Modulation of reactive oxygen species by Rac1 or catalase prevents asbestos-induced pulmonary fibrosis

American Journal of Physiology - Lung Cellular and Molecular Physiology

Volumn 297, Issue 5, 2009, Pages

  Murthy, Shubha ^a   Adamcakova Dodd, Andrea ^b   Perry, Sarah S ^b   Tephly, Linda A ^a   Keller, Richard M ^b   Metwali, Nervana ^b   Meyerholz, David K ^a   Wang, Yongqiang ^c   Glogauer, Michael ^c   Thorne, Peter S ^b   Carter, A Brent ^a,b  

^a UNIVERSITY OF IOWA   (United States)

^b UNIVERSITY OF IOWA   (United States)

^c UNIVERSITY OF TORONTO   (Canada)

Author keywords

Macrophages

Indexed keywords

ASBESTOS; CATALASE; INTERLEUKIN 1BETA; RAC1 PROTEIN; REACTIVE OXYGEN METABOLITE; TRANSFORMING GROWTH FACTOR BETA1; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BIOCHEMISTRY; DISEASE COURSE; DISEASE MODEL; HISTOLOGY; HUMAN; HUMAN CELL; IN VITRO STUDY; LUNG FIBROSIS; LUNG LAVAGE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION;

ANIMALS; ASBESTOS; BRONCHOALVEOLAR LAVAGE FLUID; CATALASE; CELL COUNT; CELL LINE; CELL MOVEMENT; ENZYME ACTIVATION; HUMANS; INTERLEUKIN-1BETA; LUNG; MICE; PULMONARY FIBROSIS; RAC1 GTP-BINDING PROTEIN; REACTIVE OXYGEN SPECIES; TRANSFORMING GROWTH FACTOR BETA1; TUMOR NECROSIS FACTOR-ALPHA;

EID: 72449147779     PISSN: 10400605     EISSN: 15221504     Source Type: Journal    
DOI: 10.1152/ajplung.90590.2008     Document Type: Article

References (46)

1. Adam O, Frost G, Custodis F, Sussman MA, Schafers HJ, Bohm M, Laufs U. Role of Rac1 GTPase activation in atrial fibrillation. J Am Coll Cardiol 50: 359-367, 2007. (Pubitemid 47064499)
2. Anonymous. Diagnosis and initial management of nonmalignant diseases related to asbestos. Am J Respir Crit Care Med 170: 691-715, 2004.
3. Begin R, Martel M, Desmarais Y, Drapeau G, Boileau R, Rola- Pleszczynski M, Masse S. Fibronectin and procollagen 3 levels in bronchoalveolar lavage of asbestos-exposed human subjects and sheep. Chest 89: 237-243, 1986. (Pubitemid 16156423)
4. Bokoch GM. Regulation of innate immunity by Rho GTPases. Trends Cell Biol 15: 163-171, 2005. (Pubitemid 40332539)
5. Brenner DA, O'Hara M, Angel P, Chojkier M, Karin M. Prolonged activation of jun and collagenase genes by tumour necrosis factor-α. Nature 337: 661-663, 1989. (Pubitemid 19054296)
6. Cantrell DA. GTPases and T cell activation. Immunol Rev 192: 122-130, 2003.
7. Carter AB, Knudtson KL, Monick MM, Hunninghake GW. The p38 mitogen-activated protein kinase is required for NF-κB-dependent gene expression. The role of TATA-binding protein (TBP). J Biol Chem 274: 30858-30863, 1999. (Pubitemid 129576833)
8. 2 signaling in human alveolar macrophages. Am J Respir Cell Mol Biol 31: 43-53, 2004.
9. 1 controls reactive oxygen species synthesis by negatively regulating epidermal growth factor receptor-mediated Rac activation. Mol Cell Biol 27: 3313-3326, 2007.
10. De Minicis S, Brenner DA. NOX in liver fibrosis. Arch Biochem Biophys 462: 266-272, 2007.
11. Demedts M, Behr J, Buhl R, Costabel U, Dekhuijzen R, Jansen HM, MacNee W, Thomeer M, Wallaert B, Laurent F, Nicholson AG, Verbeken EK, Verschakelen J, Flower CD, Capron F, Petruzzelli S, De Vuyst P, van den Bosch JM, Rodriguez-Becerra E, Corvasce G, Lankhorst I, Sardina M, Montanari M. High-dose acetylcysteine in idiopathic pulmonary fibrosis. N Engl J Med 353: 2229-2242, 2005. (Pubitemid 41697286)
12. Didsbury J, Weber RF, Bokoch GM, Evans T, Snyderman R. Rac, a novel Ras-related family of proteins that are botulinum toxin substrates. J Biol Chem 264: 16378-16382, 1989. (Pubitemid 19243522)
13. Dubin W, Martin TR, Swoveland P, Leturcq DJ, Moriarty AM, Tobias PS, Bleecker ER, Goldblum SE, Hasday JD. Asthma and endotoxin: lipopolysaccharide- binding protein and soluble CD14 in bronchoalveolar compartment. Am J Physiol Lung Cell Mol Physiol 270: L736-L744, 1996. (Pubitemid 26182575)
14. Englert JM, Hanford LE, Kaminski N, Tobolewski JM, Tan RJ, Fattman CL, Ramsgaard L, Richards TJ, Loutaev I, Nawroth PP, Kasper M, Bierhaus A, Oury TD. A role for the receptor for advanced glycation end products in idiopathic pulmonary fibrosis. Am J Pathol 172: 583-591, 2008. (Pubitemid 351354532)
15. Fjeld CC, Rice AE, Kim Y, Gee KR, Denu JM. Mechanistic basis for catalytic activation of mitogen-activated protein kinase phosphatase 3 by extracellular signal-regulated kinase. J Biol Chem 275: 6749-6757, 2000. (Pubitemid 30146211)
16. Gasse P, Mary C, Guenon I, Noulin N, Charron S, Schnyder-Candrian S, Schnyder B, Akira S, Quesniaux VF, Lagente V, Ryffel B, Couillin I. IL-1R1/MyD88 signaling and the inflammasome are essential in pulmonary inflammation and fibrosis in mice. J Clin Invest 117: 3786-3799, 2007. (Pubitemid 350224089)
17. Glogauer M, Marchal CC, Zhu F, Worku A, Clausen BE, Foerster I, Marks P, Downey GP, Dinauer M, Kwiatkowski DJ. Rac1 deletion in mouse neutrophils has selective effects on neutrophil functions. J Immunol 170: 5652-5657, 2003. (Pubitemid 36617857)
18. Goodglick LA, Kane AB. Role of reactive oxygen metabolites in crocidolite asbestos toxicity to mouse macrophages. Cancer Res 46: 5558-5566, 1986.
19. Heasman SJ, Ridley AJ. Mammalian Rho GTPases: new insights into their functions from in vivo studies. Nat Rev Mol Cell Biol 9: 690-701, 2008.
20. Janssen YM, Marsh JP, Absher MP, Hemenway D, Vacek PM, Leslie KO, Borm PJ, Mossman BT. Expression of antioxidant enzymes in rat lungs after inhalation of asbestos or silica. J Biol Chem 267: 10625-10630, 1992.
21. Kamp DW, Weitzman SA. The molecular basis of asbestos induced lung injury. Thorax 54: 638-652, 1999. (Pubitemid 29296687)
22. Kheradmand F, Werner E, Tremble P, Symons M, Werb Z. Role of Rac1 and oxygen radicals in collagenase-1 expression induced by cell shape change. Science 280: 898-902, 1998. (Pubitemid 28215599)
23. Kinnula VL, Fattman CL, Tan RJ, Oury TD. Oxidative stress in pulmonary fibrosis: a possible role for redox modulatory therapy. Am J Respir Crit Care Med 172: 417-422, 2005.
24. Larsen K, Tufvesson E, Malmstrom J, Morgelin M, Wildt M, Andersson A, Lindstrom A, Malmstrom A, Lofdahl CG, Marko-Varga G, Bjermer L, Westergren-Thorsson G. Presence of activated mobile fibroblasts in bronchoalveolar lavage from patients with mild asthma. Am J Respir Crit Care Med 170: 1049-1056, 2004. (Pubitemid 39488616)
25. Lasky JA, Brody AR. Interstitial fibrosis and growth factors. Environ Health Perspect 108 Suppl 4: 751-762, 2000.
26. Lenz AG, Costabel U, Maier KL. Oxidized BAL fluid proteins in patients with interstitial lung diseases. Eur Respir J 9: 307-312, 1996. (Pubitemid 26069826)
27. Liu JY, Brass DM, Hoyle GW, Brody AR. TNF-α receptor knockout mice are protected from the fibroproliferative effects of inhaled asbestos fibers. Am J Pathol 153: 1839-1847, 1998.
28. Mossman BT, Marsh JP, Sesko A, Hill S, Shatos MA, Doherty J, Petruska J, Adler KB, Hemenway D, Mickey R, et al. Inhibition of lung injury, inflammation, and interstitial pulmonary fibrosis by polyethylene glycol-conjugated catalase in a rapid inhalation model of asbestosis. Am Rev Respir Dis 141: 1266-1271, 1990. (Pubitemid 20172583)
29. Ortiz LA, Lasky J, Lungarella G, Cavarra E, Martorana P, Banks WA, Peschon JJ, Schmidts HL, Brody AR, Friedman M. Upregulation of the p75 but not the p55 TNF-α receptor mRNA after silica and bleomycin exposure and protection from lung injury in double receptor knockout mice. Am J Respir Cell Mol Biol 20: 825-833, 1999. (Pubitemid 129495671)
30. Ozaki M, Deshpande SS, Angkeow P, Suzuki S, Irani K. Rac1 regulates stress-induced, redox-dependent heat shock factor activation. J Biol Chem 275: 35377-35383, 2000. (Pubitemid 30832560)
31. Park HS, Lee SH, Park D, Lee JS, Ryu SH, Lee WJ, Rhee SG, Bae YS. Sequential activation of phosphatidylinositol 3-kinase, β-Pix, Rac1, and Nox1 in growth factor-induced production of H2O2. Mol Cell Biol 24: 4384-4394, 2004. (Pubitemid 41071008)
32. Piguet PF, Vesin C. Treatment by human recombinant soluble TNF receptor of pulmonary fibrosis induced by bleomycin or silica in mice. Eur Respir J 7: 515-518, 1994. (Pubitemid 24099014)
33. Roberts AW, Kim C, Zhen L, Lowe JB, Kapur R, Petryniak B, Spaetti A, Pollock JD, Borneo JB, Bradford GB, Atkinson SJ, Dinauer MC, Williams DA. Deficiency of the hematopoietic cell-specific Rho family GTPase Rac2 is characterized by abnormalities in neutrophil function and host defense. Immunity 10: 183-196, 1999. (Pubitemid 29115624)
34. Rom WN, Bitterman PB, Rennard SI, Cantin A, Crystal RG. Characterization of the lower respiratory tract inflammation of nonsmoking individuals with interstitial lung disease associated with chronic inhalation of inorganic dusts. Am Rev Respir Dis 136: 1429-1434, 1987. (Pubitemid 18030278)
35. Rucklidge GJ, Milne G, McGaw BA, Milne E, Robins SP. Turnover rates of different collagen types measured by isotope ratio mass spectrometry. Biochim Biophys Acta 1156: 57-61, 1992. (Pubitemid 23004905)
36. Schwartz DA, Galvin JR, Frees KL, Dayton CS, Burmeister LF, Merchant JA, Hunninghake GW. Clinical relevance of cellular mediators of inflammation in workers exposed to asbestos. Am Rev Respir Dis 148: 68-74, 1993.
37. Sulciner DJ, Irani K, Yu ZX, Ferrans VJ, Goldschmidt-Clermont P, Finkel T. Rac1 regulates a cytokine-stimulated, redox-dependent pathway necessary for NF-κB activation. Mol Cell Biol 16: 7115-7121, 1996. (Pubitemid 26389771)
38. Sun CX, Downey GP, Zhu F, Koh AL, Thang H, Glogauer M. Rac1 is the small GTPase responsible for regulating the neutrophil chemotaxis compass. Blood 104: 3758-3765, 2004. (Pubitemid 39564455)
39. Tephly LA, Carter AB. Asbestos-induced MKP-3 expression augments TNF-α gene expression in human monocytes. Am J Respir Cell Mol Biol 39: 113-123, 2008.
40. Wang Y, Lebowitz D, Sun C, Thang H, Grynpas MD, Glogauer M. Identifying the relative contributions of Rac1 and Rac2 to osteoclastogenesis. J Bone Miner Res 23: 260-270, 2008. (Pubitemid 351160040)
41. Wells CM, Walmsley M, Ooi S, Tybulewicz V, Ridley AJ. Rac1- deficient macrophages exhibit defects in cell spreading and membrane ruffling but not migration. J Cell Sci 117: 1259-1268, 2004. (Pubitemid 38456106)
42. Woo CH, You HJ, Cho SH, Eom YW, Chun JS, Yoo YJ, Kim JH. Leukotriene B4 stimulates Rac-ERK cascade to generate reactive oxygen species that mediates chemotaxis. J Biol Chem 277: 8572-8578, 2002.
43. Yamauchi A, Kim C, Li S, Marchal CC, Towe J, Atkinson SJ, Dinauer MC. Rac2-deficient murine macrophages have selective defects in superoxide production and phagocytosis of opsonized particles. J Immunol 173: 5971-5979, 2004. (Pubitemid 39487751)
44. Zhang HJ, Drake VJ, Xu L, Hu J, Domann FE, Oberley LW, Kregel KC. Redox regulation of adenovirus-induced AP-1 activation by overexpression of manganese-containing superoxide dismutase. J Virol 76: 355-363, 2002. (Pubitemid 33139020)
45. Zhang Y, Lee TC, Guillemin B, Yu MC, Rom WN. Enhanced IL-1β and tumor necrosis factor-α release and messenger RNA expression in macrophages from idiopathic pulmonary fibrosis or after asbestos exposure. J Immunol 150: 4188-4196, 1993. (Pubitemid 23129800)
46. Zhao X, Carnevale KA, Cathcart MK. Human monocytes use Rac1, not Rac2, in the NADPH oxidase complex. J Biol Chem 278: 40788-40792, 2003. (Pubitemid 37280896)