Frequency modulation of ERK activation dynamics rewires cell fate

Molecular Systems Biology

Volumn 11, Issue 11, 2015, Pages

  Ryu, Hyunryul ^a,b   Chung, Minhwan ^a   Dobrzyński, Maciej ^c   Fey, Dirk ^c   Blum, Yannick ^d   Lee, Sung Sik ^e   Peter, Matthias ^e   Kholodenko, Boris N ^c   Jeon, Noo Li ^a,b   Pertz, Olivier ^d,f  

^a Seoul National University   (South Korea)

^b Seoul National University   (South Korea)

^c UNIVERSITY COLLEGE DUBLIN   (Ireland)

^d UNIVERSITY OF BASEL   (Switzerland)

^e Institute of Biochemistry   (Switzerland)

^f UNIVERSITY OF BERN   (Switzerland)

Author keywords

cell fate decisions; ERK activity dynamics; FRET biosensor; signaling heterogeneity; single cell biology

Indexed keywords

MITOGEN ACTIVATED PROTEIN KINASE; SIGNAL PEPTIDE;

ARTICLE; CELL DIFFERENTIATION; CELL FATE; CELL HETEROGENEITY; CELL POPULATION; CELL SUBPOPULATION; CYTOSOL; ENZYME ACTIVATION; FREQUENCY MODULATION; INTERNALIZATION; MOLECULAR DYNAMICS; NERVE FIBER GROWTH; PC12 CELL LINE; PRIORITY JOURNAL; SHEAR STRESS; ANIMAL; BIOLOGICAL MODEL; DRUG EFFECTS; FLUORESCENCE RESONANCE ENERGY TRANSFER; GENETIC PROCEDURES; METABOLISM; MICROFLUIDIC ANALYSIS; PROCEDURES; RAT; SIGNAL TRANSDUCTION; SYSTEMS BIOLOGY;

ANIMALS; BIOSENSING TECHNIQUES; CELL DIFFERENTIATION; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; FLUORESCENCE RESONANCE ENERGY TRANSFER; INTERCELLULAR SIGNALING PEPTIDES AND PROTEINS; MICROFLUIDIC ANALYTICAL TECHNIQUES; MODELS, BIOLOGICAL; PC12 CELLS; RATS; SIGNAL TRANSDUCTION; SYSTEMS BIOLOGY;

EID: 84948705576     PISSN: None     EISSN: 17444292     Source Type: Journal    
DOI: 10.15252/msb.20156458     Document Type: Article

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