FGFR1 activation is an escape mechanism in human lung cancer cells resistant to afatinib, a pan-EGFR family kinase inhibitor

Oncotarget

Volumn 5, Issue 15, 2014, Pages 5908-5919

  Azuma, Koichi ^a   Kawahara, Akihiko ^b   Sonoda, Kahori ^c   Nakashima, Kazutaka ^b   Tashiro, Kousuke ^c   Watari, Kosuke ^c   Izumi, Hiroto ^d   Kage, Masayoshi ^b   Kuwano, Michihiko ^c   Ono, Mayumi ^c   Hoshino, Tomoaki ^a  

^a KURUME UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^b KURUME UNIVERSITY HOSPITAL   (Japan)

^c KYUSHU UNIVERSITY   (Japan)

^d UNIVERSITY OF OCCUPATIONAL AND ENVIRONMENTAL HEALTH   (Japan)

Author keywords

Activating EGFR mutation; Afatinib; FGFR1; Non small cell lung cancer

Indexed keywords

1 TERT BUTYL 3 [6 (3,5 DIMETHOXYPHENYL) 2 (4 DIETHYLAMINOBUTYLAMINO)PYRIDO[2,3 D]PYRIMIDIN 7 YL]UREA; AFATINIB; AXITINIB; CISPLATIN; DASATINIB; EPIDERMAL GROWTH FACTOR RECEPTOR; FIBROBLAST GROWTH FACTOR 2; FIBROBLAST GROWTH FACTOR RECEPTOR 1; FORETINIB; GEFITINIB; LAPATINIB; MITOGEN ACTIVATED PROTEIN KINASE; PACLITAXEL; PROTEIN KINASE B; SMALL INTERFERING RNA; TRANSCRIPTION FACTOR TWIST; EGFR PROTEIN, HUMAN; FGFR1 PROTEIN, HUMAN; NUCLEAR PROTEIN; ONCOPROTEIN; PROTEIN KINASE INHIBITOR; QUINAZOLINE DERIVATIVE; TWIST1 PROTEIN, HUMAN;

ARTICLE; CANCER CELL; CELL SURVIVAL; CONTROLLED STUDY; DOWN REGULATION; DRUG SENSITIVITY; HUMAN; HUMAN CELL; LUNG CANCER; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; UPREGULATION; ANTAGONISTS AND INHIBITORS; CARCINOMA, NON-SMALL-CELL LUNG; DRUG RESISTANCE; ENZYMOLOGY; GENE SILENCING; GENETIC TRANSFECTION; GENETICS; LUNG NEOPLASMS; METABOLISM; MUTATION; TUMOR CELL LINE;

CARCINOMA, NON-SMALL-CELL LUNG; CELL LINE, TUMOR; DRUG RESISTANCE, NEOPLASM; GENE KNOCKDOWN TECHNIQUES; HUMANS; LUNG NEOPLASMS; MUTATION; NUCLEAR PROTEINS; ONCOGENE PROTEIN V-AKT; PROTEIN KINASE INHIBITORS; QUINAZOLINES; RECEPTOR, EPIDERMAL GROWTH FACTOR; RECEPTOR, FIBROBLAST GROWTH FACTOR, TYPE 1; TRANSFECTION; TWIST TRANSCRIPTION FACTOR;

EID: 84906217556     PISSN: None     EISSN: 19492553     Source Type: Journal    
DOI: 10.18632/oncotarget.1866     Document Type: Article

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