PINK1 deficiency impairs mitochondrial homeostasis and promotes lung fibrosis

Journal of Clinical Investigation

Volumn 125, Issue 2, 2015, Pages 521-538

  Bueno, Marta ^a,b   Lai, Yen Chun ^a   Romero, Yair ^c   Brands, Judith ^a,b   St Croix, Claudette M ^a   Kamga, Christelle ^a   Corey, Catherine ^a   Herazo Maya, Jose D ^d   Sembrat, John ^a,b   Lee, Janet S ^b   Duncan, Steve R ^b   Rojas, Mauricio ^b   Shiva, Sruti ^a,b   Chu, Charleen T ^b   Mora, Ana L ^a,b  

^a UNIVERSITY OF PITTSBURGH   (United States)

^b UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

^c UNIVERSIDAD NACIONAL AUTÓNOMA DE MÉXICO   (Mexico)

^d YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

PHOSPHOTRANSFERASE; PTEN INDUCED PUTATIVE KINASE 1; UNCLASSIFIED DRUG; PROTEIN KINASE; PTEN-INDUCED PUTATIVE KINASE;

AGING; ANIMAL EXPERIMENT; APOPTOSIS; ARTICLE; AUTOPHAGY; CONTROLLED STUDY; DEPOLARIZATION; DISORDERS OF MITOCHONDRIAL FUNCTIONS; ENDOPLASMIC RETICULUM STRESS; ENZYME DEFICIENCY; FIBROSING ALVEOLITIS; HOMEOSTASIS; HUMAN; HUMAN CELL; IMMUNOFLUORESCENCE TEST; IMMUNOHISTOCHEMISTRY; LUNG ALVEOLUS CELL; LUNG ALVEOLUS EPITHELIUM; MITOCHONDRIAL MEMBRANE POTENTIAL; MITOCHONDRIAL RESPIRATION; MITOCHONDRION; MOUSE; NONHUMAN; OXIDATIVE PHOSPHORYLATION; PINK1 DEFICIENCY; PRIORITY JOURNAL; PROTEIN EXPRESSION; UPREGULATION; ANIMAL; BAGG ALBINO MOUSE; DEFICIENCY; ENZYMOLOGY; GENETICS; KNOCKOUT MOUSE; LUNG ALVEOLUS; METABOLISM; MITOPHAGY; PATHOLOGY; TUMOR CELL LINE;

AGING; ANIMALS; APOPTOSIS; CELL LINE, TUMOR; ENDOPLASMIC RETICULUM STRESS; HUMANS; IDIOPATHIC PULMONARY FIBROSIS; MICE; MICE, INBRED BALB C; MICE, KNOCKOUT; MITOCHONDRIA; MITOCHONDRIAL DEGRADATION; PROTEIN KINASES; PULMONARY ALVEOLI; UP-REGULATION;

EID: 84961290427     PISSN: 00219738     EISSN: 15588238     Source Type: Journal    
DOI: 10.1172/JCI74942     Document Type: Article

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