Mitochondrially targeted ceramides preferentially promote autophagy, retard cell growth, and induce apoptosis

Journal of Lipid Research

Volumn 52, Issue 2, 2011, Pages 278-288

  Hou, Qi ^a,b   Jin, Junfei ^b,c   Zhou, Hui ^b   Novgorodov, Sergei A ^b   Bielawska, Alicja ^b   Szulc, Zdzislaw M ^b   Hannun, Yusuf A ^b   Obeid, Lina M ^b,d   Hsu, Yi Te ^b  

^a INSTITUTE OF MATERIA MEDICA   (China)

^b MEDICAL UNIVERSITY OF SOUTH CAROLINA   (United States)

^c UNIVERSITY OF SOUTH CHINA   (China)

^d RALPH H JOHNSON VA MEDICAL CENTER   (United States)

Author keywords

Bax; Ceramide; Mitochondria

Indexed keywords

BENZYLOXYCARBONYLVALYLALANYLASPARTYL FLUOROMETHYL KETONE; CERAMIDE DERIVATIVE; DEXTRO ERYTHRO 2 N [6' (1'PYRIDINIUM)HEXANOYL]SPHINGOSINE BROMIDE; PROTEIN BAX; PROTEIN BID; STAUROSPORINE; TAMOXIFEN; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

APOPTOSIS; ARTICLE; AUTOPHAGY; BREAST CANCER; BREAST EPITHELIUM; CANCER CELL; CANCER CELL CULTURE; CELL DEATH; CELL GROWTH; CELL STRAIN MCF 7; CONTROLLED STUDY; DRUG TARGETING; EPITHELIUM CELL; GROWTH INHIBITION; HUMAN; HUMAN CELL; MITOCHONDRIAL PERMEABILITY; PHAGOSOME; PRIORITY JOURNAL; PROTEIN LOCALIZATION; SIGNAL TRANSDUCTION;

AMINO ACID CHLOROMETHYL KETONES; APOPTOSIS; AUTOPHAGY; BCL-2-ASSOCIATED X PROTEIN; CASPASES; CELLS, CULTURED; CERAMIDES; GROWTH INHIBITORS; HUMANS; MITOCHONDRIA; PYRIDINIUM COMPOUNDS;

EID: 78751486963     PISSN: 00222275     EISSN: 15397262     Source Type: Journal    
DOI: 10.1194/jlr.M012161     Document Type: Article

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