Asbestos-induced peribronchiolar cell proliferation and cytokine production are attenuated in lungs of protein kinase C-δ knockout mice

American Journal of Pathology

Volumn 170, Issue 1, 2007, Pages 140-151

  Shukla, Arti ^a   Lounsbury, Karen M ^a   Barrett, Trisha F ^a   Gell, Joanna ^a   Rincon, Mercedes ^b   Butnor, Kelly J ^a   Taatjes, Douglas J ^a   Davis, Gerald S ^b   Vacek, Pamela ^b   Nakayama, Keiichi I ^d   Nakayama, Keiko ^d   Steele, Chad ^c   Mossman, Brooke T ^a,b  

^a UNIVERSITY OF VERMONT   (United States)

^b UNIVERSITY OF VERMONT COLLEGE OF MEDICINE   (United States)

^c CHILDREN S HOSPITAL OF PITTSBURGH   (United States)

^d KYUSHU UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ASBESTOS; IMMUNOGLOBULIN; INTERLEUKIN 13; INTERLEUKIN 4; INTERLEUKIN 6; MESSENGER RNA; PROTEIN KINASE C GAMMA; CD45 ANTIGEN; CHRYSOTILE; INTERLEUKIN DERIVATIVE; PROTEIN KINASE C DELTA;

ANIMAL CELL; ANIMAL MODEL; ARTICLE; B LYMPHOCYTE; BRONCHIOLE; CELL PROLIFERATION; CYTOKINE PRODUCTION; KNOCKOUT MOUSE; LUNG INFILTRATE; LUNG LAVAGE; MICROARRAY ANALYSIS; MOUSE; NONHUMAN; PLASMA CELL; POLYMORPHONUCLEAR CELL; PRIORITY JOURNAL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; ANIMAL; BIOSYNTHESIS; C57BL MOUSE; DRUG ANTAGONISM; DRUG EFFECT; ENZYMOLOGY; GENE EXPRESSION REGULATION; GENETICS; INFLAMMATION; LUNG DISEASE; LUNG FIBROSIS; LYMPHOCYTE SUBPOPULATION; MACROPHAGE; METABOLISM; MOUSE MUTANT; NATURAL KILLER CELL; PATHOLOGY; SIGNAL TRANSDUCTION;

ANIMALS; ANTIGENS, CD45; ASBESTOS, SERPENTINE; CELL PROLIFERATION; GENE EXPRESSION REGULATION, ENZYMOLOGIC; INFLAMMATION; INTERLEUKINS; KILLER CELLS, NATURAL; LUNG DISEASES; LYMPHOCYTE SUBSETS; MACROPHAGES; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; PROTEIN KINASE C-DELTA; PULMONARY FIBROSIS; SIGNAL TRANSDUCTION;

EID: 33847061759     PISSN: 00029440     EISSN: None     Source Type: Journal    
DOI: 10.2353/ajpath.2007.060381     Document Type: Article

References (45)

1. Mossman BT, Bignon J, Corn M, Seaton A, Gee JB: Asbestos: scientific developments and implications for public policy. Science 1990, 247:294-301
2. Mossman BT, Churg A: Mechanisms in the pathogenesis of asbestosis and silicosis. Am J Respir Crit Care Med 1998, 157:1666-1680
3. Buchner K: The role of protein kinase C in the regulation of cell growth and in signalling to the cell nucleus. J Cancer Res Clin Oncol 2000, 126:1-11
4. Mellor H, Parker PJ: The extended protein kinase C superfamily. Biochem J 1998, 332:281-292
5. Tan SL, Parker PJ: Emerging and diverse roles of protein kinase C in immune cell signalling. Biochem J 2003, 376:545-552
6. Lounsbury KM, Stern M, Taatjes D, Jaken S, Mossman BT: Increased localization and substrate activation of protein kinase C delta in lung epithelial cells following exposure to asbestos. Am J Pathol 2002, 160:1991-2000
7. Shukla A, Stern M, Lounsbury KM, Flanders T, Mossman BT: Asbestos-induced apoptosis is protein kinase C delta-dependent. Am J Respir Cell Mol Biol 2003, 29:198-205
8. Zhang L, Keane MP, Zhu LX, Sharma S, Rozengurt E, Strieter RM, Dubinett SM, Huang M: Interleukin-7 and transforming growth factor-beta play counter-regulatory roles in protein kinase C-delta-dependent control of fibroblast collagen synthesis in pulmonary fibrosis. J Biol Chem 2004, 279:28315-28319
9. Jimenez SA, Gaidarova S, Saitta B, Sandorfi N, Herrich DJ, Rosenbloom JC, Kucich U, Abrams WR, Rosenbloom J: Role of protein kinase C-delta in the regulation of collagen gene expression in scleroderma fibroblasts. J Clin Invest 2001, 108:1395-1403
10. Mimura Y, Ihn H, Jinnin M, Asano Y, Yamane K, Tamaki K: Epidermal growth factor induces fibronectin expression in human dermal fibroblasts via protein kinase C delta signaling pathway. J Invest Dermatol 2004, 122:1390-1398
11. Shukla A, Barrett TF, Nakayama KI, Nakayama K, Mossman BT, Lounsbury KM: Transcriptional up-regulation of MMP12 and MMP13 by asbestos occurs via a PKCdelta-dependent pathway in murine lung. FASEB J 2006, 20:997-999
12. Kontny E, Ziolkowska M, Ryzewska A, Maslinski W: Protein kinase c-dependent pathway is critical for the production of pro-inflammatory cytokines (TNF-alpha, IL-1beta, IL-6). Cytokine 1999, 11:839-848
13. Robledo RF, Buder-Hoffmann SA, Cummins AB, Walsh ES, Taatjes DJ, Mossman BT: Increased phosphorylated extracellular signal-regulated kinase immunoreactivity associated with proliferative and morphologic lung alterations after chrysotile asbestos inhalation in mice. Am J Pathol 2000, 156:1307-1316
14. Sabo-Attwood T, Ramos-Nino M, Bond J, Butnor KJ, Heintz N, Gruber AD, Steele C, Taatjes DJ, Vacek P, Mossman BT: Gene expression profiles reveal increased mClca3 (Gob5) expression and mucin production in a murine model of asbestos-induced fibrogenesis. Am J Pathol 2005, 167:1243-1256
15. Miyamoto A, Nakayama K, Imaki H, Hirose S, Jiang Y, Abe M, Tsukiyama T, Nagahama H, Ohno S, Hatakeyama S, Nakayama KI: Increased proliferation of B cells and auto-immunity in mice lacking protein kinase Cdelta. Nature 2002, 416:865-869
16. Wylie AG, Skinner HC, Marsh J, Snyder H, Garzione C, Hodkinson D, Winters R, Mossman BT: Mineralogical features associated with cytotoxic and proliferative effects of fibrous talc and asbestos on rodent tracheal epithelial and pleural mesothelial cells. Toxicol Appl Pharmacol 1997, 147:143-150
17. Peng SL, Gerth AJ, Ranger AM, Glimcher LH: NFATc1 and NFATc2 together control both T and B cell activation and differentiation. Immunity 2001, 14:13-20
18. Craighead JE, Abraham JL, Churg A, Green FH, Kleinerman J, Pratt PC, Seemayer TA, Vallyathan V, Weill H: The pathology of asbestos-associated diseases of the lungs and pleural cavities: diagnostic criteria and proposed grading schema. Report of the Pneumoconiosis Committee of the College of American Pathologists and the National Institute for Occupational Safety and Health. Arch Pathol Lab Med 1982, 106:544-596
19. Evans CM, Williams OW, Tuvim MJ, Nigam R, Mixides GP, Blackburn MR, DeMayo FJ, Burns AR, Smith C, Reynolds SD, Stripp BR, Dickey BF: Mucin is produced by Clara cells in the proximal airways of antigen-challenged mice. Am J Respir Cell Mol Biol 2004, 31:382-394
20. Haegens A, van der Vliet A, Butnor KJ, Heintz N, Taatjes D, Hemenway D, Vacek P, Freeman BA, Hazen SL, Brennan ML, Mossman BT: Asbestos-induced lung inflammation and epithelial cell proliferation are altered in myeloperoxidase-null mice. Cancer Res 2005, 65:9670-9677
21. Davis GS, Pfeiffer LM, Hemenway DR: Interferon-gamma production by specific lung lymphocyte phenotypes in silicosis in mice. Am J Respir Cell Mol Biol 2000, 22:491-501
22. Shukla A, Timblin C, BeruBe K, Gordon T, McKinney W, Driscoll K, Vacek P, Mossman BT: Inhaled particulate matter causes expression of nuclear factor (NF)-kappaB-related genes and oxidant-dependent NF-kappaB activation in vitro. Am J Respir Cell Mol Biol 2000, 23:182-187
23. Crystal RG, Bitterman PB, Mossman B, Schwarz MI, Sheppard D, Almasy L, Chapman HA, Friedman SL, King Jr TE, Leinwand LA, Liotta L, Martin GR, Schwartz DA, Schultz GS, Wagner CR, Musson RA: Future research directions in idiopathic pulmonary fibrosis: summary of a National Heart, Lung, and Blood Institute working group. Am J Respir Crit Care Med 2002, 166:236-246
24. BéruBé KA, Quinlan TR, Moulton G, Hemenway D, O'Shaughnessy P, Vacek P, Mossman BT: Comparative proliferative and histopathologic changes in rat lungs after inhalation of chrysotile or crocidolite asbestos. Toxicol Appl Pharmacol 1996, 137:67-74
25. Jackson DN, Foster DA: The enigmatic protein kinase Cdelta: complex roles in cell proliferation and survival. FASEB J 2004, 18:627-636
26. Chou WH, Choi DS, Zhang H, Mu D, McMahon T, Kharazia VN, Lowell CA, Ferriero DM, Messing RO: Neutrophil protein kinase Cdelta as a mediator of stroke-reperfusion injury. J Clin Invest 2004, 114:49-56
27. Armstrong DA, Major JA, Chudyk A, Hamilton TA: Neutrophil chemoattractant genes KC and MIP-2 are expressed in different cell populations at sites of surgical injury. J Leukoc Biol 2004, 75:641-648
28. Kamp DW, Dunn MM, Sbalchiero JS, Knap AM, Weitzman SA: Contrasting effects of alveolar macrophages and neutrophils on asbestos-induced pulmonary epithelial cell injury. Am J Physiol 1994, 266:L84-L91
29. Kim JH, Kim HY, Kim S, Chung JH, Park WS, Chung DH: Natural killer T (NKT) cells attenuate bleomycin-induced pulmonary fibrosis by producing interferon-gamma. Am J Pathol 2005, 167:1231-1241
30. Gonzalez-Moya JE, Hueto J, Ruiz de Azua AY, Sanchez J, Franquet T: Evolution of a case of lung plasma cell granuloma. Eur Respir J 1991, 4:755-757
31. Spencer H: The pulmonary plasma cell/histiocytoma complex. Histopathology 1984, 8:903-916
32. Balachandran A, Shivbalan S: Plasma cell granuloma of the lung. Indian Pediatr 2004, 41:292-293
33. Mecklenbräuker I, Saijo K, Zheng NY, Leitges M, Tarakhovsky A: Protein kinase Cdelta controls self-antigen-induced B-cell tolerance. Nature 2002, 416:860-865
34. Hagimoto N, Kuwano K, Nomoto Y, Kunitake R, Hara N: Apoptosis and expression of Fas/Fas ligand mRNA in bleomycin-induced pulmonary fibrosis in mice. Am J Respir Cell Mol Biol 1997, 16:91-101
35. Harrison NK, Myers AR, Corrin B, Soosay G, Dewar A, Black CM, Du Bois RM, Turner-Warwick M: Structural features of interstitial lung disease in systemic sclerosis. Am Rev Respir Dis 1991, 144:706-713
36. Elias JA, Lee CG, Zheng T, Shim Y, Zhu Z: Interleukin-13 and leukotrienes: an intersection of pathogenetic schema. Am J Respir Cell Mol Biol 2003, 28:401-404
37. Lee PJ, Zhang X, Shan P, Ma B, Lee CG, Homer RJ, Zhu Z, Rincon M, Mossman BT, Elias JA: ERK1/2 mitogen-activated protein kinase selectively mediates IL-13-induced lung inflammation and remodeling in vivo. J Clin Invest 2006, 116:163-173
38. Smith RE, Strieter RM, Phan SH, Kunkel SL: C-C chemokines: novel mediators of the profibrotic inflammatory response to bleomycin challenge. Am J Respir Cell Mol Biol 1996, 15:693-702
39. Driscoll KE, Hassenbein DG, Carter J, Poynter J, Asquith TN, Grant RA, Whitten J, Purdon MP, Takigiku R: Macrophage inflammatory proteins 1 and 2: expression by rat alveolar macrophages, fibroblasts, and epithelial cells and in rat lung after mineral dust exposure. Am J Respir Cell Mol Biol 1993, 8:311-318
40. Liu C, Lu J, Tan J, Li L, Huang B: Human interleukin-5 expression is synergistically regulated by histone acetyltransferase CBP/p300 and transcription factors C/EBP, NF-AT and AP-1. Cytokine 2004, 27:93-100
41. Takeuchi E, Yanagawa H, Suzuki Y, Shinkawa K, Ohmoto Y, Bando H, Sone S: IL-12-induced production of IL-10 and interferon-gamma by mononuclear cells in lung cancer-associated malignant pleural effusions. Lung Cancer 2002, 35:171-177
42. Fronhofer V, Lennartz MR, Loegering DJ: Role of PKC isoforms in the Fc(gamma)R-mediated inhibition of LPS-stimulated IL-12 secretion by macrophages. J Leukoc Biol 2006, 79:408-415
43. Contreras X, Bennasser Y, Bahraoui E: IL-10 production induced by HIV-1 Tat stimulation of human monocytes is dependent on the activation of PKC beta(II) and delta isozymes. Microbes Infect 2004, 6:1182-1190
44. Page K, Li J, Zhou L, Iasvovskaia S, Corbit KC, Soh JW, Weinstein IB, Brasier AR, Lin A, Hershenson MB: Regulation of airway epithelial cell NF-kappa B-dependent gene expression by protein kinase C delta. J Immunol 2003, 170:5681-5689
45. Sesko A, Cabot M, Mossman B: Hydrolysis of inositol phospholipids precedes cellular proliferation in asbestos-stimulated tracheobronchial epithelial cells. Proc Natl Acad Sci USA 1990, 87:7385-7389