An excitable gene regulatory circuit induces transient cellular differentiation

Nature

Volumn 440, Issue 7083, 2006, Pages 545-550

  Süel, Gürol M ^a   Garcia Ojalvo, Jordi ^b   Liberman, Louisa M ^a   Elowitz, Michael B ^a  

^a California Institute of Technology   (United States)

^b UNIVERSITAT POLITÈCNICA DE CATALUNYA   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

CELL CULTURE; DNA; MATHEMATICAL MODELS; PROBABILISTIC LOGICS;

FEEDBACK LOOPS; QUANTITATIVE FLUORESCENCE TIMELAPSE MICROSCOPY; TRANSIENT CELLULAR DIFFERENTIATION;

GENES;

SCIENCE AND TECHNOLOGY;

ARTICLE; BACILLUS SUBTILIS; BACTERIAL GENE; CELL DIFFERENTIATION; CELL FUNCTION; FEEDBACK SYSTEM; FLUORESCENCE MICROSCOPY; GENE CONTROL; GENETIC ENGINEERING; MATHEMATICAL MODEL; NONHUMAN; PRIORITY JOURNAL;

BACILLUS SUBTILIS; BACTERIA (MICROORGANISMS);

EID: 33645293152     PISSN: 00280836     EISSN: 14764687     Source Type: Journal    
DOI: 10.1038/nature04588     Document Type: Article

References (28)

1. Dupin, E., Real, C., Glavieux-Pardanaud, C., Vaigot, P. & Le Douarin, N. M. Reversal of developmental restrictions in neural crest lineages: transition from Schwann cells to glial-melanocytic precursors in vitro. Proc. Natl Acad. Sci. USA 100, 5229-5233 (2003).
2. Lee, E. J., Russell, T., Hurley, L. & Jameson, J. L. Pituitary transcription factor-1 induces transient differentiation of adult hepatic stem cells into prolactin-producing cells in vivo. Mol. Endocrinol. 19, 964-971 (2005).
3. Meeks, J. C., Campbell, E. L., Summers, M. L. & Wong, F. C. Cellular differentiation in the cyanobacterium Nostoc punctiforme. Arch. Microbiol. 178, 395-403 (2002).
4. Grossman, A. D. Genetic networks controlling the initiation of sporulation and the development of genetic competence in Bacillus subtilis. Annu. Rev. Genet. 29, 477-508 (1995).
5. Hamoen, L. W., Venema, G. & Kuipers, O. P. Controlling competence in Bacillus subtilis: shared use of regulators. Microbiology 149, 9-17 (2003).
6. Lindner, B., Garcia-Ojalvo, J., Neiman, A. & Schimansky-Geier, L. Effects of noise in excitable systems. Phys. Rep. 392, 321-424 (2004).
7. Hahn, J., Kong, L. & Dubnau, D. The regulation of competence transcription factor synthesis constitutes a critical control point in the regulation of competence in Bacillus subtilis. J. Bacteriol. 176, 5753-5761 (1994).
8. Hahn, J., Luttinger, A. & Dubnau, D. Regulatory inputs for the synthesis of ComK, the competence transcription factor of Bacillus subtilis. Mol. Microbiol. 21, 763-775 (1996).
9. van Sinderen, D. et al. comK encodes the competence transcription factor, the key regulatory protein for competence development in Bacillus subtilis. Mol. Microbiol. 15, 455-462 (1995).
10. van Sinderen, D. & Venema, G. comK acts as an autoregulatory control switch in the signal transduction route to competence in Bacillus subtilis. J. Bacteriol. 176, 5762-5770 (1994).
11. Maamar, H. & Dubnau, D. Bistability in the Bacillus subtilis K-state (competence) system requires a positive feedback loop. Mol. Microbiol. 56, 615-624 (2005).
12. Smits, W. K. et al. Stripping Bacillus: ComK auto-stimulation is responsible for the bistable response in competence development. Mol. Microbiol. 56, 604-614 (2005).
13. Turgay, K., Hahn, J., Burghoorn, J. & Dubnau, D. Competence in Bacillus subtilis is controlled by regulated proteolysis of a transcription factor. EMBO J. 17, 6730-6738 (1998).
14. Ogura, M., Liu, L., Lacelle, M., Nakano, M. M. & Zuber, P. Mutational analysis of ComS: evidence for the interaction of ComS and MecA in the regulation of competence development in Bacillus subtilis. Mol. Microbiol. 32, 799-812 (1999).
15. Rosenfeld, N., Young, J. W., Alon, U., Swain, P. S. & Elowitz, M. B. Gene regulation at the single-cell level. Science 307, 1962-1965 (2005).
16. Ozbudak, E. M., Thattai, M., Kurtser, I., Grossman, A. D. & van Oudenaarden, A. Regulation of noise in the expression of a single gene. Nature Genet. 31, 69-73 (2002).
17. Elowitz, M. B., Levine, A. J., Siggia, E. D. & Swain, P. S. Stochastic gene expression in a single cell. Science 297, 1183-1186 (2002).
18. Haijema, B. J., Hahn, J., Haynes, J. & Dubnau, D. A. ComGA-dependent checkpoint limits growth during the escape from competence. Mol. Microbiol. 40, 52-64 (2001).
19. Serror, P. & Sonenshein, A. L. CodY is required for nutritional repression of Bacillus subtilis genetic competence. J. Bacteriol. 178, 5910-5915 (1996).
20. Nakano, M. M. & Zuber, P. The primary role of comA in establishment of the competent state in Bacillus subtilis is to activate expression of srfA. J. Bacteriol. 173, 7269-7274 (1991).
21. Hahn, J. & Dubnau, D. Growth stage signal transduction and the requirements for srfA induction in development of competence. J. Bacteriol. 173, 7275-7282 (1991).
22. Isaacs, F. J., Hasty, J., Cantor, C. R. & Collins, J. J. Prediction and measurement of an autoregulatory genetic module. Proc. Natl Acad. Sci. USA 100, 7714-7719 (2003).
23. Xiong, W. & Ferrell, J. E. Jr. A positive-feedback-based bistable 'memory module' that governs a cell fate decision. Nature 426, 460-465 (2003).
24. Pomerening, J. R., Kim, S. Y. & Ferrell, J. E. Jr. Systems-level dissection of the cell-cycle oscillator: bypassing positive feedback produces damped oscillations. Cell 122, 565-578 (2005).
25. Lahav, G. et al. Dynamics of the p53-Mdm2 feedback loop in individual cells. Nature Genet. 36, 147-150 (2004).
26. Hardin, P. E. The circadian timekeeping system of Drosophila. Curr. Biol. 15, R714-R722 (2005).
27. Vilar, J. M., Kueh, H. Y., Barkai, N. & Leibler, S. Mechanisms of noise-resistance in genetic oscillators. Proc. Natl Acad. Sci. USA 99, 5988-5992 (2002).
28. Keener, J. & Sneyd, J. Mathematical Physiology (Springer, New York, 1998).