A single amino acid substitution (Leu160His) in cytochrome P450 CYP2A6 causes switching from 7-hydroxylation to 3-hydroxylation of coumarin

Food and Chemical Toxicology

Volumn 35, Issue 9, 1997, Pages 903-907

  Hadidi, H ^a,d   Zahlsen, K ^b   Idle, J R ^a,b   Cholerton, S ^c  

^a NORWEGIAN UNIVERSITY OF SCIENCE AND TECHNOLOGY   (Norway)

^b TRONDHEIM UNIVERSITY HOSPITAL   (Norway)

^c NEWCASTLE UNIVERSITY   (United Kingdom)

^d JORDAN UNIVERSITY OF SCIENCE AND TECHNOLOGY   (Jordan)

Author keywords

[No Author keywords available]

Indexed keywords

COUMARIN; CYTOCHROME P450 ISOENZYME;

ADOLESCENT; AMINO ACID SUBSTITUTION; ARTICLE; CHILD; DRUG HYDROXYLATION; FEMALE; HUMAN; HUMAN EXPERIMENT; MALE; ORAL DRUG ADMINISTRATION; SCHOOL CHILD; URINARY EXCRETION;

ADOLESCENT; ADULT; ARYL HYDROCARBON HYDROXYLASES; CHILD; COUMARINS; CYTOCHROME P-450 ENZYME SYSTEM; FEMALE; HUMANS; HYDROXYLATION; MALE; MIDDLE AGED; MIXED FUNCTION OXYGENASES; MUTATION; POLYMORPHISM, GENETIC; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0030697098     PISSN: 02786915     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0278-6915(97)00066-5     Document Type: Article

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