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Volumn 30, Issue 8, 2013, Pages 1009-1018

Interleukin-6 is overexpressed and augments invasiveness of human glioma stem cells in vitro

Author keywords

Glioma; Glioma stem cells; Interleukin 6; Invasiveness; Overexpression

Indexed keywords

INTERLEUKIN 6; MESSENGER RNA;

EID: 84890439524     PISSN: 02620898     EISSN: 15737276     Source Type: Journal    
DOI: 10.1007/s10585-013-9599-0     Document Type: Article
Times cited : (17)

References (36)
  • 2
    • 7644224186 scopus 로고    scopus 로고
    • Adult glioma incidence trends in the United States, 1977-2000
    • 10.1002/cncr.20621 15476282 10.1002/cncr.20621
    • Hess KR, Broglio KR, Bondy ML (2004) Adult glioma incidence trends in the United States, 1977-2000. Cancer 101(10):2293-2299. doi: 10.1002/cncr.20621
    • (2004) Cancer , vol.101 , Issue.10 , pp. 2293-2299
    • Hess, K.R.1    Broglio, K.R.2    Bondy, M.L.3
  • 4
    • 69849099673 scopus 로고    scopus 로고
    • Biology of glioma cancer stem cells
    • 10.1007/s10059-009-0111-2 19655094 10.1007/s10059-009-0111-2 1:CAS:528:DC%2BD1MXhtVCgu7jI
    • Park DM, Rich JN (2009) Biology of glioma cancer stem cells. Mol Cells 28(1):7-12. doi: 10.1007/s10059-009-0111-2
    • (2009) Mol Cells , vol.28 , Issue.1 , pp. 7-12
    • Park, D.M.1    Rich, J.N.2
  • 5
    • 33847052535 scopus 로고    scopus 로고
    • Mechanisms of malignant glioma immune resistance and sources of immunosuppression
    • Gomez GG, Kruse CA (2006) Mechanisms of malignant glioma immune resistance and sources of immunosuppression. Gene therapy & molecular biology 10 (A):133-146
    • (2006) Gene Therapy & Molecular Biology , vol.10 A , pp. 133-146
    • Gomez, G.G.1    Kruse, C.A.2
  • 6
    • 77951735629 scopus 로고    scopus 로고
    • IL-6 augments the invasiveness of U87MG human glioblastoma multiforme cells via up-regulation of MMP-2 and fascin-1
    • 10.3892/or-00000795 20428809 1:CAS:528:DC%2BC3cXmvFyqsbY%3D
    • Li R, Li G, Deng L, Liu Q, Dai J, Shen J, Zhang J (2010) IL-6 augments the invasiveness of U87MG human glioblastoma multiforme cells via up-regulation of MMP-2 and fascin-1. Oncol Rep 23(6):1553-1559. doi: 10.3892/or-00000795
    • (2010) Oncol Rep , vol.23 , Issue.6 , pp. 1553-1559
    • Li, R.1    Li, G.2    Deng, L.3    Liu, Q.4    Dai, J.5    Shen, J.6    Zhang, J.7
  • 7
    • 79952189567 scopus 로고    scopus 로고
    • IL-6 promotion of glioblastoma cell invasion and angiogenesis in U251 and T98G cell lines
    • 10.1007/s11060-010-0158-0 20361349 10.1007/s11060-010-0158-0 1:CAS:528:DC%2BC3cXhsVCjsL%2FJ
    • Liu Q, Li G, Li R, Shen J, He Q, Deng L, Zhang C, Zhang J (2010) IL-6 promotion of glioblastoma cell invasion and angiogenesis in U251 and T98G cell lines. J Neurooncol 100(2):165-176. doi: 10.1007/s11060-010-0158-0
    • (2010) J Neurooncol , vol.100 , Issue.2 , pp. 165-176
    • Liu, Q.1    Li, G.2    Li, R.3    Shen, J.4    He, Q.5    Deng, L.6    Zhang, C.7    Zhang, J.8
  • 9
    • 4944250781 scopus 로고    scopus 로고
    • Isolation and characterization of tumorigenic, stem-like neural precursors from human glioblastoma
    • 10.1158/0008-5472.can-04-1364 15466194 10.1158/0008-5472.CAN-04-1364 1:CAS:528:DC%2BD2cXotFalsLs%3D
    • Galli R, Binda E, Orfanelli U, Cipelletti B, Gritti A, De Vitis S, Fiocco R, Foroni C, Dimeco F, Vescovi A (2004) Isolation and characterization of tumorigenic, stem-like neural precursors from human glioblastoma. Cancer Res 64(19):7011-7021. doi: 10.1158/0008-5472.can-04-1364
    • (2004) Cancer Res , vol.64 , Issue.19 , pp. 7011-7021
    • Galli, R.1    Binda, E.2    Orfanelli, U.3    Cipelletti, B.4    Gritti, A.5    De Vitis, S.6    Fiocco, R.7    Foroni, C.8    Dimeco, F.9    Vescovi, A.10
  • 10
    • 11244293572 scopus 로고    scopus 로고
    • Isolation of cancer stem cells from adult glioblastoma multiforme
    • 10.1038/sj.onc.1208311 15558011 10.1038/sj.onc.1208311 1:CAS:528:DC%2BD2cXhtVOnu73O
    • Yuan X, Curtin J, Xiong Y, Liu G, Waschsmann-Hogiu S, Farkas DL, Black KL, Yu JS (2004) Isolation of cancer stem cells from adult glioblastoma multiforme. Oncogene 23(58):9392-9400. doi: 10.1038/sj.onc.1208311
    • (2004) Oncogene , vol.23 , Issue.58 , pp. 9392-9400
    • Yuan, X.1    Curtin, J.2    Xiong, Y.3    Liu, G.4    Waschsmann-Hogiu, S.5    Farkas, D.L.6    Black, K.L.7    Yu, J.S.8
  • 11
    • 55649085987 scopus 로고    scopus 로고
    • Brain tumor stem cells as research and treatment targets
    • 10.1007/s10014-008-0237-5 18987831 10.1007/s10014-008-0237-5
    • Hide T, Takezaki T, Nakamura H, Kuratsu J, Kondo T (2008) Brain tumor stem cells as research and treatment targets. Brain Tumor Pathol 25(2):67-72. doi: 10.1007/s10014-008-0237-5
    • (2008) Brain Tumor Pathol , vol.25 , Issue.2 , pp. 67-72
    • Hide, T.1    Takezaki, T.2    Nakamura, H.3    Kuratsu, J.4    Kondo, T.5
  • 12
    • 68349116898 scopus 로고    scopus 로고
    • Cancer stem cells in brain tumor biology
    • 10.1101/sqb.2008.73.060 19329578 10.1101/sqb.2008.73.060 1:CAS:528:DC%2BD1MXos1erur8%3D
    • Rich JN, Eyler CE (2008) Cancer stem cells in brain tumor biology. Cold Spring Harb Symp Quant Biol 73:411-420. doi: 10.1101/sqb.2008.73.060
    • (2008) Cold Spring Harb Symp Quant Biol , vol.73 , pp. 411-420
    • Rich, J.N.1    Eyler, C.E.2
  • 14
    • 17844396959 scopus 로고    scopus 로고
    • Interleukin-6 induces transcriptional activation of vascular endothelial growth factor (VEGF) in astrocytes in vivo and regulates VEGF promoter activity in glioblastoma cells via direct interaction between STAT3 and Sp1
    • 10.1002/ijc.20871 15688401 10.1002/ijc.20871 1:CAS:528: DC%2BD2MXjvFWjs78%3D
    • Loeffler S, Fayard B, Weis J, Weissenberger J (2005) Interleukin-6 induces transcriptional activation of vascular endothelial growth factor (VEGF) in astrocytes in vivo and regulates VEGF promoter activity in glioblastoma cells via direct interaction between STAT3 and Sp1. Int J Cancer 115(2):202-213. doi: 10.1002/ijc.20871
    • (2005) Int J Cancer , vol.115 , Issue.2 , pp. 202-213
    • Loeffler, S.1    Fayard, B.2    Weis, J.3    Weissenberger, J.4
  • 15
    • 0036935383 scopus 로고    scopus 로고
    • Cytokine and cytokine receptor mRNA expression in human glioblastomas: Evidence of Th1, Th2 and Th3 cytokine dysregulation
    • 10.1007/s004010100448 11810184 10.1007/s004010100448 1:CAS:528: DC%2BD38XjsFGgsA%3D%3D
    • Hao C, Parney IF, Roa WH, Turner J, Petruk KC, Ramsay DA (2002) Cytokine and cytokine receptor mRNA expression in human glioblastomas: evidence of Th1, Th2 and Th3 cytokine dysregulation. Acta Neuropathol 103(2):171-178. doi: 10.1007/s004010100448
    • (2002) Acta Neuropathol , vol.103 , Issue.2 , pp. 171-178
    • Hao, C.1    Parney, I.F.2    Roa, W.H.3    Turner, J.4    Petruk, K.C.5    Ramsay, D.A.6
  • 16
    • 0034018970 scopus 로고    scopus 로고
    • Human glioma immunobiology in vitro: Implications for immunogene therapy
    • discussion 1177-1168. doi: 10.1097/00006123-200005000-00030
    • Parney IF, Farr-Jones MA, Chang LJ, Petruk KC (2000) Human glioma immunobiology in vitro: implications for immunogene therapy. Neurosurgery 46 (5):1169-1177; discussion 1177-1168. doi: 10.1097/00006123-200005000-00030
    • (2000) Neurosurgery , vol.46 , Issue.5 , pp. 1169-1177
    • Parney, I.F.1    Ma, F.2    Chang, L.J.3    Petruk, K.C.4
  • 17
    • 79960790320 scopus 로고    scopus 로고
    • IL-10 and TGF-beta2 are overexpressed in tumor spheres cultured from human gliomas
    • 10.1007/s11033-010-0469-4 21088899 10.1007/s11033-010-0469-4 1:CAS:528:DC%2BC3MXlsVGisbo%3D
    • Qiu B, Zhang D, Wang C, Tao J, Tie X, Qiao Y, Xu K, Wang Y, Wu A (2011) IL-10 and TGF-beta2 are overexpressed in tumor spheres cultured from human gliomas. Mol Biol Rep 38(5):3585-3591. doi: 10.1007/s11033-010-0469-4
    • (2011) Mol Biol Rep , vol.38 , Issue.5 , pp. 3585-3591
    • Qiu, B.1    Zhang, D.2    Wang, C.3    Tao, J.4    Tie, X.5    Qiao, Y.6    Xu, K.7    Wang, Y.8    Wu, A.9
  • 18
    • 84855193284 scopus 로고    scopus 로고
    • Human brain glioma stem cells are more invasive than their differentiated progeny cells in vitro
    • 10.1016/j.jocn.2011.06.014 22153826 10.1016/j.jocn.2011.06.014
    • Qiu B, Zhang D, Tao J, Tie X, Wu A, Wang Y (2012) Human brain glioma stem cells are more invasive than their differentiated progeny cells in vitro. J Clin Neurosci 19(1):130-134. doi: 10.1016/j.jocn.2011.06.014
    • (2012) J Clin Neurosci , vol.19 , Issue.1 , pp. 130-134
    • Qiu, B.1    Zhang, D.2    Tao, J.3    Tie, X.4    Wu, A.5    Wang, Y.6
  • 21
    • 78650126756 scopus 로고    scopus 로고
    • Brain tumor stem cells maintain overall phenotype and tumorigenicity after in vitro culturing in serum-free conditions
    • 10.1093/neuonc/noq102 20843775
    • Vik-Mo EO, Sandberg C, Olstorn H, Varghese M, Brandal P, Ramm-Pettersen J, Murrell W, Langmoen IA (2010) Brain tumor stem cells maintain overall phenotype and tumorigenicity after in vitro culturing in serum-free conditions. Neuro Oncol 12(12):1220-1230. doi: 10.1093/neuonc/noq102
    • (2010) Neuro Oncol , vol.12 , Issue.12 , pp. 1220-1230
    • Vik-Mo, E.O.1    Sandberg, C.2    Olstorn, H.3    Varghese, M.4    Brandal, P.5    Ramm-Pettersen, J.6    Murrell, W.7    Langmoen, I.A.8
  • 22
    • 67650087998 scopus 로고    scopus 로고
    • Combined targeting of interleukin-6 and vascular endothelial growth factor potently inhibits glioma growth and invasiveness
    • 10.1002/ijc.24380 19431143 10.1002/ijc.24380 1:CAS:528: DC%2BD1MXovVersrY%3D
    • Saidi A, Hagedorn M, Allain N, Verpelli C, Sala C, Bello L, Bikfalvi A, Javerzat S (2009) Combined targeting of interleukin-6 and vascular endothelial growth factor potently inhibits glioma growth and invasiveness. Int J Cancer 125(5):1054-1064. doi: 10.1002/ijc.24380
    • (2009) Int J Cancer , vol.125 , Issue.5 , pp. 1054-1064
    • Saidi, A.1    Hagedorn, M.2    Allain, N.3    Verpelli, C.4    Sala, C.5    Bello, L.6    Bikfalvi, A.7    Javerzat, S.8
  • 23
    • 35648995976 scopus 로고    scopus 로고
    • Interleukin-6 and its receptor in cancer: Implications for translational therapeutics
    • 10.1002/cncr.22999 17849470 10.1002/cncr.22999 1:CAS:528: DC%2BD2sXhtlertbrN
    • Hong DS, Angelo LS, Kurzrock R (2007) Interleukin-6 and its receptor in cancer: implications for translational therapeutics. Cancer 110(9):1911-1928. doi: 10.1002/cncr.22999
    • (2007) Cancer , vol.110 , Issue.9 , pp. 1911-1928
    • Hong, D.S.1    Angelo, L.S.2    Kurzrock, R.3
  • 24
    • 0025027767 scopus 로고
    • Human glioblastoma cells release interleukin six in vivo and in vitro
    • 2208133
    • Van Meir E, Sawamura Y, Diserens AC, Hamou MF, de Tribolet N (1990) Human glioblastoma cells release interleukin six in vivo and in vitro. Cancer Res 50(20):6683-6688
    • (1990) Cancer Res , vol.50 , Issue.20 , pp. 6683-6688
    • Van Meir, E.1    Sawamura, Y.2    Diserens, A.C.3    Hamou, M.F.4    De Tribolet, N.5
  • 25
    • 2442657786 scopus 로고    scopus 로고
    • IL-6 is required for glioma development in a mouse model
    • 10.1038/sj.onc.1207455 15064729 10.1038/sj.onc.1207455 1:CAS:528:DC%2BD2cXjtlChu7s%3D
    • Weissenberger J, Loeffler S, Kappeler A, Kopf M, Lukes A, Afanasieva TA, Aguzzi A, Weis J (2004) IL-6 is required for glioma development in a mouse model. Oncogene 23(19):3308-3316. doi: 10.1038/sj.onc.1207455
    • (2004) Oncogene , vol.23 , Issue.19 , pp. 3308-3316
    • Weissenberger, J.1    Loeffler, S.2    Kappeler, A.3    Kopf, M.4    Lukes, A.5    Afanasieva, T.A.6    Aguzzi, A.7    Weis, J.8
  • 26
    • 33846804009 scopus 로고    scopus 로고
    • Interleukin-6 gene amplification and shortened survival in glioblastoma patients
    • 10.1038/sj.bjc.6603586 17224923 10.1038/sj.bjc.6603586 1:CAS:528:DC%2BD2sXhtlKjt7g%3D
    • Tchirkov A, Khalil T, Chautard E, Mokhtari K, Veronese L, Irthum B, Vago P, Kemeny JL, Verrelle P (2007) Interleukin-6 gene amplification and shortened survival in glioblastoma patients. Br J Cancer 96(3):474-476. doi: 10.1038/sj.bjc.6603586
    • (2007) Br J Cancer , vol.96 , Issue.3 , pp. 474-476
    • Tchirkov, A.1    Khalil, T.2    Chautard, E.3    Mokhtari, K.4    Veronese, L.5    Irthum, B.6    Vago, P.7    Kemeny, J.L.8    Verrelle, P.9
  • 27
    • 0035902847 scopus 로고    scopus 로고
    • IL-6 gene amplification and expression in human glioblastomas
    • 10.1054/bjoc.2001.1942 11506489 10.1054/bjoc.2001.1942 1:CAS:528:DC%2BD3MXmvFKksr0%3D
    • Tchirkov A, Rolhion C, Bertrand S, Dore JF, Dubost JJ, Verrelle P (2001) IL-6 gene amplification and expression in human glioblastomas. Br J Cancer 85(4):518-522. doi: 10.1054/bjoc.2001.1942
    • (2001) Br J Cancer , vol.85 , Issue.4 , pp. 518-522
    • Tchirkov, A.1    Rolhion, C.2    Bertrand, S.3    Dore, J.F.4    Dubost, J.J.5    Verrelle, P.6
  • 29
    • 0142250392 scopus 로고    scopus 로고
    • Targeted anti-interleukin-6 monoclonal antibody therapy for cancer: A review of the rationale and clinical evidence
    • 14581334 1:CAS:528:DC%2BD3sXosVGjsrw%3D
    • Trikha M, Corringham R, Klein B, Rossi JF (2003) Targeted anti-interleukin-6 monoclonal antibody therapy for cancer: a review of the rationale and clinical evidence. Clin Cancer Res 9(13):4653-4665
    • (2003) Clin Cancer Res , vol.9 , Issue.13 , pp. 4653-4665
    • Trikha, M.1    Corringham, R.2    Klein, B.3    Rossi, J.F.4
  • 30
    • 0036207460 scopus 로고    scopus 로고
    • Interleukin-6-producing cells in a human glioblastoma cell line are not affected by ionizing radiation
    • 10.1023/A:1014467804488 11949824 10.1023/A:1014467804488
    • Dubost JJ, Rolhion C, Tchirkov A, Bertrand S, Chassagne J, Dosgilbert A, Verrelle P (2002) Interleukin-6-producing cells in a human glioblastoma cell line are not affected by ionizing radiation. J Neurooncol 56(1):29-34. doi: 10.1023/A:1014467804488
    • (2002) J Neurooncol , vol.56 , Issue.1 , pp. 29-34
    • Dubost, J.J.1    Rolhion, C.2    Tchirkov, A.3    Bertrand, S.4    Chassagne, J.5    Dosgilbert, A.6    Verrelle, P.7
  • 31
    • 34948892058 scopus 로고    scopus 로고
    • Diffuse glioma growth: A guerilla war
    • 10.1007/s00401-007-0293-7 17805551 10.1007/s00401-007-0293-7
    • Claes A, Idema AJ, Wesseling P (2007) Diffuse glioma growth: a guerilla war. Acta Neuropathol 114(5):443-458. doi: 10.1007/s00401-007-0293-7
    • (2007) Acta Neuropathol , vol.114 , Issue.5 , pp. 443-458
    • Claes, A.1    Idema, A.J.2    Wesseling, P.3
  • 32
    • 36048994736 scopus 로고    scopus 로고
    • Autocrine factors that sustain glioma invasion and paracrine biology in the brain microenvironment
    • 10.1093/jnci/djm187 17971532 10.1093/jnci/djm187 1:CAS:528: DC%2BD2sXhsVKjsrzO
    • Hoelzinger DB, Demuth T, Berens ME (2007) Autocrine factors that sustain glioma invasion and paracrine biology in the brain microenvironment. J Natl Cancer Inst 99(21):1583-1593. doi: 10.1093/jnci/djm187
    • (2007) J Natl Cancer Inst , vol.99 , Issue.21 , pp. 1583-1593
    • Hoelzinger, D.B.1    Demuth, T.2    Berens, M.E.3
  • 33
    • 33750339604 scopus 로고    scopus 로고
    • Cancer stem cells and metastasis: Lethal seeds
    • 10.1158/1078-0432.CCR-06-1537 17020960 10.1158/1078-0432.CCR-06-1537
    • Wicha MS (2006) Cancer stem cells and metastasis: lethal seeds. Clin Cancer Res 12(19):5606-5607. doi: 10.1158/1078-0432.CCR-06-1537
    • (2006) Clin Cancer Res , vol.12 , Issue.19 , pp. 5606-5607
    • Wicha, M.S.1
  • 34
    • 2942700004 scopus 로고    scopus 로고
    • Getting at the root and stem of brain tumors
    • 10.1016/j.neuron.2004.06.011 15207233 10.1016/j.neuron.2004.06.011 1:CAS:528:DC%2BD2cXlsleju70%3D
    • Oliver TG, Wechsler-Reya RJ (2004) Getting at the root and stem of brain tumors. Neuron 42(6):885-888. doi: 10.1016/j.neuron.2004.06.011
    • (2004) Neuron , vol.42 , Issue.6 , pp. 885-888
    • Oliver, T.G.1    Wechsler-Reya, R.J.2
  • 35
    • 77953215319 scopus 로고    scopus 로고
    • Invasive glioblastoma cells acquire stemness and increased Akt activation
    • 10.1593/Neo.10126 20563248 1:CAS:528:DC%2BC3cXntFWjtb8%3D
    • Molina JR, Hayashi Y, Stephens C, Georgescu MM (2010) Invasive glioblastoma cells acquire stemness and increased Akt activation. Neoplasia 12(6):453-463. doi: 10.1593/Neo.10126
    • (2010) Neoplasia , vol.12 , Issue.6 , pp. 453-463
    • Molina, J.R.1    Hayashi, Y.2    Stephens, C.3    Georgescu, M.M.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.