Differential expression of the fibroblast growth factor receptor (FGFR) multigene family in normal human adult tissues

Journal of Histochemistry and Cytochemistry

Volumn 45, Issue 7, 1997, Pages 1005-1019

  Hughes, Siân E ^a  

^a KING'S COLLEGE LONDON   (United Kingdom)

Author keywords

Differential expression; Fibroblast growth factor; Human tissues; Immunolocalization; Receptor

Indexed keywords

FIBROBLAST GROWTH FACTOR RECEPTOR;

ARTICLE; CELL DIFFERENTIATION; ENZYME ACTIVITY; FIBROBLAST; GENE EXPRESSION REGULATION; HOMEOSTASIS; HUMAN; HUMAN TISSUE; IMMUNOPEROXIDASE STAINING; MULTIGENE FAMILY; PRIORITY JOURNAL; RECEPTOR AFFINITY; TISSUE REPAIR; TISSUE SPECIFICITY; WOUND HEALING;

EID: 0030834170     PISSN: 00221554     EISSN: None     Source Type: Journal    
DOI: 10.1177/002215549704500710     Document Type: Article

References (60)

1. Abraham JA, Whang JL, Tumolo A, Mergia A, Friedman J, Gospodarowicz D, Fiddes JC (1986) Human basic fibroblast growth factor: nucleotide sequence and genomic organization. EMBO J 5:2523-2528
2. Armstrong E, Vainikka S, Partanen J, Korhonen J, Alitalo R (1992) Expression of fibroblast growth factor receptors in human leukemia cells. Cancer Res 52:2004-2007
3. Baird A, Bohlen P (1990) Fibroblast growth factors. In Sporn MB, Roberts AB, eds. Handbook of Experimental Pharmacology: Peptide Growth Factors and their Receptors. Berlin, Springer-Verlag, 369-418
4. Barritault D, Groux-Muscatelli B, Caruelle D, Voisin M-C, Chopin D, Palcy S, Caruelle JP (1991) Acidic fibroblast growth factor content increases with malignancy in human chondrosarcoma and bladder cancer. Ann NY Acad Sci 638:387-393
5. Basilico C, Moscatelli D (1992) The FGF family of growth factors and oncogenes. Adv Cancer Res 59:115-165
6. Becker D, Lee PL, Rodeck U, Herlyn M (1992) Inhibition of the fibroblast growth factor receptor 1 (FGFR-1) gene in human melanocytes and malignant melanomas leads to inhibition of proliferation and signs indicative of differentiation. Oncogene 7:2303-2313
7. Bellot F, Crumley G, Kaplow JM, Schlessinger J, Jaye M, Dionne CA (1991) Ligand-induced transphosphorylation between different FGF receptors. EMBO J 10:2849-2854
8. Bernard O, Li M, Reid HH (1991) Expression of two different forms of fibroblast growth factor receptor 1 in different mouse tissues and cell lines. Proc Natl Acad Sci USA 88:7625-7629
9. Brem S, Tsanaclis AMC, Gately S, Gross JL, Herblin WF (1992) Immunolocalization of basic fibroblast growth factor to the microvasculature of human brain tumours. Cancer 70:2673-2680
10. Champion-Arnaud P, Ronsin C, Gilbert E, Gesnel MC, Houssaint E, Breathnach R (1991) Multiple mRNAs code for proteins related to the BEK fibroblast growth factor receptor. Oncogene 6:979-987
11. Chodak GW, Hospelhorn V, Judge SM, Mayforth R, Koeppen H, Sasse J (1988) Increased levels of fibroblast growth factor-like activity in urine from patients with bladder or kidney cancer. Cancer Res 48:2083-2088
12. Cordon-Cardo C, Vlodavsky I, Haimovitz-Friedman A, Hicklin D, Fuks Z (1990) Expression of basic fibroblast growth factor in normal human tissues. Lab Invest 63:832-840
13. Crumley G, Bellot F, Kaplow JM, Schlessinger J, Jaye M, Dionne CA (1991) High-affinity binding and activation of a truncated FGF receptor by both aFGF and bFGF. Oncogene 6:2255-2262
14. DeLapeyriere O, Rosnet O, Benharroch E, Raybaud S, Marchetto J, Planche F, Galland F, Mattei M-G, Copeland NG, Jenkins NA, Coulier F, Birnbaum D (1990) Structure, chromosome mapping and expression of the murine FGF-6 gene. Oncogene 5:823-831
15. Dionne CA, Crumley G, Bellot F, Kaplow JM, Searfoss G, Ruta M, Burgess WH, Jaye M, Schlessinger J (1990) Cloning and expression of two distinct high-affinity receptors cross-reacting with acidic and basic fibroblast growth factors. EMBO J 9:2685-2692
16. Eisemann A, Ahn JA, Graziani G, Tronick SR, Ron D (1991) Alternative splicing generates at least five different isoforms of the human basic-FGF receptor. Oncogene 6:1195-1202
17. Engelmann GL, Dionne CA, Jaye MC (1993) Acidic fibroblast growth factor and heart development. Role in myocyte proliferation and capillary angiogenesis. Circ Res 72:7-19
18. Finch PW, Rubin JS, Miki T, Ron D, Aaronson SA (1989) Human KGF is FGF-related with properties of a paracrine effector of epithelial cell growth. Science 245:752-755
19. Givol D, Yayon A (1992) Complexity of FGF receptors: genetic basis for structural diversity and functional specificity. FASEB J 6:3362-3369
20. Hattori Y, Odagiri H, Nakatani H, Miyagawa K, Naito K, Sakamoto H, Katoh O, Yoshida T, Sugimura T, Terada M (1990) K-sam, an amplified gene in stomach cancer, is a member of the heparin-binding growth factor receptor genes. Proc Natl Acad Sci USA 87:5983-5987
21. Haub O, Goldfarb M (1991) Expression of the fibroblast growth factor-5 gene in the mouse embryo. Development 112:397-406
22. Hebert J, Basilico C, Goldfarb M, Haub O, Martin GR (1990) Isolation of cDNAs encoding four mouse FGF family members and characterization of their expression patterns during embryogenesis. Dev Biol 138:454-463
23. Holtrich U, Brauninger A, Strebhardt K, Rubsamen-Waigmann H (1991) Two additional protein-tyrosine kinases expressed in human lung: fourth member of the fibroblast growth factor receptor family and an intracellular protein-tyrosine kinase. Proc Natl Acad Sci USA 88:10411-10415
24. Hou J, Kan M, McKeehan K, McBride G, Adams P, McKeehan WL (1991) Fibroblast growth factor receptors from liver vary in three structural domains. Science 251:665-668
25. Hughes SE, Hall PA (1993a) Immunolocalization of fibroblast growth factor receptor 1 and its ligands in human tissues. Lab Invest 71:173-182
26. Hughes SE, Hall PA (1993b) Editorial - the fibroblast growth factor and receptor multigene families. J Pathol 170:219-221
27. Hughes SE, Hobbs C, Hall PA (1994) Expression of the fibroblast growth factor receptor (FGFR) multigene family in normal and atherosclerotic human arteries. J Pathol 172:1-49
28. Jakobovits A, Shackleford G, Varmus H, Martin G (1986) Two proto-oncogenes implicated in mammary carcinogenesis, int-1 and int-2, are independently regulated during mouse development. Proc Natl Acad Sci USA 83:7806-7810
29. Jaye M, Howk R, Burgess W, Ricca GA, Chiu IM, Ravera MW, O'Brien SJ, Modi WS, Maciag T, Drohan WN (1986) Human endothelial cell growth factor: cloning nucleotide sequence, and chromosome localization. Science 233:541-545
30. Katoh M, Hattori Y, Sasaki H, Tanaka M, Sugano K, Yazaki Y, Sugimura T, Terada M (1992) K-sam gene encodes secreted as well as transmembrane receptor tyrosine kinase. Proc Natl Acad Sci USA 89:2960-2964
31. Keegan K, Johnson DE, Williams LT, Hayman MJ (1991a) Isolation of an additional member of the fibroblast growth factor receptor family, FGFR-3. Proc Natl Acad Sci USA 88:1095-1099
32. Keegan K, Johnson DE, Williams LT, Hayman MJ (1991c) Characterization of the FGFR-3 gene and its product. Ann NY Acad Sci 638:400-402
33. Keegan K, Meyer S, Hayman MJ (1991b) Structural and biosynthetic characterization of the fibroblast growth factor receptor 3 (FGFR-3) protein. Oncogene 6:2229-2236
34. Korhonen J, Partanen J, Eerola E, Vainikka S, Ilvesmaki V, Voutilainen, Julkunen M, Makela T, Alitalo K (1991) Novel human FGF receptors with distinct expression patterns. Ann NY Acad Sci 638:403-405
35. Kornbluth S, Paulson KE, Hanafusa H (1988) Novel tyrosine kinase identified by phosphotyrosine antibody screening of cDNA libraries. Mol Cell Biol 8:5541-5544
36. Luqmani YA, Graham M, Coombes RC (1992) Expression of basic fibroblast growth factor, FGFR1 and FGFR2 in normal and malignant human breast, and comparison with other normal tissues. Br J Cancer 66:273-280
37. Mignatti P, Morimoto T, Rifkin DB (1992) Basic fibroblast growth factor, a protein devoid of secretory signal sequence, is released by cells via a pathway independent of the endoplasmic reticulum-Golgi complex. J Cell Physiol 151:81-93
38. Miki T, Bottaro DP, Fleming TP, Smith CL, Burgess WH, Chan A, Aaronson SA (1992) Determination of ligand-binding specificity by alternative splicing: two distinct growth factor receptors encoded by a single gene. Proc Natl Acad Sci USA 89:246-250
39. New BA, Yeoman LC (1992) Identification of basic fibroblast growth factor sensitivity and receptor and ligand expression in human colon tumor cell lines. J Cell Physiol 150:320-326
40. Orr-Urtreger A, Givol D, Yayon A, Yarden Y, Lonai P (1991) Developmental expression of two murine fibroblast growth factor receptors, flg and bek. Development 113:1419-1434
41. Partanen J, Makela TP, Alitalo R, Lehvaslaiho H, Alitalo K (1990) Putative tyrosine kinases expressed in K-562 human leukemia cells. Proc Natl Acad Sci USA 87:8913-8917
42. Partanen J, Makela TP, Eerola E, Korhonen H, Hirvonen H, Claesson-Welsh L, Alitalo K (1991) FGFR-4, a novel acidic fibroblast growth factor receptor with a distinct expression pattern. EMBO J 10:1347-1354
43. Patstone G, Pasquale EB, Maher PA (1993) Different members of the fibroblast growth factor receptor family are specific to distinct cell types in the developing chick embryo. Development 155:107-123
44. Peters KG, Werner S, Chen G, Williams LT (1992) Two FGF receptor genes are differentially expressed in epithelial and mesenchymal tissues during limb formation and organogenesis in the mouse. Development 114:233-243
45. Reid HH, Wilks AF, Bernard O (1990) Two forms of the basic fibroblast growth factor receptor-like mRNA are expressed in the developing mouse brain. Proc Natl Acad Sci USA 87:1596-1600
46. Safran A, Avivi A, Orr-Urtereger A, Neufeld G, Lonai P, Givol D, Yarden Y (1990) The murine flg gene encodes a receptor for fibroblast growth factor. Oncogene 5:635-643
47. Schlessinger J, Ullrich A (1992) Growth factor signalling by receptor tyrosine kinases. Neuron 9:383-391
48. Shi E, Kan M, Xu J, Wang F, Hou J, McKeehan WE (1993) Control of fibroblast growth factor receptor kinase signal transduction by heterodimerization of combinatorial splice variants. Mol Cell Biol 13:3907-3917
49. Stark KL, McMahon JA, McMahon AP (1991) FGFR-4, a new member of the fibroblast growth factor receptor family, expressed in the definitive endoderm and skeletal muscle lineages of the mouse. Development 113:641-651
50. Takahashi K, Sawasaki Y, Hata J-I, Mukai K, Goto T (1990) Spontaneous transformation and immortalization of human endothelial cells. In Vitro Cell Dev Biol 25:265-274
51. Takahashi JA, Suzui H, Yasuda Y, Ito N, Ohta M, Jaye M, Fukumoto M, Oda Y, Kikuchi H, Hatanaka M (1991) Gene expression of fibroblast growth factor receptors in the tissues of human gliomas and meningiomas. Biochem Biophys Res Commun 177: 1-7
52. Templeton TJ, Hauschka SD (1992) FGF-mediated aspects of skeletal muscle growth and differentiation are controlled by a high affinity receptor, FGFR1. Dev Biol 154:169-181
53. Vainikka S, Partanen J, Bellosta P, Coulier F, Basilico C, Jaye M, Alitalo K (1992) Fibroblast growth factor receptor-4 shows novel features in genomic structure, ligand binding and signal transduction. EMBO J 11:4273-4280
54. Wanaka A, Milbrandt J, Johnson EM Jr (1990) Localization of FGF receptor mRNA in the adult rat central nervous system by in situ hybridization. Neuron 5:267-281
55. Wanaka A, Milbrandt J, Johnson EM Jr (1991) Expression of FGF receptor gene in rat development. Development 111:455-468
56. Werner S, Duan D-S, de Vries C, Peters KG, Johnson DE, Williams LT (1992) Differential splicing in the extracellular region of fibroblast growth factor receptor 1 generates receptor variants with different ligand-binding specificities. Mol Cell Biol 12: 82-88
57. Wilkinson D, Bhatt S, McMahon A (1989) Expression pattern of the FGF-related proto-oncogene int-2 suggests multiple roles in fetal development. Development 105:131-136
58. Van G, Fukabori Y, McBride G, Nikolaropolous S, McKeehan WL (1993) Exon switching and activation of stromal and embryonic fibroblast growth factor (FGF)-FGF receptor genes in prostate epithelial cells accompany stromal independence and malignancy. Mol Cell Biol 13:4513-4522
59. Yan G, Wang F, Fukabori Y, Sussman D, Hou J, McKeehan WL (1992) Expression and transformation of a variant of the heparin-binding fibroblast growth factor receptor (flg) gene resulting from splicing of the α exon at alternate 3′-acceptor site. Biochem Biophys Res Commun 183:423-430
60. Yoshida T, Tsutsumi H, Sakamoto K, Miyagawa S, Teshima S, Sugimura T, Terada M (1988) Expression of the HST1 oncogene in human germ cell tumors. Biochem Biophys Res Commun 155:1324-1329