메뉴 건너뛰기




Volumn 79, Issue , 2017, Pages 495-515

Mitochondrial Dysfunction in Lung Pathogenesis

Author keywords

Inflammasome; Mitochondrial biogenesis; Mitophagy; Oxidants; Reactive oxygen species; Respiration

Indexed keywords

INFLAMMASOME;

EID: 85013040966     PISSN: 00664278     EISSN: 15451585     Source Type: Book Series    
DOI: 10.1146/annurev-physiol-022516-034322     Document Type: Review
Times cited : (86)

References (148)
  • 1
    • 84975755192 scopus 로고    scopus 로고
    • MitochondrialROSsignaling in organismal homeostasis
    • ShadelGS, HorvathTL. 2015. MitochondrialROSsignaling in organismal homeostasis. Cell 163(3):560-69
    • (2015) Cell , vol.163 , Issue.3 , pp. 560-569
    • Shadel, G.S.1    Horvath, T.L.2
  • 2
    • 84857388966 scopus 로고    scopus 로고
    • Transcriptional control of mitochondrial biogenesis and its interface with inflammatory processes
    • Piantadosi CA, Suliman HB. 2012. Transcriptional control of mitochondrial biogenesis and its interface with inflammatory processes. Biochim. Biophys. Acta 1820(4):532-41
    • (2012) Biochim. Biophys. Acta , vol.1820 , Issue.4 , pp. 532-541
    • Piantadosi, C.A.1    Suliman, H.B.2
  • 3
    • 84880809979 scopus 로고    scopus 로고
    • Respiratory supercomplexes: Structure, function and assembly
    • Vartak R, Porras CA, Bai Y. 2013. Respiratory supercomplexes: structure, function and assembly. Protein Cell 4(8):582-90
    • (2013) Protein Cell , vol.4 , Issue.8 , pp. 582-590
    • Vartak, R.1    Porras, C.A.2    Bai, Y.3
  • 4
    • 84880387219 scopus 로고    scopus 로고
    • A stabilizing factor for mitochondrial respiratory supercomplex assembly regulates energy metabolism in muscle
    • Ikeda K, Shiba S, Horie-Inoue K, Shimokata K, Inoue S. 2013. A stabilizing factor for mitochondrial respiratory supercomplex assembly regulates energy metabolism in muscle. Nat. Commun. 4:2147
    • (2013) Nat. Commun , vol.4 , pp. 2147
    • Ikeda, K.1    Shiba, S.2    Horie-Inoue, K.3    Shimokata, K.4    Inoue, S.5
  • 5
    • 0020560675 scopus 로고
    • Cells of the lung: Biology and clinical implications
    • Gail DB, Lenfant CJ. 1983. Cells of the lung: biology and clinical implications. Am. Rev. Respir. Dis. 127(3):366-87
    • (1983) Am. Rev. Respir. Dis , vol.127 , Issue.3 , pp. 366-387
    • Gail, D.B.1    Lenfant, C.J.2
  • 7
    • 0018337607 scopus 로고
    • Assay of citric acid cycle intermediates and related compounds-update with tissue metabolite levels and intracellular distribution
    • Williamson JR, Corkey BE. 1979. Assay of citric acid cycle intermediates and related compounds-update with tissue metabolite levels and intracellular distribution. Methods Enzymol. 55:200-22
    • (1979) Methods Enzymol , vol.55 , pp. 200-222
    • Williamson, J.R.1    Corkey, B.E.2
  • 8
    • 0016186809 scopus 로고
    • Effects of short-term ozone exposure on lung mitochondrial oxidative and energy metabolism
    • Mustafa MG, Cross CE. 1974. Effects of short-term ozone exposure on lung mitochondrial oxidative and energy metabolism. Arch. Biochem. Biophys. 162(2):585-94
    • (1974) Arch. Biochem. Biophys , vol.162 , Issue.2 , pp. 585-594
    • Mustafa, M.G.1    Cross, C.E.2
  • 9
    • 84865798029 scopus 로고    scopus 로고
    • Cytochrome c oxidase subunit 4 isoform 2-knockout mice show reduced enzyme activity, airway hyporeactivity, and lung pathology
    • Hüttemann M, Lee I, Gao X, Pecina P, Pecinova A, et al. 2012. Cytochrome c oxidase subunit 4 isoform 2-knockout mice show reduced enzyme activity, airway hyporeactivity, and lung pathology. FASEB J. 26(9):3916-30
    • (2012) FASEB J , vol.26 , Issue.9 , pp. 3916-3930
    • Hüttemann, M.1    Lee, I.2    Gao, X.3    Pecina, P.4    Pecinova, A.5
  • 11
    • 84959019199 scopus 로고    scopus 로고
    • LPS impairs oxygen utilization in epithelia by triggering degradation of the mitochondrial enzyme Alcat1
    • Zou C, Synan MJ, Li J, Xiong S, Manni ML, et al. 2016. LPS impairs oxygen utilization in epithelia by triggering degradation of the mitochondrial enzyme Alcat1. J. Cell Sci. 129(1):51-64
    • (2016) J. Cell Sci. , vol.129 , Issue.1 , pp. 51-64
    • Zou, C.1    Synan, M.J.2    Li, J.3    Xiong, S.4    Manni, M.L.5
  • 12
    • 0016706791 scopus 로고
    • Lung oxygen consumption and mitochondria of alveolar epithelial and endothelial cells
    • Massaro GD, Gail DB, Massaro D. 1975. Lung oxygen consumption and mitochondria of alveolar epithelial and endothelial cells. J. Appl. Physiol. 38(4):588-92
    • (1975) J. Appl. Physiol , vol.38 , Issue.4 , pp. 588-592
    • Massaro, G.D.1    Gail, D.B.2    Massaro, D.3
  • 14
    • 0021141354 scopus 로고
    • Differentiation of human pulmonary alveolar epithelial cells revealed by peroxisome changes in pulmonary proteinosis
    • MoriguchiK,Higashi N, Kitagawa S,TakaseK,OhyaN, et al. 1984. Differentiation of human pulmonary alveolar epithelial cells revealed by peroxisome changes in pulmonary proteinosis. Exp. Mol. Pathol. 40(2):262-70
    • (1984) Exp. Mol. Pathol , vol.40 , Issue.2 , pp. 262-270
    • Moriguchi, K.1    Higashi, N.2    Kitagawa, S.3    Takase, K.4    Ohya, N.5
  • 15
    • 0022997070 scopus 로고
    • Cytochemical quantitation of cytochrome oxidase activity in rat pulmonary alveolar epithelial cells and possible defect in type i cells
    • Hirai K, Ogawa K. 1986. Cytochemical quantitation of cytochrome oxidase activity in rat pulmonary alveolar epithelial cells and possible defect in type I cells. J. Electron. Microsc. 35(1):19-28
    • (1986) J. Electron. Microsc , vol.35 , Issue.1 , pp. 19-28
    • Hirai, K.1    Ogawa, K.2
  • 17
    • 84858376953 scopus 로고    scopus 로고
    • Mitochondria: In sickness and in health
    • Nunnari J, Suomalainen A. 2012. Mitochondria: in sickness and in health. Cell 148(6):1145-59
    • (2012) Cell , vol.148 , Issue.6 , pp. 1145-1159
    • Nunnari, J.1    Suomalainen, A.2
  • 18
    • 84989336819 scopus 로고    scopus 로고
    • The role ofmitochondrialDNAmutation on neurodegenerative diseases
    • ChaMY, Kim DK,Mook-Jung I. 2015. The role ofmitochondrialDNAmutation on neurodegenerative diseases. Exp. Mol. Med. 47:e150
    • (2015) Exp. Mol. Med , vol.47 , pp. e150
    • Cha, M.Y.1    Kim, D.K.2    Mook-Jung, I.3
  • 19
    • 84920528079 scopus 로고    scopus 로고
    • Sequential actions of SIRT1-RELB-SIRT3 coordinate nuclear-mitochondrial communication during immunometabolic adaptation to acute inflammation and sepsis
    • Liu TF, Vachharajani V, Millet P, Bharadwaj MS, Molina AJ, McCall CE. 2015. Sequential actions of SIRT1-RELB-SIRT3 coordinate nuclear-mitochondrial communication during immunometabolic adaptation to acute inflammation and sepsis. J. Biol. Chem. 290(1):396-408
    • (2015) J. Biol. Chem. , vol.290 , Issue.1 , pp. 396-408
    • Liu, T.F.1    Vachharajani, V.2    Millet, P.3    Bharadwaj, M.S.4    Molina, A.J.5    McCall, C.E.6
  • 20
    • 78651393239 scopus 로고    scopus 로고
    • A role for mitochondria in NLRP3 inflammasome activation
    • Zhou R, Yazdi AS, Menu P, Tschopp J. 2011. A role for mitochondria in NLRP3 inflammasome activation. Nature 469:221-25
    • (2011) Nature , vol.469 , pp. 221-225
    • Zhou, R.1    Yazdi, A.S.2    Menu, P.3    Tschopp, J.4
  • 21
    • 84926658826 scopus 로고    scopus 로고
    • Intratracheal administration of mitochondrial DNA directly provokes lung inflammation through the TLR9-p38 MAPK pathway
    • Gu X, Wu G, Yao Y, Zeng J, Shi D, et al. 2015. Intratracheal administration of mitochondrial DNA directly provokes lung inflammation through the TLR9-p38 MAPK pathway. Free Radic. Biol. Med. 83:149-58
    • (2015) Free Radic. Biol. Med , vol.83 , pp. 149-158
    • Gu, X.1    Wu, G.2    Yao, Y.3    Zeng, J.4    Shi, D.5
  • 22
    • 70149091965 scopus 로고    scopus 로고
    • Subcellular localization ofNox4 and regulation in diabetes
    • Block K, Gorin Y, Abboud HE. 2009. Subcellular localization ofNox4 and regulation in diabetes. PNAS 106(34):14385-90
    • (2009) PNAS , vol.106 , Issue.34 , pp. 14385-14390
    • Block, K.1    Gorin, Y.2    Abboud, H.E.3
  • 23
    • 77951281040 scopus 로고    scopus 로고
    • Upregulation of Nox4 by hypertrophic stimuli promotes apoptosis and mitochondrial dysfunction in cardiac myocytes
    • Ago T, Kuroda J, Pain J, Fu C, Li H, Sadoshima J. 2010. Upregulation of Nox4 by hypertrophic stimuli promotes apoptosis and mitochondrial dysfunction in cardiac myocytes. Circ. Res. 106(7):1253-64
    • (2010) Circ. Res. , vol.106 , Issue.7 , pp. 1253-1264
    • Ago, T.1    Kuroda, J.2    Pain, J.3    Fu, C.4    Li, H.5    Sadoshima, J.6
  • 24
    • 77249126523 scopus 로고    scopus 로고
    • Mitochondrial reserve capacity in endothelial cells: The impact of nitric oxide and reactive oxygen species
    • Dranka BP, Hill BG, Darley-Usmar VM. 2010. Mitochondrial reserve capacity in endothelial cells: the impact of nitric oxide and reactive oxygen species. Free Radic. Biol. Med. 48(7):905-14
    • (2010) Free Radic. Biol. Med , vol.48 , Issue.7 , pp. 905-914
    • Dranka, B.P.1    Hill, B.G.2    Darley-Usmar, V.M.3
  • 25
    • 84901410479 scopus 로고    scopus 로고
    • Mitochondria as signaling organelles
    • Chandel NS. 2014. Mitochondria as signaling organelles. BMC Biol. 12:34
    • (2014) BMC Biol. , vol.12 , pp. 34
    • Chandel, N.S.1
  • 28
    • 84873681470 scopus 로고    scopus 로고
    • Mitochondria in vascular health and disease
    • Dromparis P, Michelakis ED. 2013. Mitochondria in vascular health and disease. Annu. Rev. Physiol. 75:95-126
    • (2013) Annu. Rev. Physiol , vol.75 , pp. 95-126
    • Dromparis, P.1    Michelakis, E.D.2
  • 29
    • 84977507268 scopus 로고    scopus 로고
    • Retrograde signaling: Organelles go networking
    • Kleine T, Leister D. 2016. Retrograde signaling: organelles go networking. Biochim. Biophys. Acta 1857:1313-25
    • (2016) Biochim. Biophys. Acta , vol.1857 , pp. 1313-1325
    • Kleine, T.1    Leister, D.2
  • 30
    • 84868007565 scopus 로고    scopus 로고
    • Physiological roles of mitochondrial reactive oxygen species
    • Sena LA, Chandel NS. 2012. Physiological roles of mitochondrial reactive oxygen species. Mol. Cell 48(2):158-67
    • (2012) Mol. Cell , vol.48 , Issue.2 , pp. 158-167
    • Sena, L.A.1    Chandel, N.S.2
  • 31
    • 78650208106 scopus 로고    scopus 로고
    • Metabolism strikes back:Metabolic flux regulates cell signaling
    • Metallo CM, VanderHeidenMG. 2010. Metabolism strikes back:metabolic flux regulates cell signaling. Genes Dev. 24(24):2717-22
    • (2010) Genes Dev , vol.24 , Issue.24 , pp. 2717-2722
    • Metallo, C.M.1    VanderHeiden, M.G.2
  • 32
    • 84875755814 scopus 로고    scopus 로고
    • Influence of metabolism on epigenetics and disease
    • KaelinWGJr., McKnight SL. 2013. Influence of metabolism on epigenetics and disease. Cell 153(1):56-69
    • (2013) Cell , vol.153 , Issue.1 , pp. 56-69
    • Kaelin, W.G.1    McKnight, S.L.2
  • 33
    • 84885670616 scopus 로고    scopus 로고
    • Fueling immunity: Insights into metabolism and lymphocyte function
    • Pearce EL, Poffenberger MC, Chang CH, Jones RG. 2013. Fueling immunity: insights into metabolism and lymphocyte function. Science 342:1242454
    • (2013) Science , vol.342 , pp. 1242454
    • Pearce, E.L.1    Poffenberger, M.C.2    Chang, C.H.3    Jones, R.G.4
  • 34
    • 84902795026 scopus 로고    scopus 로고
    • Time-dependent and somatically acquired mitochondrial DNA mutagenesis and respiratory chain dysfunction in a scleroderma model of lung fibrosis
    • Gazdhar A, Lebrecht D, Roth M, Tamm M, Venhoff N, et al. 2014. Time-dependent and somatically acquired mitochondrial DNA mutagenesis and respiratory chain dysfunction in a scleroderma model of lung fibrosis. Sci. Rep. 4:5336
    • (2014) Sci. Rep. , vol.4 , pp. 5336
    • Gazdhar, A.1    Lebrecht, D.2    Roth, M.3    Tamm, M.4    Venhoff, N.5
  • 36
    • 0037449724 scopus 로고    scopus 로고
    • Cell sorting experiments link persistent mitochondrial DNA damage with loss of mitochondrial membrane potential and apoptotic cell death
    • Santos JH,HunakovaL,ChenY,Bortner C, Van Houten B. 2003. Cell sorting experiments link persistent mitochondrial DNA damage with loss of mitochondrial membrane potential and apoptotic cell death. J. Biol. Chem. 278(3):1728-34
    • (2003) J. Biol. Chem. , vol.278 , Issue.3 , pp. 1728-1734
    • Santos, J.H.1    Hunakova, L.2    Chen, Y.3    Bortner, C.4    Van Houten, B.5
  • 37
    • 84961290427 scopus 로고    scopus 로고
    • PINK1 deficiency impairs mitochondrial homeostasis and promotes lung fibrosis
    • BuenoM, Lai YC, Romero Y, Brands J, Croix CM, et al. 2015. PINK1 deficiency impairs mitochondrial homeostasis and promotes lung fibrosis. J. Clin. Investig. 125(2):521-38
    • (2015) J. Clin. Investig , vol.125 , Issue.2 , pp. 521-538
    • Bueno, M.1    Lai, Y.C.2    Romero, Y.3    Brands, J.4    Croix, C.M.5
  • 38
    • 59649097080 scopus 로고    scopus 로고
    • A protein kinaseC-dependent protein kinaseDpathwaymodulates ERK1/2 and JNK1/2 phosphorylation and Bim-associated apoptosis by asbestos
    • Buder-Hoffmann SA, Shukla A, Barrett TF, MacPherson MB, Lounsbury KM, Mossman BT. 2009. A protein kinaseC-dependent protein kinaseDpathwaymodulates ERK1/2 and JNK1/2 phosphorylation and Bim-associated apoptosis by asbestos. Am. J. Pathol. 174(2):449-59
    • (2009) Am. J. Pathol , vol.174 , Issue.2 , pp. 449-459
    • Buder-Hoffmann, S.A.1    Shukla, A.2    Barrett, T.F.3    MacPherson, M.B.4    Lounsbury, K.M.5    Mossman, B.T.6
  • 39
    • 0036087033 scopus 로고    scopus 로고
    • Increased localization and substrate activation of protein kinase C in lung epithelial cells following exposure to asbestos
    • Lounsbury KM, Stern M, Taatjes D, Jaken S, Mossman BT. 2002. Increased localization and substrate activation of protein kinase C in lung epithelial cells following exposure to asbestos. Am. J. Pathol. 160(6):1991-2000
    • (2002) Am. J. Pathol , vol.160 , Issue.6 , pp. 1991-2000
    • Lounsbury, K.M.1    Stern, M.2    Taatjes, D.3    Jaken, S.4    Mossman, B.T.5
  • 40
    • 79951977334 scopus 로고    scopus 로고
    • Regulation of mitochondrial biogenesis
    • Jornayvaz FR, Shulman GI. 2010. Regulation of mitochondrial biogenesis. Essays Biochem. 47:69-84
    • (2010) Essays Biochem , vol.47 , pp. 69-84
    • Jornayvaz, F.R.1    Shulman, G.I.2
  • 41
    • 84866295745 scopus 로고    scopus 로고
    • Nrf2 promotes alveolar mitochondrial biogenesis and resolution of lung injury in Staphylococcus aureus pneumonia in mice
    • Athale J, Ulrich A, MacGarvey NC, Bartz RR, Welty-Wolf KE, et al. 2012. Nrf2 promotes alveolar mitochondrial biogenesis and resolution of lung injury in Staphylococcus aureus pneumonia in mice. Free Radic. Biol. Med. 53(8):1584-94
    • (2012) Free Radic. Biol. Med , vol.53 , Issue.8 , pp. 1584-1594
    • Athale, J.1    Ulrich, A.2    MacGarvey, N.C.3    Bartz, R.R.4    Welty-Wolf, K.E.5
  • 42
    • 42049114034 scopus 로고    scopus 로고
    • Transcriptional paradigms in mammalian mitochondrial biogenesis and function
    • Scarpulla RC. 2008. Transcriptional paradigms in mammalian mitochondrial biogenesis and function. Physiol. Rev. 88(2):611-38
    • (2008) Physiol. Rev , vol.88 , Issue.2 , pp. 611-638
    • Scarpulla, R.C.1
  • 43
  • 44
    • 75349112375 scopus 로고    scopus 로고
    • Mitochondrial turnover and aging of long-lived postmitotic cells: The mitochondrial-lysosomal axis theory of aging
    • Terman A, Kurz T, Navratil M, Arriaga EA, Brunk UT. 2010. Mitochondrial turnover and aging of long-lived postmitotic cells: the mitochondrial-lysosomal axis theory of aging. Antioxid. Redox Signal. 12(4):503-35
    • (2010) Antioxid. Redox Signal , vol.12 , Issue.4 , pp. 503-535
    • Terman, A.1    Kurz, T.2    Navratil, M.3    Arriaga, E.A.4    Brunk, U.T.5
  • 45
    • 78649728763 scopus 로고    scopus 로고
    • The mitochondrial UPR-protecting organelle protein homeostasis
    • Haynes CM, Ron D. 2010. The mitochondrial UPR-protecting organelle protein homeostasis. J. Cell Sci. 123(Pt. 22):3849-55
    • (2010) J. Cell Sci. , vol.123 , pp. 3849-3855
    • Haynes, C.M.1    Ron, D.2
  • 46
    • 84555195856 scopus 로고    scopus 로고
    • Autophagy, mitochondria and oxidative stress: Cross-talk and redox signalling
    • Lee J, Giordano S, Zhang J. 2012. Autophagy, mitochondria and oxidative stress: cross-talk and redox signalling. Biochem. J. 441(2):523-40
    • (2012) Biochem. J , vol.441 , Issue.2 , pp. 523-540
    • Lee, J.1    Giordano, S.2    Zhang, J.3
  • 47
    • 74049153002 scopus 로고    scopus 로고
    • Nix is a selective autophagy receptor for mitochondrial clearance
    • Novak I, Kirkin V,McEwan DG, Zhang J,Wild P, et al. 2010. Nix is a selective autophagy receptor for mitochondrial clearance. EMBO Rep. 11(1):45-51
    • (2010) EMBO Rep. , vol.11 , Issue.1 , pp. 45-51
    • Novak, I.1    Kirkin, V.2    McEwan, D.G.3    Zhang, J.4    Wild, P.5
  • 48
    • 84862789618 scopus 로고    scopus 로고
    • Mitochondrial outer-membrane protein FUNDC1 mediates hypoxia-induced mitophagy in mammalian cells
    • Liu L, Feng D, Chen G, Chen M, Zheng Q, et al. 2012. Mitochondrial outer-membrane protein FUNDC1 mediates hypoxia-induced mitophagy in mammalian cells. Nat. Cell Biol. 14(2):177-85
    • (2012) Nat. Cell Biol. , vol.14 , Issue.2 , pp. 177-185
    • Liu, L.1    Feng, D.2    Chen, G.3    Chen, M.4    Zheng, Q.5
  • 49
    • 77956252454 scopus 로고    scopus 로고
    • Nix is critical to two distinct phases ofmitophagy, reactive oxygen species-mediated autophagy induction and Parkin-ubiquitin-p62-mediated mitochondrial priming
    • Ding WX,NiHM, Li M, Liao Y, Chen X, et al. 2010. Nix is critical to two distinct phases ofmitophagy, reactive oxygen species-mediated autophagy induction and Parkin-ubiquitin-p62-mediated mitochondrial priming. J. Biol. Chem. 285(36):27879-90
    • (2010) J. Biol. Chem. , vol.285 , Issue.36 , pp. 27879-27890
    • Ding, W.X.1    Ni, H.M.2    Li, M.3    Liao, Y.4    Chen, X.5
  • 50
    • 79954520907 scopus 로고    scopus 로고
    • Broad activation of the ubiquitin-proteasome system by Parkin is critical for mitophagy
    • Chan NC, Salazar AM, Pham AH, Sweredoski MJ, Kolawa NJ, et al. 2011. Broad activation of the ubiquitin-proteasome system by Parkin is critical for mitophagy. Hum. Mol. Genet. 20(9):1726-37
    • (2011) Hum. Mol. Genet , vol.20 , Issue.9 , pp. 1726-1737
    • Chan, N.C.1    Salazar, A.M.2    Pham, A.H.3    Sweredoski, M.J.4    Kolawa, N.J.5
  • 51
    • 79957472437 scopus 로고    scopus 로고
    • Parkin mediates proteasome-dependent protein degradation and rupture of the outer mitochondrial membrane
    • Yoshii SR, Kishi C, Ishihara N, Mizushima N. 2011. Parkin mediates proteasome-dependent protein degradation and rupture of the outer mitochondrial membrane. J. Biol. Chem. 286(22):19630-40
    • (2011) J. Biol. Chem. , vol.286 , Issue.22 , pp. 19630-19640
    • Yoshii, S.R.1    Kishi, C.2    Ishihara, N.3    Mizushima, N.4
  • 53
    • 58149314211 scopus 로고    scopus 로고
    • Parkin is recruited selectively to impaired mitochondria and promotes their autophagy
    • Narendra D, Tanaka A, Suen DF,YouleRJ. 2008. Parkin is recruited selectively to impaired mitochondria and promotes their autophagy. J. Cell Biol. 183(5):795-803
    • (2008) J. Cell Biol. , vol.183 , Issue.5 , pp. 795-803
    • Narendra, D.1    Tanaka, A.2    Suen, D.F.3    Youle, R.J.4
  • 54
    • 84880506979 scopus 로고    scopus 로고
    • The scaffold protein Atg11 recruits fission machinery to drive selective mitochondria degradation by autophagy
    • Mao K, Wang K, Liu X, Klionsky DJ. 2013. The scaffold protein Atg11 recruits fission machinery to drive selective mitochondria degradation by autophagy. Dev. Cell 26(1):9-18
    • (2013) Dev. Cell , vol.26 , Issue.1 , pp. 9-18
    • Mao, K.1    Wang, K.2    Liu, X.3    Klionsky, D.J.4
  • 55
    • 49349102894 scopus 로고    scopus 로고
    • Mitochondrial fusion, fission and autophagy as a quality control axis: The bioenergetic view
    • Twig G, Hyde B, Shirihai OS. 2008. Mitochondrial fusion, fission and autophagy as a quality control axis: the bioenergetic view. Biochim. Biophys. Acta 1777(9):1092-97
    • (2008) Biochim. Biophys. Acta , vol.1777 , Issue.9 , pp. 1092-1097
    • Twig, G.1    Hyde, B.2    Shirihai, O.S.3
  • 56
    • 80053476420 scopus 로고    scopus 로고
    • The autophagy initiating kinase ULK1 is regulated via opposing phosphorylation by AMPK and mTOR
    • Egan D, Kim J, Shaw RJ, Guan KL. 2011. The autophagy initiating kinase ULK1 is regulated via opposing phosphorylation by AMPK and mTOR. Autophagy 7(6):643-44
    • (2011) Autophagy , vol.7 , Issue.6 , pp. 643-644
    • Egan, D.1    Kim, J.2    Shaw, R.J.3    Guan, K.L.4
  • 58
    • 77950275298 scopus 로고    scopus 로고
    • Circulating mitochondrial DAMPs cause inflammatory responses to injury
    • Zhang Q, Raoof M, Chen Y, Sumi Y, Sursal T, et al. 2010. Circulating mitochondrial DAMPs cause inflammatory responses to injury. Nature 464:104-7
    • (2010) Nature , vol.464 , pp. 104-107
    • Zhang, Q.1    Raoof, M.2    Chen, Y.3    Sumi, Y.4    Sursal, T.5
  • 59
    • 84875138335 scopus 로고    scopus 로고
    • Mitochondrial DAMPs increase endothelial permeability through neutrophil dependent and independent pathways
    • Sun S, Sursal T, Adibnia Y, Zhao C, Zheng Y, et al. 2013. Mitochondrial DAMPs increase endothelial permeability through neutrophil dependent and independent pathways. PLOS ONE 8(3):e59989
    • (2013) PLOS ONE , vol.8 , Issue.3 , pp. e59989
    • Sun, S.1    Sursal, T.2    Adibnia, Y.3    Zhao, C.4    Zheng, Y.5
  • 60
    • 35349016235 scopus 로고    scopus 로고
    • Recognition of microorganisms and activation of the immune response
    • Medzhitov R. 2007. Recognition of microorganisms and activation of the immune response. Nature 449:819-26
    • (2007) Nature , vol.449 , pp. 819-826
    • Medzhitov, R.1
  • 61
    • 79955532516 scopus 로고    scopus 로고
    • TLRsignalling augments macrophage bactericidal activity through mitochondrial ROS
    • West AP,Brodsky IE, RahnerC,Woo DK,Erdjument-Bromage H, et al. 2011.TLRsignalling augments macrophage bactericidal activity through mitochondrial ROS. Nature 472(7344):476-80
    • (2011) Nature , vol.472 , Issue.7344 , pp. 476-480
    • West, A.P.1    Brodsky, I.E.2    Rahner, C.3    Woo, D.K.4    Erdjument-Bromage, H.5
  • 62
    • 2642573579 scopus 로고    scopus 로고
    • Endogenously oxidized mitochondrial DNA induces in vivo and in vitro inflammatory responses
    • Collins LV, Hajizadeh S, Holme E, Jonsson IM, Tarkowski A. 2004. Endogenously oxidized mitochondrial DNA induces in vivo and in vitro inflammatory responses. J. Leukoc. Biol. 75(6):995-1000
    • (2004) J. Leukoc. Biol. , vol.75 , Issue.6 , pp. 995-1000
    • Collins, L.V.1    Hajizadeh, S.2    Holme, E.3    Jonsson, I.M.4    Tarkowski, A.5
  • 63
    • 78751486963 scopus 로고    scopus 로고
    • Mitochondrially targeted ceramides preferentially promote autophagy, retard cell growth, and induce apoptosis
    • Hou Q, Jin J, Zhou H, Novgorodov SA, Bielawska A, et al. 2011. Mitochondrially targeted ceramides preferentially promote autophagy, retard cell growth, and induce apoptosis. J. Lipid Res. 52(2):278-88
    • (2011) J. Lipid Res. , vol.52 , Issue.2 , pp. 278-288
    • Hou, Q.1    Jin, J.2    Zhou, H.3    Novgorodov, S.A.4    Bielawska, A.5
  • 64
    • 84872040983 scopus 로고    scopus 로고
    • COX5Bregulates MAVS-mediated antiviral signaling through interaction with ATG5 and repressing ROS production
    • Zhao Y, SunX,Nie X, SunL,TangTS, et al. 2012.COX5Bregulates MAVS-mediated antiviral signaling through interaction with ATG5 and repressing ROS production. PLOS Pathog. 8(12):e1003086
    • (2012) PLOS Pathog , vol.8 , Issue.12 , pp. e1003086
    • Zhao, Y.1    Sun, X.2    Nie, X.3    Sun, L.4    Tang, T.S.5
  • 65
    • 84876237736 scopus 로고    scopus 로고
    • The adaptor MAVS promotes NLRP3 mitochondrial localization and inflammasome activation
    • Subramanian N, Natarajan K, Clatworthy MR, Wang Z, Germain RN. 2013. The adaptor MAVS promotes NLRP3 mitochondrial localization and inflammasome activation. Cell 153(2):348-61
    • (2013) Cell , vol.153 , Issue.2 , pp. 348-361
    • Subramanian, N.1    Natarajan, K.2    Clatworthy, M.R.3    Wang, Z.4    Germain, R.N.5
  • 66
    • 84878831880 scopus 로고    scopus 로고
    • Posttranscriptional control of T cell effector function by aerobic glycolysis
    • Chang CH, Curtis JD, Maggi LB Jr., Faubert B, Villarino AV, et al. 2013. Posttranscriptional control of T cell effector function by aerobic glycolysis. Cell 153(6):1239-51
    • (2013) Cell , vol.153 , Issue.6 , pp. 1239-1251
    • Chang, C.H.1    Curtis, J.D.2    Maggi, L.B.3    Faubert, B.4    Villarino, A.V.5
  • 67
    • 79951642032 scopus 로고    scopus 로고
    • Autophagy proteins regulate innate immune responses by inhibiting the release of mitochondrial DNA mediated by the NALP3 inflammasome
    • Nakahira K, Haspel JA, Rathinam VA, Lee SJ, Dolinay T, et al. 2011. Autophagy proteins regulate innate immune responses by inhibiting the release of mitochondrial DNA mediated by the NALP3 inflammasome. Nat. Immunol. 12(3):222-30
    • (2011) Nat. Immunol , vol.12 , Issue.3 , pp. 222-230
    • Nakahira, K.1    Haspel, J.A.2    Rathinam, V.A.3    Lee, S.J.4    Dolinay, T.5
  • 68
    • 84925855637 scopus 로고    scopus 로고
    • Mitochondrial biogenesis: Regulation by endogenous gases during inflammation and organ stress
    • Suliman HB, Piantadosi CA. 2014. Mitochondrial biogenesis: regulation by endogenous gases during inflammation and organ stress. Curr. Pharm. Des. 20(35):5653-62
    • (2014) Curr. Pharm. des , vol.20 , Issue.35 , pp. 5653-5662
    • Suliman, H.B.1    Piantadosi, C.A.2
  • 69
    • 84917743297 scopus 로고    scopus 로고
    • Redox regulation of mitophagy in the lung during murine Staphylococcus aureus sepsis
    • Chang AL, Ulrich A, Suliman HB, Piantadosi CA. 2015. Redox regulation of mitophagy in the lung during murine Staphylococcus aureus sepsis. Free Radic. Biol. Med. 78:179-89
    • (2015) Free Radic. Biol. Med , vol.78 , pp. 179-189
    • Chang, A.L.1    Ulrich, A.2    Suliman, H.B.3    Piantadosi, C.A.4
  • 70
    • 84948809269 scopus 로고    scopus 로고
    • Mitochondrial quality control as a therapeutic target
    • Suliman HB, Piantadosi CA. 2016. Mitochondrial quality control as a therapeutic target. Pharmacol. Rev. 68(1):20-48
    • (2016) Pharmacol. Rev , vol.68 , Issue.1 , pp. 20-48
    • Suliman, H.B.1    Piantadosi, C.A.2
  • 71
    • 0037426726 scopus 로고    scopus 로고
    • The pathophysiology and treatment of sepsis
    • Hotchkiss RS, Karl IE. 2003. The pathophysiology and treatment of sepsis. N. Engl. J.Med. 348(2):138-50
    • (2003) N. Engl. J.Med , vol.348 , Issue.2 , pp. 138-150
    • Hotchkiss, R.S.1    Karl, I.E.2
  • 72
    • 79959412738 scopus 로고    scopus 로고
    • Oxidative stress and mitochondrial dysfunction in sepsis
    • Galley HF. 2011. Oxidative stress and mitochondrial dysfunction in sepsis. Br. J. Anaesth. 107(1):57-64
    • (2011) Br. J. Anaesth , vol.107 , Issue.1 , pp. 57-64
    • Galley, H.F.1
  • 73
    • 34548787792 scopus 로고    scopus 로고
    • Reactive oxygen species and cellular oxygen sensing
    • Cash TP, Pan Y, Simon MC. 2007. Reactive oxygen species and cellular oxygen sensing. Free Radic. Biol. Med. 43(9):1219-25
    • (2007) Free Radic. Biol. Med , vol.43 , Issue.9 , pp. 1219-1225
    • Cash, T.P.1    Pan, Y.2    Simon, M.C.3
  • 74
    • 84891655634 scopus 로고    scopus 로고
    • The role of mitochondrial dysfunction in sepsis-induced multi-organ failure
    • Singer M. 2014. The role of mitochondrial dysfunction in sepsis-induced multi-organ failure. Virulence 5(1):66-72
    • (2014) Virulence , vol.5 , Issue.1 , pp. 66-72
    • Singer, M.1
  • 76
    • 33847306780 scopus 로고    scopus 로고
    • Signaling of mitochondrial biogenesis following oxidant injury
    • Rasbach KA, Schnellmann RG. 2007. Signaling of mitochondrial biogenesis following oxidant injury. J. Biol. Chem. 282(4):2355-62
    • (2007) J. Biol. Chem. , vol.282 , Issue.4 , pp. 2355-2362
    • Rasbach, K.A.1    Schnellmann, R.G.2
  • 77
    • 84922080059 scopus 로고    scopus 로고
    • De novo fatty acid synthesis controls the fate between regulatory T and T helper 17 cells
    • Berod L, Friedrich C, Nandan A, Freitag J,Hagemann S, et al. 2014. De novo fatty acid synthesis controls the fate between regulatory T and T helper 17 cells. Nat. Med. 20(11):1327-33
    • (2014) Nat. Med , vol.20 , Issue.11 , pp. 1327-1333
    • Berod, L.1    Friedrich, C.2    Nandan, A.3    Freitag, J.4    Hagemann, S.5
  • 78
    • 79957597757 scopus 로고    scopus 로고
    • Mitochondria in innate immune responses
    • West AP, Shadel GS, Ghosh S. 2011. Mitochondria in innate immune responses. Nat. Rev. Immunol. 11(6):389-402
    • (2011) Nat. Rev. Immunol , vol.11 , Issue.6 , pp. 389-402
    • West, A.P.1    Shadel, G.S.2    Ghosh, S.3
  • 79
    • 33745428666 scopus 로고    scopus 로고
    • Oxidativemetabolism and PGC-1β attenuate macrophage-mediated inflammation
    • VatsD,Mukundan L,Odegaard JI, Zhang L, Smith KL, et al. 2006. Oxidativemetabolism and PGC-1β attenuate macrophage-mediated inflammation. Cell Metab. 4(1):13-24
    • (2006) Cell Metab , vol.4 , Issue.1 , pp. 13-24
    • Vats, D.1    Mukundan, L.2    Odegaard, J.I.3    Zhang, L.4    Smith, K.L.5
  • 80
    • 84860654915 scopus 로고    scopus 로고
    • Mitochondrial transfer from bone-marrowderived stromal cells to pulmonary alveoli protects against acute lung injury
    • Islam MN, Das SR, Emin MT, Wei M, Sun L, et al. 2012. Mitochondrial transfer from bone-marrowderived stromal cells to pulmonary alveoli protects against acute lung injury. Nat. Med. 18(5):759-65
    • (2012) Nat. Med , vol.18 , Issue.5 , pp. 759-765
    • Islam, M.N.1    Das, S.R.2    Emin, M.T.3    Wei, M.4    Sun, L.5
  • 82
    • 84887086945 scopus 로고    scopus 로고
    • Mitochondrial protein mitofusin 2 is required for NLRP3 inflammasome activation after RNA virus infection
    • Ichinohe T, Yamazaki T, Koshiba T, Yanagi Y. 2013. Mitochondrial protein mitofusin 2 is required for NLRP3 inflammasome activation after RNA virus infection. PNAS 110(44):17963-68
    • (2013) PNAS , vol.110 , Issue.44 , pp. 17963-17968
    • Ichinohe, T.1    Yamazaki, T.2    Koshiba, T.3    Yanagi, Y.4
  • 83
    • 84933042768 scopus 로고    scopus 로고
    • Endothelial uncoupling protein 2 regulates mitophagy and pulmonary hypertension during intermittent hypoxia
    • Haslip M, Dostanic I, Huang Y, Zhang Y, Russell KS, et al. 2015. Endothelial uncoupling protein 2 regulates mitophagy and pulmonary hypertension during intermittent hypoxia. Arterioscler. Thromb. Vasc. Biol. 35(5):1166-78
    • (2015) Arterioscler. Thromb. Vasc. Biol. , vol.35 , Issue.5 , pp. 1166-1178
    • Haslip, M.1    Dostanic, I.2    Huang, Y.3    Zhang, Y.4    Russell, K.S.5
  • 85
    • 84937583336 scopus 로고    scopus 로고
    • Alveolar macrophage-derived type i interferons orchestrate innate immunity to RSV through recruitment of antiviral monocytes
    • Goritzka M, Makris S, Kausar F, Durant LR, Pereira C, et al. 2015. Alveolar macrophage-derived type I interferons orchestrate innate immunity to RSV through recruitment of antiviral monocytes. J. Exp. Med. 212(5):699-714
    • (2015) J. Exp. Med , vol.212 , Issue.5 , pp. 699-714
    • Goritzka, M.1    Makris, S.2    Kausar, F.3    Durant, L.R.4    Pereira, C.5
  • 86
    • 84877045681 scopus 로고    scopus 로고
    • Developmental differences in hyperoxia-induced oxidative stress and cellular responses in the murine lung
    • Berkelhamer SK, Kim GA, Radder JE, Wedgwood S, Czech L, et al. 2013. Developmental differences in hyperoxia-induced oxidative stress and cellular responses in the murine lung. Free Radic. Biol. Med. 61:51-60
    • (2013) Free Radic. Biol. Med , vol.61 , pp. 51-60
    • Berkelhamer, S.K.1    Kim, G.A.2    Radder, J.E.3    Wedgwood, S.4    Czech, L.5
  • 87
    • 84891679916 scopus 로고    scopus 로고
    • Targeting mitochondrial dysfunction in lung diseases: Emphasis on mitophagy
    • Sureshbabu A, Bhandari V. 2013. Targeting mitochondrial dysfunction in lung diseases: emphasis on mitophagy. Front. Physiol. 4:384
    • (2013) Front. Physiol , vol.4 , pp. 384
    • Sureshbabu, A.1    Bhandari, V.2
  • 88
    • 84942333070 scopus 로고    scopus 로고
    • Long-chain acylcarnitines reduce lung function by inhibiting pulmonary surfactant
    • Otsubo C, Bharathi S, Uppala R, Ilkayeva OR, Wang D, et al. 2015. Long-chain acylcarnitines reduce lung function by inhibiting pulmonary surfactant. J. Biol. Chem. 290(39):23897-904
    • (2015) J. Biol. Chem. , vol.290 , Issue.39 , pp. 23897-23904
    • Otsubo, C.1    Bharathi, S.2    Uppala, R.3    Ilkayeva, O.R.4    Wang, D.5
  • 90
    • 84899633940 scopus 로고    scopus 로고
    • E3 ligase subunit Fbxo15 and PINK1 kinase regulate cardiolipin synthase 1 stability and mitochondrial function in pneumonia
    • Chen BB, Coon TA, Glasser JR, Zou C, Ellis B, et al. 2014. E3 ligase subunit Fbxo15 and PINK1 kinase regulate cardiolipin synthase 1 stability and mitochondrial function in pneumonia. Cell Rep. 7(2):476-87
    • (2014) Cell Rep. , vol.7 , Issue.2 , pp. 476-487
    • Chen, B.B.1    Coon, T.A.2    Glasser, J.R.3    Zou, C.4    Ellis, B.5
  • 92
    • 0035112481 scopus 로고    scopus 로고
    • Invited review: Contractile activity-induced mitochondrial biogenesis in skeletal muscle
    • Hood DA. 2001. Invited review: contractile activity-induced mitochondrial biogenesis in skeletal muscle. J. Appl. Physiol. 90(3):1137-57
    • (2001) J. Appl. Physiol , vol.90 , Issue.3 , pp. 1137-1157
    • Hood, D.A.1
  • 93
    • 84880079298 scopus 로고    scopus 로고
    • Oxidative stress in COPD
    • Kirkham PA, Barnes PJ. 2013. Oxidative stress in COPD. Chest 144(1):266-73
    • (2013) Chest , vol.144 , Issue.1 , pp. 266-273
    • Kirkham, P.A.1    Barnes, P.J.2
  • 94
    • 84878150850 scopus 로고    scopus 로고
    • Skeletal muscle mitochondrial dysfunction during chronic obstructive pulmonary disease: Central actor and therapeutic target
    • Meyer A, Zoll J, Charles AL, Charloux A, Blay F, et al. 2013. Skeletal muscle mitochondrial dysfunction during chronic obstructive pulmonary disease: central actor and therapeutic target. Exp. Physiol. 98(6):1063-78
    • (2013) Exp. Physiol , vol.98 , Issue.6 , pp. 1063-1078
    • Meyer, A.1    Zoll, J.2    Charles, A.L.3    Charloux, A.4    Blay, F.5
  • 95
    • 0030032344 scopus 로고    scopus 로고
    • Selective diaphragmatic mitochondrial abnormalities in a patient with marked air flow obstruction
    • Lloreta J, Orozco M, Gea J, Corominas JM, Serrano S. 1996. Selective diaphragmatic mitochondrial abnormalities in a patient with marked air flow obstruction. Ultrastruct. Pathol. 20(1):67-71
    • (1996) Ultrastruct. Pathol , vol.20 , Issue.1 , pp. 67-71
    • Lloreta, J.1    Orozco, M.2    Gea, J.3    Corominas, J.M.4    Serrano, S.5
  • 96
    • 34447576406 scopus 로고    scopus 로고
    • Cigarette smokeinduced blockade of the mitochondrial respiratory chain switches lung epithelial cell apoptosis into necrosis
    • van der Toorn M, Slebos DJ, Bruin HG, Leuvenink HG, Bakker SJ, et al. 2007. Cigarette smokeinduced blockade of the mitochondrial respiratory chain switches lung epithelial cell apoptosis into necrosis. Am. J. Physiol. Lung. Cell Mol. Physiol. 292(5):L1211-18
    • (2007) Am. J. Physiol. Lung. Cell Mol. Physiol , vol.292 , Issue.5 , pp. L1211-L1218
    • Vander Toorn, M.1    Slebos, D.J.2    Bruin, H.G.3    Leuvenink, H.G.4    Bakker, S.J.5
  • 97
    • 84930401315 scopus 로고    scopus 로고
    • Transforming growth factor-βsuperfamily in obstructive lung diseases.More suspects than TGF-βalone
    • Verhamme FM, Bracke KR, Joos GF, Brusselle GG. 2015. Transforming growth factor-βsuperfamily in obstructive lung diseases.More suspects than TGF-βalone. Am. J. Respir. CellMol. Biol. 52(6):653-62
    • (2015) Am. J. Respir. CellMol. Biol. , vol.52 , Issue.6 , pp. 653-662
    • Verhamme, F.M.1    Bracke, K.R.2    Joos, G.F.3    Brusselle, G.G.4
  • 98
    • 84867375467 scopus 로고    scopus 로고
    • Role of PGC-1αsignaling in skeletal muscle health and disease
    • Kang C, Li Ji L. 2012. Role of PGC-1αsignaling in skeletal muscle health and disease. Ann. N.Y. Acad. Sci. 1271:110-17
    • (2012) Ann. N.Y. Acad. Sci. , vol.1271 , pp. 110-117
    • Kang, C.1    Li Ji, L.2
  • 99
    • 84891696200 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptor gamma co-activator 1-α as a critical co-activator of the murine hepatic oxidative stress response and mitochondrial biogenesis in Staphylococcus aureus sepsis
    • Cherry AD, Suliman HB, Bartz RR, Piantadosi CA. 2014. Peroxisome proliferator-activated receptor gamma co-activator 1-α as a critical co-activator of the murine hepatic oxidative stress response and mitochondrial biogenesis in Staphylococcus aureus sepsis. J. Biol. Chem. 289(1):41-52
    • (2014) J. Biol. Chem. , vol.289 , Issue.1 , pp. 41-52
    • Cherry, A.D.1    Suliman, H.B.2    Bartz, R.R.3    Piantadosi, C.A.4
  • 100
    • 84969195369 scopus 로고    scopus 로고
    • Nrf2 activation as target to implement therapeutic treatments
    • Bocci V, Valacchi G. 2015. Nrf2 activation as target to implement therapeutic treatments. Front. Chem. 3:4
    • (2015) Front. Chem. , vol.3 , pp. 4
    • Bocci, V.1    Valacchi, G.2
  • 102
    • 84907010947 scopus 로고    scopus 로고
    • Mitophagy-dependent necroptosis contributes to the pathogenesis of COPD
    • Mizumura K, Cloonan SM, Nakahira K, Bhashyam AR, Cervo M, et al. 2014. Mitophagy-dependent necroptosis contributes to the pathogenesis of COPD. J. Clin. Investig. 124(9):3987-4003
    • (2014) J. Clin. Investig , vol.124 , Issue.9 , pp. 3987-4003
    • Mizumura, K.1    Cloonan, S.M.2    Nakahira, K.3    Bhashyam, A.R.4    Cervo, M.5
  • 103
    • 84943800210 scopus 로고    scopus 로고
    • PARK2-mediated mitophagy is involved in regulation of HBEC senescence in COPD pathogenesis
    • Ito S, Araya J, Kurita Y, Kobayashi K, Takasaka N, et al. 2015. PARK2-mediated mitophagy is involved in regulation of HBEC senescence in COPD pathogenesis. Autophagy 11(3):547-59
    • (2015) Autophagy , vol.11 , Issue.3 , pp. 547-559
    • Ito, S.1    Araya, J.2    Kurita, Y.3    Kobayashi, K.4    Takasaka, N.5
  • 104
    • 84940404091 scopus 로고    scopus 로고
    • Impaired mitophagy leads to cigarette smoke stress-induced cellular senescence: Implications for chronic obstructive pulmonary disease
    • Ahmad T, Sundar IK, Lerner CA, Gerloff J, Tormos AM, et al. 2015. Impaired mitophagy leads to cigarette smoke stress-induced cellular senescence: implications for chronic obstructive pulmonary disease. FASEB J. 29(7):2912-29
    • (2015) FASEB J , vol.29 , Issue.7 , pp. 2912-2929
    • Ahmad, T.1    Sundar, I.K.2    Lerner, C.A.3    Gerloff, J.4    Tormos, A.M.5
  • 105
    • 84925433501 scopus 로고    scopus 로고
    • Epithelial cell mitochondrial dysfunction and PINK1 are induced by transforming growth factor-beta1 in pulmonary fibrosis
    • Patel AS, Song JW, Chu SG,Mizumura K, Osorio JC, et al. 2015. Epithelial cell mitochondrial dysfunction and PINK1 are induced by transforming growth factor-beta1 in pulmonary fibrosis. PLOS ONE 10(3):e0121246
    • (2015) PLOS ONE , vol.10 , Issue.3 , pp. e0121246
    • Patel, A.S.1    Song, J.W.2    Chu, S.G.3    Mizumura, K.4    Osorio, J.C.5
  • 106
    • 84947430723 scopus 로고    scopus 로고
    • Leukocyte mitochondrial DNA copy number is associated with chronic obstructive pulmonary disease
    • Liu SF, Kuo HC, Tseng CW, Huang HT, Chen YC, et al. 2015. Leukocyte mitochondrial DNA copy number is associated with chronic obstructive pulmonary disease. PLOS ONE 10(9):e0138716
    • (2015) PLOS ONE , vol.10 , Issue.9 , pp. e0138716
    • Liu, S.F.1    Kuo, H.C.2    Tseng, C.W.3    Huang, H.T.4    Chen, Y.C.5
  • 107
    • 84942474807 scopus 로고    scopus 로고
    • The asthma-COPD overlap syndrome
    • Postma DS, Rabe KF. 2015. The asthma-COPD overlap syndrome. N. Engl. J. Med. 373(13):1241-49
    • (2015) N. Engl. J. Med , vol.373 , Issue.13 , pp. 1241-1249
    • Postma, D.S.1    Rabe, K.F.2
  • 108
    • 84863005150 scopus 로고    scopus 로고
    • Mitochondrial genetic background plays a role in increasing risk to asthma
    • Zifa E, Daniil Z, Skoumi E, Stavrou M, Papadimitriou K, et al. 2012. Mitochondrial genetic background plays a role in increasing risk to asthma. Mol. Biol. Rep. 39(4):4697-708
    • (2012) Mol. Biol. Rep. , vol.39 , Issue.4 , pp. 4697-4708
    • Zifa, E.1    Daniil, Z.2    Skoumi, E.3    Stavrou, M.4    Papadimitriou, K.5
  • 110
    • 51549106954 scopus 로고    scopus 로고
    • Mitochondrial structural changes and dysfunction are associated with experimental allergic asthma
    • Mabalirajan U, Dinda AK, Kumar S, Roshan R, Gupta P, et al. 2008. Mitochondrial structural changes and dysfunction are associated with experimental allergic asthma. J. Immunol. 181(5):3540-48
    • (2008) J. Immunol , vol.181 , Issue.5 , pp. 3540-3548
    • Mabalirajan, U.1    Dinda, A.K.2    Kumar, S.3    Roshan, R.4    Gupta, P.5
  • 113
    • 84899805263 scopus 로고    scopus 로고
    • Miro1 regulates intercellular mitochondrial transport &enhances mesenchymal stem cell rescue efficacy
    • Ahmad T, Mukherjee S, Pattnaik B, Kumar M, Singh S, et al. 2014. Miro1 regulates intercellular mitochondrial transport &enhances mesenchymal stem cell rescue efficacy. EMBO J. 33(9):994-1010
    • (2014) EMBO J , vol.33 , Issue.9 , pp. 994-1010
    • Ahmad, T.1    Mukherjee, S.2    Pattnaik, B.3    Kumar, M.4    Singh, S.5
  • 115
    • 84856279893 scopus 로고    scopus 로고
    • Mitochondrial Rac1 GTPase import and electron transfer from cytochrome c are required for pulmonary fibrosis
    • Osborn-Heaford HL, Ryan AJ, Murthy S, Racila AM, He C, et al. 2012. Mitochondrial Rac1 GTPase import and electron transfer from cytochrome c are required for pulmonary fibrosis. J. Biol. Chem. 287(5):3301-12
    • (2012) J. Biol. Chem. , vol.287 , Issue.5 , pp. 3301-3312
    • Osborn-Heaford, H.L.1    Ryan, A.J.2    Murthy, S.3    Racila, A.M.4    He, C.5
  • 116
    • 33847061759 scopus 로고    scopus 로고
    • Asbestos-induced peribronchiolar cell proliferation and cytokine production are attenuated in lungs of protein kinase C-knockout mice
    • Shukla A, Lounsbury KM, Barrett TF, Gell J, Rincon M, et al. 2007. Asbestos-induced peribronchiolar cell proliferation and cytokine production are attenuated in lungs of protein kinase C-knockout mice. Am. J. Pathol. 170(1):140-51
    • (2007) Am. J. Pathol , vol.170 , Issue.1 , pp. 140-151
    • Shukla, A.1    Lounsbury, K.M.2    Barrett, T.F.3    Gell, J.4    Rincon, M.5
  • 118
    • 54749094792 scopus 로고    scopus 로고
    • Expression and function of Bcl-2 proteins in melanoma
    • Eberle J, Hossini AM. 2008. Expression and function of Bcl-2 proteins in melanoma. Curr. Genom. 9(6):409-19
    • (2008) Curr. Genom , vol.9 , Issue.6 , pp. 409-419
    • Eberle, J.1    Hossini, A.M.2
  • 119
  • 120
  • 121
    • 53949083274 scopus 로고    scopus 로고
    • Air pollution induces enhanced mitochondrial oxidative stress in cystic fibrosis airway epithelium
    • Kamdar O, Le W, Zhang J, Ghio AJ, Rosen GD, Upadhyay D. 2008. Air pollution induces enhanced mitochondrial oxidative stress in cystic fibrosis airway epithelium. FEBS Lett. 582(25-26):3601-6
    • (2008) FEBS Lett , vol.582 , Issue.25-26 , pp. 3601-3606
    • Kamdar, O.1    Le, W.2    Zhang, J.3    Ghio, A.J.4    Rosen, G.D.5    Upadhyay, D.6
  • 122
    • 0023812946 scopus 로고
    • Mitochondrial dysfunction, energy expenditure, and cystic fibrosis
    • Shapiro BL. 1988. Mitochondrial dysfunction, energy expenditure, and cystic fibrosis. Lancet 2(8605):289
    • (1988) Lancet , vol.2 , Issue.8605 , pp. 289
    • Shapiro, B.L.1
  • 123
    • 0034772534 scopus 로고    scopus 로고
    • Mitochondrial genetic control of assembly and function of complex i in mammalian cells
    • Chomyn A. 2001. Mitochondrial genetic control of assembly and function of complex I in mammalian cells. J. Bioenerg. Biomembr. 33(3):251-57
    • (2001) J. Bioenerg. Biomembr , vol.33 , Issue.3 , pp. 251-257
    • Chomyn, A.1
  • 124
    • 33746891176 scopus 로고    scopus 로고
    • Mitochondrial DNA mutations in human cancer
    • Chatterjee A, Mambo E, Sidransky D. 2006. Mitochondrial DNA mutations in human cancer. Oncogene 25(34):4663-74
    • (2006) Oncogene , vol.25 , Issue.34 , pp. 4663-4674
    • Chatterjee, A.1    Mambo, E.2    Sidransky, D.3
  • 125
    • 84877584494 scopus 로고    scopus 로고
    • Mitochondrial DNA mutations in exhaled breath condensate of patients with lung cancer
    • Yang Ai SS, Hsu K, Herbert C, Cheng Z, Hunt J, et al. 2013. Mitochondrial DNA mutations in exhaled breath condensate of patients with lung cancer. Respir. Med. 107(6):911-18
    • (2013) Respir. Med , vol.107 , Issue.6 , pp. 911-918
    • Yang Ai, S.S.1    Hsu, K.2    Herbert, C.3    Cheng, Z.4    Hunt, J.5
  • 126
    • 79956191029 scopus 로고    scopus 로고
    • Chronic inflammation and cancer: The role of the mitochondria
    • 13
    • Kamp DW, Shacter E, Weitzman SA. 2011. Chronic inflammation and cancer: the role of the mitochondria. Oncology 25(5):400-10, 13
    • (2011) Oncology , vol.25 , Issue.5 , pp. 400-510
    • Kamp, D.W.1    Shacter, E.2    Weitzman, S.A.3
  • 127
    • 84880090199 scopus 로고    scopus 로고
    • Clinical response to chemotherapy in oesophageal adenocarcinoma patients is linked to defects in mitochondria
    • AichlerM,ElsnerM,Ludyga N, FeuchtingerA,ZangenV, et al. 2013. Clinical response to chemotherapy in oesophageal adenocarcinoma patients is linked to defects in mitochondria. J. Pathol. 230(4):410-19
    • (2013) J. Pathol , vol.230 , Issue.4 , pp. 410-419
    • Aichler, M.1    Elsner, M.2    Ludyga, N.3    Feuchtinger, A.4    Zangen, V.5
  • 128
    • 84878700127 scopus 로고    scopus 로고
    • The interplay between autophagy and ROS in tumorigenesis
    • Kongara S, Karantza V. 2012. The interplay between autophagy and ROS in tumorigenesis. Front. Oncol. 2:171
    • (2012) Front. Oncol , vol.2 , pp. 171
    • Kongara, S.1    Karantza, V.2
  • 129
    • 84863123131 scopus 로고    scopus 로고
    • Mitochondrial DNA mutations in respiratory complex-I in never-smoker lung cancer patients contribute to lung cancer progression and associated with EGFR gene mutation
    • Dasgupta S, Soudry E, Mukhopadhyay N, Shao C, Yee J, et al. 2012. Mitochondrial DNA mutations in respiratory complex-I in never-smoker lung cancer patients contribute to lung cancer progression and associated with EGFR gene mutation. J. Cell Physiol. 227(6):2451-60
    • (2012) J. Cell Physiol , vol.227 , Issue.6 , pp. 2451-2460
    • Dasgupta, S.1    Soudry, E.2    Mukhopadhyay, N.3    Shao, C.4    Yee, J.5
  • 130
    • 33644870379 scopus 로고    scopus 로고
    • Oxidative phosphorylation dysfunction modulates expression of extracellular matrix-remodeling genes and invasion
    • vanWaveren C, Sun Y, Cheung HS, Moraes CT. 2006. Oxidative phosphorylation dysfunction modulates expression of extracellular matrix-remodeling genes and invasion. Carcinogenesis 27(3):409-18
    • (2006) Carcinogenesis , vol.27 , Issue.3 , pp. 409-418
    • VanWaveren, C.1    Sun, Y.2    Cheung, H.S.3    Moraes, C.T.4
  • 131
    • 0343986284 scopus 로고    scopus 로고
    • Drug delivery to mitochondria: The key to mitochondrial medicine
    • Murphy MP, Smith RA. 2000. Drug delivery to mitochondria: the key to mitochondrial medicine. Adv. Drug Deliv. Rev. 41(2):235-50
    • (2000) Adv. Drug Deliv. Rev , vol.41 , Issue.2 , pp. 235-250
    • Murphy, M.P.1    Smith, R.A.2
  • 132
    • 84866854885 scopus 로고    scopus 로고
    • Biochemistry: A radical treatment
    • Garber K. 2012. Biochemistry: a radical treatment. Nature 489:S4-6
    • (2012) Nature , vol.489 , pp. S4-6
    • Garber, K.1
  • 133
    • 79954542852 scopus 로고    scopus 로고
    • Targeting Nrf2 signaling improves bacterial clearance by alveolar macrophages in patients with COPD and in a mouse model
    • Harvey CJ,Thimmulappa RK, Sethi S, Kong X, Yarmus L, et al. 2011. Targeting Nrf2 signaling improves bacterial clearance by alveolar macrophages in patients with COPD and in a mouse model. Sci. Transl. Med. 3(78):78ra32
    • (2011) Sci. Transl. Med , vol.3 , Issue.78 , pp. 78ra32
    • Harvey, C.J.1    Thimmulappa, R.K.2    Sethi, S.3    Kong, X.4    Yarmus, L.5
  • 134
    • 55449130008 scopus 로고    scopus 로고
    • Potent induction of total cellular and mitochondrial antioxidants and phase 2 enzymes by cruciferous sulforaphane in rat aortic smooth muscle cells: Cytoprotection against oxidative and electrophilic stress
    • Zhu H, Jia Z, Strobl JS, Ehrich M, Misra HP, Li Y. 2008. Potent induction of total cellular and mitochondrial antioxidants and phase 2 enzymes by cruciferous sulforaphane in rat aortic smooth muscle cells: cytoprotection against oxidative and electrophilic stress. Cardiovasc. Toxicol. 8(3):115-25
    • (2008) Cardiovasc. Toxicol , vol.8 , Issue.3 , pp. 115-125
    • Zhu, H.1    Jia, Z.2    Strobl, J.S.3    Ehrich, M.4    Misra, H.P.5    Li, Y.6
  • 135
    • 84907337366 scopus 로고    scopus 로고
    • Cytoprotection "gone astray": Nrf2 and its role in cancer
    • Geismann C, Arlt A, Sebens S, Schäfer H. 2014. Cytoprotection "gone astray": Nrf2 and its role in cancer. Onco. Targets Ther. 7:1497-518
    • (2014) Onco. Targets Ther , vol.7 , pp. 1497-1518
    • Geismann, C.1    Arlt, A.2    Sebens, S.3    Schäfer, H.4
  • 137
    • 79955542142 scopus 로고    scopus 로고
    • Heme oxygenase-1 couples activation of mitochondrial biogenesis to anti-inflammatory cytokine expression
    • Piantadosi CA, Withers CM, Bartz RR, MacGarvey NC, Fu P, et al. 2011. Heme oxygenase-1 couples activation of mitochondrial biogenesis to anti-inflammatory cytokine expression. J. Biol. Chem. 286(18):16374-85
    • (2011) J. Biol. Chem. , vol.286 , Issue.18 , pp. 16374-16385
    • Piantadosi, C.A.1    Withers, C.M.2    Bartz, R.R.3    MacGarvey, N.C.4    Fu, P.5
  • 138
    • 0347579845 scopus 로고    scopus 로고
    • Mitochondrial biogenesis in mammals: The role of endogenous nitric oxide
    • Nisoli E, ClementiE, Paolucci C, Cozzi V, Tonello C, et al. 2003. Mitochondrial biogenesis in mammals: the role of endogenous nitric oxide. Science 299:896-99
    • (2003) Science , vol.299 , pp. 896-899
    • Nisoli, E.1    Clementi, E.2    Paolucci, C.3    Cozzi, V.4    Tonello, C.5
  • 139
    • 79952319773 scopus 로고    scopus 로고
    • Mitochondria removal by autophagy
    • Wang K, Klionsky DJ. 2011. Mitochondria removal by autophagy. Autophagy 7(3):297-300
    • (2011) Autophagy , vol.7 , Issue.3 , pp. 297-300
    • Wang, K.1    Klionsky, D.J.2
  • 140
    • 67549101188 scopus 로고    scopus 로고
    • Role of BNIP3 and NIX in cell death, autophagy, and mitophagy
    • Zhang J, Ney PA. 2009. Role of BNIP3 and NIX in cell death, autophagy, and mitophagy. Cell Death Differ. 16(7):939-46
    • (2009) Cell Death Differ , vol.16 , Issue.7 , pp. 939-946
    • Zhang, J.1    Ney, P.A.2
  • 141
    • 84867005299 scopus 로고    scopus 로고
    • Resveratrol attenuates experimental allergic asthma in mice by restoring inositol polyphosphate 4 phosphatase (INPP4A)
    • Aich J, Mabalirajan U, Ahmad T, Khanna K, Rehman R, et al. 2012. Resveratrol attenuates experimental allergic asthma in mice by restoring inositol polyphosphate 4 phosphatase (INPP4A). Int. Immunopharmacol. 14(4):438-43
    • (2012) Int. Immunopharmacol , vol.14 , Issue.4 , pp. 438-443
    • Aich, J.1    Mabalirajan, U.2    Ahmad, T.3    Khanna, K.4    Rehman, R.5
  • 142
    • 78650016927 scopus 로고    scopus 로고
    • L-arginine reduces mitochondrial dysfunction and airway injury in murine allergic airway inflammation
    • Mabalirajan U, AhmadT, Leishangthem GD, Dinda AK, Agrawal A, Ghosh B. 2010. L-arginine reduces mitochondrial dysfunction and airway injury in murine allergic airway inflammation. Int. Immunopharmacol. 10(12):1514-19
    • (2010) Int. Immunopharmacol , vol.10 , Issue.12 , pp. 1514-1519
    • Mabalirajan, U.1    Ahmad, T.2    Leishangthem, G.D.3    Dinda, A.K.4    Agrawal, A.5    Ghosh, B.6
  • 143
    • 84886304307 scopus 로고    scopus 로고
    • Metformin attenuates the exacerbation of the allergic eosinophilic inflammation in high fat-diet-induced obesity in mice
    • Calixto MC, Lintomen L, André DM, Leiria LO, Ferreira D, et al. 2013. Metformin attenuates the exacerbation of the allergic eosinophilic inflammation in high fat-diet-induced obesity in mice. PLOS ONE 8(10):e76786
    • (2013) PLOS ONE , vol.8 , Issue.10 , pp. e76786
    • Calixto, M.C.1    Lintomen, L.2    André, D.M.3    Leiria, L.O.4    Ferreira, D.5
  • 144
    • 84922330185 scopus 로고    scopus 로고
    • Obesity, metabolic syndrome, and airway disease: A bioenergetic problem?
    • Agrawal A, Prakash YS. 2014. Obesity, metabolic syndrome, and airway disease: a bioenergetic problem? Immunol. Allergy Clin. North Am. 34(4):785-96
    • (2014) Immunol. Allergy Clin. North Am , vol.34 , Issue.4 , pp. 785-796
    • Agrawal, A.1    Prakash, Y.S.2
  • 145
    • 84897074033 scopus 로고    scopus 로고
    • Respiratory effects of insulin sensitisation withmetformin: A prospective observational study
    • Sexton P, Metcalf P, Kolbe J. 2014. Respiratory effects of insulin sensitisation withmetformin: a prospective observational study. COPD 11(2):133-42
    • (2014) COPD , vol.11 , Issue.2 , pp. 133-142
    • Sexton, P.1    Metcalf, P.2    Kolbe, J.3
  • 146
    • 84873684726 scopus 로고    scopus 로고
    • Metabolic control of the Treg/Th17 axis
    • Barbi J, Pardoll D, Pan F. 2013. Metabolic control of the Treg/Th17 axis. Immunol. Rev. 252(1):52-77
    • (2013) Immunol. Rev , vol.252 , Issue.1 , pp. 52-77
    • Barbi, J.1    Pardoll, D.2    Pan, F.3
  • 147
    • 84890025789 scopus 로고    scopus 로고
    • Histone deacetylase 6-mediated selective autophagy regulates COPD-associated cilia dysfunction
    • Lam HC, Cloonan SM, Bhashyam AR, Haspel JA, Singh A, et al. 2013. Histone deacetylase 6-mediated selective autophagy regulates COPD-associated cilia dysfunction. J. Clin. Investig. 123(12):5212-30
    • (2013) J. Clin. Investig , vol.123 , Issue.12 , pp. 5212-5230
    • Lam, H.C.1    Cloonan, S.M.2    Bhashyam, A.R.3    Haspel, J.A.4    Singh, A.5
  • 148
    • 84883495690 scopus 로고    scopus 로고
    • Respiratory health and disease in Europe: The new European Lung White Book
    • Gibson GJ, Loddenkemper R, Lundbäck B, Sibille Y. 2013. Respiratory health and disease in Europe: the new European Lung White Book. Eur. Respir. J. 42(3):559-63
    • (2013) Eur. Respir. J , vol.42 , Issue.3 , pp. 559-563
    • Gibson, G.J.1    Loddenkemper, R.2    Lundbäck, B.3    Sibille, Y.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.