Sequential actions of SIRT1-RELB-SIRT3 coordinate nuclear-mitochondrial communication during immunometabolic adaptation to acute inflammation and sepsis

Journal of Biological Chemistry

Volumn 290, Issue 1, 2015, Pages 396-408

  Liu, Tie Fu ^a   Vachharajani, Vidula ^a   Millet, Patrick ^a   Bharadwaj, Manish S ^a   Molina, Anthony J ^a   McCall, Charles E ^a  

^a WAKE FOREST SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BIOCHEMISTRY; BIOSYNTHESIS; BODY FLUIDS; MAMMALS; OXYGEN; PATHOLOGY; PROTEINS;

ACUTE INFLAMMATORY RESPONSE; ISOCITRATE DEHYDROGENASE; MEMBRANE DEPOLARIZATION; MITOCHONDRIAL BIOENERGETICS; MITOCHONDRIAL BIOGENESIS; MITOCHONDRIAL OXYGEN CONSUMPTION; MITOCHONDRIAL SUPEROXIDE; TRICARBOXYLIC ACID CYCLE;

FATTY ACIDS;

ADENOSINE TRIPHOSPHATE; CELL NUCLEUS DNA; CITRATE SYNTHASE; HYDROGEN PEROXIDE; ISOCITRATE DEHYDROGENASE 2; MANGANESE SUPEROXIDE DISMUTASE; REACTIVE OXYGEN METABOLITE; SIRTUIN 1; SIRTUIN 3; SUPEROXIDE; TOLL LIKE RECEPTOR 4; TRANSCRIPTION FACTOR RELB; TRICARBOXYLIC ACID; LIPOPOLYSACCHARIDE; RELB PROTEIN, MOUSE; SIRT1 PROTEIN, MOUSE; SIRT3 PROTEIN, MOUSE;

ADAPTATION; AMINO ACID SEQUENCE; ANIMAL CELL; ARTICLE; BIOENERGY; BIOGENESIS; CELL COMMUNICATION; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME ACTIVITY; EX VIVO STUDY; HOMEOSTASIS; HUMAN; HUMAN CELL; IMMUNOMETABOLISM; IMMUNOPATHOGENESIS; IMMUNOREGULATION; INFLAMMATION; MEMBRANE DEPOLARIZATION; MITOCHONDRIAL RESPIRATION; MITOCHONDRION; MONOCYTE; MONOCYTE MACROPHAGE PRECURSOR CELL; MOUSE; NONHUMAN; OXYGEN CONSUMPTION; PROTEIN EXPRESSION; SEPSIS; SPLEEN CELL; ANIMAL; C57BL MOUSE; CELL LINE; CELL NUCLEUS; DISEASE MODEL; DRUG EFFECTS; GENE EXPRESSION REGULATION; GENETICS; GLYCOLYSIS; IMMUNOLOGY; KNOCKOUT MOUSE; METABOLISM; OXIDATIVE PHOSPHORYLATION; PATHOLOGY; PRIMARY CELL CULTURE; SIGNAL TRANSDUCTION; SPLEEN;

MUS;

ANIMALS; CELL LINE; CELL NUCLEUS; DISEASE MODELS, ANIMAL; GENE EXPRESSION REGULATION; GLYCOLYSIS; HUMANS; LIPOPOLYSACCHARIDES; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MITOCHONDRIA; MONOCYTES; OXIDATIVE PHOSPHORYLATION; OXYGEN CONSUMPTION; PRIMARY CELL CULTURE; SEPSIS; SIGNAL TRANSDUCTION; SIRTUIN 1; SIRTUIN 3; SPLEEN; TRANSCRIPTION FACTOR RELB;

EID: 84920528079     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M114.566349     Document Type: Article

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