Endothelial cells create a stem cell niche in glioblastoma by providing NOTCH ligands that nurture self-renewal of cancer stem-like cells

Cancer Research

Volumn 71, Issue 18, 2011, Pages 6061-6072

  Zhu, Thant S ^a   Costello, Mark A ^a   Talsma, Caroline E ^a   Flack, Callie G ^a   Crowley, Jessica G ^a   Hamm, Lisa L ^a   He, Xiaobing ^a   Hervey Jumper, Shawn L ^a   Heth, Jason A ^a   Muraszko, Karin M ^a   DiMeco, Francesco ^b,c   Vescovi, Angelo L ^d   Fan, Xing ^a  

^a UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

^b JOHNS HOPKINS UNIVERSITY   (United States)

^c DEPARTMENT OF NEUROSURGERY   (Italy)

^d UNIVERSITY OF MILANO BICOCCA   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

BIOLOGICAL MARKER; CD133 ANTIGEN; DLL1 PROTEIN; DLL4 PROTEIN; GLIAL FIBRILLARY ACIDIC PROTEIN; JAG2 PROTEIN; JAGGED1; KI 67 ANTIGEN; LIGAND; NESTIN; NOTCH RECEPTOR; NOTCH1 RECEPTOR; TUJ1 PROTEIN; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CANCER STEM LIKE CELL; CELL DIFFERENTIATION; CELL RENEWAL; COCULTURE; CONTROLLED STUDY; ENDOTHELIUM CELL; GENE SILENCING; GLIOBLASTOMA; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; INTRACELLULAR SIGNALING; MOUSE; NONHUMAN; PRIMARY TUMOR; PRIORITY JOURNAL; PROTEIN EXPRESSION; RNA INTERFERENCE; STEM CELL; TUMOR CELL; TUMOR GROWTH;

ANIMALS; ANTIGENS, CD; BRAIN NEOPLASMS; CALCIUM-BINDING PROTEINS; CELL GROWTH PROCESSES; ENDOTHELIAL CELLS; GENE KNOCKDOWN TECHNIQUES; GLIOBLASTOMA; GLYCOPROTEINS; HUMANS; INTERCELLULAR SIGNALING PEPTIDES AND PROTEINS; INTERMEDIATE FILAMENT PROTEINS; MEMBRANE PROTEINS; MICE; NEOPLASTIC STEM CELLS; NERVE TISSUE PROTEINS; PEPTIDES; RECEPTORS, NOTCH; RNA, SMALL INTERFERING; STEM CELL NICHE; XENOGRAFT MODEL ANTITUMOR ASSAYS;

EID: 80052795862     PISSN: 00085472     EISSN: 15387445     Source Type: Journal    
DOI: 10.1158/0008-5472.CAN-10-4269     Document Type: Article

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