-
1
-
-
84903304968
-
The Alzheimer’s disease mitochondrial cascade hypothesis: Progress and perspectives
-
Swerdlow RH, Burns JM, Khan SM. The Alzheimer’s disease mitochondrial cascade hypothesis: progress and perspectives. Biochim Biophys Acta 2013; 1842: 1219–1231.
-
(2013)
Biochim Biophys Acta
, vol.1842
, pp. 1219-1231
-
-
Swerdlow, R.H.1
Burns, J.M.2
Khan, S.M.3
-
2
-
-
79960557491
-
Assessment of newly synthesized mitochondrial DNA using BrdU labeling in primary neurons from Alzheimer’s disease mice: Implications for impaired mitochondrial biogenesis and synaptic damage
-
Calkins MJ, Reddy PH. Assessment of newly synthesized mitochondrial DNA using BrdU labeling in primary neurons from Alzheimer’s disease mice: implications for impaired mitochondrial biogenesis and synaptic damage. Biochim Biophys Acta 2011; 1812: 1182–1189.
-
(2011)
Biochim Biophys Acta
, vol.1812
, pp. 1182-1189
-
-
Calkins, M.J.1
Reddy, P.H.2
-
3
-
-
0035341254
-
Mitochondrial abnormalities in Alzheimer’s disease
-
Hirai K, Aliev G, Nunomura A, Fujioka H, Russell RL, Atwood CS et al. Mitochondrial abnormalities in Alzheimer’s disease.JNeurosci2001; 21: 3017–3023.
-
(2001)
Jneurosci
, vol.21
, pp. 3017-3023
-
-
Hirai, K.1
Aliev, G.2
Nunomura, A.3
Fujioka, H.4
Russell, R.L.5
Atwood, C.S.6
-
4
-
-
84856969873
-
Mitochondrial base excision repair in mouse synaptosomes during normal aging and in a model of Alzheimer’s disease
-
Gredilla R, Weissman L, Yang J-L, Bohr VA, Stevnsner T. Mitochondrial base excision repair in mouse synaptosomes during normal aging and in a model of Alzheimer’s disease.Neurobiol Aging 2012; 33: 694–707.
-
(2012)
Neurobiol Aging
, vol.33
, pp. 694-707
-
-
Gredilla, R.1
Weissman, L.2
Yang, J.-L.3
Bohr, V.A.4
Stevnsner, T.5
-
5
-
-
0026698066
-
An update on the mitochondrial-DNA mutation hypothesis of cell aging
-
Miquel J. An update on the mitochondrial-DNA mutation hypothesis of cell aging. Mutat Res 1992; 275: 209–216.
-
(1992)
Mutat Res
, vol.275
, pp. 209-216
-
-
Miquel, J.1
-
6
-
-
79959246028
-
Mitochondria, amyloid β, and Alzheimer’s disease
-
Readnower RD, Sauerbeck AD, Sullivan PG. Mitochondria, amyloid β, and Alzheimer’s disease. Int J Alzheimers Dis 2011; 2011: 104545.
-
(2011)
Int J Alzheimers Dis
, vol.2011
-
-
Readnower, R.D.1
Sauerbeck, A.D.2
Sullivan, P.G.3
-
7
-
-
0028109380
-
Correlation between mitochondrial DNA 4977-bp deletion and respiratory chain enzyme activities in aging human skeletal muscles
-
Lezza AM, Boffoli D, Scacco S, Cantatore P, Gadaleta MN. Correlation between mitochondrial DNA 4977-bp deletion and respiratory chain enzyme activities in aging human skeletal muscles. Biochem Biophys Res Commun 1994; 205: 772–779.
-
(1994)
Biochem Biophys Res Commun
, vol.205
, pp. 772-779
-
-
Lezza, A.M.1
Boffoli, D.2
Scacco, S.3
Cantatore, P.4
Gadaleta, M.N.5
-
8
-
-
84884879594
-
Mitochondrial defects and oxidative stress in Alzheimer disease and Parkinson disease
-
Yan MH, Wang X, Zhu X. Mitochondrial defects and oxidative stress in Alzheimer disease and Parkinson disease. Free Radic Biol Med 2013; 62: 90–101.
-
(2013)
Free Radic Biol Med
, vol.62
, pp. 90-101
-
-
Yan, M.H.1
Wang, X.2
Zhu, X.3
-
9
-
-
33750347347
-
Mitochondrial dysfunction and oxidative stress in neurodegenerative diseases
-
Lin MT, Beal MF. Mitochondrial dysfunction and oxidative stress in neurodegenerative diseases. Nature 2006; 443: 787–795.
-
(2006)
Nature
, vol.443
, pp. 787-795
-
-
Lin, M.T.1
Beal, M.F.2
-
10
-
-
84867578930
-
Mitochondria, oxidative stress and neurodegeneration
-
Federico A, Cardaioli E, Da Pozzo P, Formichi P, Gallus GN, Radi E. Mitochondria, oxidative stress and neurodegeneration. JNeurolSci2012; 322: 254–262.
-
(2012)
Jneurolsci
, vol.322
, pp. 254-262
-
-
Federico, A.1
Cardaioli, E.2
da Pozzo, P.3
Formichi, P.4
Gallus, G.N.5
Radi, E.6
-
11
-
-
84877922143
-
The role of mitochondrial DNA mutations and free radicals in disease and ageing
-
Lagouge M, Larsson N-G. The role of mitochondrial DNA mutations and free radicals in disease and ageing. J Intern Med 2013; 273: 529–543.
-
(2013)
J Intern Med
, vol.273
, pp. 529-543
-
-
Lagouge, M.1
Larsson, N.-G.2
-
12
-
-
77951953060
-
Mammalian mitochondrial complex I: Biogenesis, regulation, and reactive oxygen species generation
-
Oxygen R, Nijtmans LGJ, Dieteren CEJ, Roestenberg P, Valsecchi F, Smeitink JAM et al. Mammalian mitochondrial complex I: biogenesis, regulation, and reactive oxygen species generation. Antioxid Redox Signal 2010; 12: 1431–1470.
-
(2010)
Antioxid Redox Signal
, vol.12
, pp. 1431-1470
-
-
Oxygen, R.1
Nijtmans, L.G.J.2
Dieteren, C.E.J.3
Roestenberg, P.4
Valsecchi, F.5
Smeitink, J.A.M.6
-
13
-
-
77952541558
-
The sites and topology of mitochondrial superoxide production
-
Brand MD. The sites and topology of mitochondrial superoxide production. Exp Gerontol 2010; 45: 466–472.
-
(2010)
Exp Gerontol
, vol.45
, pp. 466-472
-
-
Brand, M.D.1
-
14
-
-
84878864199
-
The hallmarks of aging
-
López-Otín C, Blasco Ma, Partridge L, Serrano M, Kroemer G. The hallmarks of aging. Cell 2013; 153: 1194–1217.
-
(2013)
Cell
, vol.153
, pp. 1194-1217
-
-
López-Otín, C.1
Ma, B.2
Partridge, L.3
Serrano, M.4
Kroemer, G.5
-
15
-
-
76049083966
-
Reactive oxygen species, cellular redox systems, and apoptosis
-
Circu ML, Aw TY. Reactive oxygen species, cellular redox systems, and apoptosis. Free Radic Biol Med 2010; 48: 749–762.
-
(2010)
Free Radic Biol Med
, vol.48
, pp. 749-762
-
-
Circu, M.L.1
Aw, T.Y.2
-
16
-
-
77950573964
-
Functional organization of mammalian mitochondrial DNA in nucleoids: History, recent developments, and future challenges
-
Spelbrink JN. Functional organization of mammalian mitochondrial DNA in nucleoids: history, recent developments, and future challenges. IUBMB Life 2010; 62: 19–32.
-
(2010)
IUBMB Life
, vol.62
, pp. 19-32
-
-
Spelbrink, J.N.1
-
17
-
-
0019423856
-
Sequence and organization of the human mitochondrial genome
-
Anderson S, Bankier AT, Barrell BG, de Bruijn MH, Coulson AR, Drouin J et al. Sequence and organization of the human mitochondrial genome. Nature 1981; 290: 457–465.
-
(1981)
Nature
, vol.290
, pp. 457-465
-
-
Anderson, S.1
Bankier, A.T.2
Barrell, B.G.3
de Bruijn, M.H.4
Coulson, A.R.5
Drouin, J.6
-
18
-
-
80051972817
-
Super-resolution microscopy reveals that mammalian mitochondrial nucleoids have a uniform size and frequently contain a single copy of mtDNA
-
Kukat C, Wurm CA, Spåhr H, Falkenberg M, Larsson N-G, Jakobs S. Super-resolution microscopy reveals that mammalian mitochondrial nucleoids have a uniform size and frequently contain a single copy of mtDNA. Proc Natl Acad Sci USA 2011; 108: 13534–13539.
-
(2011)
Proc Natl Acad Sci USA
, vol.108
, pp. 13534-13539
-
-
Kukat, C.1
Wurm, C.A.2
Spåhr, H.3
Falkenberg, M.4
Larsson, N.-G.5
Jakobs, S.6
-
19
-
-
57649210205
-
Mitochondrial DNA mutations in disease, aging, and neurodegeneration
-
Reeve AK, Krishnan KJ, Turnbull D. Mitochondrial DNA mutations in disease, aging, and neurodegeneration. Ann NY Acad Sci 2008; 1147: 21–29.
-
(2008)
Ann NY Acad Sci
, vol.1147
, pp. 21-29
-
-
Reeve, A.K.1
Krishnan, K.J.2
Turnbull, D.3
-
20
-
-
80052007901
-
The human mitochondrial transcriptome
-
Mercer TR, Neph S, Dinger ME, Crawford J, Smith MA, Shearwood A-MJ et al. The human mitochondrial transcriptome. Cell 2011; 146: 645–658.
-
(2011)
Cell
, vol.146
, pp. 645-658
-
-
Mercer, T.R.1
Neph, S.2
Dinger, M.E.3
Crawford, J.4
Smith, M.A.5
Shearwood, A.-M.6
-
21
-
-
0035157544
-
Genome-wide responses to mitochondrial dysfunction
-
Epstein CB, Waddle JA, Hale W, Davé V, Thornton J, Macatee TL et al. Genome-wide responses to mitochondrial dysfunction. Mol Biol Cell 2001; 12: 297–308.
-
(2001)
Mol Biol Cell
, vol.12
, pp. 297-308
-
-
Epstein, C.B.1
Waddle, J.A.2
Hale, W.3
Davé, V.4
Thornton, J.5
Macatee, T.L.6
-
22
-
-
84900295547
-
Mitohormesis
-
Yun J, Finkel T. Mitohormesis. Cell Metab 2014; 19: 757–766.
-
(2014)
Cell Metab
, vol.19
, pp. 757-766
-
-
Yun, J.1
Finkel, T.2
-
23
-
-
0038612839
-
Mitochondria to nucleus stress signaling: A distinctive mechanism of NFkappaB/Rel activation through calcineurin-mediated inactivation of IkappaBbeta
-
Biswas G, Anandatheerthavarada HK, Zaidi M, Avadhani NG. Mitochondria to nucleus stress signaling: a distinctive mechanism of NFkappaB/Rel activation through calcineurin-mediated inactivation of IkappaBbeta. JCell Biol 2003; 161: 507–519.
-
(2003)
Jcell Biol
, vol.161
, pp. 507-519
-
-
Biswas, G.1
Anandatheerthavarada, H.K.2
Zaidi, M.3
Avadhani, N.G.4
-
24
-
-
66049087696
-
The coordination of nuclear and mitochondrial communication during aging and calorie restriction
-
Finley LWS, Haigis MC. The coordination of nuclear and mitochondrial communication during aging and calorie restriction. Ageing Res Rev 2009; 8: 173–188.
-
(2009)
Ageing Res Rev
, vol.8
, pp. 173-188
-
-
Finley, L.W.S.1
Haigis, M.C.2
-
25
-
-
0038054341
-
PGC-1alpha-responsive genes involved in oxidative phosphorylation are coordinately downregulated in human diabetes
-
Mootha VK, Lindgren CM, Eriksson K-F, Subramanian A, Sihag S, Lehar J et al. PGC-1alpha-responsive genes involved in oxidative phosphorylation are coordinately downregulated in human diabetes. Nat Genet 2003; 34: 267–273.
-
(2003)
Nat Genet
, vol.34
, pp. 267-273
-
-
Mootha, V.K.1
Lindgren, C.M.2
Eriksson, K.-F.3
Subramanian, A.4
Sihag, S.5
Lehar, J.6
-
26
-
-
84893442805
-
Declining NAD+ induces a pseudohypoxic state disrupting nuclear-mitochondrial communication during aging
-
Gomes AP, Price NL, Ling AJY, Moslehi JJ, Montgomery MK, Rajman L et al. Declining NAD+ induces a pseudohypoxic state disrupting nuclear-mitochondrial communication during aging. Cell 2013; 155: 1624–1638.
-
(2013)
Cell
, vol.155
, pp. 1624-1638
-
-
Gomes, A.P.1
Price, N.L.2
Ling, A.J.Y.3
Moslehi, J.J.4
Montgomery, M.K.5
Rajman, L.6
-
27
-
-
85136041237
-
Mitochondrial disulfide relay mediates translocation of p53 and partitions its subcellular activity
-
Zhuang J, Wang P-Y, Huang X, Chen X, Kang J-G, Hwang PM. Mitochondrial disulfide relay mediates translocation of p53 and partitions its subcellular activity. Proc Natl Acad Sci USA 2013; 2: 2–7.
-
(2013)
Proc Natl Acad Sci USA
, vol.2
, pp. 2-7
-
-
Zhuang, J.1
Wang, P.-Y.2
Huang, X.3
Chen, X.4
Kang, J.-G.5
Hwang, P.M.6
-
29
-
-
78649413837
-
Mitochondrial fusion and fission in cell life and death
-
Westermann B. Mitochondrial fusion and fission in cell life and death. Nat Rev Mol Cell Biol 2010; 11: 872–884.
-
(2010)
Nat Rev Mol Cell Biol
, vol.11
, pp. 872-884
-
-
Westermann, B.1
-
30
-
-
76249088524
-
Genome-wide deletion mutant analysis reveals genes required for respiratory growth, mitochondrial genome maintenance and mitochondrial protein synthesis in Saccharomyces cerevisiae
-
Merz S, Westermann B. Genome-wide deletion mutant analysis reveals genes required for respiratory growth, mitochondrial genome maintenance and mitochondrial protein synthesis in Saccharomyces cerevisiae. Genome Biol 2009; 10: R95.
-
(2009)
Genome Biol
, vol.10
, pp. R95
-
-
Merz, S.1
Westermann, B.2
-
31
-
-
45349094984
-
Mitochondrial dynamics and apoptosis
-
Suen D, Norris K, Youle R. Mitochondrial dynamics and apoptosis. Genes Dev 2008;: 1577–1590.
-
(2008)
Genes Dev
, pp. 1577-1590
-
-
Suen, D.1
Norris, K.2
Youle, R.3
-
32
-
-
34547442346
-
Bak regulates mitochondrial morphology and pathology during apoptosis by interacting with mitofusins
-
Brooks C, Wei Q, Feng L, Dong G, Tao Y, Mei L et al. Bak regulates mitochondrial morphology and pathology during apoptosis by interacting with mitofusins. Proc Natl Acad Sci USA 2007; 104: 11649–11654.
-
(2007)
Proc Natl Acad Sci USA
, vol.104
, pp. 11649-11654
-
-
Brooks, C.1
Wei, Q.2
Feng, L.3
Dong, G.4
Tao, Y.5
Mei, L.6
-
33
-
-
80051781073
-
Redox modulation by S-nitrosylation contributes to protein misfolding, mitochondrial dynamics, and neuronal synaptic damage in neurodegenerative diseases
-
Nakamura T, Lipton SA. Redox modulation by S-nitrosylation contributes to protein misfolding, mitochondrial dynamics, and neuronal synaptic damage in neurodegenerative diseases. Cell Death Differ 2011; 18: 1478–1486.
-
(2011)
Cell Death Differ
, vol.18
, pp. 1478-1486
-
-
Nakamura, T.1
Lipton, S.A.2
-
34
-
-
33748028841
-
Nitric oxide-induced mitochondrial fission is regulated by dynamin-related GTPases in neurons
-
Barsoum MJ, Yuan H, Gerencser AA, Liot G, Kushnareva Y, Gräber S et al. Nitric oxide-induced mitochondrial fission is regulated by dynamin-related GTPases in neurons. EMBO J 2006; 25: 3900–3911.
-
(2006)
EMBO J
, vol.25
, pp. 3900-3911
-
-
Barsoum, M.J.1
Yuan, H.2
Gerencser, A.A.3
Liot, G.4
Kushnareva, Y.5
Gräber, S.6
-
35
-
-
84939985504
-
CR6-interacting factor 1 is a key regulator in Aβ-induced mitochondrial disruption and pathogenesis of Alzheimer’s disease
-
e-pub ahead of print 7 November 2014
-
Byun J, Son SM, Cha M-Y, Shong M, Hwang YJ, Kim Y et al. CR6-interacting factor 1 is a key regulator in Aβ-induced mitochondrial disruption and pathogenesis of Alzheimer’s disease. Cell Death Differ (e-pub ahead of print 7 November 2014; doi:10.1038/cdd.2014.184).
-
Cell Death Differ
-
-
Byun, J.1
Son, S.M.2
Cha, M.-Y.3
Shong, M.4
Hwang, Y.J.5
Kim, Y.6
-
36
-
-
84858677223
-
Sensing and reacting to microbes through the inflammasomes
-
Franchi L, Muñoz-Planillo R, Núñez G. Sensing and reacting to microbes through the inflammasomes. Nat Immunol 2012; 13: 325–332.
-
(2012)
Nat Immunol
, vol.13
, pp. 325-332
-
-
Franchi, L.1
Muñoz-Planillo, R.2
Núñez, G.3
-
37
-
-
60749104683
-
The inflammasome: A caspase-1-activation platform that regulates immune responses and disease pathogenesis
-
Franchi L, Eigenbrod T, Muñoz-Planillo R, Nuñez G. The inflammasome: a caspase-1-activation platform that regulates immune responses and disease pathogenesis. Nat Immunol 2009; 10: 241–247.
-
(2009)
Nat Immunol
, vol.10
, pp. 241-247
-
-
Franchi, L.1
Eigenbrod, T.2
Muñoz-Planillo, R.3
Nuñez, G.4
-
38
-
-
84895524321
-
Ambiguities in NLRP3 inflammasome regulation: Is there a role for mitochondria?
-
Lawlor KE, Vince JE. Ambiguities in NLRP3 inflammasome regulation: is there a role for mitochondria? Biochim Biophys Acta 2013; 1840: 1433–1440.
-
(2013)
Biochim Biophys Acta
, vol.1840
, pp. 1433-1440
-
-
Lawlor, K.E.1
Vince, J.E.2
-
39
-
-
0041784698
-
Inflammatory neurodegeneration mediated by nitric oxide, glutamate, and mitochondria
-
Brown GC, Bal-Price A. Inflammatory neurodegeneration mediated by nitric oxide, glutamate, and mitochondria. Mol Neurobiol 2003; 27: 325–355.
-
(2003)
Mol Neurobiol
, vol.27
, pp. 325-355
-
-
Brown, G.C.1
Bal-Price, A.2
-
40
-
-
84876237736
-
The adaptor MAVS promotes NLRP3 mitochondrial localization and inflamma-some activation
-
Subramanian N, Natarajan K, Clatworthy MR, Wang Z, Germain RN. The adaptor MAVS promotes NLRP3 mitochondrial localization and inflamma-some activation. Cell 2013; 153: 348–361.
-
(2013)
Cell
, vol.153
, pp. 348-361
-
-
Subramanian, N.1
Natarajan, K.2
Clatworthy, M.R.3
Wang, Z.4
Germain, R.N.5
-
41
-
-
84858630049
-
A role for the NLRP3 inflammasome in metabolic diseases–did Warburg miss inflammation?
-
Wen H, Ting JP-Y, O’Neill LAJ. A role for the NLRP3 inflammasome in metabolic diseases–did Warburg miss inflammation? Nat Immunol 2012; 13: 352–357.
-
(2012)
Nat Immunol
, vol.13
, pp. 352-357
-
-
Wen, H.1
Ting, J.-Y.2
O’Neill, L.A.J.3
-
42
-
-
84871726622
-
Where the endoplasmic reticulum and the mitochon-drion tie the knot: The mitochondria-associated membrane (MAM)
-
Raturi A, Simmen T. Where the endoplasmic reticulum and the mitochon-drion tie the knot: the mitochondria-associated membrane (MAM). Biochim Biophys Acta 2013; 1833: 213–224.
-
(2013)
Biochim Biophys Acta
, vol.1833
, pp. 213-224
-
-
Raturi, A.1
Simmen, T.2
-
43
-
-
77953725586
-
Oxidative protein folding in the endoplasmic reticulum: Tight links to the mitochondria-associated membrane (MAM)
-
Simmen T, Lynes EM, Gesson K, Thomas G. Oxidative protein folding in the endoplasmic reticulum: tight links to the mitochondria-associated membrane (MAM). Biochim Biophys Acta 2010; 1798: 1465–1473.
-
(2010)
Biochim Biophys Acta
, vol.1798
, pp. 1465-1473
-
-
Simmen, T.1
Lynes, E.M.2
Gesson, K.3
Thomas, G.4
-
44
-
-
84875365804
-
Autophagosomes form at ER-mitochondria contact sites
-
Hamasaki M, Furuta N, Matsuda A, Nezu A, Yamamoto A, Fujita N et al. Autophagosomes form at ER-mitochondria contact sites. Nature 2013; 495: 389–393.
-
(2013)
Nature
, vol.495
, pp. 389-393
-
-
Hamasaki, M.1
Furuta, N.2
Matsuda, A.3
Nezu, A.4
Yamamoto, A.5
Fujita, N.6
-
45
-
-
84870984470
-
PERK is required at the ER-mitochondrial contact sites to convey apoptosis after ROS-based ER stress
-
Verfaillie T, Rubio N, Garg AD, Bultynck G, Rizzuto R, Decuypere J-P et al. PERK is required at the ER-mitochondrial contact sites to convey apoptosis after ROS-based ER stress. Cell Death Differ 2012; 19: 1880–1891.
-
(2012)
Cell Death Differ
, vol.19
, pp. 1880-1891
-
-
Verfaillie, T.1
Rubio, N.2
Garg, A.D.3
Bultynck, G.4
Rizzuto, R.5
Decuypere, J.-P.6
-
46
-
-
79551600416
-
Fis1 and Bap31 bridge the mitochondria-ER interface to establish a platform for apoptosis induction
-
Iwasawa R, Mahul-Mellier A-L, Datler C, Pazarentzos E, Grimm S. Fis1 and Bap31 bridge the mitochondria-ER interface to establish a platform for apoptosis induction. EMBO J 2011; 30: 556–568.
-
(2011)
EMBO J
, vol.30
, pp. 556-568
-
-
Iwasawa, R.1
Mahul-Mellier, A.-L.2
Datler, C.3
Pazarentzos, E.4
Grimm, S.5
-
47
-
-
84868524156
-
Upregulated function of mitochondria-associated ER membranes in Alzheimer disease
-
Area-Gomez E, Del Carmen Lara Castillo M, Tambini MD, Guardia-Laguarta C, de Groof AJC, Madra M et al. Upregulated function of mitochondria-associated ER membranes in Alzheimer disease. EMBO J 2012; 31: 4106–4123.
-
(2012)
EMBO J
, vol.31
, pp. 4106-4123
-
-
Area-Gomez, E.1
Carmen Lara Castillo, D.2
Tambini, M.D.3
Guardia-Laguarta, C.4
de Groof, A.J.C.5
Madra, M.6
-
48
-
-
84877337663
-
Modulation of the endoplasmic reticulum–mitochondria interface in Alzheimer’s disease and related models
-
Hedskog L, Moreira C, Filadi R, Rönnbäck A, Hertwig L, Wiehager B. Modulation of the endoplasmic reticulum–mitochondria interface in Alzheimer’s disease and related models. Proc Natl Acad Sci USA 2013; 110: 7916–7921.
-
(2013)
Proc Natl Acad Sci USA
, vol.110
, pp. 7916-7921
-
-
Hedskog, L.1
Moreira, C.2
Filadi, R.3
Rönnbäck, A.4
Hertwig, L.5
Wiehager, B.6
-
49
-
-
84859709003
-
Mitochondria-specific accumulation of amyloid β induces mitochondrial dysfunction leading to apoptotic cell death
-
Cha M-Y, Han S-H, Son SM, Hong H-S, Choi Y-J, Byun J et al. Mitochondria-specific accumulation of amyloid β induces mitochondrial dysfunction leading to apoptotic cell death. PLoS One 2012; 7: e34929.
-
(2012)
Plos One
, vol.7
-
-
Cha, M.-Y.1
Han, S.-H.2
Son, S.M.3
Hong, H.-S.4
Choi, Y.-J.5
Byun, J.6
-
50
-
-
67649803186
-
Amyloid beta, mitochondrial structural and functional dynamics in Alzheimer’s disease
-
Reddy PH. Amyloid beta, mitochondrial structural and functional dynamics in Alzheimer’s disease.Exp Neurol 2009; 218: 286–292.
-
(2009)
Exp Neurol
, vol.218
, pp. 286-292
-
-
Reddy, P.H.1
-
51
-
-
84903370950
-
Base excision DNA repair levels in mitochondrial lysates of Alzheimer’s disease
-
Canugovi C, Shamanna RA, Croteau DL, Bohr VA. Base excision DNA repair levels in mitochondrial lysates of Alzheimer’s disease. Neurobiol Aging 2014; 35: 1–8.
-
(2014)
Neurobiol Aging
, vol.35
, pp. 1-8
-
-
Canugovi, C.1
Shamanna, R.A.2
Croteau, D.L.3
Bohr, V.A.4
-
52
-
-
84863446929
-
Mitochondrial DNA deletions cause the biochemical defect observed in Alzheimer’s disease
-
Krishnan KJ, Ratnaike TE, De Gruyter HLM, Jaros E, Turnbull DM. Mitochondrial DNA deletions cause the biochemical defect observed in Alzheimer’s disease.Neurobiol Aging 2012; 33: 2210–2214.
-
(2012)
Neurobiol Aging
, vol.33
, pp. 2210-2214
-
-
Krishnan, K.J.1
Ratnaike, T.E.2
de Gruyter, H.L.M.3
Jaros, E.4
Turnbull, D.M.5
-
53
-
-
71849084134
-
Mitochondrial dysfunction in Parkinson’s disease
-
Winklhofer KF, Haass C. Mitochondrial dysfunction in Parkinson’s disease. Biochim Biophys Acta 2010; 1802: 29–44.
-
(2010)
Biochim Biophys Acta
, vol.1802
, pp. 29-44
-
-
Winklhofer, K.F.1
Haass, C.2
-
54
-
-
84903301367
-
Mitochondria-targeted antioxidants for treatment of Parkinson’s disease: Preclinical and clinical outcomes
-
Jin H, Kanthasamy A, Ghosh A, Anantharam V, Kalyanaraman B, Kanthasamy AG. Mitochondria-targeted antioxidants for treatment of Parkinson’s disease: preclinical and clinical outcomes. Biochim Biophys Acta 2013; 1842: 1282–1294.
-
(2013)
Biochim Biophys Acta
, vol.1842
, pp. 1282-1294
-
-
Jin, H.1
Kanthasamy, A.2
Ghosh, A.3
Anantharam, V.4
Kalyanaraman, B.5
Kanthasamy, A.G.6
-
55
-
-
79961239061
-
Impaired mitochondrial transport and Parkin-independent degeneration of respiratory chain-deficient dopamine neurons in vivo
-
Sterky FH, Lee S, Wibom R, Olson L, Larsson N-G. Impaired mitochondrial transport and Parkin-independent degeneration of respiratory chain-deficient dopamine neurons in vivo. Proc Natl Acad Sci USA 2011; 108: 12937–12942.
-
(2011)
Proc Natl Acad Sci USA
, vol.108
, pp. 12937-12942
-
-
Sterky, F.H.1
Lee, S.2
Wibom, R.3
Olson, L.4
Larsson, N.-G.5
-
56
-
-
79961233786
-
Pink1 regulates the oxidative phosphorylation machinery via mitochondrial fission
-
Liu W, Acín-Peréz R, Geghman KD, Manfredi G, Lu B, Li C. Pink1 regulates the oxidative phosphorylation machinery via mitochondrial fission. Proc Natl Acad Sci USA 2011; 108: 12920–12924.
-
(2011)
Proc Natl Acad Sci USA
, vol.108
, pp. 12920-12924
-
-
Liu, W.1
Acín-Peréz, R.2
Geghman, K.D.3
Manfredi, G.4
Lu, B.5
Li, C.6
-
57
-
-
84895904175
-
Enhancing nucleotide metabolism protects against mitochondrial dysfunction and neurodegeneration in a PINK1 model of Parkinson’s disease
-
Tufi R, Gandhi S, de Castro IP, Lehmann S, Angelova PR, Dinsdale D et al. Enhancing nucleotide metabolism protects against mitochondrial dysfunction and neurodegeneration in a PINK1 model of Parkinson’s disease. Nat Cell Biol 2014; 16: 157–166.
-
(2014)
Nat Cell Biol
, vol.16
, pp. 157-166
-
-
Tufi, R.1
Gandhi, S.2
de Castro, I.P.3
Lehmann, S.4
Angelova, P.R.5
Dinsdale, D.6
-
58
-
-
33646351299
-
Mitochondrial DNA deletions are abundant and cause functional impairment in aged human substantia nigra neurons
-
Kraytsberg Y, Kudryavtseva E, McKee AC, Geula C, Kowall NW, Khrapko K. Mitochondrial DNA deletions are abundant and cause functional impairment in aged human substantia nigra neurons. Nat Genet 2006; 38: 518–520.
-
(2006)
Nat Genet
, vol.38
, pp. 518-520
-
-
Kraytsberg, Y.1
Kudryavtseva, E.2
McKee, A.C.3
Geula, C.4
Kowall, N.W.5
Khrapko, K.6
-
59
-
-
82555174637
-
Striatal dysfunctions associated with mitochondrial DNA damage in dopaminergic neurons in a mouse model of Parkinson’s disease
-
Pickrell AM, Pinto M, Hida A, Moraes CT. Striatal dysfunctions associated with mitochondrial DNA damage in dopaminergic neurons in a mouse model of Parkinson’s disease.JNeurosci2011; 31: 17649–17658.
-
(2011)
Jneurosci
, vol.31
, pp. 17649-17658
-
-
Pickrell, A.M.1
Pinto, M.2
Hida, A.3
Moraes, C.T.4
-
60
-
-
34247880172
-
Early decrease of mitochondrial DNA repair enzymes in spinal motor neurons of presymptomatic transgenic mice carrying a mutant SOD1 gene
-
Murakami T, Nagai M, Miyazaki K, Morimoto N, Ohta Y, Kurata T et al. Early decrease of mitochondrial DNA repair enzymes in spinal motor neurons of presymptomatic transgenic mice carrying a mutant SOD1 gene. Brain Res 2007; 1150: 182–189.
-
(2007)
Brain Res
, vol.1150
, pp. 182-189
-
-
Murakami, T.1
Nagai, M.2
Miyazaki, K.3
Morimoto, N.4
Ohta, Y.5
Kurata, T.6
-
61
-
-
77955961922
-
Misfolded mutant SOD1 directly inhibits VDAC1 conductance in a mouse model of inherited ALS
-
Israelson A, Arbel N, Da Cruz S, Ilieva H, Yamanaka K, Shoshan-Barmatz V et al. Misfolded mutant SOD1 directly inhibits VDAC1 conductance in a mouse model of inherited ALS. Neuron 2010; 67: 575–587.
-
(2010)
Neuron
, vol.67
, pp. 575-587
-
-
Israelson, A.1
Arbel, N.2
da Cruz, S.3
Ilieva, H.4
Yamanaka, K.5
Shoshan-Barmatz, V.6
-
62
-
-
0034601407
-
Mitochondrial DNA deletion mutation levels are elevated in ALS brains
-
Dhaliwal GK, Grewal RP. Mitochondrial DNA deletion mutation levels are elevated in ALS brains. NeuroReport 2000; 11: 2507–2509.
-
(2000)
Neuroreport
, vol.11
, pp. 2507-2509
-
-
Dhaliwal, G.K.1
Grewal, R.P.2
-
63
-
-
0035906260
-
Oxidative damage to mitochondrial DNA in spinal motoneurons of transgenic ALS mice
-
Warita H, Hayashi T, Murakami T, Manabe Y, Abe K. Oxidative damage to mitochondrial DNA in spinal motoneurons of transgenic ALS mice. Brain Res Mol Brain Res 2001; 89: 147–152.
-
(2001)
Brain Res Mol Brain Res
, vol.89
, pp. 147-152
-
-
Warita, H.1
Hayashi, T.2
Murakami, T.3
Manabe, Y.4
Abe, K.5
-
64
-
-
0036946576
-
Impairment of mitochondrial DNA repair enzymes against accumulation of 8-oxo-guanine in the spinal motor neurons of amyotrophic lateral sclerosis
-
Kikuchi H, Furuta A, Nishioka K, Suzuki SO, Nakabeppu Y, Iwaki T. Impairment of mitochondrial DNA repair enzymes against accumulation of 8-oxo-guanine in the spinal motor neurons of amyotrophic lateral sclerosis. Acta Neuropathol 2002; 103: 408–414.
-
(2002)
Acta Neuropathol
, vol.103
, pp. 408-414
-
-
Kikuchi, H.1
Furuta, A.2
Nishioka, K.3
Suzuki, S.O.4
Nakabeppu, Y.5
Iwaki, T.6
-
65
-
-
84884910504
-
Role of oxidative DNA damage in mitochondrial dysfunction and Huntington’s disease pathogenesis
-
Ayala-Peña S. Role of oxidative DNA damage in mitochondrial dysfunction and Huntington’s disease pathogenesis. Free Radic Biol Med 2013; 62: 102–110.
-
(2013)
Free Radic Biol Med
, vol.62
, pp. 102-110
-
-
Ayala-Peña, S.1
-
66
-
-
78650279311
-
Could successful (mitochondrial) networking help prevent Huntington’s disease?
-
Oliveira JMa, Lightowlers RN. Could successful (mitochondrial) networking help prevent Huntington’s disease?EMBO Mol Med 2010; 2: 487–489.
-
(2010)
EMBO Mol Med
, vol.2
, pp. 487-489
-
-
Jma, O.1
Lightowlers, R.N.2
-
67
-
-
84866395321
-
Mitochondrial DNA damage is associated with reduced mitochondrial bioenergetics in Huntington’s disease
-
Siddiqui A, Rivera-Sánchez S, Castro Mdel R, Acevedo-Torres K, Rane A, Torres-Ramos CA et al. Mitochondrial DNA damage is associated with reduced mitochondrial bioenergetics in Huntington’s disease. Free Radic Biol Med 2012; 53: 1478–1488.
-
(2012)
Free Radic Biol Med
, vol.53
, pp. 1478-1488
-
-
Siddiqui, A.1
Rivera-Sánchez, S.2
Castro Mdel, R.3
Acevedo-Torres, K.4
Rane, A.5
Torres-Ramos, C.A.6
-
68
-
-
84873312255
-
Dysregulation of mitochondrial calcium signaling and superoxide flashes cause mitochondrial genomic DNA damage in Huntington disease
-
Wang J-Q, Chen Q, Wang X, Wang Q-C, Wang Y, Cheng H-P et al. Dysregulation of mitochondrial calcium signaling and superoxide flashes cause mitochondrial genomic DNA damage in Huntington disease. JBiol Chem 2013; 288: 3070–3084.
-
(2013)
Jbiol Chem
, vol.288
, pp. 3070-3084
-
-
Wang, J.-Q.1
Chen, Q.2
Wang, X.3
Wang, Q.-C.4
Wang, Y.5
Cheng, H.-P.6
-
69
-
-
84897528338
-
Pathogenesis of human mitochondrial diseases is modulated by reduced activity of the ubiquitin/proteasome system
-
Segref A, Kevei E, Pokrzywa W, Schmeisser K, Mansfeld J, Livnat-Levanon N et al. Pathogenesis of human mitochondrial diseases is modulated by reduced activity of the ubiquitin/proteasome system. Cell Metab 2014; 19: 642–652.
-
(2014)
Cell Metab
, vol.19
, pp. 642-652
-
-
Segref, A.1
Kevei, E.2
Pokrzywa, W.3
Schmeisser, K.4
Mansfeld, J.5
Livnat-Levanon, N.6
-
70
-
-
84880673845
-
Pharmacological approaches to restore mitochondrial function
-
Andreux Pa, Houtkooper RH, Auwerx J. Pharmacological approaches to restore mitochondrial function. Nat Rev Drug Discov 2013; 12: 465–483.
-
(2013)
Nat Rev Drug Discov
, vol.12
, pp. 465-483
-
-
Andreux Pa, H.R.H.1
Auwerx, J.2
-
71
-
-
79957887761
-
Mitochondria breathe for autophagy
-
Okamoto K. Mitochondria breathe for autophagy. EMBO J 2011; 30: 2095–2096.
-
(2011)
EMBO J
, vol.30
, pp. 2095-2096
-
-
Okamoto, K.1
-
72
-
-
79951642032
-
Autophagy proteins regulate innate immune responses by inhibiting the release of mitochondrial DNA mediated by the NALP3 inflammasome
-
Nakahira K, Haspel JA, Rathinam VAK, Lee S-J, Dolinay T, Lam HC et al. Autophagy proteins regulate innate immune responses by inhibiting the release of mitochondrial DNA mediated by the NALP3 inflammasome. Nat Immunol 2011; 12: 222–230.
-
(2011)
Nat Immunol
, vol.12
, pp. 222-230
-
-
Nakahira, K.1
Haspel, J.A.2
Rathinam, V.A.K.3
Lee, S.-J.4
Dolinay, T.5
Lam, H.C.6
-
73
-
-
79959354999
-
Mitochondria and the autophagy-inflammation-cell death axis in organismal aging
-
Green DR, Galluzzi L, Kroemer G. Mitochondria and the autophagy-inflammation-cell death axis in organismal aging. Science 2011; 333: 1109–1112.
-
(2011)
Science
, vol.333
, pp. 1109-1112
-
-
Green, D.R.1
Galluzzi, L.2
Kroemer, G.3
-
74
-
-
84856244072
-
Mitophagy plays an essential role in reducing mitochondrial production of reactive oxygen species and mutation of mitochondrial DNA by maintaining mitochondrial quantity and quality in yeast
-
Kurihara Y, Kanki T, Aoki Y, Hirota Y, Saigusa T, Uchiumi T et al. Mitophagy plays an essential role in reducing mitochondrial production of reactive oxygen species and mutation of mitochondrial DNA by maintaining mitochondrial quantity and quality in yeast. J Biol Chem 2012; 287: 3265–3272.
-
(2012)
J Biol Chem
, vol.287
, pp. 3265-3272
-
-
Kurihara, Y.1
Kanki, T.2
Aoki, Y.3
Hirota, Y.4
Saigusa, T.5
Uchiumi, T.6
-
77
-
-
33847071146
-
Targeting antioxidants to mitochondria by conjugation to lipophilic cations
-
Murphy MP, Smith RAJ. Targeting antioxidants to mitochondria by conjugation to lipophilic cations. Annu Rev Pharmacol Toxicol 2007; 47: 629–656.
-
(2007)
Annu Rev Pharmacol Toxicol
, vol.47
, pp. 629-656
-
-
Murphy, M.P.1
Smith, R.A.J.2
-
78
-
-
80155148269
-
The mitochondria-targeted anti-oxidant MitoQ prevents loss of spatial memory retention and early neuropathology in a transgenic mouse model of Alzheimer’s disease
-
McManus MJ, Murphy MP, Franklin JL. The mitochondria-targeted anti-oxidant MitoQ prevents loss of spatial memory retention and early neuropathology in a transgenic mouse model of Alzheimer’s disease. J Neurosci 2011; 31: 15703–15715.
-
(2011)
J Neurosci
, vol.31
, pp. 15703-15715
-
-
McManus, M.J.1
Murphy, M.P.2
Franklin, J.L.3
-
79
-
-
74149087396
-
Consequences of long-term oral administration of the mitochondria-targeted antioxidant MitoQ to wild-type mice
-
Rodriguez-Cuenca S, Cochemé HM, Logan A, Abakumova I, Prime TA, Rose C et al. Consequences of long-term oral administration of the mitochondria-targeted antioxidant MitoQ to wild-type mice. Free Radic Biol Med 2010; 48: 161–172.
-
(2010)
Free Radic Biol Med
, vol.48
, pp. 161-172
-
-
Rodriguez-Cuenca, S.1
Cochemé, H.M.2
Logan, A.3
Abakumova, I.4
Prime, T.A.5
Rose, C.6
-
80
-
-
77956207531
-
Mitochondria-targeted antioxidants protect against amyloid-beta toxicity in Alzheimer’s disease neurons
-
Manczak M, Mao P, Calkins MJ, Cornea A, Reddy AP, Murphy MP et al. Mitochondria-targeted antioxidants protect against amyloid-beta toxicity in Alzheimer’s disease neurons. J Alzheimers Dis 2010; 20(Suppl 2): S609–S631.
-
(2010)
J Alzheimers Dis
, vol.20
, pp. S609-S631
-
-
Manczak, M.1
Mao, P.2
Calkins, M.J.3
Cornea, A.4
Reddy, A.P.5
Murphy, M.P.6
-
81
-
-
84900401998
-
Modelling of antigenomic therapy of mitochondrial diseases by mitochondrially addressed RNA targeting a pathogenic point mutation in mtDNA
-
Tonin Y, Heckel A-M, Vysokikh M, Dovydenko I, Meschaninova M, Rotig A et al. Modelling of antigenomic therapy of mitochondrial diseases by mitochondrially addressed RNA targeting a pathogenic point mutation in mtDNA. JBiolChem2014; 289: 13323–13334.
-
Jbiolchem2014
, vol.289
, pp. 13323-13334
-
-
Tonin, Y.1
Heckel, A.-M.2
Vysokikh, M.3
Dovydenko, I.4
Meschaninova, M.5
Rotig, A.6
-
82
-
-
84898602295
-
Mitochond-rially targeted ZFNs for selective degradation of pathogenic mitochondrial genomes bearing large-scale deletions or point mutations
-
Gammage PA, Rorbach J, Vincent AI, Rebar EJ, Minczuk M. Mitochond-rially targeted ZFNs for selective degradation of pathogenic mitochondrial genomes bearing large-scale deletions or point mutations. EMBO Mol Med 2014; 6: 1509–1639.
-
(2014)
EMBO Mol Med
, vol.6
, pp. 1509-1639
-
-
Gammage, P.A.1
Rorbach, J.2
Vincent, A.I.3
Rebar, E.J.4
Minczuk, M.5
-
83
-
-
84896886750
-
Mitochondria-targeted Ogg1 and aconitase-2 prevent oxidant-induced mitochondrial DNA damage in alveolar epithelial cells
-
Kim S-J, Cheresh P, Williams D, Cheng Y, Ridge K, Schumacker PT et al. Mitochondria-targeted Ogg1 and aconitase-2 prevent oxidant-induced mitochondrial DNA damage in alveolar epithelial cells. J Biol Chem 2014; 289: 6165–6176.
-
(2014)
J Biol Chem
, vol.289
, pp. 6165-6176
-
-
Kim, S.-J.1
Cheresh, P.2
Williams, D.3
Cheng, Y.4
Ridge, K.5
Schumacker, P.T.6
-
84
-
-
84883778302
-
Specific elimination of mutant mitochondrial genomes in patient-derived cells by mitoTALENs
-
Bacman SR, Williams SL, Pinto M, Peralta S, Moraes CT. Specific elimination of mutant mitochondrial genomes in patient-derived cells by mitoTALENs. Nat Med 2013; 19: 1111–1113.
-
(2013)
Nat Med
, vol.19
, pp. 1111-1113
-
-
Bacman, S.R.1
Williams, S.L.2
Pinto, M.3
Peralta, S.4
Moraes, C.T.5
-
85
-
-
0033551701
-
Coordinate induction of energy gene expression in tissues of mitochondrial disease patients
-
Heddi A, Stepien G, Benke PJ, Wallace DC. Coordinate induction of energy gene expression in tissues of mitochondrial disease patients. JBiolChem 1999; 274: 22968–22976.
-
(1999)
Jbiolchem
, vol.274
, pp. 22968-22976
-
-
Heddi, A.1
Stepien, G.2
Benke, P.J.3
Wallace, D.C.4
|