메뉴 건너뛰기




Volumn 14, Issue 2, 2017, Pages 372-384

Brain Cancer Stem Cells in Adults and Children: Cell Biology and Therapeutic Implications

Author keywords

Cancer stem cells; Childhood brain tumors; Epigenetics; Glioblastoma; Microenvironment; Therapeutic implications

Indexed keywords

ADULT; APOPTOSIS; BRAIN CANCER; CANCER CHEMOTHERAPY; CANCER GROWTH; CANCER PATIENT; CANCER RADIOTHERAPY; CANCER RESISTANCE; CANCER STEM CELL; CANCER SURVIVAL; CHILD; CYTOTOXIC T LYMPHOCYTE; DNA DAMAGE RESPONSE; EPIGENETICS; GAIN OF FUNCTION MUTATION; GENE TARGETING; GENETIC ANALYSIS; GENETIC TRANSCRIPTION; GLIOMA; HUMAN; IMMUNE EVASION; LYMPHOCYTE DIFFERENTIATION; MEDULLOBLASTOMA; NONHUMAN; OVERALL SURVIVAL; PHENOTYPE; PRIORITY JOURNAL; PROGRESSION FREE SURVIVAL; REVIEW; STEM CELL SELF-RENEWAL; TUMOR MICROENVIRONMENT; TUMOR REGRESSION; UPREGULATION; BRAIN TUMOR; DRUG RESISTANCE; GENETIC EPIGENESIS; GENETICS; PATHOPHYSIOLOGY; PHYSIOLOGY; PRESCHOOL CHILD;

EID: 85016927928     PISSN: 19337213     EISSN: 18787479     Source Type: Journal    
DOI: 10.1007/s13311-017-0524-0     Document Type: Review
Times cited : (78)

References (123)
  • 1
    • 84959900894 scopus 로고    scopus 로고
    • American Brain Tumor Association. Adolescent and young adult primary brain and central nervous system tumors diagnosed in the United States in 2008–2012
    • Ostrom QT, Gittleman H, de Blank PM et al. American Brain Tumor Association. Adolescent and young adult primary brain and central nervous system tumors diagnosed in the United States in 2008–2012. Neuro Oncol 2016; Suppl 1:i1-i50.
    • (2016) Neuro Oncol , pp. i1-i50
    • Ostrom, Q.T.1    Gittleman, H.2    de Blank, P.M.3
  • 2
    • 85015461489 scopus 로고    scopus 로고
    • Beyond the World Health Organization grading of infiltrating gliomas: advances in the molecular genetics of glioma classification
    • PID: 26015937
    • Vigneswaran K, Neill S, Hadjipanayis CG. Beyond the World Health Organization grading of infiltrating gliomas: advances in the molecular genetics of glioma classification. Ann Transl Med 2015;3:95.
    • (2015) Ann Transl Med , vol.3 , pp. 95
    • Vigneswaran, K.1    Neill, S.2    Hadjipanayis, C.G.3
  • 3
    • 0014147948 scopus 로고
    • The treatment of glioblastoma multiforme of the brain
    • COI: 1:STN:280:DyaF1c%2FkvFejug%3D%3D, PID: 4293835
    • Jelsma R, Bucy PC. The treatment of glioblastoma multiforme of the brain. J Neurosurg 1967;27(5):388-400.
    • (1967) J Neurosurg , vol.27 , Issue.5 , pp. 388-400
    • Jelsma, R.1    Bucy, P.C.2
  • 4
    • 84871960565 scopus 로고    scopus 로고
    • Standards of care for treatment of recurrent glioblastoma—are we there yet?
    • PID: 23136223
    • Weller M, Cloughesy T, Perry JR, Wick W. Standards of care for treatment of recurrent glioblastoma—are we there yet? Neuro Oncol 2013;15:4-27.
    • (2013) Neuro Oncol , vol.15 , pp. 4-27
    • Weller, M.1    Cloughesy, T.2    Perry, J.R.3    Wick, W.4
  • 6
    • 84977103543 scopus 로고    scopus 로고
    • Neural stem cells and nutrients: poised between quiescence and exhaustion
    • COI: 1:CAS:528:DC%2BC28XhtVynur7O, PID: 27387597
    • Cavallucci V, Fidaleo M, Pani G. Neural stem cells and nutrients: poised between quiescence and exhaustion. Trends Endocrinol Metab 2016; 27:756-769.
    • (2016) Trends Endocrinol Metab , vol.27 , pp. 756-769
    • Cavallucci, V.1    Fidaleo, M.2    Pani, G.3
  • 7
    • 84995554090 scopus 로고    scopus 로고
    • Adult neurogenesis and gliogenesis: possible mechanisms for neurorestoration
    • PID: 27358578
    • Rusznák Z, Henskens W, Schofield E, Kim WS, Fu Y. Adult neurogenesis and gliogenesis: possible mechanisms for neurorestoration. Exp Neurobiol 2016;25:103-112.
    • (2016) Exp Neurobiol , vol.25 , pp. 103-112
    • Rusznák, Z.1    Henskens, W.2    Schofield, E.3    Kim, W.S.4    Fu, Y.5
  • 9
    • 0029983762 scopus 로고    scopus 로고
    • Clonal and population analyses demonstrate that an EGF-responsive mammalian embryonic CNS precursor is a stem cell
    • COI: 1:CAS:528:DyaK28Xitlynt7Y%3D, PID: 8608856
    • Reynolds BA, Weiss S. Clonal and population analyses demonstrate that an EGF-responsive mammalian embryonic CNS precursor is a stem cell. Dev Biol 1996;175(1):1-13.
    • (1996) Dev Biol , vol.175 , Issue.1 , pp. 1-13
    • Reynolds, B.A.1    Weiss, S.2
  • 11
    • 33846095137 scopus 로고    scopus 로고
    • Identification and expansion of human colon-cancer-initiating cells
    • COI: 1:CAS:528:DC%2BD2sXhsFOmug%3D%3D, PID: 17122771
    • Ricci-Vitiani L, Lombardi DG, Pilozzi E et al. Identification and expansion of human colon-cancer-initiating cells. Nature 2007;445:111-115.
    • (2007) Nature , vol.445 , pp. 111-115
    • Ricci-Vitiani, L.1    Lombardi, D.G.2    Pilozzi, E.3
  • 12
    • 0036737914 scopus 로고    scopus 로고
    • Human cortical glial tumors contain neural stem-like cells expressing astroglial and neuronal markers in vitro
    • PID: 12203386
    • Ignatova TN, Kukekov VG, Laywell ED, Suslov ON, Vrionis FD, Steindler DA. Human cortical glial tumors contain neural stem-like cells expressing astroglial and neuronal markers in vitro. Glia 2002;39(3):193-206.
    • (2002) Glia , vol.39 , Issue.3 , pp. 193-206
    • Ignatova, T.N.1    Kukekov, V.G.2    Laywell, E.D.3    Suslov, O.N.4    Vrionis, F.D.5    Steindler, D.A.6
  • 13
    • 17144403478 scopus 로고    scopus 로고
    • Stem and progenitor-like cells contribute to the aggressive behavior of human epithelial ovarian cancer
    • COI: 1:CAS:528:DC%2BD2MXjt1yksrk%3D, PID: 15833827
    • Bapat SA, Mali AM, Koppikar CB, Kurrey NK. Stem and progenitor-like cells contribute to the aggressive behavior of human epithelial ovarian cancer. Cancer Res 2005;65:3025-3029.
    • (2005) Cancer Res , vol.65 , pp. 3025-3029
    • Bapat, S.A.1    Mali, A.M.2    Koppikar, C.B.3    Kurrey, N.K.4
  • 14
    • 84923228764 scopus 로고    scopus 로고
    • Cancer stem cells: moving past the controversy
    • COI: 1:CAS:528:DC%2BC3sXhvFegs7fL, PID: 25054813
    • Lathia JD. Cancer stem cells: moving past the controversy. CNS Oncol 2013;2(6):465-467.
    • (2013) CNS Oncol , vol.2 , Issue.6 , pp. 465-467
    • Lathia, J.D.1
  • 15
    • 0344735881 scopus 로고    scopus 로고
    • Cancerous stem cells can arise from pediatric brain tumors
    • COI: 1:CAS:528:DC%2BD3sXpvFaqu70%3D, PID: 14645703
    • Hemmati HD, Nakano I, Lazareff JA, et al. Cancerous stem cells can arise from pediatric brain tumors. Proc Natl Acad Sci U S A 2003; 100:15178-15183.
    • (2003) Proc Natl Acad Sci U S A , vol.100 , pp. 15178-15183
    • Hemmati, H.D.1    Nakano, I.2    Lazareff, J.A.3
  • 16
    • 77956245743 scopus 로고    scopus 로고
    • Integrin alpha 6 regulates glioblastoma stem cells
    • COI: 1:CAS:528:DC%2BC3cXms1alt74%3D, PID: 20452317
    • Lathia JD, Gallagher J, Heddleston JM, et al. Integrin alpha 6 regulates glioblastoma stem cells. Cell Stem Cell 2010;6:421-432.
    • (2010) Cell Stem Cell , vol.6 , pp. 421-432
    • Lathia, J.D.1    Gallagher, J.2    Heddleston, J.M.3
  • 17
    • 84902578963 scopus 로고    scopus 로고
    • Cancer stem cell-specific scavenger receptor CD36 drives glioblastoma progression
    • COI: 1:CAS:528:DC%2BC2cXhsVSqsrrL, PID: 24737733
    • Hale JS, Otvos B, Sinyuk M, et al. Cancer stem cell-specific scavenger receptor CD36 drives glioblastoma progression. Stem Cells 2014;32:1746-1758.
    • (2014) Stem Cells , vol.32 , pp. 1746-1758
    • Hale, J.S.1    Otvos, B.2    Sinyuk, M.3
  • 18
    • 41749118669 scopus 로고    scopus 로고
    • Identification of A2B5+CD133- tumor-initiating cells in adult human gliomas
    • PID: 18382330
    • Ogden AT, Waziri AE, Lochhead RA et al. Identification of A2B5+CD133- tumor-initiating cells in adult human gliomas. Neurosurgery 2008;62:505-514.
    • (2008) Neurosurgery , vol.62 , pp. 505-514
    • Ogden, A.T.1    Waziri, A.E.2    Lochhead, R.A.3
  • 19
    • 33845671339 scopus 로고    scopus 로고
    • + cancer stem cells in glioblastoma
    • PID: 17140455
    • + cancer stem cells in glioblastoma. Mol Cancer 2006;5:67.
    • (2006) Mol Cancer , vol.5 , pp. 67
    • Liu, G.1    Yuan, X.2    Zeng, Z.3
  • 20
    • 51049101689 scopus 로고    scopus 로고
    • Targeting Cancer Stem Cells through L1CAM Suppresses glioma growth
    • COI: 1:CAS:528:DC%2BD1cXpt1Sqt7w%3D, PID: 18676824
    • Bao S, Wu Q, Li Z, et al. Targeting Cancer Stem Cells through L1CAM Suppresses glioma growth. Cancer Res 2008;68:6043-6048.
    • (2008) Cancer Res , vol.68 , pp. 6043-6048
    • Bao, S.1    Wu, Q.2    Li, Z.3
  • 21
    • 77957351780 scopus 로고    scopus 로고
    • Epidermal growth factor receptor expression identifies functionally and molecularly distinct tumor-initiating cells in human glioblastoma multiforme and is required for gliomagenesis
    • COI: 1:CAS:528:DC%2BC3cXht1akt7jP, PID: 20858720
    • Mazzoleni S, Politi LS, Pala M, et al. Epidermal growth factor receptor expression identifies functionally and molecularly distinct tumor-initiating cells in human glioblastoma multiforme and is required for gliomagenesis. Cancer Res 2010;70:7500-7513.
    • (2010) Cancer Res , vol.70 , pp. 7500-7513
    • Mazzoleni, S.1    Politi, L.S.2    Pala, M.3
  • 22
    • 84855804948 scopus 로고    scopus 로고
    • Sonic hedgehog regulates Bmi1 in human medulloblastoma brain tumor-initiating cells
    • PID: 21685941
    • Wang X, Venugopal C, Manoranjan B, et al. Sonic hedgehog regulates Bmi1 in human medulloblastoma brain tumor-initiating cells. Oncogene 2012;31:187-199.
    • (2012) Oncogene , vol.31 , pp. 187-199
    • Wang, X.1    Venugopal, C.2    Manoranjan, B.3
  • 23
    • 33846815345 scopus 로고    scopus 로고
    • Olig2-regulated lineage-restricted pathway controls replication competence in neural stem cells and malignant glioma
    • COI: 1:CAS:528:DC%2BD2sXis1altLk%3D, PID: 17296553
    • Ligon KL, Huillard E, Mehta S, et al. Olig2-regulated lineage-restricted pathway controls replication competence in neural stem cells and malignant glioma. Neuron 2007;53:503-517.
    • (2007) Neuron , vol.53 , pp. 503-517
    • Ligon, K.L.1    Huillard, E.2    Mehta, S.3
  • 24
    • 84900406316 scopus 로고    scopus 로고
    • Sox2 promotes malignancy in glioblastoma by regulating plasticity and astrocytic differentiation
    • COI: 1:CAS:528:DC%2BC2cXhs1SmsrjM, PID: 24726753
    • Berezovsky AD, Poisson LM, Cherba D, et al. Sox2 promotes malignancy in glioblastoma by regulating plasticity and astrocytic differentiation. Neoplasia 2014;16:193-206.
    • (2014) Neoplasia , vol.16 , pp. 193-206
    • Berezovsky, A.D.1    Poisson, L.M.2    Cherba, D.3
  • 25
    • 84878106525 scopus 로고    scopus 로고
    • The good, the bad and the ugly: epigenetic mechanisms in glioblastoma
    • PID: 22771539
    • Carén H, Pollard SM, Beck S. The good, the bad and the ugly: epigenetic mechanisms in glioblastoma. Mol Aspects Med 2013;34:849-862.
    • (2013) Mol Aspects Med , vol.34 , pp. 849-862
    • Carén, H.1    Pollard, S.M.2    Beck, S.3
  • 26
    • 16844378799 scopus 로고    scopus 로고
    • Leukaemia stem cells and the evolution of cancer-stem-cell research
    • Brian J. P. Huntly and D. Gary Gilliland. Leukaemia stem cells and the evolution of cancer-stem-cell research. Nat Rev Cancer 2005; 5:311-321.
    • (2005) Nat Rev Cancer , vol.5 , pp. 311-321
    • Brian, J.1    Huntly, P.2    Gary Gilliland, D.3
  • 27
    • 0030789242 scopus 로고    scopus 로고
    • Human acute myeloid leukemia is organized as a hierarchy that originates from a primitive hematopoietic cell
    • COI: 1:CAS:528:DyaK2sXkt1GrtLY%3D, PID: 9212098
    • Bonnet D, Dick JE. Human acute myeloid leukemia is organized as a hierarchy that originates from a primitive hematopoietic cell. Nat Med 1997; 3:730-737.
    • (1997) Nat Med , vol.3 , pp. 730-737
    • Bonnet, D.1    Dick, J.E.2
  • 28
    • 0141842674 scopus 로고    scopus 로고
    • Identification of a cancer stem cell in human brain tumors
    • COI: 1:CAS:528:DC%2BD3sXnvVSjtbc%3D, PID: 14522905
    • Singh SK, Clarke ID, Terasaki M et al. Identification of a cancer stem cell in human brain tumors. Cancer Res 2003; 63: 5821-5828.
    • (2003) Cancer Res , vol.63 , pp. 5821-5828
    • Singh, S.K.1    Clarke, I.D.2    Terasaki, M.3
  • 29
    • 6044221204 scopus 로고    scopus 로고
    • Cancer stem cells in nervous system tumors
    • COI: 1:CAS:528:DC%2BD2cXns1ektL0%3D, PID: 15378086
    • Singh SK, Clarke ID, Hide T, Dirks PB. Cancer stem cells in nervous system tumors. Oncogene 2004; 23: 7267-7273.
    • (2004) Oncogene , vol.23 , pp. 7267-7273
    • Singh, S.K.1    Clarke, I.D.2    Hide, T.3    Dirks, P.B.4
  • 30
    • 58649111264 scopus 로고    scopus 로고
    • Identification of CD15 as a marker for tumor-propagating cells in a mouse model of medulloblastoma
    • COI: 1:CAS:528:DC%2BD1MXltFSmtLY%3D, PID: 19185848
    • Read T-A, Fogarty MP, Markant SL, et al. Identification of CD15 as a marker for tumor-propagating cells in a mouse model of medulloblastoma. Cancer Cell 2009;15:135-147.
    • (2009) Cancer Cell , vol.15 , pp. 135-147
    • Read, T.-A.1    Fogarty, M.P.2    Markant, S.L.3
  • 31
    • 84904264545 scopus 로고    scopus 로고
    • + cells drive hierarchical growth and relapse in sonic hedgehog subgroup medulloblastoma
    • COI: 1:CAS:528:DC%2BC2cXhtVams7vM, PID: 24954133
    • + cells drive hierarchical growth and relapse in sonic hedgehog subgroup medulloblastoma. Cancer Cell 2014; 26: 33-47.
    • (2014) Cancer Cell , vol.26 , pp. 33-47
    • Vanner, R.J.1    Remke, M.2    Gallo, M.3
  • 32
    • 84865203983 scopus 로고    scopus 로고
    • A restricted cell population propagates glioblastoma growth following chemotherapy
    • COI: 1:CAS:528:DC%2BC38XhtFChu7rO, PID: 22854781
    • Chen J, Li Y, Yu T-S, et al. A restricted cell population propagates glioblastoma growth following chemotherapy. Nature 2012;488:522-526.
    • (2012) Nature , vol.488 , pp. 522-526
    • Chen, J.1    Li, Y.2    Yu, T.-S.3
  • 33
    • 33845317573 scopus 로고    scopus 로고
    • Glioma stem cells promote radioresistance by preferential activation of the DNA damage response
    • COI: 1:CAS:528:DC%2BD28Xht1OntbzP, PID: 17051156
    • Bao S, Wu Q, McLendon RE, et al. Glioma stem cells promote radioresistance by preferential activation of the DNA damage response. Nature 2006;444:756-760.
    • (2006) Nature , vol.444 , pp. 756-760
    • Bao, S.1    Wu, Q.2    McLendon, R.E.3
  • 34
    • 84920479791 scopus 로고    scopus 로고
    • Abrogation of radioresistance in glioblastoma stem-like cells by inhibition of ATM kinase
    • COI: 1:CAS:528:DC%2BC2cXhsV2ltLrL, PID: 25205037
    • Carruthers R, Ahmed SU, Strathdee K. et al. Abrogation of radioresistance in glioblastoma stem-like cells by inhibition of ATM kinase. Mol Oncol 2015;9:192-203.
    • (2015) Mol Oncol , vol.9 , pp. 192-203
    • Carruthers, R.1    Ahmed, S.U.2    Strathdee, K.3
  • 35
    • 48649104080 scopus 로고    scopus 로고
    • Temozolomide preferentially depletes cancer stem cells in glioblastoma
    • COI: 1:CAS:528:DC%2BD1cXovVCns7w%3D, PID: 18632623
    • Beier D, Röhrl S, Pillai DR. et al. Temozolomide preferentially depletes cancer stem cells in glioblastoma. Cancer Res 2008;68:5706-5715.
    • (2008) Cancer Res , vol.68 , pp. 5706-5715
    • Beier, D.1    Röhrl, S.2    Pillai, D.R.3
  • 36
    • 32544446880 scopus 로고    scopus 로고
    • O(6)-methylguanine DNA-methyltransferase (MGMT) overexpression in melanoma cells induces resistance to nitrosoureas and temozolomide but sensitizes to mitomycin C
    • COI: 1:CAS:528:DC%2BD28XhsFKrtLY%3D, PID: 16039682
    • Passagne I, Evrard A, Depeille P, Cuq P, Cupissol D, Vian L. O(6)-methylguanine DNA-methyltransferase (MGMT) overexpression in melanoma cells induces resistance to nitrosoureas and temozolomide but sensitizes to mitomycin C. Toxicol Appl Pharmacol 2006;211:97-105.
    • (2006) Toxicol Appl Pharmacol , vol.211 , pp. 97-105
    • Passagne, I.1    Evrard, A.2    Depeille, P.3    Cuq, P.4    Cupissol, D.5    Vian, L.6
  • 37
    • 84983499037 scopus 로고    scopus 로고
    • FoxO proteins or loss of functional p53 maintain stemness of glioblastoma stem cells and survival after ionizing radiation plus PI3K/mTOR inhibition
    • PID: 27448972
    • Firat E, Niedermann G. FoxO proteins or loss of functional p53 maintain stemness of glioblastoma stem cells and survival after ionizing radiation plus PI3K/mTOR inhibition. Oncotarget 2016; 7: 54883-54896.
    • (2016) Oncotarget , vol.7 , pp. 54883-54896
    • Firat, E.1    Niedermann, G.2
  • 38
    • 84944462984 scopus 로고    scopus 로고
    • HOXA13 is a potential GBM diagnostic marker and promotes glioma invasion by activating the Wnt and TGF-β pathways
    • PID: 26356815
    • Duan R, Han L, Wang Q, et al. HOXA13 is a potential GBM diagnostic marker and promotes glioma invasion by activating the Wnt and TGF-β pathways. Oncotarget 2015;6:27778-27793.
    • (2015) Oncotarget , vol.6 , pp. 27778-27793
    • Duan, R.1    Han, L.2    Wang, Q.3
  • 39
    • 84991762680 scopus 로고    scopus 로고
    • NOTCH blockade combined with radiation therapy and temozolomide prolongs survival of orthotopic glioblastoma
    • PID: 27183910
    • Yahyanejad S, King H, Iglesias VS et al. NOTCH blockade combined with radiation therapy and temozolomide prolongs survival of orthotopic glioblastoma. Oncotarget 2016;7:41251-41264.
    • (2016) Oncotarget , vol.7 , pp. 41251-41264
    • Yahyanejad, S.1    King, H.2    Iglesias, V.S.3
  • 40
    • 84959112873 scopus 로고    scopus 로고
    • Codrici E, Enciu AM, Popescu ID, Mihai S, Tanase C. Glioma stem cells and their microenvironments: providers of challenging therapeutic targets. 5728438
    • Codrici E, Enciu AM, Popescu ID, Mihai S, Tanase C. Glioma stem cells and their microenvironments: providers of challenging therapeutic targets. Stem Cells Int 2016; 5728438.
    • (2016) Stem Cells Int
  • 41
    • 80052795862 scopus 로고    scopus 로고
    • Endothelial cells create a stem cell niche in glioblastoma by providing Notch ligands that nurture self-renewal of cancer stem-like cells
    • COI: 1:CAS:528:DC%2BC3MXhtFKntb3L, PID: 21788346
    • Zhu TS, Costello MA, Talsma CE, et al. Endothelial cells create a stem cell niche in glioblastoma by providing Notch ligands that nurture self-renewal of cancer stem-like cells. Cancer Res 2011;71:6061-6072.
    • (2011) Cancer Res , vol.71 , pp. 6061-6072
    • Zhu, T.S.1    Costello, M.A.2    Talsma, C.E.3
  • 42
    • 84939514262 scopus 로고    scopus 로고
    • Endothelial cells induce cancer stem cell features in differentiated glioblastoma cells via bFGF
    • PID: 26282129
    • Fessler E, Borovski T, Medema JP. Endothelial cells induce cancer stem cell features in differentiated glioblastoma cells via bFGF. Mol Cancer 2015;14:157.
    • (2015) Mol Cancer , vol.14 , pp. 157
    • Fessler, E.1    Borovski, T.2    Medema, J.P.3
  • 43
    • 75349091751 scopus 로고    scopus 로고
    • Perivascular nitric oxide activates Notch signaling and promotes stem-like character in PDGF-induced glioma cells
    • Charles N, Ozawa T, Squatrito M, et al. Perivascular nitric oxide activates Notch signaling and promotes stem-like character in PDGF-induced glioma cells. Cell Stem Cell 2010;6.
    • (2010) Cell Stem Cell , pp. 6
    • Charles, N.1    Ozawa, T.2    Squatrito, M.3
  • 44
    • 33846237601 scopus 로고    scopus 로고
    • HEDGEHOG-GLI1 signaling regulates human glioma growth, cancer stem cell self-renewal, and tumorigenicity
    • COI: 1:CAS:528:DC%2BD2sXnslOmuw%3D%3D, PID: 17196391
    • Clement V, Sanchez P, de Tribolet N, Radovanovic I, Ruiz i Altaba A. HEDGEHOG-GLI1 signaling regulates human glioma growth, cancer stem cell self-renewal, and tumorigenicity. Curr Biol 2007;17:165-172.
    • (2007) Curr Biol , vol.17 , pp. 165-172
    • Clement, V.1    Sanchez, P.2    de Tribolet, N.3    Radovanovic, I.4    Ruiz i Altaba, A.5
  • 45
    • 84866340817 scopus 로고    scopus 로고
    • Hypoxia and hypoxia-inducible factors in glioblastoma multiforme progression and therapeutic implications
    • COI: 1:CAS:528:DC%2BC38XhtlSntr3L, PID: 22906859
    • Yang L, Lin C, Wang L, Guo H, Wang X. Hypoxia and hypoxia-inducible factors in glioblastoma multiforme progression and therapeutic implications. Exp Cell Res 2012;318:2417-2426.
    • (2012) Exp Cell Res , vol.318 , pp. 2417-2426
    • Yang, L.1    Lin, C.2    Wang, L.3    Guo, H.4    Wang, X.5
  • 46
    • 65749106405 scopus 로고    scopus 로고
    • Hypoxia-inducible factors regulate tumorigenic capacity of glioma stem cells
    • COI: 1:CAS:528:DC%2BD1MXntlegtbo%3D, PID: 19477429
    • Li Z, Bao S, Wu Q, et al. Hypoxia-inducible factors regulate tumorigenic capacity of glioma stem cells. Cancer Cell 2009;15:501-513.
    • (2009) Cancer Cell , vol.15 , pp. 501-513
    • Li, Z.1    Bao, S.2    Wu, Q.3
  • 47
    • 33747874155 scopus 로고    scopus 로고
    • Notch pathway inhibition depletes stem-like cells and blocks engraftment in embryonal brain tumors
    • COI: 1:CAS:528:DC%2BD28XnsFyrtLY%3D, PID: 16885340
    • Xing Fan, William Matsui, Leila Khaki, et al. Notch pathway inhibition depletes stem-like cells and blocks engraftment in embryonal brain tumors. Cancer Res 2006;66:7445-7452.
    • (2006) Cancer Res , vol.66 , pp. 7445-7452
    • Fan, X.1    Matsui, W.2    Khaki, L.3
  • 48
    • 33646358694 scopus 로고    scopus 로고
    • Tumor stem cells derived from glioblastomas cultured in bFGF and EGF more closely mirror the phenotype and genotype of primary tumors than do serum-cultured cell lines
    • COI: 1:CAS:528:DC%2BD28XltF2nsLk%3D, PID: 16697959
    • Lee J, Kotliarova S, Kotliarov Y et al. Tumor stem cells derived from glioblastomas cultured in bFGF and EGF more closely mirror the phenotype and genotype of primary tumors than do serum-cultured cell lines. Cancer Cell 2006;9:391-403.
    • (2006) Cancer Cell , vol.9 , pp. 391-403
    • Lee, J.1    Kotliarova, S.2    Kotliarov, Y.3
  • 49
    • 84985931281 scopus 로고    scopus 로고
    • TGFβ-responsive HMOX1 expression is associated with stemness and invasion in glioblastoma multiforme
    • COI: 1:CAS:528:DC%2BC28XhsVOit7bO, PID: 27354342
    • Ghosh D, Ulasov IV, Chen L. et al. TGFβ-responsive HMOX1 expression is associated with stemness and invasion in glioblastoma multiforme. Stem Cells 2016;34:2276-2289.
    • (2016) Stem Cells , vol.34 , pp. 2276-2289
    • Ghosh, D.1    Ulasov, I.V.2    Chen, L.3
  • 50
    • 84979743444 scopus 로고    scopus 로고
    • The ID1-CULLIN3 axis regulates intracellular SHH and WNT signaling in glioblastoma stem cells
    • COI: 1:CAS:528:DC%2BC28Xht1KlsbjI, PID: 27477274
    • Jin X, Jeon HM, Jin X et al. The ID1-CULLIN3 axis regulates intracellular SHH and WNT signaling in glioblastoma stem cells. Cell Rep 2016;16:1629-1641.
    • (2016) Cell Rep , vol.16 , pp. 1629-1641
    • Jin, X.1    Jeon, H.M.2    Jin, X.3
  • 51
    • 79953029992 scopus 로고    scopus 로고
    • Elevated invasive potential of glioblastoma stem cells
    • COI: 1:CAS:528:DC%2BC3MXjvFart7c%3D, PID: 21371437
    • Cheng L, Wu Q, Guryanova OA, et al. Elevated invasive potential of glioblastoma stem cells. Biochem Biophys Res Commun 2011;406:643-648.
    • (2011) Biochem Biophys Res Commun , vol.406 , pp. 643-648
    • Cheng, L.1    Wu, Q.2    Guryanova, O.A.3
  • 52
    • 33748051406 scopus 로고    scopus 로고
    • Stem cell-like glioma cells promote tumor angiogenesis through vascular endothelial growth factor
    • COI: 1:CAS:528:DC%2BD28XotFWqsb8%3D, PID: 16912155
    • Bao S, Wu Q, Sathornsumetee S. et al. Stem cell-like glioma cells promote tumor angiogenesis through vascular endothelial growth factor. Cancer Res 2006;66:7843-7848.
    • (2006) Cancer Res , vol.66 , pp. 7843-7848
    • Bao, S.1    Wu, Q.2    Sathornsumetee, S.3
  • 53
    • 84955207765 scopus 로고    scopus 로고
    • CD133 and DNA-PK regulate MDR1 via the PI3K- or Akt-NF-κB pathway in multidrug-resistant glioblastoma cells in vitro
    • COI: 1:CAS:528:DC%2BC2MXlsVOgu7w%3D, PID: 25823028
    • Xi G, Hayes E, Lewis R, et al. CD133 and DNA-PK regulate MDR1 via the PI3K- or Akt-NF-κB pathway in multidrug-resistant glioblastoma cells in vitro. Oncogene 2016;35:241-250.
    • (2016) Oncogene , vol.35 , pp. 241-250
    • Xi, G.1    Hayes, E.2    Lewis, R.3
  • 54
    • 84970951402 scopus 로고    scopus 로고
    • Pharmacological targeting of the histone chaperone complex FACT preferentially eliminates glioblastoma stem cells and prolongs survival in preclinical models
    • COI: 1:CAS:528:DC%2BC28XmtVagsLo%3D, PID: 26921329
    • Dermawan JK, Hitomi M, Silver DJ, et al. Pharmacological targeting of the histone chaperone complex FACT preferentially eliminates glioblastoma stem cells and prolongs survival in preclinical models. Cancer Res 2016;76:2432-2442.
    • (2016) Cancer Res , vol.76 , pp. 2432-2442
    • Dermawan, J.K.1    Hitomi, M.2    Silver, D.J.3
  • 56
    • 84925175304 scopus 로고    scopus 로고
    • TRPM7 channels regulate glioma stem cell through STAT3 and Notch signaling pathways
    • COI: 1:CAS:528:DC%2BC2cXhs1Squ7rI, PID: 25192910
    • Liu M, Inoue K, Leng T, Guo S, Xiong Z. TRPM7 channels regulate glioma stem cell through STAT3 and Notch signaling pathways. Cell Signal 2014;26:2773-2781.
    • (2014) Cell Signal , vol.26 , pp. 2773-2781
    • Liu, M.1    Inoue, K.2    Leng, T.3    Guo, S.4    Xiong, Z.5
  • 57
    • 85008426303 scopus 로고    scopus 로고
    • Deubiquitinase USP13 maintains glioblastoma stem cells by antagonizing FBXL14-mediated Myc ubiquitination
    • PID: 27923907
    • Fang X, Zhou W, Wu Q, et al. Deubiquitinase USP13 maintains glioblastoma stem cells by antagonizing FBXL14-mediated Myc ubiquitination. J Exp Med 2017;214:245-267.
    • (2017) J Exp Med , vol.214 , pp. 245-267
    • Fang, X.1    Zhou, W.2    Wu, Q.3
  • 58
    • 85011999794 scopus 로고    scopus 로고
    • Astrocyte elevated gene-1 regulates beta-catenin signaling to maintain glioma stem-like stemness and self-renewal
    • COI: 1:CAS:528:DC%2BC2sXhsl2qtL8%3D, PID: 27903708
    • Hu B, Emdad L, Kegelman TP, et al. Astrocyte elevated gene-1 regulates beta-catenin signaling to maintain glioma stem-like stemness and self-renewal. Mol Cancer Res 2017;15:225-233.
    • (2017) Mol Cancer Res , vol.15 , pp. 225-233
    • Hu, B.1    Emdad, L.2    Kegelman, T.P.3
  • 59
    • 2942700004 scopus 로고    scopus 로고
    • Getting at the root and stem of brain tumors
    • COI: 1:CAS:528:DC%2BD2cXlsleju70%3D, PID: 15207233
    • Oliver TG, Wechsler-Reya RJ. Getting at the root and stem of brain tumors. Neuron 2004; 42: 885-888.
    • (2004) Neuron , vol.42 , pp. 885-888
    • Oliver, T.G.1    Wechsler-Reya, R.J.2
  • 60
    • 0031036694 scopus 로고    scopus 로고
    • Sporadic medulloblastomas contain PTCH mutations
    • COI: 1:CAS:528:DyaK2sXhs1Kis7c%3D, PID: 9041183
    • Raffel C, Jenkins RB, Frederick L, et al. Sporadic medulloblastomas contain PTCH mutations. Cancer Res 1997; 57: 842-845.
    • (1997) Cancer Res , vol.57 , pp. 842-845
    • Raffel, C.1    Jenkins, R.B.2    Frederick, L.3
  • 61
    • 0032080853 scopus 로고    scopus 로고
    • Missense mutations in SMOH in sporadic basal cell carcinomas of the skin and primitive neuroectodermal tumors of the central nervous system
    • COI: 1:CAS:528:DyaK1cXislensb0%3D, PID: 9581815
    • Reifenberger J, Wolter M, Weber RG, et al. Missense mutations in SMOH in sporadic basal cell carcinomas of the skin and primitive neuroectodermal tumors of the central nervous system. Cancer Res 1998; 58: 1798-1803.
    • (1998) Cancer Res , vol.58 , pp. 1798-1803
    • Reifenberger, J.1    Wolter, M.2    Weber, R.G.3
  • 62
    • 0032030894 scopus 로고    scopus 로고
    • Sporadic medulloblastomas contain oncogenic β-catenin mutations
    • COI: 1:CAS:528:DyaK1cXhsFersr8%3D, PID: 9500446
    • Zurawel RH, Chiappa SA, Allen C, Raffel C. Sporadic medulloblastomas contain oncogenic β-catenin mutations. Cancer Res 1998; 58: 896-899.
    • (1998) Cancer Res , vol.58 , pp. 896-899
    • Zurawel, R.H.1    Chiappa, S.A.2    Allen, C.3    Raffel, C.4
  • 63
    • 7444228699 scopus 로고    scopus 로고
    • The SmoA1 mouse model reveals that notch signaling is critical for the growth and survival of sonic hedgehog-induced medulloblastomas
    • COI: 1:CAS:528:DC%2BD2cXptFemu7o%3D, PID: 15520185
    • Hallahan AR, Pritchard JI, Hansen S, et al. The SmoA1 mouse model reveals that notch signaling is critical for the growth and survival of sonic hedgehog-induced medulloblastomas. Cancer Res 2004; 64: 7794-7800.
    • (2004) Cancer Res , vol.64 , pp. 7794-7800
    • Hallahan, A.R.1    Pritchard, J.I.2    Hansen, S.3
  • 64
    • 84925431286 scopus 로고    scopus 로고
    • Molecular and in vivo characterization of cancer-propagating cells derived from MYCN-dependent medulloblastoma
    • PID: 25785590
    • Ahmad Z, Jasnos L, Gil V, et al. Molecular and in vivo characterization of cancer-propagating cells derived from MYCN-dependent medulloblastoma. PLOS ONE 2015;10(3):e0119834.
    • (2015) PLOS ONE , vol.10 , Issue.3
    • Ahmad, Z.1    Jasnos, L.2    Gil, V.3
  • 65
    • 39449135834 scopus 로고    scopus 로고
    • PI3K pathway regulates survival of cancer stem cells residing in the perivascular niche following radiation in medulloblastoma in vivo
    • COI: 1:CAS:528:DC%2BD1cXivVaitrw%3D, PID: 18281460
    • Dolores Hambardzumyan, Oren J. Becher, et al. PI3K pathway regulates survival of cancer stem cells residing in the perivascular niche following radiation in medulloblastoma in vivo. Genes Dev 2008;22:436-448.
    • (2008) Genes Dev , vol.22 , pp. 436-448
    • Hambardzumyan, D.1    Becher, O.J.2
  • 66
    • 84863012675 scopus 로고    scopus 로고
    • An animal model of Myc-driven medduloblastoma
    • COI: 1:CAS:528:DC%2BC38Xit12gtLg%3D, PID: 22340590
    • Pei Y, Moore CE, Wang J, et al. An animal model of Myc-driven medduloblastoma. Cancer Cell 2012; 21: 155-167.
    • (2012) Cancer Cell , vol.21 , pp. 155-167
    • Pei, Y.1    Moore, C.E.2    Wang, J.3
  • 67
    • 84974687001 scopus 로고    scopus 로고
    • The Long Non-coding RNA HIF1A-AS2 facilitates the maintenance of mesenchymal glioblastoma stem-like cells in hypoxic niches
    • COI: 1:CAS:528:DC%2BC28Xpt1enurg%3D, PID: 27264189
    • Mineo M, Ricklefs F, Rooj AK, et al. The Long Non-coding RNA HIF1A-AS2 facilitates the maintenance of mesenchymal glioblastoma stem-like cells in hypoxic niches. Cell Rep 2016; 15:2500-2509.
    • (2016) Cell Rep , vol.15 , pp. 2500-2509
    • Mineo, M.1    Ricklefs, F.2    Rooj, A.K.3
  • 68
    • 84969816481 scopus 로고    scopus 로고
    • Transforming growth factor-β and stem cell markers are highly expressed around necrotic areas in glioblastoma
    • COI: 1:CAS:528:DC%2BC28Xot1Gktro%3D, PID: 27193555
    • Iwadate Y, Matsutani T, Hirono S, Shinozaki N, Saeki N. Transforming growth factor-β and stem cell markers are highly expressed around necrotic areas in glioblastoma. J Neurooncol 2016;129:101-107.
    • (2016) J Neurooncol , vol.129 , pp. 101-107
    • Iwadate, Y.1    Matsutani, T.2    Hirono, S.3    Shinozaki, N.4    Saeki, N.5
  • 69
    • 84899986078 scopus 로고    scopus 로고
    • Profilin-1 phosphorylation directs angiocrine expression and glioblastoma progression through HIF-1α accumulation
    • COI: 1:CAS:528:DC%2BC2cXmsVKrtrk%3D, PID: 24747440
    • Fan Y, Potdar AA, Gong Y, et al. Profilin-1 phosphorylation directs angiocrine expression and glioblastoma progression through HIF-1α accumulation. Nat Cell Biol 2014;16:445-456.
    • (2014) Nat Cell Biol , vol.16 , pp. 445-456
    • Fan, Y.1    Potdar, A.A.2    Gong, Y.3
  • 70
    • 84954235083 scopus 로고    scopus 로고
    • An ID2-dependent mechanism for VHL inactivation in cancer
    • COI: 1:CAS:528:DC%2BC28Xns1Kgsw%3D%3D, PID: 26735018
    • Lee SB, Frattin V, Bansal M, et al. An ID2-dependent mechanism for VHL inactivation in cancer. Nature 2016;529:172-177.
    • (2016) Nature , vol.529 , pp. 172-177
    • Lee, S.B.1    Frattin, V.2    Bansal, M.3
  • 71
    • 84934343090 scopus 로고    scopus 로고
    • targeting hypoxia-inducible factor 1α in a new orthotopic model of glioblastoma recapitulating the hypoxic tumor microenvironment
    • COI: 1:CAS:528:DC%2BC2MXhtVaksLrK, PID: 26083570
    • Nigim F, Cavanaugh J, Patel AP, et al. targeting hypoxia-inducible factor 1α in a new orthotopic model of glioblastoma recapitulating the hypoxic tumor microenvironment. J Neuropathol Exp Neurol 2015;74:710-722.
    • (2015) J Neuropathol Exp Neurol , vol.74 , pp. 710-722
    • Nigim, F.1    Cavanaugh, J.2    Patel, A.P.3
  • 72
    • 59849096400 scopus 로고    scopus 로고
    • Hypoxia and HIF1alpha repress the differentiative effects of BMPs in high-grade glioma
    • COI: 1:CAS:528:DC%2BD1MXisVeqsb8%3D, PID: 18832593
    • Pistollato F, Chen HL, Rood BR, et al. Hypoxia and HIF1alpha repress the differentiative effects of BMPs in high-grade glioma. Stem Cells 2009;27:7-17.
    • (2009) Stem Cells , vol.27 , pp. 7-17
    • Pistollato, F.1    Chen, H.L.2    Rood, B.R.3
  • 73
    • 84960422749 scopus 로고    scopus 로고
    • Pediatric medulloblastoma xenografts including molecular subgroup 3 and CD133+ and CD15+ cells are sensitive to killing by oncolytic herpes simplex viruses
    • PID: 26188016
    • Friedman GK, Moore BP, Nan L, et al. Pediatric medulloblastoma xenografts including molecular subgroup 3 and CD133+ and CD15+ cells are sensitive to killing by oncolytic herpes simplex viruses. Neuro Oncol 2016;18:227-235.
    • (2016) Neuro Oncol , vol.18 , pp. 227-235
    • Friedman, G.K.1    Moore, B.P.2    Nan, L.3
  • 74
    • 0030778631 scopus 로고    scopus 로고
    • Interleukin 10 is expressed in human gliomas in vivo and increases glioma cell proliferation and motility in vitro
    • COI: 1:CAS:528:DyaK1cXkvFKksg%3D%3D, PID: 9413151
    • Huettner C, Czub S, Kerkau S, Roggendorf W, Tonn JC. Interleukin 10 is expressed in human gliomas in vivo and increases glioma cell proliferation and motility in vitro. Anticancer Res 1997;17:3217-3224.
    • (1997) Anticancer Res , vol.17 , pp. 3217-3224
    • Huettner, C.1    Czub, S.2    Kerkau, S.3    Roggendorf, W.4    Tonn, J.C.5
  • 75
    • 84855604775 scopus 로고    scopus 로고
    • Challenges in immunotherapy presented by the glioblastoma multiforme microenvironment
    • Jackson C, Ruzevick J, Phallen J, Belcaid Z, Lim M. Challenges in immunotherapy presented by the glioblastoma multiforme microenvironment. Clin Dev Immunol 2011;732413.
    • (2011) Clin Dev Immunol , vol.2011 , Issue.73
    • Jackson, C.1    Ruzevick, J.2    Phallen, J.3    Belcaid, Z.4    Lim, M.5
  • 76
    • 84982845015 scopus 로고    scopus 로고
    • Cancer stem cell-secreted macrophage migration inhibitory factor stimulates myeloid derived suppressor cell function and facilitates glioblastoma immune evasion
    • COI: 1:CAS:528:DC%2BC28Xht1Kku7rL, PID: 27145382
    • Otvos B, Silver DJ, Mulkearns-Hubert EE, et al. Cancer stem cell-secreted macrophage migration inhibitory factor stimulates myeloid derived suppressor cell function and facilitates glioblastoma immune evasion. Stem Cells 2016; 34: 2026-2039.
    • (2016) Stem Cells , vol.34 , pp. 2026-2039
    • Otvos, B.1    Silver, D.J.2    Mulkearns-Hubert, E.E.3
  • 77
    • 84923068676 scopus 로고    scopus 로고
    • Periostin secreted by glioblastoma stem cells recruits M2 tumor-associated macrophages and promotes malignant growth
    • COI: 1:CAS:528:DC%2BC2MXmtFSgsw%3D%3D, PID: 25580734
    • Zhou W, Ke SQ, Huang Z, et al. Periostin secreted by glioblastoma stem cells recruits M2 tumor-associated macrophages and promotes malignant growth. Nat Cell Biol 2015;17:170-182.
    • (2015) Nat Cell Biol , vol.17 , pp. 170-182
    • Zhou, W.1    Ke, S.Q.2    Huang, Z.3
  • 78
    • 84960470595 scopus 로고    scopus 로고
    • The intersection of cancer, cancer stem cells, and the immune system: therapeutic opportunities
    • PID: 26264894
    • Silver DJ, Sinyuk M, Vogelbaum MA, Ahluwalia MS, Lathia JD. The intersection of cancer, cancer stem cells, and the immune system: therapeutic opportunities. Neuro Oncol 2016; 18: 153-159.
    • (2016) Neuro Oncol , vol.18 , pp. 153-159
    • Silver, D.J.1    Sinyuk, M.2    Vogelbaum, M.A.3    Ahluwalia, M.S.4    Lathia, J.D.5
  • 79
    • 84890439524 scopus 로고    scopus 로고
    • Interleukin-6 is overexpressed and augments invasiveness of human glioma stem cells in vitro
    • COI: 1:CAS:528:DC%2BC3sXhvVOisLvK, PID: 23832741
    • Qiu B, Zhang D, Wang Y, et al. Interleukin-6 is overexpressed and augments invasiveness of human glioma stem cells in vitro. Clin Exp Metastasis 2013;30:1009-1018.
    • (2013) Clin Exp Metastasis , vol.30 , pp. 1009-1018
    • Qiu, B.1    Zhang, D.2    Wang, Y.3
  • 81
    • 68149169092 scopus 로고    scopus 로고
    • Gliomas induce and exploit microglial MT1-MMP expression for tumor expansion
    • COI: 1:CAS:528:DC%2BD1MXpslCitLg%3D, PID: 19617536
    • Markovic DS, Vinnakota K, Chirasani S, et al. Gliomas induce and exploit microglial MT1-MMP expression for tumor expansion. Proc Natl Acad Sci U S A 2009;106:12530-12535.
    • (2009) Proc Natl Acad Sci U S A , vol.106 , pp. 12530-12535
    • Markovic, D.S.1    Vinnakota, K.2    Chirasani, S.3
  • 82
    • 84862879740 scopus 로고    scopus 로고
    • Tumor-associated microglia/macrophages enhance the invasion of glioma stem-like cells via TGF-beta1 signaling pathway
    • COI: 1:CAS:528:DC%2BC38XovVyrtbo%3D, PID: 22664874
    • Ye XZ, Xu SL, Xin YH, et al. Tumor-associated microglia/macrophages enhance the invasion of glioma stem-like cells via TGF-beta1 signaling pathway. J Immunol 2012;189:444-453.
    • (2012) J Immunol , vol.189 , pp. 444-453
    • Ye, X.Z.1    Xu, S.L.2    Xin, Y.H.3
  • 83
    • 84855188858 scopus 로고    scopus 로고
    • Microglial stress inducible protein 1 promotes proliferation and migration in human glioblastoma cells
    • PID: 22062133
    • Fonseca AC, Romao L, Amaral RF, et al. Microglial stress inducible protein 1 promotes proliferation and migration in human glioblastoma cells. Neuroscience 2012;200:130-141.
    • (2012) Neuroscience , vol.200 , pp. 130-141
    • Fonseca, A.C.1    Romao, L.2    Amaral, R.F.3
  • 84
    • 84982275958 scopus 로고    scopus 로고
    • IDO1 involvement in mTOR pathway: A molecular mechanism of resistance to mTOR targeting in medulloblastoma
    • PID: 27174915
    • Folgiero V, Miele E, Carai A, et al. IDO1 involvement in mTOR pathway: A molecular mechanism of resistance to mTOR targeting in medulloblastoma. Oncotarget 2016; 7: 52900-52911.
    • (2016) Oncotarget , vol.7 , pp. 52900-52911
    • Folgiero, V.1    Miele, E.2    Carai, A.3
  • 85
    • 84962529567 scopus 로고    scopus 로고
    • Pediatric primitive neuroectodermal tumors of the central nervous system differentially express granzyme inhibitors
    • PID: 26963506
    • Vermeulen JF, van Hecke W, Spliet WG, et al. Pediatric primitive neuroectodermal tumors of the central nervous system differentially express granzyme inhibitors. PLOS ONE 2016;11:e0151465.
    • (2016) PLOS ONE , vol.11
    • Vermeulen, J.F.1    van Hecke, W.2    Spliet, W.G.3
  • 86
    • 84906302984 scopus 로고    scopus 로고
    • T-cell TGF-β signaling abrogation restricts medulloblastoma progression
    • COI: 1:CAS:528:DC%2BC2cXht1Cgtr%2FN, PID: 25082897
    • Gate D, Danielpour M, Rodriguez J Jr, et al. T-cell TGF-β signaling abrogation restricts medulloblastoma progression. Proc Natl Acad Sci U S A 2014;111:E3458-E3466.
    • (2014) Proc Natl Acad Sci U S A , vol.111 , pp. E3458-E3466
    • Gate, D.1    Danielpour, M.2    Rodriguez, J.3
  • 87
    • 84873180351 scopus 로고    scopus 로고
    • Discovering gene-environment interactions in glioblastoma through a comprehensive data integration bioinformatics method
    • COI: 1:CAS:528:DC%2BC3sXktlKru78%3D, PID: 23261424
    • Kunkle B, Yoo C, Roy D. Discovering gene-environment interactions in glioblastoma through a comprehensive data integration bioinformatics method. Neurotoxicology 2013;35:1-14.
    • (2013) Neurotoxicology , vol.35 , pp. 1-14
    • Kunkle, B.1    Yoo, C.2    Roy, D.3
  • 88
    • 52949127312 scopus 로고    scopus 로고
    • An integrated genomic analysis of human glioblastoma multiforme
    • COI: 1:CAS:528:DC%2BD1cXhtFCrtLrE, PID: 18772396
    • Parsons DW, Jones S, Zhang X, et al. An integrated genomic analysis of human glioblastoma multiforme. Science 2008;321:1807-1812.
    • (2008) Science , vol.321 , pp. 1807-1812
    • Parsons, D.W.1    Jones, S.2    Zhang, X.3
  • 89
    • 54549108740 scopus 로고    scopus 로고
    • Comprehensive genomic characterization defines human glioblastoma genes and core pathways
    • Cancer Genome Atlas Research Network. Comprehensive genomic characterization defines human glioblastoma genes and core pathways. Nature 2008;455:1061-1068.
    • (2008) Nature , vol.455 , pp. 1061-1068
  • 90
    • 84880791777 scopus 로고    scopus 로고
    • Molecular neuro-oncology in clinical practice: a new horizon
    • COI: 1:CAS:528:DC%2BC3sXhtF2iurbJ, PID: 23896276
    • Weller M, Pfister SM, Wick W, Hegi ME, Reifenberger G, Stupp R. Molecular neuro-oncology in clinical practice: a new horizon. Lancet Oncol 2013;14: e370-e379.
    • (2013) Lancet Oncol , vol.14 , pp. e370-e379
    • Weller, M.1    Pfister, S.M.2    Wick, W.3    Hegi, M.E.4    Reifenberger, G.5    Stupp, R.6
  • 91
    • 84921415076 scopus 로고    scopus 로고
    • Single cell-derived clonal analysis of human glioblastoma links functional and genomic heterogeneity
    • Meyera M, Reimandb J, Lan X, et al. Single cell-derived clonal analysis of human glioblastoma links functional and genomic heterogeneity. PNAS 2015;112: 851-856.
    • (2015) PNAS , vol.112 , pp. 851-856
    • Meyera, M.1    Reimandb, J.2    Lan, X.3
  • 92
    • 84885426091 scopus 로고    scopus 로고
    • Medulloblastoma molecular dissection: the way toward targeted therapy
    • COI: 1:CAS:528:DC%2BC3sXhs1SisLbL, PID: 24076581
    • Remke M, Ramaswamy V, Taylor MD. Medulloblastoma molecular dissection: the way toward targeted therapy. Curr Opin Oncol 2013;25:674-681.
    • (2013) Curr Opin Oncol , vol.25 , pp. 674-681
    • Remke, M.1    Ramaswamy, V.2    Taylor, M.D.3
  • 93
    • 84930188532 scopus 로고    scopus 로고
    • Unique genetic and epigenetic mechanisms driving paediatric diffuse high-grade glioma
    • Jones C, Baker SJ. Unique genetic and epigenetic mechanisms driving paediatric diffuse high-grade glioma. Nat Rev Cancer 2014;14:10.
    • (2014) Nat Rev Cancer , vol.14 , pp. 10
    • Jones, C.1    Baker, S.J.2
  • 94
    • 84893519542 scopus 로고    scopus 로고
    • Molecular genetics of gliomas
    • COI: 1:CAS:528:DC%2BC2cXhtlShtLs%3D, PID: 24445767
    • Appin CL, Brat DJ. Molecular genetics of gliomas. Cancer J 2014;20:66-72.
    • (2014) Cancer J , vol.20 , pp. 66-72
    • Appin, C.L.1    Brat, D.J.2
  • 95
    • 84963976310 scopus 로고    scopus 로고
    • A Novel mouse model of diffuse intrinsic pontine glioma initiated in Pax3-expressing cells
    • COI: 1:CAS:528:DC%2BC2MXitV2nur7K, PID: 26806352
    • Misuraca KL, Hu G, Barton KL, Chung A, Becher OJ. A Novel mouse model of diffuse intrinsic pontine glioma initiated in Pax3-expressing cells. Neoplasia 2016;18:60-70.
    • (2016) Neoplasia , vol.18 , pp. 60-70
    • Misuraca, K.L.1    Hu, G.2    Barton, K.L.3    Chung, A.4    Becher, O.J.5
  • 96
    • 84874194072 scopus 로고    scopus 로고
    • DNA methylation: roles in mammalian development
    • COI: 1:CAS:528:DC%2BC3sXitlaku7Y%3D, PID: 23400093
    • Smith ZD, Meissner A. DNA methylation: roles in mammalian development. Nat Rev Genet 2013;14:204-220.
    • (2013) Nat Rev Genet , vol.14 , pp. 204-220
    • Smith, Z.D.1    Meissner, A.2
  • 97
    • 80053515159 scopus 로고    scopus 로고
    • Glioma stem cell maintenance: the role of the microenvironment
    • COI: 1:CAS:528:DC%2BC3MXhtlGksrrL, PID: 21827414
    • Heddleston JM, Hitomi M, Venere M, et al. Glioma stem cell maintenance: the role of the microenvironment. Curr Pharm Des 2011;17:2386-2401.
    • (2011) Curr Pharm Des , vol.17 , pp. 2386-2401
    • Heddleston, J.M.1    Hitomi, M.2    Venere, M.3
  • 98
    • 84857042390 scopus 로고    scopus 로고
    • Hypoxia-induced mixed-lineage leukemia 1 regulates glioma stem cell tumorigenic potential
    • COI: 1:CAS:528:DC%2BC38XitlGqu7w%3D, PID: 21836617
    • Heddleston JM, Wu Q, Rivera M, et al. Hypoxia-induced mixed-lineage leukemia 1 regulates glioma stem cell tumorigenic potential. Cell Death Differ 2012;19:428-439.
    • (2012) Cell Death Differ , vol.19 , pp. 428-439
    • Heddleston, J.M.1    Wu, Q.2    Rivera, M.3
  • 99
    • 84871955637 scopus 로고    scopus 로고
    • A tumorigenic MLL-homeobox network in human glioblastoma stem cells
    • COI: 1:CAS:528:DC%2BC3sXjs1aiuw%3D%3D, PID: 23108137
    • Gallo M, Ho J, Coutinho FJ, et al. A tumorigenic MLL-homeobox network in human glioblastoma stem cells. Cancer Res 2013;73:417-427.
    • (2013) Cancer Res , vol.73 , pp. 417-427
    • Gallo, M.1    Ho, J.2    Coutinho, F.J.3
  • 100
    • 37349067098 scopus 로고    scopus 로고
    • Epigenetic-mediated dysfunction of the bone morphogenetic protein pathway inhibits differentiation of glioblastoma-initiating cells
    • COI: 1:CAS:528:DC%2BD1cXnsVKmsQ%3D%3D, PID: 18167341
    • Lee J, Son MJ, Woolard K, et al. Epigenetic-mediated dysfunction of the bone morphogenetic protein pathway inhibits differentiation of glioblastoma-initiating cells. Cancer Cell 2008;13:69-80.
    • (2008) Cancer Cell , vol.13 , pp. 69-80
    • Lee, J.1    Son, M.J.2    Woolard, K.3
  • 101
    • 59849125142 scopus 로고    scopus 로고
    • SOX2 silencing in glioblastoma tumor-initiating cells causes stop of proliferation and loss of tumorigenicity
    • COI: 1:CAS:528:DC%2BD1MXisVeqsbo%3D, PID: 18948646
    • Gangemi RM, Griffero F, Marubbi D, et al. SOX2 silencing in glioblastoma tumor-initiating cells causes stop of proliferation and loss of tumorigenicity. Stem Cells 2009;27:40-48.
    • (2009) Stem Cells , vol.27 , pp. 40-48
    • Gangemi, R.M.1    Griffero, F.2    Marubbi, D.3
  • 102
    • 84878000228 scopus 로고    scopus 로고
    • MELK-dependent FOXM1 phosphorylation is essential for proliferation of glioma stem cells
    • COI: 1:CAS:528:DC%2BC3sXps1Gjtbg%3D, PID: 23404835
    • Joshi K, Banasavadi-Siddegowda Y, Mo X, et al. MELK-dependent FOXM1 phosphorylation is essential for proliferation of glioma stem cells. Stem Cells 2013;31:1051-1063.
    • (2013) Stem Cells , vol.31 , pp. 1051-1063
    • Joshi, K.1    Banasavadi-Siddegowda, Y.2    Mo, X.3
  • 103
    • 84890943320 scopus 로고    scopus 로고
    • Transcription factors FOXG1 and Groucho/TLE promote glioblastoma growth
    • PID: 24356439
    • Verginelli F, Perin A, Dali R, et al. Transcription factors FOXG1 and Groucho/TLE promote glioblastoma growth. Nat Commun 2013;4:2956.
    • (2013) Nat Commun , vol.4 , pp. 2956
    • Verginelli, F.1    Perin, A.2    Dali, R.3
  • 104
    • 77955428416 scopus 로고    scopus 로고
    • NANOG regulates glioma stem cells and is essential in vivo acting in a cross-functional network with GLI1 and p53
    • COI: 1:CAS:528:DC%2BC3cXnvVShu7Y%3D, PID: 20581802
    • Zbinden M, Duquet A, Lorente-Trigos A, Ngwabyt SN, Borges I, Ruiz i Altaba A. NANOG regulates glioma stem cells and is essential in vivo acting in a cross-functional network with GLI1 and p53. EMBO J 2010;29:2659-2674.
    • (2010) EMBO J , vol.29 , pp. 2659-2674
    • Zbinden, M.1    Duquet, A.2    Lorente-Trigos, A.3    Ngwabyt, S.N.4    Borges, I.5    Ruiz i Altaba, A.6
  • 105
    • 70350212976 scopus 로고    scopus 로고
    • STAT3 is required for proliferation and maintenance of multipotency in glioblastoma stem cells
    • Sherry MM, Reeves A, Wu JK, Cochran BH. STAT3 is required for proliferation and maintenance of multipotency in glioblastoma stem cells. Stem Cells 2009;10:2383-2392.
    • (2009) Stem Cells , vol.10 , pp. 2383-2392
    • Sherry, M.M.1    Reeves, A.2    Wu, J.K.3    Cochran, B.H.4
  • 106
    • 84878543522 scopus 로고    scopus 로고
    • An aberrant transcription factor network essential for Wnt signaling and stem cell maintenance in glioblastoma
    • COI: 1:CAS:528:DC%2BC3sXotlGku7w%3D, PID: 23707066
    • Rheinbay E, Suva ML, Gillespie SM, et al. An aberrant transcription factor network essential for Wnt signaling and stem cell maintenance in glioblastoma. Cell Rep 2013;3:1567-1579.
    • (2013) Cell Rep , vol.3 , pp. 1567-1579
    • Rheinbay, E.1    Suva, M.L.2    Gillespie, S.M.3
  • 107
    • 84904409295 scopus 로고    scopus 로고
    • The zinc finger transcription factor ZFX is required for maintaining the tumorigenic potential of glioblastoma stem cells
    • COI: 1:CAS:528:DC%2BC2cXhs1Chs7%2FK, PID: 24831540
    • Fang X, Huang Z, Zhou W, et al. The zinc finger transcription factor ZFX is required for maintaining the tumorigenic potential of glioblastoma stem cells. Stem Cells 2014;32:2033-2047.
    • (2014) Stem Cells , vol.32 , pp. 2033-2047
    • Fang, X.1    Huang, Z.2    Zhou, W.3
  • 108
    • 84895903445 scopus 로고    scopus 로고
    • ZFHX4 interacts with the NuRD core member CHD4 and regulates the glioblastoma tumor-initiating cell state
    • COI: 1:CAS:528:DC%2BC2cXhs1KmsbY%3D, PID: 24440720
    • Chudnovsky Y, Kim D, Zheng S, et al. ZFHX4 interacts with the NuRD core member CHD4 and regulates the glioblastoma tumor-initiating cell state. Cell Rep 2014;6:313-324.
    • (2014) Cell Rep , vol.6 , pp. 313-324
    • Chudnovsky, Y.1    Kim, D.2    Zheng, S.3
  • 109
    • 84958181186 scopus 로고    scopus 로고
    • Genetics and epigenetics of glioblastoma: applications and overall incidence of IDH1 mutation
    • PID: 26858939
    • Liu A, Hou C, Chen H, Zong X, Zong P. Genetics and epigenetics of glioblastoma: applications and overall incidence of IDH1 mutation. Front Oncol 2016;6:16.
    • (2016) Front Oncol , vol.6 , pp. 16
    • Liu, A.1    Hou, C.2    Chen, H.3    Zong, X.4    Zong, P.5
  • 110
    • 84899524502 scopus 로고    scopus 로고
    • Reconstructing and reprogramming the tumor-propagating potential of glioblastoma stem-like cells
    • PID: 24726434
    • Suvà ML, Rheinbay E, Gillespie SM, et al. Reconstructing and reprogramming the tumor-propagating potential of glioblastoma stem-like cells. Cell 2014;157:580-594.
    • (2014) Cell , vol.157 , pp. 580-594
    • Suvà, M.L.1    Rheinbay, E.2    Gillespie, S.M.3
  • 111
    • 84862777410 scopus 로고    scopus 로고
    • St. Jude Children’s Research Hospital-Washington University Pediatric Cancer Genome Project. Somatic histone H3 alterations in pediatric diffuse intrinsic pontine gliomas and non-brainstem glioblastomas
    • COI: 1:CAS:528:DC%2BC38XhtlOlsb4%3D, PID: 22286216
    • Wu G, Broniscer A, McEachron TA, et al.; St. Jude Children’s Research Hospital-Washington University Pediatric Cancer Genome Project. Somatic histone H3 alterations in pediatric diffuse intrinsic pontine gliomas and non-brainstem glioblastomas. Nat Genet 2012;44:251-253.
    • (2012) Nat Genet , vol.44 , pp. 251-253
    • Wu, G.1    Broniscer, A.2    McEachron, T.A.3
  • 112
    • 84882273357 scopus 로고    scopus 로고
    • Evaluation of histone 3 lysine 27 trimethylation (H3K27me3) and enhancer of Zest 2 (EZH2) in pediatric glial and glioneuronal tumors shows decreased H3K27me3 in H3F3A K27M mutant glioblastomas
    • COI: 1:CAS:528:DC%2BC3sXhs12mt7rO, PID: 23414300
    • Venneti S, Garimella MT, Sullivan LM, et al. Evaluation of histone 3 lysine 27 trimethylation (H3K27me3) and enhancer of Zest 2 (EZH2) in pediatric glial and glioneuronal tumors shows decreased H3K27me3 in H3F3A K27M mutant glioblastomas. Brain Pathol 2013;23:558-564.
    • (2013) Brain Pathol , vol.23 , pp. 558-564
    • Venneti, S.1    Garimella, M.T.2    Sullivan, L.M.3
  • 113
    • 84919458472 scopus 로고    scopus 로고
    • Use of human embryonic stem cells to model pediatric gliomas with H3.3K27M histone mutation
    • COI: 1:CAS:528:DC%2BC2cXitV2gtrzK, PID: 25525250
    • Funato K, Major T, Lewis PW, Allis CD, Tabar V. Use of human embryonic stem cells to model pediatric gliomas with H3.3K27M histone mutation. Science 2014;346:1529-1533.
    • (2014) Science , vol.346 , pp. 1529-1533
    • Funato, K.1    Major, T.2    Lewis, P.W.3    Allis, C.D.4    Tabar, V.5
  • 114
    • 84899526966 scopus 로고    scopus 로고
    • St. Jude Children's Research Hospital-Washington University Pediatric Cancer Genome Project. The genomic landscape of diffuse intrinsic pontine glioma and pediatric non-brainstem high-grade glioma
    • COI: 1:CAS:528:DC%2BC2cXls1Gkurg%3D, PID: 24705251
    • Wu G, Diaz AK, Paugh BS, et al. St. Jude Children's Research Hospital-Washington University Pediatric Cancer Genome Project. The genomic landscape of diffuse intrinsic pontine glioma and pediatric non-brainstem high-grade glioma. Nat Genet 2014;46:444-450.
    • (2014) Nat Genet , vol.46 , pp. 444-450
    • Wu, G.1    Diaz, A.K.2    Paugh, B.S.3
  • 115
    • 84876067164 scopus 로고    scopus 로고
    • TERT promoter mutations occur frequently in gliomas and a subset of tumors derived from cells with low rates of self-renewal
    • COI: 1:CAS:528:DC%2BC3sXnsFKksbc%3D, PID: 23530248
    • Killela PJ, Reitman ZJ, Jiao Y, et al. TERT promoter mutations occur frequently in gliomas and a subset of tumors derived from cells with low rates of self-renewal. Proc Natl Acad Sci U S A 2013;110:6021-6026.
    • (2013) Proc Natl Acad Sci U S A , vol.110 , pp. 6021-6026
    • Killela, P.J.1    Reitman, Z.J.2    Jiao, Y.3
  • 116
    • 84879917277 scopus 로고    scopus 로고
    • FoxG1 interacts with Bmi1 to regulate self-renewal and tumorigenicity of medulloblastoma stem cells
    • COI: 1:CAS:528:DC%2BC3sXhtlWjsL%2FL, PID: 23592496
    • Manoranjan B, Wang X, Hallett RM, et al. FoxG1 interacts with Bmi1 to regulate self-renewal and tumorigenicity of medulloblastoma stem cells. Stem Cells 2013;31:1266-1277.
    • (2013) Stem Cells , vol.31 , pp. 1266-1277
    • Manoranjan, B.1    Wang, X.2    Hallett, R.M.3
  • 117
    • 83255162011 scopus 로고    scopus 로고
    • Receptor tyrosine kinases and targeted cancer therapeutics
    • COI: 1:CAS:528:DC%2BC38Xhs1Kis7w%3D, PID: 22130229
    • Takeuchi K, Ito F. Receptor tyrosine kinases and targeted cancer therapeutics. Biol Pharm Bull 2011;34:1774-1780.
    • (2011) Biol Pharm Bull , vol.34 , pp. 1774-1780
    • Takeuchi, K.1    Ito, F.2
  • 118
    • 84883458285 scopus 로고    scopus 로고
    • Therapeutic vaccination against autologous cancer stem cells with mRNA-transfected dendritic cells in patients with glioblastoma
    • COI: 1:CAS:528:DC%2BC3sXhsFKjur%2FF, PID: 23817721
    • Vik-Mo EO, Nyakas M, Mikkelsen BV, et al. Therapeutic vaccination against autologous cancer stem cells with mRNA-transfected dendritic cells in patients with glioblastoma. Cancer Immunol Immunother 2013;62:1499-1509.
    • (2013) Cancer Immunol Immunother , vol.62 , pp. 1499-1509
    • Vik-Mo, E.O.1    Nyakas, M.2    Mikkelsen, B.V.3
  • 119
    • 4644306516 scopus 로고    scopus 로고
    • A distinct “side population” of cells with high drug efflux capacity in human tumor cells
    • COI: 1:CAS:528:DC%2BD2cXosVyltr8%3D, PID: 15381773
    • Hirschmann-Jax C, Foster AE, Wulf GG, et al. A distinct “side population” of cells with high drug efflux capacity in human tumor cells. Proc Natl Acad Sci U S A 2004;101:14228-14233.
    • (2004) Proc Natl Acad Sci U S A , vol.101 , pp. 14228-14233
    • Hirschmann-Jax, C.1    Foster, A.E.2    Wulf, G.G.3
  • 120
    • 84926665383 scopus 로고    scopus 로고
    • MiRNA-21 silencing mediated by tumor-targeted nanoparticles combined with sunitinib: a new multimodal gene therapy approach for glioblastoma
    • COI: 1:CAS:528:DC%2BC2MXmtVaqsLw%3D, PID: 25861727
    • Costa PM, Cardoso AL, Custódia C, et al. MiRNA-21 silencing mediated by tumor-targeted nanoparticles combined with sunitinib: a new multimodal gene therapy approach for glioblastoma. J Control Release 2015;207:31-39.
    • (2015) J Control Release , vol.207 , pp. 31-39
    • Costa, P.M.1    Cardoso, A.L.2    Custódia, C.3
  • 121
    • 84954108890 scopus 로고    scopus 로고
    • Pyrvinium targets CD133 in human glioblastoma brain tumor-initiating cells
    • COI: 1:CAS:528:DC%2BC2MXhvFKlurzL, PID: 26152745
    • Venugopal C, Hallett R, Vora P, et al. Pyrvinium targets CD133 in human glioblastoma brain tumor-initiating cells. Clin Cancer Res 2015;21:5324-5337.
    • (2015) Clin Cancer Res , vol.21 , pp. 5324-5337
    • Venugopal, C.1    Hallett, R.2    Vora, P.3
  • 122
    • 80053040376 scopus 로고    scopus 로고
    • Phase I trial of MK-0752 in children with refractory CNS malignancies: a Pediatric Brain Tumor Consortium study
    • COI: 1:CAS:528:DC%2BC3MXhtlWqsLrO, PID: 21825264
    • Fouladi M, Stewart CF, Olson J, et al. Phase I trial of MK-0752 in children with refractory CNS malignancies: a Pediatric Brain Tumor Consortium study. J Clin Oncol 2011;29:3529-3534.
    • (2011) J Clin Oncol , vol.29 , pp. 3529-3534
    • Fouladi, M.1    Stewart, C.F.2    Olson, J.3
  • 123
    • 84940482116 scopus 로고    scopus 로고
    • Vismodegib exerts targeted efficacy against recurrent sonic hedgehog-subgroup medulloblastoma: results from phase II pediatric brain tumor consortium studies PBTC-025B and PBTC032
    • COI: 1:CAS:528:DC%2BC2MXitV2qsbnM, PID: 26169613
    • Robinson GW, Orr BA, Wu G, et al. Vismodegib exerts targeted efficacy against recurrent sonic hedgehog-subgroup medulloblastoma: results from phase II pediatric brain tumor consortium studies PBTC-025B and PBTC032. J Clin Oncol 2015;33:2646-2654.
    • (2015) J Clin Oncol , vol.33 , pp. 2646-2654
    • Robinson, G.W.1    Orr, B.A.2    Wu, G.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.