Reactivation of Mitogen-activated Protein Kinase (MAPK) pathway by FGF Receptor 3 (FGFR3)/Ras mediates resistance to vemurafenib in human B-RAF V600E mutant melanoma

Journal of Biological Chemistry

Volumn 287, Issue 33, 2012, Pages 28087-28098

  Yadav, Vipin ^a   Zhang, Xiaoyi ^a   Liu, Jiangang ^a   Estrem, Shawn ^a   Li, Shuyu ^a   Gong, Xue Qian ^a   Buchanan, Sean ^a   Henry, James R ^a   Starling, James J ^a   Peng, Sheng Bin ^a  

^a ELI LILLY AND COMPANY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BIOCHEMICAL ANALYSIS; CANCER PROGRESSION; CONTEXT DEPENDENT; FGF RECEPTORS; FIBROBLAST GROWTH FACTOR RECEPTORS; GENETIC INHIBITION; MELANOMA CELLS; MITOGEN ACTIVATED PROTEIN KINASE; RESISTANCE MECHANISMS; THERAPEUTIC STRATEGY; TUMOR PROGRESSIONS; UNDERLYING MECHANISM;

CELL CULTURE; GENE EXPRESSION; ONCOLOGY;

DERMATOLOGY;

B RAF KINASE; FIBROBLAST GROWTH FACTOR RECEPTOR 3; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE KINASE; RAS PROTEIN; VEMURAFENIB;

ARTICLE; CANCER CELL CULTURE; CANCER GROWTH; CELL PROLIFERATION; CONTROLLED STUDY; DNA SEQUENCE; ENZYME INHIBITION; ENZYME REACTIVATION; GENE EXPRESSION; GENE MUTATION; HUMAN; HUMAN CELL; IMMUNOBLOTTING; IMMUNOPRECIPITATION; MELANOMA; MICROARRAY ANALYSIS; MUTATIONAL ANALYSIS; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN PHOSPHORYLATION; RNA ISOLATION; SIGNAL TRANSDUCTION; WESTERN BLOTTING;

AMINO ACID SUBSTITUTION; CELL LINE, TUMOR; DRUG RESISTANCE, NEOPLASM; ENZYME ACTIVATION; HUMANS; INDOLES; MAP KINASE SIGNALING SYSTEM; MELANOMA; MUTATION, MISSENSE; PROTO-ONCOGENE PROTEINS B-RAF; RAS PROTEINS; RECEPTOR, FIBROBLAST GROWTH FACTOR, TYPE 3; SULFONAMIDES;

EID: 84864994126     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M112.377218     Document Type: Article

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