A new CYP2A6 gene deletion responsible for the in vivo polymorphic metabolism of (+)-cis-3,5-dimethyl-2-(3-pyridyl)thiazolidin-4-one hydrochloride in humans

Journal of Pharmacology and Experimental Therapeutics

Volumn 289, Issue 1, 1999, Pages 437-442

  Nunoya, Ken Ichi ^a   Yokoi, Tsuyoshi ^a   Kimura, Kanzo ^b   Kainuma, Tadashi ^c   Satoh, Kunio ^d   Kinoshita, Moritoshi ^e   Kamataki, Tetsuya ^a  

^a HOKKAIDO UNIVERSITY   (Japan)

^b DAINIPPON SUMITOMO PHARMA CO LTD   (Japan)

^c Kouseikai Kinen Hospital   (Japan)

^d GUNMA UNIVERSITY   (Japan)

^e OTSUKA PHARMACEUTICAL CO LTD   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

3,5 DIMETHYL 2 (3 PYRIDYL) 4 THIAZOLIDINONE; CYTOCHROME P450 2A6; CYTOCHROME P450 ISOENZYME; DNA; THROMBOCYTE ACTIVATING FACTOR ANTAGONIST; UNCLASSIFIED DRUG;

ADULT; AREA UNDER THE CURVE; ARTICLE; CONTROLLED STUDY; DRUG BLOOD LEVEL; DRUG DISPOSITION; DRUG HALF LIFE; DRUG METABOLISM; DRUG URINE LEVEL; GENE DELETION; HUMAN; HUMAN CELL; HUMAN EXPERIMENT; INTRAVENOUS DRUG ADMINISTRATION; JAPAN; LEUKOCYTE; MALE; NORMAL HUMAN; PHENOTYPE; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; RESTRICTION FRAGMENT LENGTH POLYMORPHISM; SOUTHERN BLOTTING;

ADULT; ALLELES; ARYL HYDROCARBON HYDROXYLASES; BASE SEQUENCE; BLOTTING, SOUTHERN; CYTOCHROME P-450 ENZYME SYSTEM; DEOXYRIBONUCLEASES, TYPE II SITE-SPECIFIC; DNA; EXONS; GENE LIBRARY; HUMANS; LEUKOCYTES; MALE; MIXED FUNCTION OXYGENASES; MOLECULAR SEQUENCE DATA; PHENOTYPE; PLATELET AGGREGATION INHIBITORS; POLYMORPHISM, RESTRICTION FRAGMENT LENGTH; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; SEQUENCE DELETION; THIAZOLES; THIAZOLIDINES;

EID: 0032945691     PISSN: 00223565     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

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