-
1
-
-
0035958277
-
Identification of a new fibroblast growth factor receptor FGFR5
-
Sleeman, M., et al. Identification of a new fibroblast growth factor receptor, FGFR5. Gene 271, 171-182 (2001).
-
(2001)
Gene
, vol.271
, pp. 171-182
-
-
Sleeman, M.1
-
2
-
-
79251501315
-
Fibroblast growth factors: From molecular evolution to roles in development, metabolism and disease
-
Itoh, N., Ornitz, D. M. Fibroblast growth factors: From molecular evolution to roles in development, metabolism and disease. J. Biochem. 149, 121-130 (2011).
-
(2011)
J. Biochem.
, vol.149
, pp. 121-130
-
-
Itoh, N.1
Ornitz, D.M.2
-
3
-
-
84896691579
-
Genomic aberrations in the FGFR pathway: Opportunities for targeted therapies in solid tumors
-
Dienstmann, R., et al. Genomic aberrations in the FGFR pathway: Opportunities for targeted therapies in solid tumors. Ann. Oncol. 25, 552-563 (2014).
-
(2014)
Ann. Oncol.
, vol.25
, pp. 552-563
-
-
Dienstmann, R.1
-
4
-
-
84876048479
-
Fibroblast growth factor receptor inhibitors as a cancer treatment: From a biologic rationale to medical perspectives
-
Dieci, M. V., Arnedos, M., Andre, F., Soria, J. C. Fibroblast growth factor receptor inhibitors as a cancer treatment: From a biologic rationale to medical perspectives. Cancer Discov. 3, 264-279 (2013).
-
(2013)
Cancer Discov.
, vol.3
, pp. 264-279
-
-
Dieci, M.V.1
Arnedos, M.2
Andre, F.3
Soria, J.C.4
-
5
-
-
84944924581
-
Phase II multicenter proof of concept study of AZD4547 in FGFR amplified tumours
-
abstr 2508
-
Smyth, E. C., et al. Phase II multicenter proof of concept study of AZD4547 in FGFR amplified tumours. J. Clin. Oncol. 33 (Suppl.), abstr. 2508 (2015).
-
(2015)
J. Clin. Oncol.
, vol.33
-
-
Smyth, E.C.1
-
6
-
-
84945186800
-
Phase I dose-escalation study of JNJ-42756493, an oral pan-fibroblast growth factor receptor inhibitor, in patients with advanced solid tumors
-
Tabernero, J., et al. Phase I dose-escalation study of JNJ-42756493, an oral pan-fibroblast growth factor receptor inhibitor, in patients with advanced solid tumors. J. Clin. Oncol. 33, 3401-3408 (2015).
-
(2015)
J. Clin. Oncol.
, vol.33
, pp. 3401-3408
-
-
Tabernero, J.1
-
7
-
-
84879859652
-
Targeting FGFR with dovitinib (TKI258): Preclinical and clinical data in breast cancer
-
Andre, F., et al. Targeting FGFR with dovitinib (TKI258): Preclinical and clinical data in breast cancer. Clin. Cancer Res. 19, 3693-3702 (2013).
-
(2013)
Clin. Cancer Res.
, vol.19
, pp. 3693-3702
-
-
Andre, F.1
-
8
-
-
84930255300
-
Second-line dovitinib (TKI258) in patients with FGFR2-mutated or FGFR2-non-mutated advanced or metastatic endometrial cancer: A non-randomised, open-label, two-group, two-stage, phase 2 study
-
Konecny, G. E., et al. Second-line dovitinib (TKI258) in patients with FGFR2-mutated or FGFR2-non-mutated advanced or metastatic endometrial cancer: A non-randomised, open-label, two-group, two-stage, phase 2 study. Lancet Oncol. 16, 686-694 (2015).
-
(2015)
Lancet Oncol.
, vol.16
, pp. 686-694
-
-
Konecny, G.E.1
-
9
-
-
84904892476
-
Prognostic value of FGFR1 gene copy number in patients with non-small cell lung cancer: A meta-analysis
-
Yang, W., et al. Prognostic value of FGFR1 gene copy number in patients with non-small cell lung cancer: A meta-analysis. J. Thorac. Dis. 6, 803-809 (2014).
-
(2014)
J. Thorac. Dis.
, vol.6
, pp. 803-809
-
-
Yang, W.1
-
10
-
-
78650451788
-
Frequent and focal FGFR1 amplification associates with therapeutically tractable FGFR1 dependency in squamous cell lung cancer
-
Weiss, J., et al. Frequent and focal FGFR1 amplification associates with therapeutically tractable FGFR1 dependency in squamous cell lung cancer. Sci. Transl Med. 2, 62ra93 (2010).
-
(2010)
Sci. Transl Med.
, vol.2
, pp. 62-93
-
-
Weiss, J.1
-
11
-
-
84866851740
-
Integrative genome analyses identify key somatic driver mutations of small-cell lung cancer
-
Peifer, M., et al. Integrative genome analyses identify key somatic driver mutations of small-cell lung cancer. Nat. Genet. 44, 1104-1110 (2012).
-
(2012)
Nat. Genet.
, vol.44
, pp. 1104-1110
-
-
Peifer, M.1
-
12
-
-
84902548159
-
Prognostic role of FGFR1 amplification in early-stage non-small cell lung cancer
-
Cihoric, N., et al. Prognostic role of FGFR1 amplification in early-stage non-small cell lung cancer. Br. J. Cancer 110, 2914-2922 (2014).
-
(2014)
Br. J. Cancer
, vol.110
, pp. 2914-2922
-
-
Cihoric, N.1
-
13
-
-
33845331706
-
FGFR1 emerges as a potential therapeutic target for lobular breast carcinomas
-
Reis-Filho, J. S., et al. FGFR1 emerges as a potential therapeutic target for lobular breast carcinomas. Clin. Cancer Res. 12, 6652-6662 (2006).
-
(2006)
Clin. Cancer Res.
, vol.12
, pp. 6652-6662
-
-
Reis-Filho, J.S.1
-
14
-
-
0030845817
-
Mapping of DNA amplifications at 15 chromosomal localizations in 1875 breast tumors: Definition of phenotypic groups
-
Courjal, F., et al. Mapping of DNA amplifications at 15 chromosomal localizations in 1875 breast tumors: Definition of phenotypic groups. Cancer Res. 57, 4360-4367 (1997).
-
(1997)
Cancer Res.
, vol.57
, pp. 4360-4367
-
-
Courjal, F.1
-
15
-
-
84898845401
-
Low prognostic implication of fibroblast growth factor family activation in triple-negative breast cancer subsets
-
Lee, H. J., et al. Low prognostic implication of fibroblast growth factor family activation in triple-negative breast cancer subsets. Ann. Surg. Oncol. 21, 1561-1568 (2014).
-
(2014)
Ann. Surg. Oncol.
, vol.21
, pp. 1561-1568
-
-
Lee, H.J.1
-
16
-
-
84945556079
-
Kinome RNAi screens reveal synergistic targeting of MTOR and FGFR1 pathways for treatment of lung cancer and HNSCC
-
Singleton, K. R., et al. Kinome RNAi screens reveal synergistic targeting of MTOR and FGFR1 pathways for treatment of lung cancer and HNSCC. Cancer Res. 75, 4398-4406 (2015).
-
(2015)
Cancer Res.
, vol.75
, pp. 4398-4406
-
-
Singleton, K.R.1
-
17
-
-
77950278598
-
FGFR1 amplification drives endocrine therapy resistance and is a therapeutic target in breast cancer
-
Turner, N., et al. FGFR1 amplification drives endocrine therapy resistance and is a therapeutic target in breast cancer. Cancer Res. 70, 2085-2094 (2010).
-
(2010)
Cancer Res.
, vol.70
, pp. 2085-2094
-
-
Turner, N.1
-
18
-
-
0032531929
-
Crystal structure of an angiogenesis inhibitor bound to the FGF receptor tyrosine kinase domain
-
Mohammadi, M., et al. Crystal structure of an angiogenesis inhibitor bound to the FGF receptor tyrosine kinase domain. EMBO J. 17, 5896-5904 (1998).
-
(1998)
EMBO J.
, vol.17
, pp. 5896-5904
-
-
Mohammadi, M.1
-
19
-
-
47249122523
-
Drug-sensitive FGFR2 mutations in endometrial carcinoma
-
Dutt, A., et al. Drug-sensitive FGFR2 mutations in endometrial carcinoma. Proc. Natl Acad. Sci. USA 105, 8713-8717 (2008).
-
(2008)
Proc. Natl Acad. Sci. USA
, vol.105
, pp. 8713-8717
-
-
Dutt, A.1
-
20
-
-
84960407495
-
Large-scale profiling of kinase dependencies in cancer cell lines
-
Campbell, J., et al. Large-scale profiling of kinase dependencies in cancer cell lines. Cell Rep. 14, 2490-2501 (2016).
-
(2016)
Cell Rep.
, vol.14
, pp. 2490-2501
-
-
Campbell, J.1
-
21
-
-
84871491773
-
FGFR genetic alterations predict for sensitivity to NVP-BGJ398, a selective pan-FGFR inhibitor
-
Guagnano, V., et al. FGFR genetic alterations predict for sensitivity to NVP-BGJ398, a selective pan-FGFR inhibitor. Cancer Discov. 2, 1118-1133 (2012).
-
(2012)
Cancer Discov.
, vol.2
, pp. 1118-1133
-
-
Guagnano, V.1
-
22
-
-
84856829698
-
FGFR2 gene amplification and clinicopathological features in gastric cancer
-
Matsumoto, K., et al. FGFR2 gene amplification and clinicopathological features in gastric cancer. Br. J. Cancer 106, 727-732 (2012).
-
(2012)
Br. J. Cancer
, vol.106
, pp. 727-732
-
-
Matsumoto, K.1
-
23
-
-
77950866696
-
Integrative molecular profiling of triple negative breast cancers identifies amplicon drivers and potential therapeutic targets
-
Turner, N., et al. Integrative molecular profiling of triple negative breast cancers identifies amplicon drivers and potential therapeutic targets. Oncogene 29, 2013-2023 (2010).
-
(2010)
Oncogene
, vol.29
, pp. 2013-2023
-
-
Turner, N.1
-
24
-
-
0033572418
-
Deletion of the carboxyl-terminal exons of K-sam/FGFR2 by short homology-mediated recombination, generating preferential expression of specific messenger RNAs
-
Ueda, T., et al. Deletion of the carboxyl-terminal exons of K-sam/FGFR2 by short homology-mediated recombination, generating preferential expression of specific messenger RNAs. Cancer Res. 59, 6080-6086 (1999).
-
(1999)
Cancer Res.
, vol.59
, pp. 6080-6086
-
-
Ueda, T.1
-
25
-
-
84982958036
-
High-level clonal FGFR amplification and response to FGFR inhibition in a translational clinical trial
-
Pearson, A., et al. High-level clonal FGFR amplification and response to FGFR inhibition in a translational clinical trial. Cancer Discov. 6, 838-851 (2016).
-
(2016)
Cancer Discov.
, vol.6
, pp. 838-851
-
-
Pearson, A.1
-
26
-
-
84959121178
-
In vitro and in vivo evaluation of the radiosensitizing effect of a selective FGFR inhibitor (JNJ-42756493) for rectal cancer
-
Verstraete, M., et al. In vitro and in vivo evaluation of the radiosensitizing effect of a selective FGFR inhibitor (JNJ-42756493) for rectal cancer. BMC Cancer 15, 946 (2015).
-
(2015)
BMC Cancer
, vol.15
, pp. 946
-
-
Verstraete, M.1
-
27
-
-
84902110153
-
High expression of ZNF703 independent of amplification indicates worse prognosis in patients with luminal B breast cancer
-
Reynisdottir, I., et al. High expression of ZNF703 independent of amplification indicates worse prognosis in patients with luminal B breast cancer. Cancer Med. 2, 437-446 (2013).
-
(2013)
Cancer Med.
, vol.2
, pp. 437-446
-
-
Reynisdottir, I.1
-
28
-
-
84923689907
-
Amplification of chromosome 8 genes in lung cancer
-
Baykara, O., Bakir, B., Buyru, N., Kaynak, K., Dalay, N. Amplification of chromosome 8 genes in lung cancer. J. Cancer 6, 270-275 (2015).
-
(2015)
J. Cancer
, vol.6
, pp. 270-275
-
-
Baykara, O.1
Bakir, B.2
Buyru, N.3
Kaynak, K.4
Dalay, N.5
-
29
-
-
84883159846
-
Luminal breast cancer cell lines overexpressing ZNF703 are resistant to tamoxifen through activation of Akt/mTOR signaling
-
Zhang, X., et al. Luminal breast cancer cell lines overexpressing ZNF703 are resistant to tamoxifen through activation of Akt/mTOR signaling. PLoS ONE 8, e72053 (2013).
-
(2013)
PLoS ONE
, vol.8
, pp. e72053
-
-
Zhang, X.1
-
30
-
-
84924633293
-
Fibroblast growth factor receptor (FGFR) gene amplifications are rare events in bladder cancer
-
Fischbach, A., et al. Fibroblast growth factor receptor (FGFR) gene amplifications are rare events in bladder cancer. Histopathology 66, 639-649 (2015).
-
(2015)
Histopathology
, vol.66
, pp. 639-649
-
-
Fischbach, A.1
-
31
-
-
34548407864
-
FGFR3 protein expression and its relationship to mutation status and prognostic variables in bladder cancer
-
Tomlinson, D. C., Baldo, O., Harnden, P., Knowles, M. A. FGFR3 protein expression and its relationship to mutation status and prognostic variables in bladder cancer. J. Pathol. 213, 91-98 (2007).
-
(2007)
J. Pathol.
, vol.213
, pp. 91-98
-
-
Tomlinson, D.C.1
Baldo, O.2
Harnden, P.3
Knowles, M.A.4
-
32
-
-
84954469968
-
The FGFR landscape in cancer: Analysis of 4, 853 tumors by next-generation sequencing
-
Helsten, T., et al. The FGFR landscape in cancer: Analysis of 4, 853 tumors by next-generation sequencing. Clin. Cancer Res. 22, 259-267 (2015).
-
(2015)
Clin. Cancer Res.
, vol.22
, pp. 259-267
-
-
Helsten, T.1
-
33
-
-
33947101019
-
Patterns of somatic mutation in human cancer genomes
-
Greenman, C., et al. Patterns of somatic mutation in human cancer genomes. Nature 446, 153-158 (2007).
-
(2007)
Nature
, vol.446
, pp. 153-158
-
-
Greenman, C.1
-
34
-
-
84875740314
-
Integrative analysis of complex cancer genomics and clinical profiles using the cBioPortal
-
Gao, J., et al. Integrative analysis of complex cancer genomics and clinical profiles using the cBioPortal. Sci. Signal. 6, pl1 (2013).
-
(2013)
Sci. Signal.
, vol.6
, pp. pl1
-
-
Gao, J.1
-
35
-
-
5444250989
-
Biochemical analysis of pathogenic ligand-dependent FGFR2 mutations suggests distinct pathophysiological mechanisms for craniofacial and limb abnormalities
-
Ibrahimi, O. A., et al. Biochemical analysis of pathogenic ligand-dependent FGFR2 mutations suggests distinct pathophysiological mechanisms for craniofacial and limb abnormalities. Hum. Mol. Genet. 13, 2313-2324 (2004).
-
(2004)
Hum. Mol. Genet.
, vol.13
, pp. 2313-2324
-
-
Ibrahimi, O.A.1
-
36
-
-
0035912715
-
Structural basis for fibroblast growth factor receptor 2 activation in Apert syndrome
-
Ibrahimi, O. A., et al. Structural basis for fibroblast growth factor receptor 2 activation in Apert syndrome. Proc. Natl Acad. Sci. USA 98, 7182-7187 (2001).
-
(2001)
Proc. Natl Acad. Sci. USA
, vol.98
, pp. 7182-7187
-
-
Ibrahimi, O.A.1
-
37
-
-
0037108225
-
FGFs their receptors, human limb malformations: Clinical and molecular correlations
-
Wilkie, A. O., Patey, S. J., Kan, S. H., van den Ouweland, A. M., Hamel, B. C. FGFs, their receptors, human limb malformations: Clinical and molecular correlations. Am. J. Med. Genet. 112, 266-278 (2002).
-
(2002)
Am. J. Med. Genet.
, vol.112
, pp. 266-278
-
-
Wilkie, A.O.1
Patey, S.J.2
Kan, S.H.3
Vanden Ouweland, A.M.4
Hamel, B.C.5
-
38
-
-
84942901008
-
Identification of oncogenic and drug-sensitizing mutations in the extracellular domain of FGFR2
-
Tanizaki, J., et al. Identification of oncogenic and drug-sensitizing mutations in the extracellular domain of FGFR2. Cancer Res. 75, 3139-3146 (2015).
-
(2015)
Cancer Res.
, vol.75
, pp. 3139-3146
-
-
Tanizaki, J.1
-
39
-
-
0032841519
-
Frequent activating mutations of FGFR3 in human bladder and cervix carcinomas
-
Cappellen, D., et al. Frequent activating mutations of FGFR3 in human bladder and cervix carcinomas. Nat. Genet. 23, 18-20 (1999).
-
(1999)
Nat. Genet.
, vol.23
, pp. 18-20
-
-
Cappellen, D.1
-
40
-
-
26944455629
-
Clinical and biological characteristics of cervical neoplasias with FGFR3 mutation
-
Rosty, C., et al. Clinical and biological characteristics of cervical neoplasias with FGFR3 mutation. Mol. Cancer 4, 15 (2005).
-
(2005)
Mol. Cancer
, vol.4
, pp. 15
-
-
Rosty, C.1
-
41
-
-
33645288557
-
Oncogenic properties of the mutated forms of fibroblast growth factor receptor 3b
-
Bernard-Pierrot, I., et al. Oncogenic properties of the mutated forms of fibroblast growth factor receptor 3b. Carcinogenesis 27, 740-747 (2006).
-
(2006)
Carcinogenesis
, vol.27
, pp. 740-747
-
-
Bernard-Pierrot, I.1
-
42
-
-
34548250374
-
A molecular brake in the kinase hinge region regulates the activity of receptor tyrosine kinases
-
Chen, H., et al. A molecular brake in the kinase hinge region regulates the activity of receptor tyrosine kinases. Mol. Cell 27, 717-730 (2007).
-
(2007)
Mol. Cell
, vol.27
, pp. 717-730
-
-
Chen, H.1
-
43
-
-
0034612592
-
Transformation and Stat activation by derivatives of FGFR1, FGFR3, FGFR4
-
Hart, K. C., et al. Transformation and Stat activation by derivatives of FGFR1, FGFR3, FGFR4. Oncogene 19, 3309-3320 (2000).
-
(2000)
Oncogene
, vol.19
, pp. 3309-3320
-
-
Hart, K.C.1
-
44
-
-
70449450426
-
Identification of FGFR4-activating mutations in human rhabdomyosarcomas that promote metastasis in xenotransplanted models
-
Taylor, J. G. VI, et al. Identification of FGFR4-activating mutations in human rhabdomyosarcomas that promote metastasis in xenotransplanted models. J. Clin. Invest. 119, 3395-3407 (2009).
-
(2009)
J. Clin. Invest.
, vol.119
, pp. 3395-3407
-
-
Taylor, J.G.V.I.1
-
45
-
-
85027935283
-
Breast cancer susceptibility associated with rs1219648 (fibroblast growth factor receptor 2) and postmenopausal hormone therapy use in a population-based United States study
-
Andersen, S. W., et al. Breast cancer susceptibility associated with rs1219648 (fibroblast growth factor receptor 2) and postmenopausal hormone therapy use in a population-based United States study. Menopause 20, 354-358 (2013).
-
(2013)
Menopause
, vol.20
, pp. 354-358
-
-
Andersen, S.W.1
-
46
-
-
34250001297
-
A genome-wide association study identifies alleles in FGFR2 associated with risk of sporadic postmenopausal breast cancer
-
Hunter, D. J., et al. A genome-wide association study identifies alleles in FGFR2 associated with risk of sporadic postmenopausal breast cancer. Nat. Genet. 39, 870-874 (2007).
-
(2007)
Nat. Genet.
, vol.39
, pp. 870-874
-
-
Hunter, D.J.1
-
47
-
-
45149099137
-
Allele-specific up-regulation of FGFR2 increases susceptibility to breast cancer
-
Meyer, K. B., et al. Allele-specific up-regulation of FGFR2 increases susceptibility to breast cancer. PLoS Biol. 6, e108 (2008).
-
(2008)
PLoS Biol.
, vol.6
, pp. e108
-
-
Meyer, K.B.1
-
48
-
-
79958829857
-
Meta and pooled analyses of FGFR4 Gly388Arg polymorphism as a cancer prognostic factor
-
Frullanti, E., et al. Meta and pooled analyses of FGFR4 Gly388Arg polymorphism as a cancer prognostic factor. Eur. J. Cancer Prev. 20, 340-347 (2011).
-
(2011)
Eur. J. Cancer Prev.
, vol.20
, pp. 340-347
-
-
Frullanti, E.1
-
49
-
-
0036468871
-
Cancer progression and tumor cell motility are associated with the FGFR4 Arg(388) allele
-
Bange, J., et al. Cancer progression and tumor cell motility are associated with the FGFR4 Arg(388) allele. Cancer Res. 62, 840-847 (2002).
-
(2002)
Cancer Res.
, vol.62
, pp. 840-847
-
-
Bange, J.1
-
50
-
-
84951320585
-
Germline variant FGFR4 p.G388R exposes a membrane-proximal STAT3 binding site
-
Ulaganathan, V. K., Sperl, B., Rapp, U. R., Ullrich, A. Germline variant FGFR4 p.G388R exposes a membrane-proximal STAT3 binding site. Nature 528, 570-574 (2015).
-
(2015)
Nature
, vol.528
, pp. 570-574
-
-
Ulaganathan, V.K.1
Sperl, B.2
Rapp, U.R.3
Ullrich, A.4
-
51
-
-
84865805666
-
Transforming fusions of FGFR and TACC genes in human glioblastoma
-
Singh, D., et al. Transforming fusions of FGFR and TACC genes in human glioblastoma. Science 337, 1231-1235 (2012).
-
(2012)
Science
, vol.337
, pp. 1231-1235
-
-
Singh, D.1
-
52
-
-
84878781242
-
Identification of targetable FGFR gene fusions in diverse cancers
-
Wu, Y. M., et al. Identification of targetable FGFR gene fusions in diverse cancers. Cancer Discov. 3, 636-647 (2013).
-
(2013)
Cancer Discov.
, vol.3
, pp. 636-647
-
-
Wu, Y.M.1
-
53
-
-
84878974844
-
Transforming acidic coiled-coil proteins (TACCs) in human cancer
-
Ha, G. H., Kim, J. L., Breuer, E. K. Transforming acidic coiled-coil proteins (TACCs) in human cancer. Cancer Lett. 336, 24-33 (2013).
-
(2013)
Cancer Lett.
, vol.336
, pp. 24-33
-
-
Ha, G.H.1
Kim, J.L.2
Breuer, E.K.3
-
54
-
-
84992254967
-
Pulling it together: The mitotic function of TACC3
-
Hood, F. E., Royle, S. J. Pulling it together: The mitotic function of TACC3. Bioarchitecture 1, 105-109 (2011).
-
(2011)
Bioarchitecture
, vol.1
, pp. 105-109
-
-
Hood, F.E.1
Royle, S.J.2
-
55
-
-
84873045850
-
Oncogenic FGFR3 gene fusions in bladder cancer
-
Williams, S. V., Hurst, C. D., Knowles, M. A. Oncogenic FGFR3 gene fusions in bladder cancer. Hum. Mol. Genet. 22, 795-803 (2013).
-
(2013)
Hum. Mol. Genet.
, vol.22
, pp. 795-803
-
-
Williams, S.V.1
Hurst, C.D.2
Knowles, M.A.3
-
56
-
-
84929292324
-
Massive parallel sequencing uncovers actionable FGFR2-PPHLN1 fusion and ARAF mutations in intrahepatic cholangiocarcinoma
-
Sia, D., et al. Massive parallel sequencing uncovers actionable FGFR2-PPHLN1 fusion and ARAF mutations in intrahepatic cholangiocarcinoma. Nat. Commun. 6, 6087 (2015).
-
(2015)
Nat. Commun.
, vol.6
, pp. 6087
-
-
Sia, D.1
-
57
-
-
84896492774
-
Fibroblast growth factor receptor 2 tyrosine kinase fusions define a unique molecular subtype of cholangiocarcinoma
-
Arai, Y., et al. Fibroblast growth factor receptor 2 tyrosine kinase fusions define a unique molecular subtype of cholangiocarcinoma. Hepatology 59, 1427-1434 (2014).
-
(2014)
Hepatology
, vol.59
, pp. 1427-1434
-
-
Arai, Y.1
-
58
-
-
84931088261
-
A long pentraxin-3-derived pentapeptide for the therapy of FGF8b-driven steroid hormone-regulated cancers
-
Giacomini, A., et al. A long pentraxin-3-derived pentapeptide for the therapy of FGF8b-driven steroid hormone-regulated cancers. Oncotarget 6, 13790-13802 (2015).
-
(2015)
Oncotarget
, vol.6
, pp. 13790-13802
-
-
Giacomini, A.1
-
59
-
-
84907289340
-
Prostate cancer cell-stromal cell crosstalk via FGFR1 mediates antitumor activity of dovitinib in bone metastases
-
Wan, X., et al. Prostate cancer cell-stromal cell crosstalk via FGFR1 mediates antitumor activity of dovitinib in bone metastases. Sci. Transl Med. 6, 252ra122 (2014).
-
(2014)
Sci. Transl Med.
, vol.6
, pp. 252ra122
-
-
Wan, X.1
-
60
-
-
84951102104
-
Dysregulated FGF signalling in neoplastic disorders
-
Tanner, Y., Grose, R. P. Dysregulated FGF signalling in neoplastic disorders. Semin. Cell Dev. Biol. 53, 126-135 (2015).
-
(2015)
Semin. Cell Dev. Biol.
, vol.53
, pp. 126-135
-
-
Tanner, Y.1
Grose, R.P.2
-
61
-
-
84897619747
-
Tumor models for prostate cancer exemplified by fibroblast growth factor 8-induced tumorigenesis and tumor progression
-
Tuomela, J., Harkonen, P. Tumor models for prostate cancer exemplified by fibroblast growth factor 8-induced tumorigenesis and tumor progression. Reprod. Biol. 14, 16-24 (2014).
-
(2014)
Reprod. Biol.
, vol.14
, pp. 16-24
-
-
Tuomela, J.1
Harkonen, P.2
-
62
-
-
84876916275
-
Endocrine fibroblast growth factor FGF19 promotes prostate cancer progression
-
Feng, S., Dakhova, O., Creighton, C. J., Ittmann, M. Endocrine fibroblast growth factor FGF19 promotes prostate cancer progression. Cancer Res. 73, 2551-2562 (2013).
-
(2013)
Cancer Res.
, vol.73
, pp. 2551-2562
-
-
Feng, S.1
Dakhova, O.2
Creighton, C.J.3
Ittmann, M.4
-
63
-
-
84929024583
-
FGF19 promotes progression of prostate cancer
-
Nagamatsu, H., et al. FGF19 promotes progression of prostate cancer. Prostate 75, 1092-1101 (2015).
-
(2015)
Prostate
, vol.75
, pp. 1092-1101
-
-
Nagamatsu, H.1
-
64
-
-
84938272297
-
FGF23 promotes prostate cancer progression
-
Feng, S., Wang, J., Zhang, Y., Creighton, C. J., Ittmann, M. FGF23 promotes prostate cancer progression. Oncotarget 6, 17291-17301 (2015).
-
(2015)
Oncotarget
, vol.6
, pp. 17291-17301
-
-
Feng, S.1
Wang, J.2
Zhang, Y.3
Creighton, C.J.4
Ittmann, M.5
-
65
-
-
84923922508
-
FGF23: Mediator of poor prognosis in a sizeable subgroup of patients with castration-resistant prostate cancer presenting with severe hypophosphatemia?
-
Lee, E. K., et al. FGF23: Mediator of poor prognosis in a sizeable subgroup of patients with castration-resistant prostate cancer presenting with severe hypophosphatemia? Med. Hypotheses 83, 482-487 (2014).
-
(2014)
Med. Hypotheses
, vol.83
, pp. 482-487
-
-
Lee, E.K.1
-
66
-
-
0029043876
-
The involvement of the chromosome 11q13 region in human malignancies: Cyclin D1 and EMS1 are two new candidate oncogenes-a review
-
Schuuring, E. The involvement of the chromosome 11q13 region in human malignancies: Cyclin D1 and EMS1 are two new candidate oncogenes-a review. Gene 159, 83-96 (1995).
-
(1995)
Gene
, vol.159
, pp. 83-96
-
-
Schuuring, E.1
-
67
-
-
80051558985
-
High-resolution genomic analysis of the 11q13 amplicon in breast cancers identifies synergy with 8p12 amplification, involving the mTOR targets S6K2 and 4EBP1
-
Karlsson, E., et al. High-resolution genomic analysis of the 11q13 amplicon in breast cancers identifies synergy with 8p12 amplification, involving the mTOR targets S6K2 and 4EBP1. Genes Chromosomes Cancer 50, 775-787 (2011).
-
(2011)
Genes Chromosomes Cancer
, vol.50
, pp. 775-787
-
-
Karlsson, E.1
-
68
-
-
0038752987
-
Cyclin D1 EMS1 and 11q13 amplification in breast cancer
-
Ormandy, C. J., Musgrove, E. A., Hui, R., Daly, R. J., Sutherland, R. L. Cyclin D1, EMS1 and 11q13 amplification in breast cancer. Breast Cancer Res. Treat. 78, 323-335 (2003).
-
(2003)
Breast Cancer Res. Treat.
, vol.78
, pp. 323-335
-
-
Ormandy, C.J.1
Musgrove, E.A.2
Hui, R.3
Daly, R.J.4
Sutherland, R.L.5
-
69
-
-
79952497178
-
Identification of a therapeutic strategy targeting amplified FGF19 in liver cancer by oncogenomic screening
-
Sawey, E. T., et al. Identification of a therapeutic strategy targeting amplified FGF19 in liver cancer by oncogenomic screening. Cancer Cell 19, 347-358 (2011).
-
(2011)
Cancer Cell
, vol.19
, pp. 347-358
-
-
Sawey, E.T.1
-
70
-
-
0036086285
-
A mouse model of hepatocellular carcinoma: Ectopic expression of fibroblast growth factor 19 in skeletal muscle of transgenic mice
-
Nicholes, K., et al. A mouse model of hepatocellular carcinoma: Ectopic expression of fibroblast growth factor 19 in skeletal muscle of transgenic mice. Am. J. Pathol. 160, 2295-2307 (2002).
-
(2002)
Am. J. Pathol.
, vol.160
, pp. 2295-2307
-
-
Nicholes, K.1
-
71
-
-
84903474977
-
Separating tumorigenicity from bile acid regulatory activity for endocrine hormone FGF19
-
Zhou, M., et al. Separating tumorigenicity from bile acid regulatory activity for endocrine hormone FGF19. Cancer Res. 74, 3306-3316 (2014).
-
(2014)
Cancer Res.
, vol.74
, pp. 3306-3316
-
-
Zhou, M.1
-
72
-
-
79952803104
-
FGF19 regulates cell proliferation, glucose and bile acid metabolism via FGFR4-dependent and independent pathways
-
Wu, A. L., et al. FGF19 regulates cell proliferation, glucose and bile acid metabolism via FGFR4-dependent and independent pathways. PLoS ONE 6, e17868 (2011).
-
(2011)
PLoS ONE
, vol.6
, pp. e17868
-
-
Wu, A.L.1
-
73
-
-
84904660258
-
TGF-beta1 and FGF2 stimulate the epithelial-mesenchymal transition of HERS cells through a MEK-dependent mechanism
-
Chen, J., et al. TGF-beta1 and FGF2 stimulate the epithelial-mesenchymal transition of HERS cells through a MEK-dependent mechanism. J. Cell. Physiol. 229, 1647-1659 (2014).
-
(2014)
J. Cell. Physiol.
, vol.229
, pp. 1647-1659
-
-
Chen, J.1
-
74
-
-
79951813692
-
TGF-beta regulates isoform switching of FGF receptors and epithelial-mesenchymal transition
-
Shirakihara, T., et al. TGF-beta regulates isoform switching of FGF receptors and epithelial-mesenchymal transition. EMBO J. 30, 783-795 (2011).
-
(2011)
EMBO J.
, vol.30
, pp. 783-795
-
-
Shirakihara, T.1
-
75
-
-
78650732630
-
Estrogen expands breast cancer stem-like cells through paracrine FGF/Tbx3 signaling
-
Fillmore, C. M., et al. Estrogen expands breast cancer stem-like cells through paracrine FGF/Tbx3 signaling. Proc. Natl Acad. Sci. USA 107, 21737-21742 (2010).
-
(2010)
Proc. Natl Acad. Sci. USA
, vol.107
, pp. 21737-21742
-
-
Fillmore, C.M.1
-
76
-
-
36649025928
-
Inducible FGFR-1 activation leads to irreversible prostate adenocarcinoma and an epithelial-to-mesenchymal transition
-
Acevedo, V. D., et al. Inducible FGFR-1 activation leads to irreversible prostate adenocarcinoma and an epithelial-to-mesenchymal transition. Cancer Cell 12, 559-571 (2007).
-
(2007)
Cancer Cell
, vol.12
, pp. 559-571
-
-
Acevedo, V.D.1
-
77
-
-
58849122812
-
Fibroblast growth factor (FGF) and FGF receptor-mediated autocrine signaling in non-small-cell lung cancer cells
-
Marek, L., et al. Fibroblast growth factor (FGF) and FGF receptor-mediated autocrine signaling in non-small-cell lung cancer cells. Mol. Pharmacol. 75, 1 96-207 (2009).
-
(2009)
Mol. Pharmacol.
, vol.75
, Issue.1
, pp. 96-207
-
-
Marek, L.1
-
78
-
-
80051685673
-
FGFR signaling promotes the growth of triple-negative and basal-like breast cancer cell lines both in vitro and in vivo
-
Sharpe, R., et al. FGFR signaling promotes the growth of triple-negative and basal-like breast cancer cell lines both in vitro and in vivo. Clin. Cancer Res. 17, 5275-5286 (2011).
-
(2011)
Clin. Cancer Res.
, vol.17
, pp. 5275-5286
-
-
Sharpe, R.1
-
79
-
-
84919383828
-
Subtyping of triple-negative breast cancer: Implications for therapy
-
Abramson, V. G., Lehmann, B. D., Ballinger, T. J., Pietenpol, J. A. Subtyping of triple-negative breast cancer: Implications for therapy. Cancer 121, 8-16 (2015).
-
(2015)
Cancer
, vol.121
, pp. 8-16
-
-
Abramson, V.G.1
Lehmann, B.D.2
Ballinger, T.J.3
Pietenpol, J.A.4
-
80
-
-
0036847635
-
High pretreatment serum concentration of basic fibroblast growth factor is a predictor of poor prognosis in small cell lung cancer
-
Ruotsalainen, T., Joensuu, H., Mattson, K., Salven, P. High pretreatment serum concentration of basic fibroblast growth factor is a predictor of poor prognosis in small cell lung cancer. Cancer Epidemiol. Biomarkers Prev. 11, 1492-1495 (2002).
-
(2002)
Cancer Epidemiol. Biomarkers Prev.
, vol.11
, pp. 1492-1495
-
-
Ruotsalainen, T.1
Joensuu, H.2
Mattson, K.3
Salven, P.4
-
81
-
-
0028328983
-
Elevated levels of an angiogenic peptide, basic fibroblast growth factor, in the urine of patients with a wide spectrum of cancers
-
Nguyen, M., et al. Elevated levels of an angiogenic peptide, basic fibroblast growth factor, in the urine of patients with a wide spectrum of cancers. J. Natl Cancer Inst. 86, 356-361 (1994).
-
(1994)
J. Natl Cancer Inst.
, vol.86
, pp. 356-361
-
-
Nguyen, M.1
-
82
-
-
0027198248
-
Exon switching and activation of stromal and embryonic fibroblast growth factor (FGF)-FGF receptor genes in prostate epithelial cells accompany stromal independence and malignancy
-
Yan, G., Fukabori, Y., McBride, G., Nikolaropolous, S., McKeehan, W. L. Exon switching and activation of stromal and embryonic fibroblast growth factor (FGF)-FGF receptor genes in prostate epithelial cells accompany stromal independence and malignancy. Mol. Cell. Biol. 13, 4513-4522 (1993).
-
(1993)
Mol. Cell. Biol.
, vol.13
, pp. 4513-4522
-
-
Yan, G.1
Fukabori, Y.2
McBride, G.3
Nikolaropolous, S.4
McKeehan, W.L.5
-
83
-
-
84930418435
-
HPV16 E5 expression induces switching from FGFR2b to FGFR2c and epithelial-mesenchymal transition
-
Ranieri, D., Belleudi, F., Magenta, A., Torrisi, M. R. HPV16 E5 expression induces switching from FGFR2b to FGFR2c and epithelial-mesenchymal transition. Int. J. Cancer 137, 61-72 (2015).
-
(2015)
Int. J. Cancer
, vol.137
, pp. 61-72
-
-
Ranieri, D.1
Belleudi, F.2
Magenta, A.3
Torrisi, M.R.4
-
84
-
-
33845809125
-
Mesenchymal-to-epithelial transition facilitates bladder cancer metastasis: Role of fibroblast growth factor receptor-2
-
Chaffer, C. L., et al. Mesenchymal-to-epithelial transition facilitates bladder cancer metastasis: Role of fibroblast growth factor receptor-2. Cancer Res. 66, 11271-11278 (2006).
-
(2006)
Cancer Res.
, vol.66
, pp. 11271-11278
-
-
Chaffer, C.L.1
-
85
-
-
84860255645
-
Enhanced expression of fibroblast growth factor receptor 2 IIIc promotes human pancreatic cancer cell proliferation
-
Ishiwata, T., et al. Enhanced expression of fibroblast growth factor receptor 2 IIIc promotes human pancreatic cancer cell proliferation. Am. J. Pathol. 180, 1928-1941 (2012).
-
(2012)
Am. J. Pathol.
, vol.180
, pp. 1928-1941
-
-
Ishiwata, T.1
-
86
-
-
84866095723
-
Fibroblast growth factor receptor 2 IIIc as a therapeutic target for colorectal cancer cells
-
Matsuda, Y., Hagio, M., Seya, T., Ishiwata, T. Fibroblast growth factor receptor 2 IIIc as a therapeutic target for colorectal cancer cells. Mol. Cancer Ther. 11, 2010-2020 (2012).
-
(2012)
Mol. Cancer Ther.
, vol.11
, pp. 2010-2020
-
-
Matsuda, Y.1
Hagio, M.2
Seya, T.3
Ishiwata, T.4
-
87
-
-
0024369393
-
Monospecific antibodies implicate basic fibroblast growth factor in normal wound repair
-
Broadley, K. N., et al. Monospecific antibodies implicate basic fibroblast growth factor in normal wound repair. Lab. Invest. 61, 571-575 (1989).
-
(1989)
Lab. Invest.
, vol.61
, pp. 571-575
-
-
Broadley, K.N.1
-
88
-
-
0032510806
-
Neuronal defects and delayed wound healing in mice lacking fibroblast growth factor
-
Ortega, S., Ittmann, M., Tsang, S. H., Ehrlich, M., Basilico, C. Neuronal defects and delayed wound healing in mice lacking fibroblast growth factor. Proc. Natl Acad. Sci. USA 95, 5672-5677 (1998).
-
(1998)
Proc. Natl Acad. Sci. USA
, vol.95
, pp. 5672-5677
-
-
Ortega, S.1
Ittmann, M.2
Tsang, S.H.3
Ehrlich, M.4
Basilico, C.5
-
89
-
-
0034671392
-
Fibroblast growth factors are required for efficient tumor angiogenesis
-
Compagni, A., Wilgenbus, P., Impagnatiello, M. A., Cotten, M., Christofori, G. Fibroblast growth factors are required for efficient tumor angiogenesis. Cancer Res. 60, 7163-7169 (2000).
-
(2000)
Cancer Res.
, vol.60
, pp. 7163-7169
-
-
Compagni, A.1
Wilgenbus, P.2
Impagnatiello, M.A.3
Cotten, M.4
Christofori, G.5
-
90
-
-
84939454821
-
The potential of fibroblast growth factor/fibroblast growth factor receptor signaling as a therapeutic target in tumor angiogenesis
-
Ronca, R., Giacomini, A., Rusnati, M., Presta, M. The potential of fibroblast growth factor/fibroblast growth factor receptor signaling as a therapeutic target in tumor angiogenesis. Expert Opin. Ther. Targets 19, 1361-1377 (2015).
-
(2015)
Expert Opin. Ther. Targets
, vol.19
, pp. 1361-1377
-
-
Ronca, R.1
Giacomini, A.2
Rusnati, M.3
Presta, M.4
-
91
-
-
0031784561
-
Vascular endothelial growth factor (VEGF)-C synergizes with basic fibroblast growth factor and VEGF in the induction of angiogenesis in vitro and alters endothelial cell extracellular proteolytic activity
-
Pepper, M. S., Mandriota, S. J., Jeltsch, M., Kumar, V., Alitalo, K. Vascular endothelial growth factor (VEGF)-C synergizes with basic fibroblast growth factor and VEGF in the induction of angiogenesis in vitro and alters endothelial cell extracellular proteolytic activity. J. Cell. Physiol. 177, 439-452 (1998).
-
(1998)
J. Cell. Physiol.
, vol.177
, pp. 439-452
-
-
Pepper, M.S.1
Mandriota, S.J.2
Jeltsch, M.3
Kumar, V.4
Alitalo, K.5
-
92
-
-
48249099239
-
Distinct angiogenic mediators are required for basic fibroblast growth factor-A nd vascular endothelial growth factor-induced angiogenesis: The role of cytoplasmic tyrosine kinase c-Abl in tumor angiogenesis
-
Yan, W., Bentley, B., Shao, R. Distinct angiogenic mediators are required for basic fibroblast growth factor-A nd vascular endothelial growth factor-induced angiogenesis: The role of cytoplasmic tyrosine kinase c-Abl in tumor angiogenesis. Mol. Biol. Cell 19, 2278-2288 (2008).
-
(2008)
Mol. Biol. Cell
, vol.19
, pp. 2278-2288
-
-
Yan, W.1
Bentley, B.2
Shao, R.3
-
93
-
-
75749096309
-
Phase II trial of infusional fluorouracil, irinotecan, bevacizumab for metastatic colorectal cancer: Efficacy and circulating angiogenic biomarkers associated with therapeutic resistance
-
Kopetz, S., et al. Phase II trial of infusional fluorouracil, irinotecan, bevacizumab for metastatic colorectal cancer: Efficacy and circulating angiogenic biomarkers associated with therapeutic resistance. J. Clin. Oncol. 28, 453-459 (2010).
-
(2010)
J. Clin. Oncol.
, vol.28
, pp. 453-459
-
-
Kopetz, S.1
-
94
-
-
80051690789
-
Brivanib a dual FGF/VEGF inhibitor, is active both first and second line against mouse pancreatic neuroendocrine tumors developing adaptive/evasive resistance to VEGF inhibition
-
Allen, E., Walters, I. B., Hanahan, D. Brivanib, a dual FGF/VEGF inhibitor, is active both first and second line against mouse pancreatic neuroendocrine tumors developing adaptive/evasive resistance to VEGF inhibition. Clin. Cancer Res. 17, 5299-5310 (2011).
-
(2011)
Clin. Cancer Res.
, vol.17
, pp. 5299-5310
-
-
Allen, E.1
Walters, I.B.2
Hanahan, D.3
-
95
-
-
84874304239
-
Amplification of FRS2 and activation of FGFR/FRS2 signaling pathway in high-grade liposarcoma
-
Zhang, K., et al. Amplification of FRS2 and activation of FGFR/FRS2 signaling pathway in high-grade liposarcoma. Cancer Res. 73, 1298-1307 (2013).
-
(2013)
Cancer Res.
, vol.73
, pp. 1298-1307
-
-
Zhang, K.1
-
96
-
-
84928009182
-
The tyrosine kinase adaptor protein FRS2 is oncogenic and amplified in high-grade serous ovarian cancer
-
Luo, L. Y., et al. The tyrosine kinase adaptor protein FRS2 is oncogenic and amplified in high-grade serous ovarian cancer. Mol. Cancer Res. 13, 502-509 (2015).
-
(2015)
Mol. Cancer Res.
, vol.13
, pp. 502-509
-
-
Luo, L.Y.1
-
97
-
-
84893769451
-
Competition between Grb2 and Plcgamma1 for FGFR2 regulates basal phospholipase activity and invasion
-
Timsah, Z., et al. Competition between Grb2 and Plcgamma1 for FGFR2 regulates basal phospholipase activity and invasion. Nat. Struct. Mol. Biol. 21, 180-188 (2014).
-
(2014)
Nat. Struct. Mol. Biol.
, vol.21
, pp. 180-188
-
-
Timsah, Z.1
-
98
-
-
84937822650
-
Grb2 depletion under non-stimulated conditions inhibits PTEN, promotes Akt-induced tumor formation and contributes to poor prognosis in ovarian cancer
-
Timsah, Z., et al. Grb2 depletion under non-stimulated conditions inhibits PTEN, promotes Akt-induced tumor formation and contributes to poor prognosis in ovarian cancer. Oncogene 35, 2186-2196 (2016).
-
(2016)
Oncogene
, vol.35
, pp. 2186-2196
-
-
Timsah, Z.1
-
99
-
-
85006210801
-
Expression pattern of FGFR2 Grb2 and Plcgamma1 acts as a novel prognostic marker of recurrence recurrence-free survival in lung adenocarcinoma
-
Timsah, Z., et al. Expression pattern of FGFR2, Grb2 and Plcgamma1 acts as a novel prognostic marker of recurrence recurrence-free survival in lung adenocarcinoma. Am. J. Cancer Res. 5, 3135-3148 (2015).
-
(2015)
Am. J. Cancer Res.
, vol.5
, pp. 3135-3148
-
-
Timsah, Z.1
-
100
-
-
84874851836
-
Phase I study of dovitinib (TKI258), an oral FGFR, VEGFR, PDGFR inhibitor, in advanced or metastatic renal cell carcinoma
-
Angevin, E., et al. Phase I study of dovitinib (TKI258), an oral FGFR, VEGFR, PDGFR inhibitor, in advanced or metastatic renal cell carcinoma. Clin. Cancer Res. 19, 1257-1268 (2013).
-
(2013)
Clin. Cancer Res.
, vol.19
, pp. 1257-1268
-
-
Angevin, E.1
-
101
-
-
84896713052
-
Dovitinib versus sorafenib for third-line targeted treatment of patients with metastatic renal cell carcinoma: An open-label, randomised phase 3 trial
-
Motzer, R. J., et al. Dovitinib versus sorafenib for third-line targeted treatment of patients with metastatic renal cell carcinoma: An open-label, randomised phase 3 trial. Lancet Oncol. 15, 286-296 (2014).
-
(2014)
Lancet Oncol.
, vol.15
, pp. 286-296
-
-
Motzer, R.J.1
-
102
-
-
84925408760
-
Phase I/IIa study evaluating the safety, efficacy, pharmacokinetics, pharmacodynamics of lucitanib in advanced solid tumors
-
Soria, J. C., et al. Phase I/IIa study evaluating the safety, efficacy, pharmacokinetics, pharmacodynamics of lucitanib in advanced solid tumors. Ann. Oncol. 25, 2244-2251 (2014).
-
(2014)
Ann. Oncol.
, vol.25
, pp. 2244-2251
-
-
Soria, J.C.1
-
103
-
-
77958038695
-
Phase I safety, pharmacokinetic, biomarker study of BIBF 1120, an oral triple tyrosine kinase inhibitor in patients with advanced solid tumors
-
Okamoto, I., et al. Phase I safety, pharmacokinetic, biomarker study of BIBF 1120, an oral triple tyrosine kinase inhibitor in patients with advanced solid tumors. Mol. Cancer Ther. 9, 2825-2833 (2010).
-
(2010)
Mol. Cancer Ther.
, vol.9
, pp. 2825-2833
-
-
Okamoto, I.1
-
104
-
-
84887127701
-
A phase 2 trial of ponatinib in Philadelphia chromosome-positive leukemias
-
Cortes, J. E., et al. A phase 2 trial of ponatinib in Philadelphia chromosome-positive leukemias. N. Engl. J. Med. 369, 1783-1796 (2013).
-
(2013)
N. Engl. J. Med.
, vol.369
, pp. 1783-1796
-
-
Cortes, J.E.1
-
105
-
-
0027344852
-
Structural and functional diversity in the FGF receptor multigene family
-
Johnson, D. E., Williams, L. T. Structural and functional diversity in the FGF receptor multigene family. Adv. Cancer Res. 60, 1-41 (1993).
-
(1993)
Adv. Cancer Res.
, vol.60
, pp. 1-41
-
-
Johnson, D.E.1
Williams, L.T.2
-
106
-
-
84908080486
-
Structural analysis of the human fibroblast growth factor receptor 4 kinase
-
Lesca, E., Lammens, A., Huber, R., Augustin, M. Structural analysis of the human fibroblast growth factor receptor 4 kinase. J. Mol. Biol. 426, 3744-3756 (2014).
-
(2014)
J. Mol. Biol.
, vol.426
, pp. 3744-3756
-
-
Lesca, E.1
Lammens, A.2
Huber, R.3
Augustin, M.4
-
107
-
-
84922981864
-
Results of a phase I study of AZD4547, an inhibitor of fibroblast growth factor receptor (FGFR), in patients with advanced solid tumors
-
abstr. LB-145
-
Andre, F., et al. Results of a phase I study of AZD4547, an inhibitor of fibroblast growth factor receptor (FGFR), in patients with advanced solid tumors. Cancer Res. 73 (Suppl.), abstr. LB-145 (2013).
-
(2013)
Cancer Res.
, vol.73
-
-
Andre, F.1
-
108
-
-
85009882036
-
Evaluation of BGJ398, a fibroblast growth factor receptor 1-3 kinase inhibitor, in patients with advanced solid tumors harboring genetic alterations in fibroblast growth factor receptors: Results of a global phase I, dose-escalation and dose-expansion study
-
Nogova, L., et al. Evaluation of BGJ398, a fibroblast growth factor receptor 1-3 kinase inhibitor, in patients with advanced solid tumors harboring genetic alterations in fibroblast growth factor receptors: Results of a global phase I, dose-escalation and dose-expansion study. J. Clin. Oncol. 35, 157-165 (2017).
-
(2017)
J. Clin. Oncol.
, vol.35
, pp. 157-165
-
-
Nogova, L.1
-
109
-
-
84940585870
-
A randomized, open-label phase II study of AZD4547 (AZD) versus paclitaxel (P) in previously treated patients with advanced gastric cancer (AGC) with fibroblast growth factor receptor 2 (FGFR2) polysomy or gene amplification (amp): SHINE study
-
abstr 4014
-
Bang, Y.-J., et al. A randomized, open-label phase II study of AZD4547 (AZD) versus paclitaxel (P) in previously treated patients with advanced gastric cancer (AGC) with fibroblast growth factor receptor 2 (FGFR2) polysomy or gene amplification (amp): SHINE study. J. Clin. Oncol. 33 (Suppl.), abstr. 4014 (2015).
-
(2015)
J. Clin. Oncol.
, vol.33
-
-
Bang, Y.-J.1
-
110
-
-
84962251251
-
-
ClinicalTrials.gov
-
US National Library of Medicine. ClinicalTrials.gov https://clinicaltrials.gov/ct2/show/NCT02150967 (2016).
-
(2016)
US National Library of Medicine
-
-
-
111
-
-
84962251251
-
-
ClinicalTrials.gov
-
US National Library of Medicine. ClinicalTrials.gov https://clinicaltrials.gov/ct2/show/NCT02257541 (2016).
-
(2016)
US National Library of Medicine
-
-
-
112
-
-
84962251251
-
-
ClinicalTrials.gov
-
US National Library of Medicine. ClinicalTrials.gov https://clinicaltrials.gov/ct2/show/NCT02160041 (2016).
-
(2016)
US National Library of Medicine
-
-
-
113
-
-
85017940817
-
-
ClinicalTrials.gov
-
US National Library of Medicine. ClinicalTrials.gov https://clinicaltrials.gov/ct2/show/NCT02365597 (2017).
-
(2017)
US National Library of Medicine
-
-
-
114
-
-
84973302297
-
-
ClinicalTrials.gov
-
US National Library of Medicine. ClinicalTrials.gov https://clinicaltrials.gov/ct2/show/NCT01212107 (2015).
-
(2015)
US National Library of Medicine
-
-
-
115
-
-
84962251251
-
-
ClinicalTrials.gov
-
US National Library of Medicine. ClinicalTrials.gov https://clinicaltrials.gov/ct2/show/NCT01363024 (2016).
-
(2016)
US National Library of Medicine
-
-
-
116
-
-
84896870634
-
A phase I dose-escalation study of MFGR1877S, a human monoclonal anti-fibroblast growth factor receptor 3 (FGFR3) antibody, in patients (pts) with advanced solid tumors
-
ODonnell, P., et al. A phase I dose-escalation study of MFGR1877S, a human monoclonal anti-fibroblast growth factor receptor 3 (FGFR3) antibody, in patients (pts) with advanced solid tumors. Eur. J. Cancer 48, 191-192 (2012).
-
(2012)
Eur. J. Cancer
, vol.48
, pp. 191-192
-
-
O'Donnell, P.1
-
117
-
-
33947108356
-
Monoclonal antibody antagonists of hypothalamic FGFR1 cause potent but reversible hypophagia and weight loss in rodents and monkeys
-
Sun, H. D., et al. Monoclonal antibody antagonists of hypothalamic FGFR1 cause potent but reversible hypophagia and weight loss in rodents and monkeys. Am. J. Physiol. 292, E964-E976 (2007).
-
(2007)
Am. J. Physiol.
, vol.292
, pp. E964-E976
-
-
Sun, H.D.1
-
118
-
-
84945164840
-
FPA144: A therapeutic antibody for treating patients with gastric cancers bearing FGFR2 gene amplification
-
5446
-
Gemo, A. T., et al. FPA144: A therapeutic antibody for treating patients with gastric cancers bearing FGFR2 gene amplification. Cancer Res. 74 (Suppl.), abstr. 5446 (2014).
-
(2014)
Cancer Res.
, vol.74
-
-
Gemo, A.T.1
-
119
-
-
85017940817
-
-
ClinicalTrials.gov
-
US National Library of Medicine. ClinicalTrials.gov https://clinicaltrials.gov/ct2/show/NCT02318329 (2017).
-
(2017)
US National Library of Medicine
-
-
-
120
-
-
85019808916
-
FPA144-001: A first in human study of FPA 144, an ADCC-enhanced, FGFR2b isoform-selective monoclonal antibody in patients with advanced solid tumors
-
Bendell, J. C., et al. FPA144-001: A first in human study of FPA 144, an ADCC-enhanced, FGFR2b isoform-selective monoclonal antibody in patients with advanced solid tumors. J. Clin. Oncol. 34 (Suppl. 4S), 140 (2016).
-
(2016)
J. Clin. Oncol.
, vol.34
, pp. 140
-
-
Bendell, J.C.1
-
121
-
-
84876103735
-
Blockade of nonhormonal fibroblast growth factors by FP-1039 inhibits growth of multiple types of cancer
-
Harding, T. C., et al. Blockade of nonhormonal fibroblast growth factors by FP-1039 inhibits growth of multiple types of cancer. Sci. Transl Med. 5, 178ra39 (2013).
-
(2013)
Sci. Transl Med.
, vol.5
, pp. 178ra39
-
-
Harding, T.C.1
-
122
-
-
84959935277
-
A phase I, first in human study of FP-1039 (GSK3052230), a novel FGF ligand trap, in patients with advanced solid tumors
-
Tolcher, A. W., et al. A phase I, first in human study of FP-1039 (GSK3052230), a novel FGF ligand trap, in patients with advanced solid tumors. Ann. Oncol. 27, 526-532 (2016).
-
(2016)
Ann. Oncol.
, vol.27
, pp. 526-532
-
-
Tolcher, A.W.1
-
123
-
-
79953879710
-
Biology-driven phase II trials: What is the optimal model for molecular selection?
-
Andre, F., Delaloge, S., Soria, J. C. Biology-driven phase II trials: What is the optimal model for molecular selection? J. Clin. Oncol. 29, 1236-1238 (2011).
-
(2011)
J. Clin. Oncol.
, vol.29
, pp. 1236-1238
-
-
Andre, F.1
Delaloge, S.2
Soria, J.C.3
-
124
-
-
84896737448
-
Cell-autonomous and non-cell-autonomous mechanisms of transformation by amplified FGFR1 in lung cancer
-
Malchers, F., et al. Cell-autonomous and non-cell-autonomous mechanisms of transformation by amplified FGFR1 in lung cancer. Cancer Discov. 4, 246-257 (2014).
-
(2014)
Cancer Discov.
, vol.4
, pp. 246-257
-
-
Malchers, F.1
-
125
-
-
84902669919
-
FGFR1 mRNA and protein expression, not gene copy number, predict FGFR TKI sensitivity across all lung cancer histologies
-
Wynes, M. W., et al. FGFR1 mRNA and protein expression, not gene copy number, predict FGFR TKI sensitivity across all lung cancer histologies. Clin. Cancer Res. 20, 3299-3309 (2014).
-
(2014)
Clin. Cancer Res.
, vol.20
, pp. 3299-3309
-
-
Wynes, M.W.1
-
126
-
-
84977664894
-
Co-active receptor tyrosine kinases mitigate the effect of FGFR inhibitors in FGFR1-amplified lung cancers with low FGFR1 protein expression
-
Kotani, H., et al. Co-active receptor tyrosine kinases mitigate the effect of FGFR inhibitors in FGFR1-amplified lung cancers with low FGFR1 protein expression. Oncogene 35, 3587-3597 (2015).
-
(2015)
Oncogene
, vol.35
, pp. 3587-3597
-
-
Kotani, H.1
-
127
-
-
0023639110
-
Synergistic induction of mesoderm by FGF and TGF-beta and the identification of an mRNA coding for FGF in the early Xenopus embryo
-
Kimelman, D., Kirschner, M. Synergistic induction of mesoderm by FGF and TGF-beta and the identification of an mRNA coding for FGF in the early Xenopus embryo. Cell 51, 869-877 (1987).
-
(1987)
Cell
, vol.51
, pp. 869-877
-
-
Kimelman, D.1
Kirschner, M.2
-
128
-
-
84962448787
-
Genetic insights into the mechanisms of Fgf signaling
-
Brewer, J. R., Mazot, P., Soriano, P. Genetic insights into the mechanisms of Fgf signaling. Genes Dev. 30, 751-771 (2016).
-
(2016)
Genes Dev.
, vol.30
, pp. 751-771
-
-
Brewer, J.R.1
Mazot, P.2
Soriano, P.3
-
129
-
-
0142074405
-
Spatial and temporal patterns of ERK signaling during mouse embryogenesis
-
Corson, L. B., Yamanaka, Y., Lai, K. M., Rossant, J. Spatial and temporal patterns of ERK signaling during mouse embryogenesis. Development 130, 4527-4537 (2003).
-
(2003)
Development
, vol.130
, pp. 4527-4537
-
-
Corson, L.B.1
Yamanaka, Y.2
Lai, K.M.3
Rossant, J.4
-
130
-
-
79952116987
-
Amplification of fibroblast growth factor receptor-1 in breast cancer and the effects of brivanib alaninate
-
Shiang, C. Y., et al. Amplification of fibroblast growth factor receptor-1 in breast cancer and the effects of brivanib alaninate. Breast Cancer Res. Treat. 123, 747-755 (2010).
-
(2010)
Breast Cancer Res. Treat.
, vol.123
, pp. 747-755
-
-
Shiang, C.Y.1
-
131
-
-
27944452744
-
Pleiotropic effects of FGFR1 on cell proliferation, survival, migration in a 3D mammary epithelial cell model
-
Xian, W., Schwertfeger, K. L., Vargo-Gogola, T., Rosen, J. M. Pleiotropic effects of FGFR1 on cell proliferation, survival, migration in a 3D mammary epithelial cell model. J. Cell Biol. 171, 663-673 (2005).
-
(2005)
J. Cell Biol.
, vol.171
, pp. 663-673
-
-
Xian, W.1
Schwertfeger, K.L.2
Vargo-Gogola, T.3
Rosen, J.M.4
-
132
-
-
0037071550
-
Inducible dimerization of FGFR1: Development of a mouse model to analyze progressive transformation of the mammary gland
-
Welm, B. E., et al. Inducible dimerization of FGFR1: Development of a mouse model to analyze progressive transformation of the mammary gland. J. Cell Biol. 157, 703-714 (2002).
-
(2002)
J. Cell Biol.
, vol.157
, pp. 703-714
-
-
Welm, B.E.1
-
133
-
-
84866171951
-
Targeting FGFR4 inhibits hepatocellular carcinoma in preclinical mouse models
-
French, D. M., et al. Targeting FGFR4 inhibits hepatocellular carcinoma in preclinical mouse models. PLoS ONE 7, e36713 (2012).
-
(2012)
PLoS ONE
, vol.7
, pp. e36713
-
-
French, D.M.1
-
134
-
-
84939482520
-
First selective small molecule inhibitor of FGFR4 for the treatment of hepatocellular carcinomas with an activated FGFR4 signaling pathway
-
Hagel, M., et al. First selective small molecule inhibitor of FGFR4 for the treatment of hepatocellular carcinomas with an activated FGFR4 signaling pathway. Cancer Discov. 5, 424-437 (2015).
-
(2015)
Cancer Discov.
, vol.5
, pp. 424-437
-
-
Hagel, M.1
-
135
-
-
85017940817
-
-
ClinicalTrials.gov
-
US National Library of Medicine. ClinicalTrials.gov https://clinicaltrials.gov/ct2/show/NCT02421185 (2017).
-
(2017)
US National Library of Medicine
-
-
-
136
-
-
84882709305
-
Inhibitor-sensitive FGFR2 and FGFR3 mutations in lung squamous cell carcinoma
-
Liao, R. G., et al. Inhibitor-sensitive FGFR2 and FGFR3 mutations in lung squamous cell carcinoma. Cancer Res. 73, 5195-5205 (2013).
-
(2013)
Cancer Res.
, vol.73
, pp. 5195-5205
-
-
Liao, R.G.1
-
137
-
-
84877928037
-
Combined targeting of FGFR2 and mTOR by ponatinib and ridaforolimus results in synergistic antitumor activity in FGFR2 mutant endometrial cancer models
-
Gozgit, J. M., et al. Combined targeting of FGFR2 and mTOR by ponatinib and ridaforolimus results in synergistic antitumor activity in FGFR2 mutant endometrial cancer models. Cancer Chemother. Pharmacol. 71, 1315-1323 (2013).
-
(2013)
Cancer Chemother. Pharmacol.
, vol.71
, pp. 1315-1323
-
-
Gozgit, J.M.1
-
138
-
-
84928706270
-
MTOR inhibition improves fibroblast growth factor receptor targeting in hepatocellular carcinoma
-
Scheller, T., et al. mTOR inhibition improves fibroblast growth factor receptor targeting in hepatocellular carcinoma. Br. J. Cancer 112, 841-850 (2015).
-
(2015)
Br. J. Cancer
, vol.112
, pp. 841-850
-
-
Scheller, T.1
-
139
-
-
84860120185
-
AZD4547: An orally bioavailable, potent, selective inhibitor of the fibroblast growth factor receptor tyrosine kinase family
-
Gavine, P. R., et al. AZD4547: An orally bioavailable, potent, selective inhibitor of the fibroblast growth factor receptor tyrosine kinase family. Cancer Res. 72, 2045-2056 (2012).
-
(2012)
Cancer Res.
, vol.72
, pp. 2045-2056
-
-
Gavine, P.R.1
-
140
-
-
81055124246
-
A novel, selective inhibitor of fibroblast growth factor receptors that shows a potent broad spectrum of antitumor activity in several tumor xenograft models
-
Zhao, G., et al. A novel, selective inhibitor of fibroblast growth factor receptors that shows a potent broad spectrum of antitumor activity in several tumor xenograft models. Mol. Cancer Ther. 10, 2200-2210 (2011).
-
(2011)
Mol. Cancer Ther.
, vol.10
, pp. 2200-2210
-
-
Zhao, G.1
-
141
-
-
84939444543
-
Long-pentraxin 3 derivative as a small-molecule FGF trap for cancer therapy
-
Ronca, R., et al. Long-pentraxin 3 derivative as a small-molecule FGF trap for cancer therapy. Cancer Cell 28, 225-239 (2015).
-
(2015)
Cancer Cell
, vol.28
, pp. 225-239
-
-
Ronca, R.1
-
142
-
-
2642558897
-
Characterization of a conserved structural determinant controlling protein kinase sensitivity to selective inhibitors
-
Blencke, S., et al. Characterization of a conserved structural determinant controlling protein kinase sensitivity to selective inhibitors. Chem. Biol. 11, 691-701 (2004).
-
(2004)
Chem. Biol.
, vol.11
, pp. 691-701
-
-
Blencke, S.1
-
143
-
-
84881039897
-
The N550K/H mutations in FGFR2 confer differential resistance to PD173074, dovitinib, ponatinib ATP-competitive inhibitors
-
Byron, S. A., et al. The N550K/H mutations in FGFR2 confer differential resistance to PD173074, dovitinib, ponatinib ATP-competitive inhibitors. Neoplasia 15, 975-988 (2013).
-
(2013)
Neoplasia
, vol.15
, pp. 975-988
-
-
Byron, S.A.1
-
144
-
-
84879417823
-
Tumour cell responses to new fibroblast growth factor receptor tyrosine kinase inhibitors and identification of a gatekeeper mutation in FGFR3 as a mechanism of acquired resistance
-
Chell, V., et al. Tumour cell responses to new fibroblast growth factor receptor tyrosine kinase inhibitors and identification of a gatekeeper mutation in FGFR3 as a mechanism of acquired resistance. Oncogene 32, 3059-3070 (2013).
-
(2013)
Oncogene
, vol.32
, pp. 3059-3070
-
-
Chell, V.1
-
145
-
-
85014739217
-
Polyclonal secondary FGFR2 mutations drive acquired resistance to FGFR inhibition in patients with FGFR2 fusion-positive cholangiocarcinoma
-
Goyal, L., et al. Polyclonal secondary FGFR2 mutations drive acquired resistance to FGFR inhibition in patients with FGFR2 fusion-positive cholangiocarcinoma. Cancer Discov. http://dx.doi.org/10.1158/2159-8290.CD-16-1000 (2016).
-
(2016)
Cancer Discov.
-
-
Goyal, L.1
-
146
-
-
84909594628
-
Development of covalent inhibitors that can overcome resistance to first-generation FGFR kinase inhibitors
-
Tan, L., et al. Development of covalent inhibitors that can overcome resistance to first-generation FGFR kinase inhibitors. Proc. Natl Acad. Sci. USA 111, E4869-E4877 (2014).
-
(2014)
Proc. Natl Acad. Sci. USA
, vol.111
, pp. E4869-E4877
-
-
Tan, L.1
-
147
-
-
84939881957
-
Ligand-associated ERBB2/3 activation confers acquired resistance to FGFR inhibition in FGFR3-dependent cancer cells
-
Wang, J., et al. Ligand-associated ERBB2/3 activation confers acquired resistance to FGFR inhibition in FGFR3-dependent cancer cells. Oncogene 34, 2167-2177 (2015).
-
(2015)
Oncogene
, vol.34
, pp. 2167-2177
-
-
Wang, J.1
-
148
-
-
84885229945
-
Parallel RNA interference screens identify EGFR activation as an escape mechanism in FGFR3-mutant cancer
-
Herrera-Abreu, M. T., et al. Parallel RNA interference screens identify EGFR activation as an escape mechanism in FGFR3-mutant cancer. Cancer Discov. 3, 1058-1071 (2013).
-
(2013)
Cancer Discov.
, vol.3
, pp. 1058-1071
-
-
Herrera-Abreu, M.T.1
-
149
-
-
0030834170
-
Differential expression of the fibroblast growth factor receptor (FGFR) multigene family in normal human adult tissues
-
Hughes, S. E. Differential expression of the fibroblast growth factor receptor (FGFR) multigene family in normal human adult tissues. J. Histochem. Cytochem. 45, 1005-1019 (1997).
-
(1997)
J. Histochem. Cytochem.
, vol.45
, pp. 1005-1019
-
-
Hughes, S.E.1
-
150
-
-
84871127930
-
Roles of intracellular fibroblast growth factors in neural development and functions
-
Zhang, X., Bao, L., Yang, L., Wu, Q., Li, S. Roles of intracellular fibroblast growth factors in neural development and functions. Sci. China Life Sci. 55, 1038-1044 (2012).
-
(2012)
Sci. China Life Sci.
, vol.55
, pp. 1038-1044
-
-
Zhang, X.1
Bao, L.2
Yang, L.3
Wu, Q.4
Li, S.5
-
151
-
-
61649100307
-
The FGF family: Biology, pathophysiology and therapy
-
Beenken, A., Mohammadi, M. The FGF family: Biology, pathophysiology and therapy. Nat. Rev. Drug Discov. 8, 235-253 (2009).
-
(2009)
Nat. Rev. Drug Discov.
, vol.8
, pp. 235-253
-
-
Beenken, A.1
Mohammadi, M.2
-
152
-
-
84988807890
-
Metabolic roles of endocrine fibroblast growth factors
-
Fernandes-Freitas, I., Owen, B. M. Metabolic roles of endocrine fibroblast growth factors. Curr. Opin. Pharmacol. 25, 30-35 (2015).
-
(2015)
Curr. Opin. Pharmacol.
, vol.25
, pp. 30-35
-
-
Fernandes-Freitas, I.1
Owen, B.M.2
-
153
-
-
84955209323
-
Therapeutic potential of the endocrine fibroblast growth factors FGF19 FGF21 and FGF23
-
Degirolamo, C., Sabba, C., Moschetta, A. Therapeutic potential of the endocrine fibroblast growth factors FGF19, FGF21 and FGF23. Nat. Rev. Drug Discov. 15, 51-69 (2015).
-
(2015)
Nat. Rev. Drug Discov.
, vol.15
, pp. 51-69
-
-
Degirolamo, C.1
Sabba, C.2
Moschetta, A.3
-
154
-
-
44449108785
-
Regulation of growth factor signaling by FRS2 family docking/scaffold adaptor proteins
-
Gotoh, N. Regulation of growth factor signaling by FRS2 family docking/scaffold adaptor proteins. Cancer Sci. 99, 1319-1325 (2008).
-
(2008)
Cancer Sci.
, vol.99
, pp. 1319-1325
-
-
Gotoh, N.1
-
155
-
-
84893731921
-
Grb-ing receptor activation by the tail
-
Fearon, A. E., Grose, R. P. Grb-ing receptor activation by the tail. Nat. Struct. Mol. Biol. 21, 113-114 (2014).
-
(2014)
Nat. Struct. Mol. Biol.
, vol.21
, pp. 113-114
-
-
Fearon, A.E.1
Grose, R.P.2
-
156
-
-
0037076329
-
FRS2 alpha attenuates FGF receptor signaling by Grb2-mediated recruitment of the ubiquitin ligase Cbl
-
Wong, A., Lamothe, B., Lee, A., Schlessinger, J., Lax, I. FRS2 alpha attenuates FGF receptor signaling by Grb2-mediated recruitment of the ubiquitin ligase Cbl. Proc. Natl Acad. Sci. USA 99, 6684-6689 (2002).
-
(2002)
Proc. Natl Acad. Sci. USA
, vol.99
, pp. 6684-6689
-
-
Wong, A.1
Lamothe, B.2
Lee, A.3
Schlessinger, J.4
Lax, I.5
-
157
-
-
0041856153
-
Tyrosine phosphorylation of Sprouty2 enhances its interaction with c-Cbl and is crucial for its function
-
Fong, C. W., et al. Tyrosine phosphorylation of Sprouty2 enhances its interaction with c-Cbl and is crucial for its function. J. Biol. Chem. 278, 33456-33464 (2003).
-
(2003)
J. Biol. Chem.
, vol.278
, pp. 33456-33464
-
-
Fong, C.W.1
-
158
-
-
84888156818
-
Antagonistic feedback loops involving Rau and Sprouty in the Drosophila eye control neuronal and glial differentiation
-
Sieglitz, F., et al. Antagonistic feedback loops involving Rau and Sprouty in the Drosophila eye control neuronal and glial differentiation. Sci. Signal. 6, ra96 (2013).
-
(2013)
Sci. Signal.
, vol.6
, pp. ra96
-
-
Sieglitz, F.1
-
159
-
-
84989914537
-
FGFR1 is associated with resistance to interaction with estrogen receptor (ER) ? Endocrine therapy in ER+/FGFR1-amplified breast cancer
-
2435
-
Formisano, L., et al. FGFR1 is associated with resistance to interaction with estrogen receptor (ER) ? endocrine therapy in ER+/FGFR1-amplified breast cancer. Cancer Res. 75 (Suppl.), abstr. 2435 (2015).
-
(2015)
Cancer Res.
, vol.75
-
-
Formisano, L.1
-
160
-
-
84929142961
-
Fibroblastic growth factor receptor 1 amplification in osteosarcoma is associated with poor response to neo-adjuvant chemotherapy
-
Fernanda Amary, M., et al. Fibroblastic growth factor receptor 1 amplification in osteosarcoma is associated with poor response to neo-adjuvant chemotherapy. Cancer Med. 3, 980-987 (2014).
-
(2014)
Cancer Med.
, vol.3
, pp. 980-987
-
-
Fernanda Amary, M.1
-
161
-
-
84962251251
-
-
ClinicalTrials.gov
-
US National Library of Medicine. ClinicalTrials.gov https://clinicaltrials.gov/ct2/show/NCT01202591 (2016).
-
(2016)
US National Library of Medicine
-
-
-
162
-
-
84973302297
-
-
ClinicalTrials.gov
-
US National Library of Medicine. ClinicalTrials.gov https://clinicaltrials.gov/ct2/show/NCT01791985 (2015).
-
(2015)
US National Library of Medicine
-
-
-
163
-
-
84979497068
-
A combinatorial strategy for treating KRAS-mutant lung cancer
-
Manchado, E., et al. A combinatorial strategy for treating KRAS-mutant lung cancer. Nature 534, 647-651 (2016).
-
(2016)
Nature
, vol.534
, pp. 647-651
-
-
Manchado, E.1
-
164
-
-
79955675804
-
Rapidly acquired resistance to EGFR tyrosine kinase inhibitors in NSCLC cell lines through de-repression of FGFR2 and FGFR3 expression
-
Ware, K. E., et al. Rapidly acquired resistance to EGFR tyrosine kinase inhibitors in NSCLC cell lines through de-repression of FGFR2 and FGFR3 expression. PLoS ONE 5, e14117 (2010).
-
(2010)
PLoS ONE
, vol.5
, pp. e14117
-
-
Ware, K.E.1
-
165
-
-
84864994126
-
Reactivation of mitogen-activated protein kinase (MAPK) pathway by FGF receptor 3 (FGFR3)/Ras mediates resistance to vemurafenib in human B-RAF V600E mutant melanoma
-
Yadav, V., et al. Reactivation of mitogen-activated protein kinase (MAPK) pathway by FGF receptor 3 (FGFR3)/Ras mediates resistance to vemurafenib in human B-RAF V600E mutant melanoma. J. Biol. Chem. 287, 28087-28098 (2012).
-
(2012)
J. Biol. Chem.
, vol.287
, pp. 28087-28098
-
-
Yadav, V.1
-
166
-
-
84938544763
-
Synthetic lethal screening reveals FGFR as one of the combinatorial targets to overcome resistance to Met-targeted therapy
-
Kim, B., et al. Synthetic lethal screening reveals FGFR as one of the combinatorial targets to overcome resistance to Met-targeted therapy. Oncogene 34, 1083-1093 (2015).
-
(2015)
Oncogene
, vol.34
, pp. 1083-1093
-
-
Kim, B.1
-
167
-
-
84940416459
-
Mutation tracking in circulating tumor DNA predicts relapse in early breast cancer
-
Garcia-Murillas, I., et al. Mutation tracking in circulating tumor DNA predicts relapse in early breast cancer. Sci. Transl Med. 7, 302ra133 (2015).
-
(2015)
Sci. Transl Med.
, vol.7
, pp. 302ra133
-
-
Garcia-Murillas, I.1
-
168
-
-
84904121066
-
Cancer therapy. Ex vivo culture of circulating breast tumor cells for individualized testing of drug susceptibility
-
Yu, M., et al. Cancer therapy. Ex vivo culture of circulating breast tumor cells for individualized testing of drug susceptibility. Science 345, 216-220 (2014).
-
(2014)
Science
, vol.345
, pp. 216-220
-
-
Yu, M.1
-
169
-
-
84919443958
-
Patient-derived models of acquired resistance can identify effective drug combinations for cancer
-
Crystal, A. S., et al. Patient-derived models of acquired resistance can identify effective drug combinations for cancer. Science 346, 1480-1486 (2014).
-
(2014)
Science
, vol.346
, pp. 1480-1486
-
-
Crystal, A.S.1
-
170
-
-
84880547779
-
Activation of the FGF2-FGFR1 autocrine pathway: A novel mechanism of acquired resistance to gefitinib in NSCLC
-
Terai, H., et al. Activation of the FGF2-FGFR1 autocrine pathway: A novel mechanism of acquired resistance to gefitinib in NSCLC. Mol. Cancer Res. 11, 759-767 (2013).
-
(2013)
Mol. Cancer Res.
, vol.11
, pp. 759-767
-
-
Terai, H.1
-
171
-
-
84880525684
-
A mechanism of resistance to gefitinib mediated by cellular reprogramming and the acquisition of an FGF2-FGFR1 autocrine growth loop
-
Ware, K. E., et al. A mechanism of resistance to gefitinib mediated by cellular reprogramming and the acquisition of an FGF2-FGFR1 autocrine growth loop. Oncogenesis 2, e39 (2013).
-
(2013)
Oncogenesis
, vol.2
, pp. e39
-
-
Ware, K.E.1
-
172
-
-
84906217556
-
FGFR1 activation is an escape mechanism in human lung cancer cells resistant to afatinib, a pan-EGFR family kinase inhibitor
-
Azuma, K., et al. FGFR1 activation is an escape mechanism in human lung cancer cells resistant to afatinib, a pan-EGFR family kinase inhibitor. Oncotarget 5, 5908-5919 (2014).
-
(2014)
Oncotarget
, vol.5
, pp. 5908-5919
-
-
Azuma, K.1
-
173
-
-
38849202330
-
Functions of paracrine PDGF signaling in the proangiogenic tumor stroma revealed by pharmacological targeting
-
Pietras, K., Pahler, J., Bergers, G., Hanahan, D. Functions of paracrine PDGF signaling in the proangiogenic tumor stroma revealed by pharmacological targeting. PLoS Med. 5, e19 (2008).
-
(2008)
PLoS Med.
, vol.5
, pp. e19
-
-
Pietras, K.1
Pahler, J.2
Bergers, G.3
Hanahan, D.4
-
174
-
-
84928803593
-
Crosstalk between KIT and FGFR3 promotes gastrointestinal stromal tumor cell growth and drug resistance
-
Javidi-Sharifi, N., et al. Crosstalk between KIT and FGFR3 promotes gastrointestinal stromal tumor cell growth and drug resistance. Cancer Res. 75, 880-891 (2015).
-
(2015)
Cancer Res.
, vol.75
, pp. 880-891
-
-
Javidi-Sharifi, N.1
-
175
-
-
84946040120
-
COSMIC: Exploring the world's knowledge of somatic mutations in human cancer
-
Forbes, S. A., et al. COSMIC: Exploring the world's knowledge of somatic mutations in human cancer. Nucleic Acids Res. 43, D805-D811 (2015).
-
(2015)
Nucleic Acids Res.
, vol.43
, pp. D805-D811
-
-
Forbes, S.A.1
-
176
-
-
84871578629
-
Predicting the functional, molecular, phenotypic consequences of amino acid substitutions using hidden Markov models
-
Shihab, H. A., et al. Predicting the functional, molecular, phenotypic consequences of amino acid substitutions using hidden Markov models. Hum. Mutat. 34, 57-65 (2013).
-
(2013)
Hum. Mutat.
, vol.34
, pp. 57-65
-
-
Shihab, H.A.1
-
177
-
-
15944378835
-
CHIR-258, a novel, multitargeted tyrosine kinase inhibitor for the potential treatment of t(4;14) multiple myeloma
-
Trudel, S., et al. CHIR-258, a novel, multitargeted tyrosine kinase inhibitor for the potential treatment of t(4;14) multiple myeloma. Blood 105, 2941-2948 (2005).
-
(2005)
Blood
, vol.105
, pp. 2941-2948
-
-
Trudel, S.1
-
178
-
-
70350507997
-
AP24534, a pan-BCR-ABL inhibitor for chronic myeloid leukemia, potently inhibits the T315I mutant and overcomes mutation-based resistance
-
O'Hare, T., et al. AP24534, a pan-BCR-ABL inhibitor for chronic myeloid leukemia, potently inhibits the T315I mutant and overcomes mutation-based resistance. Cancer Cell 16, 401-412 (2009).
-
(2009)
Cancer Cell
, vol.16
, pp. 401-412
-
-
O'Hare, T.1
-
179
-
-
79951826312
-
E-3810 is a potent dual inhibitor of VEGFR and FGFR that exerts antitumor activity in multiple preclinical models
-
Bello, E., et al. E-3810 is a potent dual inhibitor of VEGFR and FGFR that exerts antitumor activity in multiple preclinical models. Cancer Res. 71, 1396-1405 (2011).
-
(2011)
Cancer Res.
, vol.71
, pp. 1396-1405
-
-
Bello, E.1
-
180
-
-
80054900437
-
Discovery of 3-(2, 6-dichloro-3, 5-dimethoxy-phenyl)-1-{6-[4-(4-ethyl-piperazin-1-yl)-phenylamin o]-pyrimidin-4-yl}-1-methyl-urea (NVP-BGJ398), a potent and selective inhibitor of the fibroblast growth factor receptor family of receptor tyrosine kinase
-
Guagnano, V., et al. Discovery of 3-(2, 6-dichloro-3, 5-dimethoxy-phenyl)-1-{6-[4-(4-ethyl-piperazin-1-yl)-phenylamin o]-pyrimidin-4-yl}-1-methyl-urea (NVP-BGJ398), a potent and selective inhibitor of the fibroblast growth factor receptor family of receptor tyrosine kinase. J. Med. Chem. 54, 7066-7083 (2011).
-
(2011)
J. Med. Chem.
, vol.54
, pp. 7066-7083
-
-
Guagnano, V.1
-
181
-
-
84937634731
-
Discovery of JNJ-42756493, a potent fibroblast growth factor receptor (FGFR) inhibitor using a fragment based approach
-
4748
-
Angibaud, P. R., et al. Discovery of JNJ-42756493, a potent fibroblast growth factor receptor (FGFR) inhibitor using a fragment based approach. Cancer Res. 74 (Suppl.), abstr. 4748 (2014).
-
(2014)
Cancer Res.
, vol.74
-
-
Angibaud, P.R.1
-
182
-
-
84967117073
-
TAS-120, a highly potent and selective irreversible FGFR inhibitor, is effective in tumors harboring various FGFR gene abnormalities
-
A270
-
Ochiiwa, H., et al. TAS-120, a highly potent and selective irreversible FGFR inhibitor, is effective in tumors harboring various FGFR gene abnormalities. Mol. Cancer Ther. 12 (11 Suppl.), abstr. A270 (2013).
-
(2013)
Mol. Cancer Ther.
, vol.12
, Issue.11
-
-
Ochiiwa, H.1
-
183
-
-
84918793590
-
The fibroblast growth factor receptor genetic status as a potential predictor of the sensitivity to CH5183284/Debio 1347, a novel selective FGFR inhibitor
-
Nakanishi, Y., et al. The fibroblast growth factor receptor genetic status as a potential predictor of the sensitivity to CH5183284/Debio 1347, a novel selective FGFR inhibitor. Mol. Cancer Ther. 13, 2547-2558 (2014).
-
(2014)
Mol. Cancer Ther.
, vol.13
, pp. 2547-2558
-
-
Nakanishi, Y.1
|