P.J., Irvine, K.M., Lassmann, T., Ravasi, T., Hasegawa, Y., et al. (2009). The transcriptional network that controls growth arrest and differentiation in a human myeloid leukemia cell line. Nat. Genet. 41, 553-562.
    • (2009) Nat. Genet. , vol.41 , pp. 553-562
    • Suzuki, H.1    Forrest, A.R.2    Van Nimwegen, E.3    Daub, C.O.4    Balwierz, P.J.5    Irvine, K.M.6    Lassmann, T.7    Ravasi, T.8    Hasegawa, Y.9
  • 28
    • 34250823515 scopus 로고    scopus 로고
    • Gene-specific control of inflammation by TLR-induced chromatin modifications
    • DOI 10.1038/nature05836, PII NATURE05836
    • Foster, S.L., Hargreaves, D.C., and Medzhitov, R. (2007). Gene-specific control of inflammation by TLR-induced chromatin modifications. Nature 447, 972-978. (Pubitemid 46975746)
    • (2007) Nature , vol.447 , Issue.7147 , pp. 972-978
    • Foster, S.L.1    Hargreaves, D.C.2    Medzhitov, R.3
  • 29
    • 22744432208 scopus 로고    scopus 로고
    • Precise temporal modulation in the response of the SOS DNA repair network in individual bacteria
    • Friedman, N., Vardi, S., Ronen, M., Alon, U., and Stavans, J. (2005). Precise temporal modulation in the response of the SOS DNA repair network in individual bacteria. PLoS Biol. 3, e238.
    • (2005) PLoS Biol. , vol.3
    • Friedman, N.1    Vardi, S.2    Ronen, M.3    Alon, U.4    Stavans, J.5
  • 32
    • 58149354385 scopus 로고    scopus 로고
    • Analysis of combinatorial cisregulation in synthetic and genomic promoters
    • Gertz, J., Siggia, E.D., and Cohen, B.A. (2009). Analysis of combinatorial cisregulation in synthetic and genomic promoters. Nature 457, 215-218.
    • (2009) Nature , vol.457 , pp. 215-218
    • Gertz, J.1    Siggia, E.D.2    Cohen, B.A.3
  • 35
    • 71149099313 scopus 로고    scopus 로고
    • The incoherent feedforward loop can provide fold-change detection in gene regulation
    • Goentoro, L., Shoval, O., Kirschner, M.W., and Alon, U. (2009). The incoherent feedforward loop can provide fold-change detection in gene regulation. Mol. Cell 36, 894-899.
    • (2009) Mol. Cell , vol.36 , pp. 894-899
    • Goentoro, L.1    Shoval, O.2    Kirschner, M.W.3    Alon, U.4
  • 38
    • 14844358192 scopus 로고    scopus 로고
    • Ultrasensitivity and noise propagation in a synthetic transcriptional cascade
    • Hooshangi, S., Thiberge, S., and Weiss, R. (2005). Ultrasensitivity and noise propagation in a synthetic transcriptional cascade. Proc. Natl. Acad. Sci. USA 102, 3581-3586.
    • (2005) Proc. Natl. Acad. Sci. USA , vol.102 , pp. 3581-3586
    • Hooshangi, S.1    Thiberge, S.2    Weiss, R.3
  • 39
    • 34247629588 scopus 로고    scopus 로고
    • Genetic reconstruction of a functional transcriptional regulatory network
    • Hu, Z., Killion, P.J., and Iyer, V.R. (2007). Genetic reconstruction of a functional transcriptional regulatory network. Nat. Genet. 39, 683-687.
    • (2007) Nat. Genet. , vol.39 , pp. 683-687
    • Hu, Z.1    Killion, P.J.2    Iyer, V.R.3
  • 40
    • 0346095291 scopus 로고    scopus 로고
    • Principles of transcriptional control in the metabolic network of Saccharomyces cerevisiae
    • Ihmels, J., Levy, R., and Barkai, N. (2004). Principles of transcriptional control in the metabolic network of Saccharomyces cerevisiae. Nat. Biotechnol. 22, 86-92.
    • (2004) Nat. Biotechnol. , vol.22 , pp. 86-92
    • Ihmels, J.1    Levy, R.2    Barkai, N.3
  • 41
    • 70350778443 scopus 로고    scopus 로고
    • An epigenetic switch involving NF-kappaB, Lin28, Let-7 MicroRNA, and IL6 links inflammation to cell transformation
    • Iliopoulos, D., Hirsch, H.A., and Struhl, K. (2009). An epigenetic switch involving NF-kappaB, Lin28, Let-7 MicroRNA, and IL6 links inflammation to cell transformation. Cell 139, 693-706.
    • (2009) Cell , vol.139 , pp. 693-706
    • Iliopoulos, D.1    Hirsch, H.A.2    Struhl, K.3
  • 42
    • 27644443808 scopus 로고    scopus 로고
    • Cross talking of network motifs in gene regulation that generates temporal pulses and spatial stripes
    • DOI 10.1111/j.1365-2443.2005.00897.x
    • Ishihara, S., Fujimoto, K., and Shibata, T. (2005). Cross talking of network motifs in gene regulation that generates temporal pulses and spatial stripes. Genes Cells 10, 1025-1038. (Pubitemid 41556072)
    • (2005) Genes to Cells , vol.10 , Issue.11 , pp. 1025-1038
    • Ishihara, S.1    Fujimoto, K.2    Shibata, T.3
  • 43
    • 33746428728 scopus 로고    scopus 로고
    • A coherent feed-forward loop with a SUM input function prolongs flagella expression in Escherichia coli
    • Kalir, S., Mangan, S., and Alon, U. (2005). A coherent feed-forward loop with a SUM input function prolongs flagella expression in Escherichia coli. Mol. Syst. Biol. 1, 0006.
    • (2005) Mol. Syst. Biol. , vol.1 , pp. 0006
    • Kalir, S.1    Mangan, S.2    Alon, U.3
  • 45
    • 47349095809 scopus 로고    scopus 로고
    • The incoherent feed-forward loop can generate non-monotonic input functions for genes
    • Kaplan, S., Bren, A., Dekel, E., and Alon, U. (2008). The incoherent feed-forward loop can generate non-monotonic input functions for genes. Mol. Syst. Biol. 4, 203.
    • (2008) Mol. Syst. Biol. , vol.4 , pp. 203
    • Kaplan, S.1    Bren, A.2    Dekel, E.3    Alon, U.4
  • 46
    • 52649087274 scopus 로고    scopus 로고
    • Modelling and analysis of gene regulatory networks
    • Karlebach, G., and Shamir, R. (2008). Modelling and analysis of gene regulatory networks. Nat. Rev. Mol. Cell Biol. 9, 770-780.
    • (2008) Nat. Rev. Mol. Cell Biol. , vol.9 , pp. 770-780
    • Karlebach, G.1    Shamir, R.2
  • 48
    • 67749113808 scopus 로고    scopus 로고
    • Transcriptional regulatory circuits: Predicting numbers from alphabets
    • Kim, H.D., Shay, T., O'Shea, E.K., and Regev, A. (2009). Transcriptional regulatory circuits: predicting numbers from alphabets. Science 325, 429-432.
    • (2009) Science , vol.325 , pp. 429-432
    • Kim, H.D.1    Shay, T.2    O'Shea, E.K.3    Regev, A.4
  • 49
    • 40749104852 scopus 로고    scopus 로고
    • An Extended Transcriptional Network for Pluripotency of Embryonic Stem Cells
    • DOI 10.1016/j.cell.2008.02.039, PII S0092867408003280
    • Kim, J., Chu, J., Shen, X., Wang, J., and Orkin, S.H. (2008). An extended transcriptional network for pluripotency of embryonic stem cells. Cell 132, 1049-1061. (Pubitemid 351381745)
    • (2008) Cell , vol.132 , Issue.6 , pp. 1049-1061
    • Kim, J.1    Chu, J.2    Shen, X.3    Wang, J.4    Orkin, S.H.5
  • 50
    • 77955830290 scopus 로고    scopus 로고
    • Biological role of noise encoded in a genetic network motif
    • Kittisopikul, M., and Suel, G.M. (2010). Biological role of noise encoded in a genetic network motif. Proc. Natl. Acad. Sci. USA 107, 13300-13305.
    • (2010) Proc. Natl. Acad. Sci. USA , vol.107 , pp. 13300-13305
    • Kittisopikul, M.1    Suel, G.M.2
  • 51
    • 15544377794 scopus 로고    scopus 로고
    • Molecular and evolutionary basis of the cellular stress response
    • Kultz, D. (2005). Molecular and evolutionary basis of the cellular stress response. Annu. Rev. Physiol. 67, 225-257.
    • (2005) Annu. Rev. Physiol. , vol.67 , pp. 225-257
    • Kultz, D.1
  • 52
    • 77957243164 scopus 로고    scopus 로고
    • ChEA: Transcription factor regulation inferred from integrating genome-wide ChIP-X experiments
    • Lachmann, A., Xu, H., Krishnan, J., Berger, S.I., Mazloom, A.R., and Ma'ayan, A. (2010). ChEA: transcription factor regulation inferred from integrating genome-wide ChIP-X experiments. Bioinformatics 26, 2438-2444.
    • (2010) Bioinformatics , vol.26 , pp. 2438-2444
    • Lachmann, A.1    Xu, H.2    Krishnan, J.3    Berger, S.I.4    Mazloom, A.R.5    Ma'Ayan, A.6
  • 54
    • 43449096915 scopus 로고    scopus 로고
    • Chromatin decouples promoter threshold from dynamic range
    • DOI 10.1038/nature06867, PII NATURE06867
    • Lam, F.H., Steger, D.J., and O'Shea, E.K. (2008). Chromatin decouples promoter threshold from dynamic range. Nature 453, 246-250. (Pubitemid 351667976)
    • (2008) Nature , vol.453 , Issue.7192 , pp. 246-250
    • Lam, F.H.1    Steger, D.J.2    O'Shea, E.K.3
  • 56
    • 46349096129 scopus 로고    scopus 로고
    • Regulatory module network of basic/helix-loop-helix transcription factors in mouse brain
    • Li, J., Liu, Z.J., Pan, Y.C., Liu, Q., Fu, X., Cooper, N.G., Li, Y., Qiu, M., and Shi, T. (2007). Regulatory module network of basic/helix-loop-helix transcription factors in mouse brain. Genome Biol. 8, R244.
    • (2007) Genome Biol. , vol.8
    • Li, J.1    Liu, Z.J.2    Pan, Y.C.3    Liu, Q.4    Fu, X.5    Cooper, N.G.6    Li, Y.7    Qiu, M.8    Shi, T.9
  • 58
    • 64749116742 scopus 로고    scopus 로고
    • Using movies to analyse gene circuit dynamics in single cells
    • Locke, J.C., and Elowitz, M.B. (2009). Using movies to analyse gene circuit dynamics in single cells. Nat. Rev. Microbiol. 7, 383-392.
    • (2009) Nat. Rev. Microbiol. , vol.7 , pp. 383-392
    • Locke, J.C.1    Elowitz, M.B.2
  • 59
    • 77954312224 scopus 로고    scopus 로고
    • Basal dynamics of p53 reveal transcriptionally attenuated pulses in cycling cells
    • Loewer, A., Batchelor, E., Gaglia, G., and Lahav, G. (2010). Basal dynamics of p53 reveal transcriptionally attenuated pulses in cycling cells. Cell 142, 89-100.
    • (2010) Cell , vol.142 , pp. 89-100
    • Loewer, A.1    Batchelor, E.2    Gaglia, G.3    Lahav, G.4
  • 60
    • 47649125318 scopus 로고    scopus 로고
    • Tuning gene expression to changing environments: From rapid responses to evolutionary adaptation
    • Lopez-Maury, L., Marguerat, S., and Bahler, J. (2008). Tuning gene expression to changing environments: from rapid responses to evolutionary adaptation. Nat. Rev. Genet. 9, 583-593.
    • (2008) Nat. Rev. Genet. , vol.9 , pp. 583-593
    • Lopez-Maury, L.1    Marguerat, S.2    Bahler, J.3
  • 61
    • 13544269611 scopus 로고    scopus 로고
    • An extended transcriptional regulatory network of Escherichia coli and analysis of its hierarchical structure and network motifs
    • DOI 10.1093/nar/gkh1009
    • Ma, H.W., Kumar, B., Ditges, U., Gunzer, F., Buer, J., and Zeng, A.P. (2004). An extended transcriptional regulatory network of Escherichia coli and analysis of its hierarchical structure and network motifs. Nucleic Acids Res. 32, 6643-6649. (Pubitemid 40220376)
    • (2004) Nucleic Acids Research , vol.32 , Issue.22 , pp. 6643-6649
    • Ma, H.-W.1    Kumar, B.2    Ditges, U.3    Gunzer, F.4    Buer, J.5    Zeng, A.-P.6
  • 62
  • 63
    • 71049182983 scopus 로고    scopus 로고
    • Specialized or flexible feed-forward loop motifs: A question of topology
    • Macia, J., Widder, S., and Sole, R. (2009). Specialized or flexible feed-forward loop motifs: a question of topology. BMC Syst. Biol. 3, 84.
    • (2009) BMC Syst. Biol. , vol.3 , pp. 84
    • Macia, J.1    Widder, S.2    Sole, R.3
  • 64
    • 0242364231 scopus 로고    scopus 로고
    • The coherent feedforward loop serves as a sign-sensitive delay element in transcription networks
    • Mangan, S., Zaslaver, A., and Alon, U. (2003). The coherent feedforward loop serves as a sign-sensitive delay element in transcription networks. J. Mol. Biol. 334, 197-204.
    • (2003) J. Mol. Biol. , vol.334 , pp. 197-204
    • Mangan, S.1    Zaslaver, A.2    Alon, U.3
  • 65
    • 32044462728 scopus 로고    scopus 로고
    • The incoherent feed-forward loop accelerates the response-time of the gal system of Escherichia coli
    • Mangan, S., Itzkovitz, S., Zaslaver, A., and Alon, U. (2006). The incoherent feed-forward loop accelerates the response-time of the gal system of Escherichia coli. J. Mol. Biol. 356, 1073-1081.
    • (2006) J. Mol. Biol. , vol.356 , pp. 1073-1081
    • Mangan, S.1    Itzkovitz, S.2    Zaslaver, A.3    Alon, U.4
  • 67
    • 46249106990 scopus 로고    scopus 로고
    • Mapping and quantifying mammalian transcriptomes by RNA-Seq
    • DOI 10.1038/nmeth.1226, PII NMETH.1226
    • Mortazavi, A., Williams, B.A., McCue, K., Schaeffer, L., and Wold, B. (2008). Mapping and quantifying mammalian transcriptomes by RNA-Seq. Nat. Methods 5, 621-628. (Pubitemid 351911867)
    • (2008) Nature Methods , vol.5 , Issue.7 , pp. 621-628
    • Mortazavi, A.1    Williams, B.A.2    McCue, K.3    Schaeffer, L.4    Wold, B.5
  • 68
    • 0036051342 scopus 로고    scopus 로고
    • Molecular interpretation of ERK signal duration by immediate early gene products
    • Murphy, L.O., Smith, S., Chen, R.H., Fingar, D.C., and Blenis, J. (2002). Molecular interpretation of ERK signal duration by immediate early gene products. Nat. Cell Biol. 4, 556-564.
    • (2002) Nat. Cell Biol. , vol.4 , pp. 556-564
    • Murphy, L.O.1    Smith, S.2    Chen, R.H.3    Fingar, D.C.4    Blenis, J.5
  • 70
    • 70350230233 scopus 로고    scopus 로고
    • Quantitative time-lapse fluorescence microscopy in single cells
    • Muzzey, D., and van Oudenaarden, A. (2009). Quantitative time-lapse fluorescence microscopy in single cells. Annu. Rev. Cell Dev. Biol. 25, 301-327.
    • (2009) Annu. Rev. Cell Dev. Biol. , vol.25 , pp. 301-327
    • Muzzey, D.1    Van Oudenaarden, A.2
  • 71
    • 35548960975 scopus 로고    scopus 로고
    • Dissecting Timing Variability in Yeast Meiosis
    • DOI 10.1016/j.cell.2007.09.044, PII S0092867407012858
    • Nachman, I., Regev, A., and Ramanathan, S. (2007). Dissecting timing variability in yeast meiosis. Cell 131, 544-556. (Pubitemid 350007698)
    • (2007) Cell , vol.131 , Issue.3 , pp. 544-556
    • Nachman, I.1    Regev, A.2    Ramanathan, S.3
  • 73
    • 43149086112 scopus 로고    scopus 로고
    • Global regulatory logic for specification of an embryonic cell lineage
    • Oliveri, P., Tu, Q., and Davidson, E.H. (2008). Global regulatory logic for specification of an embryonic cell lineage. Proc. Natl. Acad. Sci. USA 105, 5955-5962.
    • (2008) Proc. Natl. Acad. Sci. USA , vol.105 , pp. 5955-5962
    • Oliveri, P.1    Tu, Q.2    Davidson, E.H.3
  • 75
    • 71849118573 scopus 로고    scopus 로고
    • High-resolution analysis of DNA regulatory elements by synthetic saturation mutagenesis
    • Patwardhan, R.P., Lee, C., Litvin, O., Young, D.L., Pe'er, D., and Shendure, J. (2009). High-resolution analysis of DNA regulatory elements by synthetic saturation mutagenesis. Nat. Biotechnol. 27, 1173-1175.
    • (2009) Nat. Biotechnol. , vol.27 , pp. 1173-1175
    • Patwardhan, R.P.1    Lee, C.2    Litvin, O.3    Young, D.L.4    Pe'er, D.5    Shendure, J.6
  • 78
    • 68049083831 scopus 로고    scopus 로고
    • Incorporating nucleosomes into thermodynamic models of transcription regulation
    • Raveh-Sadka, T., Levo, M., and Segal, E. (2009). Incorporating nucleosomes into thermodynamic models of transcription regulation. Genome Res. 19, 1480-1496.
    • (2009) Genome Res. , vol.19 , pp. 1480-1496
    • Raveh-Sadka, T.1    Levo, M.2    Segal, E.3
  • 79
    • 0036428761 scopus 로고    scopus 로고
    • Negative autoregulation speeds the response times of transcription networks
    • Rosenfeld, N., Elowitz, M.B., and Alon, U. (2002). Negative autoregulation speeds the response times of transcription networks. J. Mol. Biol. 323, 785-793.
    • (2002) J. Mol. Biol. , vol.323 , pp. 785-793
    • Rosenfeld, N.1    Elowitz, M.B.2    Alon, U.3
  • 80
    • 0037941585 scopus 로고    scopus 로고
    • Module networks: Identifying regulatory modules and their condition-specific regulators from gene expression data
    • Segal, E., Shapira, M., Regev, A., Pe'er, D., Botstein, D., Koller, D., and Friedman, N. (2003). Module networks: identifying regulatory modules and their condition-specific regulators from gene expression data. Nat. Genet. 34, 166-176.
    • (2003) Nat. Genet. , vol.34 , pp. 166-176
    • Segal, E.1    Shapira, M.2    Regev, A.3    Pe'er, D.4    Botstein, D.5    Koller, D.6    Friedman, N.7
  • 81
    • 53949098609 scopus 로고    scopus 로고
    • Transient transcriptional responses to stress are generated by opposing effects of mRNA production and degradation
    • Shalem, O., Dahan, O., Levo, M., Martinez, M.R., Furman, I., Segal, E., and Pilpel, Y. (2008). Transient transcriptional responses to stress are generated by opposing effects of mRNA production and degradation. Mol. Syst. Biol. 4, 223.
    • (2008) Mol. Syst. Biol. , vol.4 , pp. 223
    • Shalem, O.1    Dahan, O.2    Levo, M.3    Martinez, M.R.4    Furman, I.5    Segal, E.6    Pilpel, Y.7
  • 83
    • 0036578795 scopus 로고    scopus 로고
    • Network motifs in the transcriptional regulation network of Escherichia coli
    • Shen-Orr, S.S., Milo, R., Mangan, S., and Alon, U. (2002). Network motifs in the transcriptional regulation network of Escherichia coli. Nat. Genet. 31, 64-68.
    • (2002) Nat. Genet. , vol.31 , pp. 64-68
    • Shen-Orr, S.S.1    Milo, R.2    Mangan, S.3    Alon, U.4
  • 84
    • 41749091787 scopus 로고    scopus 로고
    • Dynamic remodeling of individual nucleosomes across a eukaryotic genome in response to transcriptional perturbation
    • Shivaswamy, S., Bhinge, A., Zhao, Y., Jones, S., Hirst, M., and Iyer, V.R. (2008). Dynamic remodeling of individual nucleosomes across a eukaryotic genome in response to transcriptional perturbation. PLoS Biol. 6, e65.
    • (2008) PLoS Biol. , vol.6
    • Shivaswamy, S.1    Bhinge, A.2    Zhao, Y.3    Jones, S.4    Hirst, M.5    Iyer, V.R.6
  • 85
    • 28644440465 scopus 로고    scopus 로고
    • Combined static and dynamic analysis for determining the quality of time-series expression profiles
    • Simon, I., Siegfried, Z., Ernst, J., and Bar-Joseph, Z. (2005). Combined static and dynamic analysis for determining the quality of time-series expression profiles. Nat. Biotechnol. 23, 1503-1508.
    • (2005) Nat. Biotechnol. , vol.23 , pp. 1503-1508
    • Simon, I.1    Siegfried, Z.2    Ernst, J.3    Bar-Joseph, Z.4
  • 86
  • 87
    • 4243190170 scopus 로고    scopus 로고
    • Partially phosphorylated Pho4 activates transcription of a subset of phosphate-responsive genes
    • Springer, M., Wykoff, D.D., Miller, N., and O'Shea, E.K. (2003). Partially phosphorylated Pho4 activates transcription of a subset of phosphate-responsive genes. PLoS Biol. 1, E28.
    • (2003) PLoS Biol. , vol.1
    • Springer, M.1    Wykoff, D.D.2    Miller, N.3    O'Shea, E.K.4
  • 89
    • 77956650346 scopus 로고    scopus 로고
    • Microfluidic approaches for systems and synthetic biology
    • Szita, N., Polizzi, K., Jaccard, N., and Baganz, F. (2010). Microfluidic approaches for systems and synthetic biology. Curr. Opin. Biotechnol. 21, 517-523.
    • (2010) Curr. Opin. Biotechnol. , vol.21 , pp. 517-523
    • Szita, N.1    Polizzi, K.2    Jaccard, N.3    Baganz, F.4
  • 90
    • 45549085296 scopus 로고    scopus 로고
    • Predictive behavior within microbial genetic networks
    • DOI 10.1126/science.1154456
    • Tagkopoulos, I., Liu, Y.C., and Tavazoie, S. (2008). Predictive behavior within microbial genetic networks. Science 320, 1313-1317. (Pubitemid 351929462)
    • (2008) Science , vol.320 , Issue.5881 , pp. 1313-1317
    • Tagkopoulos, I.1    Liu, Y.-C.2    Tavazoie, S.3
  • 91
    • 33746691336 scopus 로고    scopus 로고
    • Extensive low-affinity transcriptional interactions in the yeast genome
    • Tanay, A. (2006). Extensive low-affinity transcriptional interactions in the yeast genome. Genome Res. 16, 962-972.
    • (2006) Genome Res. , vol.16 , pp. 962-972
    • Tanay, A.1
  • 92
    • 77954541844 scopus 로고    scopus 로고
    • Single-cell NF-kappaB dynamics reveal digital activation and analogue information processing
    • Tay, S., Hughey, J.J., Lee, T.K., Lipniacki, T., Quake, S.R., and Covert, M.W. (2010). Single-cell NF-kappaB dynamics reveal digital activation and analogue information processing. Nature 466, 267-271.
    • (2010) Nature , vol.466 , pp. 267-271
    • Tay, S.1    Hughey, J.J.2    Lee, T.K.3    Lipniacki, T.4    Quake, S.R.5    Covert, M.W.6
  • 93
    • 0037376655 scopus 로고    scopus 로고
    • Sniffers, buzzers, toggles and blinkers: Dynamics of regulatory and signaling pathways in the cell
    • Tyson, J.J., Chen, K.C., and Novak, B. (2003). Sniffers, buzzers, toggles and blinkers: dynamics of regulatory and signaling pathways in the cell. Curr. Opin. Cell Biol. 15, 221-231.
    • (2003) Curr. Opin. Cell Biol. , vol.15 , pp. 221-231
    • Tyson, J.J.1    Chen, K.C.2    Novak, B.3
  • 94
    • 77950960454 scopus 로고    scopus 로고
    • Optimizing information flow in small genetic networks. II. Feed-forward interactions
    • Walczak, A.M., Tkacik, G., and Bialek, W. (2010). Optimizing information flow in small genetic networks. II. Feed-forward interactions. Phys. Rev. E Stat. Nonlin. Soft Matter Phys. 81, 041905.
    • (2010) Phys. Rev. E Stat. Nonlin. Soft Matter Phys. , vol.81 , pp. 041905
    • Walczak, A.M.1    Tkacik, G.2    Bialek, W.3
  • 95
    • 58149214356 scopus 로고    scopus 로고
    • Global mapping of H3K4me3 and H3K27me3 reveals specificity and plasticity in lineage fate determination of differentiating CD4+ T cells
    • Wei, G., Wei, L., Zhu, J., Zang, C., Hu-Li, J., Yao, Z., Cui, K., Kanno, Y., Roh, T.Y., Watford, W.T., et al. (2009). Global mapping of H3K4me3 and H3K27me3 reveals specificity and plasticity in lineage fate determination of differentiating CD4+ T cells. Immunity 30, 155-167.
    • (2009) Immunity , vol.30 , pp. 155-167
    • Wei, G.1    Wei, L.2    Zhu, J.3    Zang, C.4    Hu-Li, J.5    Yao, Z.6    Cui, K.7    Kanno, Y.8    Roh, T.Y.9    Watford, W.T.10
  • 96
    • 37249077649 scopus 로고    scopus 로고
    • Chromatin remodelling at promoters suppresses antisense transcription
    • DOI 10.1038/nature06391, PII NATURE06391
    • Whitehouse, I., Rando, O.J., Delrow, J., and Tsukiyama, T. (2007). Chromatin remodelling at promoters suppresses antisense transcription. Nature 450, 1031-1035. (Pubitemid 350273613)
    • (2007) Nature , vol.450 , Issue.7172 , pp. 1031-1035
    • Whitehouse, I.1    Rando, O.J.2    Delrow, J.3    Tsukiyama, T.4
  • 97
    • 58549110252 scopus 로고    scopus 로고
    • Stochastic modelling for quantitative description of heterogeneous biological systems
    • Wilkinson, D.J. (2009). Stochastic modelling for quantitative description of heterogeneous biological systems. Nat. Rev. Genet. 10, 122-133.
    • (2009) Nat. Rev. Genet. , vol.10 , pp. 122-133
    • Wilkinson, D.J.1
  • 98
    • 0035094449 scopus 로고    scopus 로고
    • Cis-regulatory logic in the endo16 gene: Switching from a specification to a differentiation mode of control
    • Yuh, C.H., Bolouri, H., and Davidson, E.H. (2001). Cis-regulatory logic in the endo16 gene: switching from a specification to a differentiation mode of control. Development 128, 617-629. (Pubitemid 32229240)
    • (2001) Development , vol.128 , Issue.5 , pp. 617-629
    • Yuh, C.-H.1    Bolouri, H.2    Davidson, E.H.3
  • 100
    • 70449132583 scopus 로고    scopus 로고
    • Combinatorial binding predicts spatio-temporal cis-regulatory activity
    • Zinzen, R.P., Girardot, C., Gagneur, J., Braun, M., and Furlong, E.E. (2009). Combinatorial binding predicts spatio-temporal cis-regulatory activity. Nature 462, 65-70.
    • (2009) Nature , vol.462 , pp. 65-70
    • Zinzen, R.P.1    Girardot, C.2    Gagneur, J.3    Braun, M.4    Furlong, E.E.5


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