메뉴 건너뛰기




Volumn 18, Issue 2, 2016, Pages 153-159

The intersection of cancer, cancer stem cells, and the immune system: Therapeutic opportunities

Author keywords

cancer stem cell; immune evasion; immune suppression; immunotherapy; tumor immune interaction

Indexed keywords

CANCER VACCINE; DCVAX L; HEAT SHOCK PROTEIN PEPTIDE COMPLEX 9; IPILIMUMAB; NIVOLUMAB; TEMOZOLOMIDE; UNCLASSIFIED DRUG;

EID: 84960470595     PISSN: 15228517     EISSN: 15235866     Source Type: Journal    
DOI: 10.1093/neuonc/nov157     Document Type: Article
Times cited : (93)

References (46)
  • 1
    • 35949002429 scopus 로고    scopus 로고
    • Malignant astrocytic glioma: Genetics, biology, and paths to treatment
    • Furnari FB, Fenton T, Bachoo RM, et al. Malignant astrocytic glioma: genetics, biology, and paths to treatment. Genes Dev. 2007; 21(21):2683-2710.
    • (2007) Genes Dev , vol.21 , Issue.21 , pp. 2683-2710
    • Furnari, F.B.1    Fenton, T.2    Bachoo, R.M.3
  • 2
    • 84884579346 scopus 로고    scopus 로고
    • Chondroitin sulfate proteoglycans potently inhibit invasion and serve as a central organizer of the brain tumor microenvironment
    • Silver DJ, Siebzehnrubl FA, Schildts MJ, et al. Chondroitin sulfate proteoglycans potently inhibit invasion and serve as a central organizer of the brain tumor microenvironment. J Neurosci. 2013;33(39):15603-15617.
    • (2013) J Neurosci , vol.33 , Issue.39 , pp. 15603-15617
    • Silver, D.J.1    Siebzehnrubl, F.A.2    Schildts, M.J.3
  • 3
  • 4
    • 84925010154 scopus 로고    scopus 로고
    • Glioma-derived versican promotes tumor expansion via glioma-associated microglial/macrophages Toll-like receptor 2 signaling
    • Hu F, Dzaye OD, Hahn A, et al. Glioma-derived versican promotes tumor expansion via glioma-associated microglial/macrophages Toll-like receptor 2 signaling. Neuro Oncol. 2015;17(2):200-210.
    • (2015) Neuro Oncol , vol.17 , Issue.2 , pp. 200-210
    • Hu, F.1    Dzaye, O.D.2    Hahn, A.3
  • 5
    • 84891873517 scopus 로고    scopus 로고
    • Toll-like receptor 2 mediates microglia/brain macrophage MT1-MMP expression and glioma expansion
    • Vinnakota K, Hu F, Ku MC, et al. Toll-like receptor 2 mediates microglia/brain macrophage MT1-MMP expression and glioma expansion. Neuro Oncol. 2013;15(11):1457-1468.
    • (2013) Neuro Oncol , vol.15 , Issue.11 , pp. 1457-1468
    • Vinnakota, K.1    Hu, F.2    Ku, M.C.3
  • 6
    • 68149169092 scopus 로고    scopus 로고
    • Gliomas induce and exploit microglial MT1-MMP expression for tumor expansion
    • Markovic DS, Vinnakota K, Chirasani S, et al. Gliomas induce and exploit microglial MT1-MMP expression for tumor expansion. Proc Natl Acad Sci USA. 2009;106(30):12530-12535.
    • (2009) Proc Natl Acad Sci USA , vol.106 , Issue.30 , pp. 12530-12535
    • Markovic, D.S.1    Vinnakota, K.2    Chirasani, S.3
  • 7
    • 84908284742 scopus 로고    scopus 로고
    • Glioma-associated microglial MMP9 expression is upregulated by TLR2 signaling and sensitive to minocycline
    • Hu F, Ku MC, Markovic D, et al. Glioma-associated microglial MMP9 expression is upregulated by TLR2 signaling and sensitive to minocycline. Int J Cancer. 2014;135(11):2569-2578.
    • (2014) Int J Cancer , vol.135 , Issue.11 , pp. 2569-2578
    • Hu, F.1    Ku, M.C.2    Markovic, D.3
  • 8
    • 84862879740 scopus 로고    scopus 로고
    • Tumor-associated microglia/macrophages enhance the invasion of glioma stem-like cells via TGF-beta1 signaling pathway
    • Ye XZ, Xu SL, Xin YH, et al. Tumor-associated microglia/macrophages enhance the invasion of glioma stem-like cells via TGF-beta1 signaling pathway. J Immunol. 2012;189(1):444-453.
    • (2012) J Immunol , vol.189 , Issue.1 , pp. 444-453
    • Ye, X.Z.1    Xu, S.L.2    Xin, Y.H.3
  • 9
    • 84855188858 scopus 로고    scopus 로고
    • Microglial stress inducible protein 1 promotes proliferation and migration in human glioblastoma cells
    • Fonseca AC, Romao L, Amaral RF, et al. Microglial stress inducible protein 1 promotes proliferation and migration in human glioblastoma cells. Neuroscience. 2012;200:130-141.
    • (2012) Neuroscience , vol.200 , pp. 130-141
    • Fonseca, A.C.1    Romao, L.2    Amaral, R.F.3
  • 10
    • 77954396042 scopus 로고    scopus 로고
    • Clearance of apoptotic cells: Implications in health and disease
    • Elliott MR, Ravichandran KS. Clearance of apoptotic cells: implications in health and disease. J Cell Biol. 2010;189(7): 1059-1070.
    • (2010) J Cell Biol , vol.189 , Issue.7 , pp. 1059-1070
    • Elliott, M.R.1    Ravichandran, K.S.2
  • 11
    • 78649981811 scopus 로고    scopus 로고
    • Cell death in the neighbourhood: Direct microenvironmental effects of apoptosis in normal and neoplastic tissues
    • Gregory CD, Pound JD. Cell death in the neighbourhood: direct microenvironmental effects of apoptosis in normal and neoplastic tissues. J Pathol. 2011;223(2):177-194.
    • (2011) J Pathol , vol.223 , Issue.2 , pp. 177-194
    • Gregory, C.D.1    Pound, J.D.2
  • 12
    • 79952284127 scopus 로고    scopus 로고
    • Hallmarks of cancer: The next generation
    • Hanahan D, Weinberg RA. Hallmarks of cancer: the next generation. Cell. 2011;144(5):646-674.
    • (2011) Cell , vol.144 , Issue.5 , pp. 646-674
    • Hanahan, D.1    Weinberg, R.A.2
  • 13
    • 84924673209 scopus 로고    scopus 로고
    • Oncogenic properties of apoptotic tumor cells in aggressive B cell lymphoma
    • Ford CA, Petrova S, Pound JD, et al. Oncogenic properties of apoptotic tumor cells in aggressive B cell lymphoma. Curr Biol. 2015;25(5):577-588.
    • (2015) Curr Biol , vol.25 , Issue.5 , pp. 577-588
    • Ford, C.A.1    Petrova, S.2    Pound, J.D.3
  • 14
    • 77952890503 scopus 로고    scopus 로고
    • CX3CR1 promotes recruitment of human glioma-infiltrating microglia/macrophages (GIMs)
    • Held-Feindt J, Hattermann K, Muerkoster SS, et al. CX3CR1 promotes recruitment of human glioma-infiltrating microglia/macrophages (GIMs). Exp Cell Res. 2010;316(9):1553-1566.
    • (2010) Exp Cell Res , vol.316 , Issue.9 , pp. 1553-1566
    • Held-Feindt, J.1    Hattermann, K.2    Muerkoster, S.S.3
  • 15
    • 84923068676 scopus 로고    scopus 로고
    • Periostin secreted by glioblastoma stem cells recruits M2 tumour-associated macrophages and promotes malignant growth
    • Zhou W, Ke SQ, Huang Z, et al. Periostin secreted by glioblastoma stem cells recruits M2 tumour-associated macrophages and promotes malignant growth. Nat Cell Biol. 2015;17(2):170-182.
    • (2015) Nat Cell Biol , vol.17 , Issue.2 , pp. 170-182
    • Zhou, W.1    Ke, S.Q.2    Huang, Z.3
  • 16
    • 84887481716 scopus 로고    scopus 로고
    • CSF-1R inhibition alters macrophage polarization and blocks glioma progression
    • Pyonteck SM, Akkari L, Schuhmacher AJ, et al. CSF-1R inhibition alters macrophage polarization and blocks glioma progression. Nat Med. 2013;19(10):1264-1272.
    • (2013) Nat Med , vol.19 , Issue.10 , pp. 1264-1272
    • Pyonteck, S.M.1    Akkari, L.2    Schuhmacher, A.J.3
  • 17
    • 16244390854 scopus 로고    scopus 로고
    • Regulatory T cells and autoimmune disease
    • Paust S, Cantor H. Regulatory T cells and autoimmune disease. Immunol Rev. 2005;204:195-207.
    • (2005) Immunol Rev , vol.204 , pp. 195-207
    • Paust, S.1    Cantor, H.2
  • 18
    • 15444377017 scopus 로고    scopus 로고
    • Intratumor depletion of CD4+ cells unmasks tumor immunogenicity leading to the rejection of late-stage tumors
    • Yu P, Lee Y, Liu W, et al. Intratumor depletion of CD4+ cells unmasks tumor immunogenicity leading to the rejection of late-stage tumors. J Exp Med. 2005;201(5):779-791.
    • (2005) J Exp Med , vol.201 , Issue.5 , pp. 779-791
    • Yu, P.1    Lee, Y.2    Liu, W.3
  • 19
    • 33748492962 scopus 로고    scopus 로고
    • Prolongation of survival following depletion of CD4+CD25+ regulatory T cells in mice with experimental brain tumors
    • El Andaloussi A, Han Y, Lesniak MS. Prolongation of survival following depletion of CD4+CD25+ regulatory T cells in mice with experimental brain tumors. J Neurosurg. 2006;105(3):430-437.
    • (2006) J Neurosurg , vol.105 , Issue.3 , pp. 430-437
    • El Andaloussi, A.1    Han, Y.2    Lesniak, M.S.3
  • 20
    • 79960003585 scopus 로고    scopus 로고
    • Myeloid-derived suppressor cell accumulation and function in patients with newly diagnosed glioblastoma
    • Raychaudhuri B, Rayman P, Ireland J, et al. Myeloid-derived suppressor cell accumulation and function in patients with newly diagnosed glioblastoma. Neuro Oncol. 2011;13(6):591-599.
    • (2011) Neuro Oncol , vol.13 , Issue.6 , pp. 591-599
    • Raychaudhuri, B.1    Rayman, P.2    Ireland, J.3
  • 21
    • 84940005453 scopus 로고    scopus 로고
    • Myeloid derived suppressor cell infiltration of murine and human gliomas is associated with reduction of tumor infiltrating lymphocytes
    • Raychaudhuri B, Rayman P, Huang P, et al. Myeloid derived suppressor cell infiltration of murine and human gliomas is associated with reduction of tumor infiltrating lymphocytes. J Neurooncol. 2015;122(2):293-301.
    • (2015) J Neurooncol , vol.122 , Issue.2 , pp. 293-301
    • Raychaudhuri, B.1    Rayman, P.2    Huang, P.3
  • 22
    • 0344735881 scopus 로고    scopus 로고
    • Cancerous stem cells can arise from pediatric brain tumors
    • Hemmati HD, Nakano I, Lazareff JA, et al. Cancerous stem cells can arise from pediatric brain tumors. Proc Natl Acad Sci USA. 2003;100(25):15178-15183.
    • (2003) Proc Natl Acad Sci USA , vol.100 , Issue.25 , pp. 15178-15183
    • Hemmati, H.D.1    Nakano, I.2    Lazareff, J.A.3
  • 23
    • 0036737914 scopus 로고    scopus 로고
    • Human cortical glial tumors contain neural stem-like cells expressing astroglial and neuronal markers in vitro
    • Ignatova TN, Kukekov VG, Laywell ED, Suslov ON, Vrionis FD, Steindler DA. Human cortical glial tumors contain neural stem-like cells expressing astroglial and neuronal markers in vitro. Glia. 2002;39(3):193-206.
    • (2002) Glia , vol.39 , Issue.3 , pp. 193-206
    • Ignatova, T.N.1    Kukekov, V.G.2    Laywell, E.D.3    Suslov, O.N.4    Vrionis, F.D.5    Steindler, D.A.6
  • 24
    • 9244241576 scopus 로고    scopus 로고
    • Identification of human brain tumour initiating cells
    • Singh SK, Hawkins C, Clarke ID, et al. Identification of human brain tumour initiating cells. Nature. 2004;432(7015):396-401.
    • (2004) Nature , vol.432 , Issue.7015 , pp. 396-401
    • Singh, S.K.1    Hawkins, C.2    Clarke, I.D.3
  • 25
    • 33845317573 scopus 로고    scopus 로고
    • Glioma stem cells promote radioresistance by preferential activation of the DNA damage response
    • Bao S, Wu Q, McLendon RE, et al. Glioma stem cells promote radioresistance by preferential activation of the DNA damage response. Nature. 2006;444(7120):756-760.
    • (2006) Nature , vol.444 , Issue.7120 , pp. 756-760
    • Bao, S.1    Wu, Q.2    McLendon, R.E.3
  • 26
    • 33748051406 scopus 로고    scopus 로고
    • Stem cell-like glioma cells promote tumor angiogenesis through vascular endothelial growth factor
    • Bao S, Wu Q, Sathornsumetee S, et al. Stem cell-like glioma cells promote tumor angiogenesis through vascular endothelial growth factor. Cancer Res. 2006;66(16):7843-7848.
    • (2006) Cancer Res , vol.66 , Issue.16 , pp. 7843-7848
    • Bao, S.1    Wu, Q.2    Sathornsumetee, S.3
  • 27
    • 33846029123 scopus 로고    scopus 로고
    • A perivascular niche for brain tumor stem cells
    • Calabrese C, Poppleton H, Kocak M, et al. A perivascular niche for brain tumor stem cells. Cancer Cell. 2007;11(1):69-82.
    • (2007) Cancer Cell , vol.11 , Issue.1 , pp. 69-82
    • Calabrese, C.1    Poppleton, H.2    Kocak, M.3
  • 28
    • 84865203983 scopus 로고    scopus 로고
    • A restricted cell population propagates glioblastoma growth after chemotherapy
    • Chen J, Li Y, Yu TS, et al. A restricted cell population propagates glioblastoma growth after chemotherapy. Nature. 2012; 488(7412):522-526.
    • (2012) Nature , vol.488 , Issue.7412 , pp. 522-526
    • Chen, J.1    Li, Y.2    Yu, T.S.3
  • 29
    • 33845671339 scopus 로고    scopus 로고
    • Analysis of gene expression and chemoresistance of CD133+ cancer stem cells in glioblastoma
    • Liu G, Yuan X, Zeng Z, et al. Analysis of gene expression and chemoresistance of CD133+ cancer stem cells in glioblastoma. Mol Cancer. 2006;5:67.
    • (2006) Mol Cancer , vol.5 , pp. 67
    • Liu, G.1    Yuan, X.2    Zeng, Z.3
  • 30
  • 31
    • 33846118474 scopus 로고    scopus 로고
    • Loss of tumor suppressor PTEN function increases B7-H1 expression and immunoresistance in glioma
    • Parsa AT, Waldron JS, Panner A, et al. Loss of tumor suppressor PTEN function increases B7-H1 expression and immunoresistance in glioma. Nat Med. 2007;13(1):84-88.
    • (2007) Nat Med , vol.13 , Issue.1 , pp. 84-88
    • Parsa, A.T.1    Waldron, J.S.2    Panner, A.3
  • 32
    • 77950221879 scopus 로고    scopus 로고
    • Transcriptional profiles of CD133+ and CD133-glioblastoma-derived cancer stem cell lines suggest different cells of origin
    • Lottaz C, Beier D, Meyer K, et al. Transcriptional profiles of CD133+ and CD133-glioblastoma-derived cancer stem cell lines suggest different cells of origin. Cancer Res. 2010;70(5):2030-2040.
    • (2010) Cancer Res , vol.70 , Issue.5 , pp. 2030-2040
    • Lottaz, C.1    Beier, D.2    Meyer, K.3
  • 33
    • 28544444135 scopus 로고    scopus 로고
    • Human leukocyte antigen and antigen processing machinery component defects in astrocytic tumors
    • Facoetti A, Nano R, Zelini P, et al. Human leukocyte antigen and antigen processing machinery component defects in astrocytic tumors. Clin Cancer Res. 2005;11(23):8304-8311.
    • (2005) Clin Cancer Res , vol.11 , Issue.23 , pp. 8304-8311
    • Facoetti, A.1    Nano, R.2    Zelini, P.3
  • 34
    • 74549187948 scopus 로고    scopus 로고
    • Glioma-associated cancer-initiating cells induce immunosuppression
    • Wei J, Barr J, Kong LY, et al. Glioma-associated cancer-initiating cells induce immunosuppression. Clin Cancer Res. 2010;16(2): 461-473.
    • (2010) Clin Cancer Res , vol.16 , Issue.2 , pp. 461-473
    • Wei, J.1    Barr, J.2    Kong, L.Y.3
  • 35
    • 78049270536 scopus 로고    scopus 로고
    • Glioma cancer stem cells induce immunosuppressive macrophages/microglia
    • Wu A, Wei J, Kong LY, et al. Glioma cancer stem cells induce immunosuppressive macrophages/microglia. Neuro Oncol. 2010; 12(11):1113-1125.
    • (2010) Neuro Oncol , vol.12 , Issue.11 , pp. 1113-1125
    • Wu, A.1    Wei, J.2    Kong, L.Y.3
  • 36
    • 77955066199 scopus 로고    scopus 로고
    • Sipuleucel-T immunotherapy for castration-resistant prostate cancer
    • Kantoff PW, Higano CS, Shore ND, et al. Sipuleucel-T immunotherapy for castration-resistant prostate cancer. N Engl J Med. 2010;363(5):411-422.
    • (2010) N Engl J Med , vol.363 , Issue.5 , pp. 411-422
    • Kantoff, P.W.1    Higano, C.S.2    Shore, N.D.3
  • 37
    • 84894288412 scopus 로고    scopus 로고
    • Targeting a glioblastoma cancer stem-cell population defined by EGF receptor variant III
    • Emlet DR, Gupta P, Holgado-Madruga M, et al. Targeting a glioblastoma cancer stem-cell population defined by EGF receptor variant III. Cancer Res. 2014;74(4):1238-1249.
    • (2014) Cancer Res , vol.74 , Issue.4 , pp. 1238-1249
    • Emlet, D.R.1    Gupta, P.2    Holgado-Madruga, M.3
  • 38
    • 84937683325 scopus 로고    scopus 로고
    • IT-30: ReACT: A phase II study of rindopepimut vaccine (CDX-110) plus bevacizumab in relapsed glioblastoma
    • November 13-16 Miami, FL
    • Reardon D, Schuster J, Tran D, et al. IT-30: ReACT: A phase II study of rindopepimut vaccine (CDX-110) plus bevacizumab in relapsed glioblastoma. Paper presented at: The 19th Annual Scientific Meeting of the Society for Neuro-Oncology; November 13-16, 2014; Miami, FL.
    • (2014) The 19th Annual Scientific Meeting of the Society for Neuro-Oncology
    • Reardon, D.1    Schuster, J.2    Tran, D.3
  • 39
    • 84934981297 scopus 로고    scopus 로고
    • A phase II, multicenter trial of rindopepimut (CDX-110) in newly diagnosed glioblastoma: The ACT III study
    • Schuster J, Lai RK, Recht LD, et al. A phase II, multicenter trial of rindopepimut (CDX-110) in newly diagnosed glioblastoma: the ACT III study. Neuro Oncol. 2015;17(6):854-861.
    • (2015) Neuro Oncol. , vol.17 , Issue.6 , pp. 854-861
    • Schuster, J.1    Lai, R.K.2    Recht, L.D.3
  • 40
    • 84975204817 scopus 로고    scopus 로고
    • AT-60: A randomized double blind placebo-controlled phase 2 trial of dendritic cell (DC) vaccine ICT-107 following standard treatment in newly diagnosed patients with GBM
    • November 13-16 Miami, FL
    • Wen P, Reardon D, Phuphanich S, et al. AT-60: A randomized double blind placebo-controlled phase 2 trial of dendritic cell (DC) vaccine ICT-107 following standard treatment in newly diagnosed patients with GBM. Paper presented at: The 19th Annual Scientific Meeting of the Society for Neuro-Oncology; November 13-16, 2014; Miami, FL.
    • (2014) The 19th Annual Scientific Meeting of the Society for Neuro-Oncology
    • Wen, P.1    Reardon, D.2    Phuphanich, S.3
  • 41
    • 84925045090 scopus 로고    scopus 로고
    • Tetanus toxoid and CCL3 improve dendritic cell vaccines in mice and glioblastoma patients
    • Mitchell DA, Batich KA, Gunn MD, et al. Tetanus toxoid and CCL3 improve dendritic cell vaccines in mice and glioblastoma patients. Nature. 2015;519(7543):366-369.
    • (2015) Nature , vol.519 , Issue.7543 , pp. 366-369
    • Mitchell, D.A.1    Batich, K.A.2    Gunn, M.D.3
  • 42
    • 84860174226 scopus 로고    scopus 로고
    • The CD47-signal regulatory protein alpha (SIRPa) interaction is a therapeutic target for human solid tumors
    • Willingham SB, Volkmer JP, Gentles AJ, et al. The CD47-signal regulatory protein alpha (SIRPa) interaction is a therapeutic target for human solid tumors. Proc Natl Acad Sci USA. 2012; 109(17):6662-6667.
    • (2012) Proc Natl Acad Sci USA , vol.109 , Issue.17 , pp. 6662-6667
    • Willingham, S.B.1    Volkmer, J.P.2    Gentles, A.J.3
  • 43
    • 77954801079 scopus 로고    scopus 로고
    • Improved survival with ipilimumab in patients with metastatic melanoma
    • Hodi FS, O'Day SJ, McDermott DF, et al. Improved survival with ipilimumab in patients with metastatic melanoma. N Engl J Med. 2010;363(8):711-723.
    • (2010) N Engl J Med , vol.363 , Issue.8 , pp. 711-723
    • Hodi, F.S.1    O'Day, S.J.2    McDermott, D.F.3
  • 44
    • 84879759020 scopus 로고    scopus 로고
    • Safety and tumor responses with lambrolizumab (anti-PD-1) in melanoma
    • Hamid O, Robert C, Daud A, et al. Safety and tumor responses with lambrolizumab (anti-PD-1) in melanoma. N Engl J Med. 2013;369(2):134-144.
    • (2013) N Engl J Med , vol.369 , Issue.2 , pp. 134-144
    • Hamid, O.1    Robert, C.2    Daud, A.3
  • 45
    • 84925222119 scopus 로고    scopus 로고
    • Nivolumab in previously untreated melanoma without BRAF mutation
    • Robert C, Long GV, Brady B, et al. Nivolumab in previously untreated melanoma without BRAF mutation. N Engl J Med. 2015;372(4):320-330.
    • (2015) N Engl J Med , vol.372 , Issue.4 , pp. 320-330
    • Robert, C.1    Long, G.V.2    Brady, B.3
  • 46
    • 84879777241 scopus 로고    scopus 로고
    • Nivolumab plus ipilimumab in advanced melanoma
    • Wolchok JD, Kluger H, Callahan MK, et al. Nivolumab plus ipilimumab in advanced melanoma. N Engl J Med. 2013;369(2):122-133.
    • (2013) N Engl J Med , vol.369 , Issue.2 , pp. 122-133
    • Wolchok, J.D.1    Kluger, H.2    Callahan, M.K.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.