Intratracheal administration of mitochondrial DNA directly provokes lung inflammation through the TLR9-p38 MAPK pathway

Free Radical Biology and Medicine

Volumn 83, Issue , 2015, Pages 149-158

  Gu, Xiaoling ^a   Wu, Guannan ^a   Yao, Yanwen ^a   Zeng, Junli ^a   Shi, Donghong ^a   Lv, Tangfeng ^a   Luo, Liang ^b   Song, Yong ^a  

^a NANJING UNIVERSITY   (China)

^b NANJING MEDICAL UNIVERSITY   (China)

Author keywords

Freeradicals; Inflammation; Lung; Mitochondrial DNA; pathway; TLR9p38 MAPKsignaltransduction

Indexed keywords

4 (4 FLUOROPHENYL) 2 (4 METHYLSULFINYLPHENYL) 5 (4 PYRIDYL)IMIDAZOLE; CHLOROQUINE; INTERLEUKIN 1BETA; INTERLEUKIN 6; MITOCHONDRIAL DNA; MITOGEN ACTIVATED PROTEIN KINASE P38; SMALL INTERFERING RNA; TOLL LIKE RECEPTOR 9; TUMOR NECROSIS FACTOR ALPHA; CYTOKINE; TLR9 PROTEIN, MOUSE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CELL INFILTRATION; CONTROLLED STUDY; CYTOKINE PRODUCTION; ENZYME LINKED IMMUNOSORBENT ASSAY; ENZYME PHOSPHORYLATION; HISTOPATHOLOGY; INFLAMMATORY CELL; MACROPHAGE; MALE; MOUSE; NONHUMAN; PNEUMONIA; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; WESTERN BLOTTING; ANIMAL; C57BL MOUSE; DRUG ADMINISTRATION ROUTE; FLUORESCENT ANTIBODY TECHNIQUE; GENETICS; METABOLISM; PATHOLOGY; PHOSPHORYLATION; TRACHEA;

MUS;

ANIMALS; BLOTTING, WESTERN; CYTOKINES; DNA, MITOCHONDRIAL; DRUG ADMINISTRATION ROUTES; ENZYME-LINKED IMMUNOSORBENT ASSAY; FLUORESCENT ANTIBODY TECHNIQUE; MACROPHAGES; MALE; MICE; MICE, INBRED C57BL; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PHOSPHORYLATION; PNEUMONIA; SIGNAL TRANSDUCTION; TOLL-LIKE RECEPTOR 9; TRACHEA;

EID: 84926658826     PISSN: 08915849     EISSN: 18734596     Source Type: Journal    
DOI: 10.1016/j.freeradbiomed.2015.02.034     Document Type: Article

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