Impaired mitophagy leads to cigarette smoke stress-induced cellular senescence: Implications for chronic obstructive pulmonary disease

FASEB Journal

Volumn 29, Issue 7, 2015, Pages 2912-2929

  Ahmad, Tanveer ^a   Sundar, Isaac K ^a   Lerner, Chad A ^a   Gerloff, Janice ^a   Tormos, Ana M ^a   Yao, Hongwei ^a   Rahman, Irfan ^a  

^a UNIVERSITY OF ROCHESTER MEDICAL CENTER   (United States)

Author keywords

DNA damage; Parkin; Perinuclear mitochondrial clustering; Pink1; Reactive oxygen species

Indexed keywords

ANTIOXIDANT; CIGARETTE SMOKE; MITO TEMPO; PARKIN; ROTENONE; UNCLASSIFIED DRUG; MITOTEMPO; ORGANOPHOSPHORUS COMPOUND; PIPERIDINE DERIVATIVE; REACTIVE OXYGEN METABOLITE; UBIQUITIN PROTEIN LIGASE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CELL AGING; CHRONIC OBSTRUCTIVE LUNG DISEASE; CONTROLLED STUDY; DNA DAMAGE; ENVIRONMENTAL EXPOSURE; EPITHELIUM CELL; GENE OVEREXPRESSION; HUMAN; HUMAN CELL; HUMAN TISSUE; IC50; IN VITRO STUDY; IN VIVO STUDY; LUNG; LUNG ALVEOLUS CELL; LUNG EMPHYSEMA; LUNG FIBROBLAST; MITOCHONDRION; MITOPHAGY; MOUSE; NONHUMAN; PRIORITY JOURNAL; RESPIRATORY EPITHELIUM; SMALL AIRWAY EPITHELIAL CELL; SMOKING; STRESS; ADVERSE EFFECTS; ANIMAL; C57BL MOUSE; CASE CONTROL STUDY; CELL CULTURE; DRUG EFFECTS; FIBROBLAST; METABOLISM; PATHOLOGY; PULMONARY DISEASE, CHRONIC OBSTRUCTIVE; RESPIRATORY TRACT MUCOSA;

VASCONCELLEA CANDICANS;

ANIMALS; ANTIOXIDANTS; CASE-CONTROL STUDIES; CELL AGING; CELLS, CULTURED; DNA DAMAGE; FIBROBLASTS; HUMANS; LUNG; MICE; MICE, INBRED C57BL; MITOCHONDRIAL DEGRADATION; ORGANOPHOSPHORUS COMPOUNDS; PIPERIDINES; PULMONARY DISEASE, CHRONIC OBSTRUCTIVE; REACTIVE OXYGEN SPECIES; RESPIRATORY MUCOSA; SMOKING; UBIQUITIN-PROTEIN LIGASES;

EID: 84940404091     PISSN: 08926638     EISSN: 15306860     Source Type: Journal    
DOI: 10.1096/fj.14-268276     Document Type: Article

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