CYP2A6*6, a Novel Polymorphism in Cytochrome P450 2A6, Has a Single Amino Acid Substitution (R128Q) that Inactivates Enzymatic Activity

Journal of Biological Chemistry

Volumn 276, Issue 21, 2001, Pages 17830-17835

  Kitagawa, Kyoko ^a   Kunugita, Naoki ^a   Kitagawa, Masatoshi ^b   Kawamoto, Toshihiro ^a  

^a UNIVERSITY OF OCCUPATIONAL AND ENVIRONMENTAL HEALTH   (Japan)

^b HAMAMATSU UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACIDS; CELLS; CYTOLOGY; HYDROXYLATION; SUBSTITUTION REACTIONS;

ISOZYMES; POLYMORPHISM;

ENZYMES;

AMINO ACID; ARGININE; COUMARIN 7 HYDROXYLASE; CYTOCHROME P450 2A6; GLUTAMINE; HEME; ISOENZYME; COUMARIN 7-HYDROXYLASE; CYTOCHROME P450; MIXED FUNCTION OXIDASE; UNSPECIFIC MONOOXYGENASE;

AMINO ACID SUBSTITUTION; ARTICLE; BACULOVIRUS; CELL LYSATE; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME INACTIVATION; FEMALE; GENETIC POLYMORPHISM; GENETIC TRANSFECTION; HUMAN; HYDROXYLATION; INSECT CELL; MALE; NORMAL HUMAN; NUCLEOTIDE SEQUENCE; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN STRUCTURE; REDUCTION; RESTRICTION FRAGMENT LENGTH POLYMORPHISM; AMINO ACID SEQUENCE; ENZYME ACTIVATION; GENETICS; GENOME; MOLECULAR GENETICS; POINT MUTATION;

INSECTA; UNIDENTIFIED BACULOVIRUS;

AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; ARYL HYDROCARBON HYDROXYLASES; CYTOCHROME P-450 ENZYME SYSTEM; ENZYME ACTIVATION; FEMALE; GENOME, HUMAN; HUMANS; MALE; MIXED FUNCTION OXYGENASES; MOLECULAR SEQUENCE DATA; POINT MUTATION; POLYMORPHISM, GENETIC;

EID: 0035947589     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M009432200     Document Type: Article

References (30)

1. Crespi, C. L., Penman, B. W., Glboin, H. V., and Gonzalez, F. J. (1991) Carcinogenesis 12, 1197-1201
2. Yamazaki, H., Inui, Y., Yun, C. H., Guengerich, F. P., and Shimada, T. (1992) Carcinogenesis 13, 1789-1794
3. Nakajima, M., Yamamoto, T., Nunoya, K., Yokoi, T., Nagashima, K., Inoue, K., Funae, Y., Shimada, N., Kamataki, T., and Kuroiwa, Y. (1996) Drug Metab. Dispos. 24, 1212-1217
4. Yamazaki, H., Inoue, K., Hashimoto, M., and Shimada, T. (1999) Arch. Toxicol. 73, 65-70
5. Nakajima, M., Yamamoto, T.; Nunoya, K., Yokoi, T., Nagashima, K., Inoue, K., Funae, Y., Shimada, N., Kamataki, T., and Kuroiwa, Y. (1996) J. Pharmacol. Exp. Ther. 277, 1010-1015
6. Kitagawa, K., Kunugita, N., Katoh, T., Yang, M., and Kawamoto, T. (1999) Biochem. Biophys. Res. Commun. 262, 146-151
7. Nakajima, M., Yamagishi, S., Yamamoto, H., Yamamoto, T., Kuroiwa, Y., and Yokoi, T. (2000) Clin. Pharmacol. Ther. 67, 57-69
8. Yamano, S., Tatsuno, J., and Gonzalez, F. J. (1990) Biochemistry 29, 1322-1329
9. Fernandez-Salguero, P., Hoffman, S. M. G., Cholerton, S., Mohreweiser, H., Raunio, H., Rautio, A., Pelkonen, O., Huang, J.-D., Evans, W. E., Idle, J. R., and Gonzalez, F. J. (1995) Am. J. Hum. Genet. 57, 651-660
10. Oscarson, M., NcLellan, R. A., Gullsten, H., Agundez, J. A. G., Benitez, J., Rautio, H., Pelkonen, O., and Ingelman-Sundberg, M. (1999) FEBS Lett. 460, 321-327
11. Lewis, D. F. V., and Moereels, H. (1992) J. Comput. Aided Mol. Des. 6, 235-252
12. Lewis, D. F. V. (1995) Xenobiotica 25, 333-366
13. Lewis, D. F. V., and Lake, B. G. (1995) Xenobiotica 25, 585-598
14. Sato, H., Ido, K., and Kimura, K. (1994) Clin. Chem. 40, 1239-1244
15. Omura, T., and Sato, R. (1964) J. Biol. Chem. 239, 2370-2378
16. Inoue, K., Yamazaki, H., and Shimada, T. (2000) Arch. Toxicol. 73, 532-539
17. Gotoh, O. (1992) J. Biol. Chem. 267, 83-90
18. Graham-Lorence, S. E., and Peterson, J. A. (1996) Methods Enzymol. 272, 315-326
19. Asseffa, A., Smith, S. J., Nagata, K., Gillette, J., Gelboin, H. V., and Gonzalez, F. J. (1989) Arch. Biochem. Biophys. 274, 481-490
20. Gonzalez, F. J., Kimura, S., Tamura, S., and Gelboin, H. V. (1995) Methods Enzymol. 206, 93-99
21. Poulos, T. L., Finzel, B. C., and Howard, A. J. (1987) J. Mol. Biol. 195, 687-700
22. Koskela, S., Hakkola, J., Hukkanen, J., Pelkonen, O., Sorri, M., Saranen, A., Anttila, S., Fernandez-Salguero, P., Gonzalez, F. J., and Raunio, H. (1999) Biochem. Pharmacol. 57, 1407-1413
23. Porter, T. D. (1994) Biochemistry 33, 5942-5946
24. Hsu, L. C., Hsu, N. C., Guzova, J. A., Guzov, V. M., Chang, S. F., and Chung, B. (1996) J. Biol. Chem. 271, 3306-3310
25. Oscarson, M., McLellan, R. A., Gullsten, H., Yue, Q., Lang, M. A., Bernal, M. L., Sinues, B., Hirvonen, A., Raunio, H., Pelkonen, O., and Ingelman-Sundberg, M. (1999) FEBS Lett. 448, 105-110
26. Chen, G. F., Tang, Y. M., Green, B., Lin, D. X., Guengerich, F. P., Daly, A. K., Caporaso, N. E., and kadlubar, F. F. (1999) Pharmacogenetics 9, 327-332
27. Bourian, M., Gullsten, H., and Legrum, W. (2000) Toxicology 144, 129-137
28. Hadidi, H., Zahlsen, K., Idle, J. R., and Cholerton, S. (1997) Food Chem. Toxicol. 35, 903-907
29. Shilling, W. H., Crampton, R. F., and Longland, R. C. (1969) Nature 221, 664-665
30. Lake, B. G., Gaudin, H., Price, R. J., and Walters, D. G. (1992) Food Chem. Toxicol. 30, 105-115