Time-dependent and somatically acquired mitochondrial DNA mutagenesis and respiratory chain dysfunction in a scleroderma model of lung fibrosis

Scientific Reports

Volumn 4, Issue , 2014, Pages

  Gazdhar, Amiq ^a,b   Lebrecht, Dirk ^c   Roth, Michael ^d,e   Tamm, Michael ^d,e   Venhoff, Nils ^c   Foocharoen, Chingching ^f   Geiser, Thomas ^a,b   Walker, Ulrich A ^c,d  

^a UNIVERSITY OF BERN   (Switzerland)

^b UNIVERSITY OF BERN   (Switzerland)

^c UNIVERSITY OF FREIBURG   (Germany)

^d UNIVERSITY OF BASEL   (Switzerland)

^e UNIVERSITY HOSPITAL BASEL   (Switzerland)

^f KHON KAEN UNIVERSITY   (Thailand)

Author keywords

[No Author keywords available]

Indexed keywords

BLEOMYCIN; CYTOCHROME C OXIDASE; MITOCHONDRIAL DNA; REACTIVE OXYGEN METABOLITE; TRANSFORMING GROWTH FACTOR BETA1;

ANIMAL; CHEMICALLY INDUCED; DISEASE MODEL; ELECTRON MICROSCOPY; ELECTRON TRANSPORT; GENETICS; HUMAN; LUNG; LUNG FIBROSIS; MALE; METABOLISM; MITOCHONDRION; MUTAGENESIS; PATHOLOGY; RAT; SYSTEMIC SCLEROSIS; TIME; ULTRASTRUCTURE; WESTERN BLOTTING; WISTAR RAT;

ANIMALS; BLEOMYCIN; BLOTTING, WESTERN; DISEASE MODELS, ANIMAL; DNA, MITOCHONDRIAL; ELECTRON TRANSPORT; ELECTRON TRANSPORT COMPLEX IV; HUMANS; LUNG; MALE; MICROSCOPY, ELECTRON; MITOCHONDRIA; MUTAGENESIS; PULMONARY FIBROSIS; RATS; RATS, WISTAR; REACTIVE OXYGEN SPECIES; SCLERODERMA, SYSTEMIC; TIME FACTORS; TRANSFORMING GROWTH FACTOR BETA1;

EID: 84902795026     PISSN: None     EISSN: 20452322     Source Type: Journal    
DOI: 10.1038/srep05336     Document Type: Article

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