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Volumn 114, Issue 6, 2017, Pages E970-E979

Immunoinhibitory checkpoint deficiency in medium & large vessel vasculitis

Author keywords

Autoimmunity; Immune checkpoint; PD 1; T cells; Vasculitis

Indexed keywords

GAMMA INTERFERON; INTERLEUKIN 17; INTERLEUKIN 21; PROGRAMMED DEATH 1 LIGAND 1; PROGRAMMED DEATH 1 RECEPTOR; TRANSCRIPTOME; CYTOKINE;

EID: 85011650396     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1616848114     Document Type: Article
Times cited : (190)

References (63)
  • 1
    • 0028082171 scopus 로고
    • Distinct vascular lesions in giant cell arteritis share identical T cell clonotypes
    • Weyand CM, et al. (1994) Distinct vascular lesions in giant cell arteritis share identical T cell clonotypes. J Exp Med 179(3):951-960.
    • (1994) J Exp Med , vol.179 , Issue.3 , pp. 951-960
    • Weyand, C.M.1
  • 2
    • 0028097104 scopus 로고
    • CD4+ and CD8+ T cell expansions using selected TCR V and J gene segments at the onset of giant cell arteritis
    • Grunewald J, et al. (1994) CD4+ and CD8+ T cell expansions using selected TCR V and J gene segments at the onset of giant cell arteritis. Arthritis Rheum 37(8):1221-1227.
    • (1994) Arthritis Rheum , vol.37 , Issue.8 , pp. 1221-1227
    • Grunewald, J.1
  • 3
    • 78650509945 scopus 로고    scopus 로고
    • IFN-γ and IL-17: The two faces of T-cell pathology in giant cell arteritis
    • Weyand CM, Younge BR, Goronzy JJ (2011) IFN-γ and IL-17: The two faces of T-cell pathology in giant cell arteritis. Curr Opin Rheumatol 23(1):43-49.
    • (2011) Curr Opin Rheumatol , vol.23 , Issue.1 , pp. 43-49
    • Weyand, C.M.1    Younge, B.R.2    Goronzy, J.J.3
  • 4
    • 84983121634 scopus 로고    scopus 로고
    • Difference in the expression of IL-9 and IL-17 correlates with different histological pattern of vascular wall injury in giant cell arteritis
    • Oxford
    • Ciccia F, et al. (2015) Difference in the expression of IL-9 and IL-17 correlates with different histological pattern of vascular wall injury in giant cell arteritis. Rheumatology (Oxford) 54(9):1596-1604.
    • (2015) Rheumatology , vol.54 , Issue.9 , pp. 1596-1604
    • Ciccia, F.1
  • 5
    • 0029797606 scopus 로고    scopus 로고
    • Correlation of the topographical arrangement and the functional pattern of tissue-infiltrating macrophages in giant cell arteritis
    • Weyand CM, Wagner AD, Björnsson J, Goronzy JJ (1996) Correlation of the topographical arrangement and the functional pattern of tissue-infiltrating macrophages in giant cell arteritis. J Clin Invest 98(7):1642-1649.
    • (1996) J Clin Invest , vol.98 , Issue.7 , pp. 1642-1649
    • Weyand, C.M.1    Wagner, A.D.2    Björnsson, J.3    Goronzy, J.J.4
  • 6
    • 0032946689 scopus 로고    scopus 로고
    • Arterial wall injury in giant cell arteritis
    • Weyand CM, Goronzy JJ (1999) Arterial wall injury in giant cell arteritis. Arthritis Rheum 42(5):844-853.
    • (1999) Arthritis Rheum , vol.42 , Issue.5 , pp. 844-853
    • Weyand, C.M.1    Goronzy, J.J.2
  • 7
    • 0033553413 scopus 로고    scopus 로고
    • Tissue-destructive macrophages in giant cell arteritis
    • Rittner HL, et al. (1999) Tissue-destructive macrophages in giant cell arteritis. Circ Res 84(9):1050-1058.
    • (1999) Circ Res , vol.84 , Issue.9 , pp. 1050-1058
    • Rittner, H.L.1
  • 8
    • 0035143510 scopus 로고    scopus 로고
    • IFN-gamma action in the media of the great elastic arteries, a novel immunoprivileged site
    • Dal Canto AJ, Swanson PE, O'Guin AK, Speck SH, Virgin HW (2001) IFN-gamma action in the media of the great elastic arteries, a novel immunoprivileged site. J Clin Invest 107(2):R15-R22.
    • (2001) J Clin Invest , vol.107 , Issue.2 , pp. R15-R22
    • Dal Canto, A.J.1    Swanson, P.E.2    O'Guin, A.K.3    Speck, S.H.4    Virgin, H.W.5
  • 9
    • 53449092909 scopus 로고    scopus 로고
    • Vessel-specific Toll-like receptor profiles in human medium and large arteries
    • Pryshchep O, Ma-Krupa W, Younge BR, Goronzy JJ, Weyand CM (2008) Vessel-specific Toll-like receptor profiles in human medium and large arteries. Circulation 118(12): 1276-1284.
    • (2008) Circulation , vol.118 , Issue.12 , pp. 1276-1284
    • Pryshchep, O.1    Ma-Krupa, W.2    Younge, B.R.3    Goronzy, J.J.4    Weyand, C.M.5
  • 10
    • 84855300285 scopus 로고    scopus 로고
    • Participation of blood vessel cells in human adaptive immune responses
    • Pober JS, Tellides G (2012) Participation of blood vessel cells in human adaptive immune responses. Trends Immunol 33(1):49-57.
    • (2012) Trends Immunol , vol.33 , Issue.1 , pp. 49-57
    • Pober, J.S.1    Tellides, G.2
  • 11
    • 2442585121 scopus 로고    scopus 로고
    • Co-inhibitory molecules of the B7-CD28 family in the control of T-cell immunity
    • Chen L (2004) Co-inhibitory molecules of the B7-CD28 family in the control of T-cell immunity. Nat Rev Immunol 4(5):336-347.
    • (2004) Nat Rev Immunol , vol.4 , Issue.5 , pp. 336-347
    • Chen, L.1
  • 12
    • 0034927194 scopus 로고    scopus 로고
    • PD-1: An inhibitory immunoreceptor involved in peripheral tolerance
    • Nishimura H, Honjo T (2001) PD-1: An inhibitory immunoreceptor involved in peripheral tolerance. Trends Immunol 22(5):265-268.
    • (2001) Trends Immunol , vol.22 , Issue.5 , pp. 265-268
    • Nishimura, H.1    Honjo, T.2
  • 13
    • 0037126021 scopus 로고    scopus 로고
    • Involvement of PD-L1 on tumor cells in the escape from host immune system and tumor immunotherapy by PD-L1 blockade
    • Iwai Y, et al. (2002) Involvement of PD-L1 on tumor cells in the escape from host immune system and tumor immunotherapy by PD-L1 blockade. Proc Natl Acad Sci USA 99(19):12293-12297.
    • (2002) Proc Natl Acad Sci USA , vol.99 , Issue.19 , pp. 12293-12297
    • Iwai, Y.1
  • 14
    • 84879759020 scopus 로고    scopus 로고
    • Safety and tumor responses with lambrolizumab (anti-PD-1) in melanoma
    • Hamid O, et al. (2013) Safety and tumor responses with lambrolizumab (anti-PD-1) in melanoma. N Engl J Med 369(2):134-144.
    • (2013) N Engl J Med , vol.369 , Issue.2 , pp. 134-144
    • Hamid, O.1
  • 15
    • 84929481480 scopus 로고    scopus 로고
    • Pembrolizumab for the treatment of non-small-cell lung cancer
    • KEYNOTE-001 Investigators
    • Garon EB, et al.; KEYNOTE-001 Investigators (2015) Pembrolizumab for the treatment of non-small-cell lung cancer. N Engl J Med 372(21):2018-2028.
    • (2015) N Engl J Med , vol.372 , Issue.21 , pp. 2018-2028
    • Garon, E.B.1
  • 16
    • 84862903106 scopus 로고    scopus 로고
    • Safety and activity of anti-PD-L1 antibody in patients with advanced cancer
    • Brahmer JR, et al. (2012) Safety and activity of anti-PD-L1 antibody in patients with advanced cancer. N Engl J Med 366(26):2455-2465.
    • (2012) N Engl J Med , vol.366 , Issue.26 , pp. 2455-2465
    • Brahmer, J.R.1
  • 17
    • 0033180181 scopus 로고    scopus 로고
    • Development of lupus-like autoimmune diseases by disruption of the PD-1 gene encoding an ITIM motif-carrying immunoreceptor
    • Nishimura H, Nose M, Hiai H, Minato N, Honjo T (1999) Development of lupus-like autoimmune diseases by disruption of the PD-1 gene encoding an ITIM motif-carrying immunoreceptor. Immunity 11(2):141-151.
    • (1999) Immunity , vol.11 , Issue.2 , pp. 141-151
    • Nishimura, H.1    Nose, M.2    Hiai, H.3    Minato, N.4    Honjo, T.5
  • 18
    • 0035846991 scopus 로고    scopus 로고
    • Autoimmune dilated cardiomyopathy in PD-1 receptordeficient mice
    • Nishimura H, et al. (2001) Autoimmune dilated cardiomyopathy in PD-1 receptordeficient mice. Science 291(5502):319-322.
    • (2001) Science , vol.291 , Issue.5502 , pp. 319-322
    • Nishimura, H.1
  • 19
    • 33645846313 scopus 로고    scopus 로고
    • Tissue expression of PD-L1 mediates peripheral T cell tolerance
    • Keir ME, et al. (2006) Tissue expression of PD-L1 mediates peripheral T cell tolerance. J Exp Med 203(4):883-895.
    • (2006) J Exp Med , vol.203 , Issue.4 , pp. 883-895
    • Keir, M.E.1
  • 20
    • 3242677686 scopus 로고    scopus 로고
    • PD-L1-deficient mice show that PD-L1 on T cells, antigenpresenting cells, and host tissues negatively regulates T cells
    • Latchman YE, et al. (2004) PD-L1-deficient mice show that PD-L1 on T cells, antigenpresenting cells, and host tissues negatively regulates T cells. Proc Natl Acad Sci USA 101(29):10691-10696.
    • (2004) Proc Natl Acad Sci USA , vol.101 , Issue.29 , pp. 10691-10696
    • Latchman, Y.E.1
  • 21
    • 13544259967 scopus 로고    scopus 로고
    • Prevention of experimental autoimmune encephalomyelitis by transfer of embryonic stem cell-derived dendritic cells expressing myelin oligodendrocyte glycoprotein peptide along with TRAIL or programmed death-1 ligand
    • Hirata S, et al. (2005) Prevention of experimental autoimmune encephalomyelitis by transfer of embryonic stem cell-derived dendritic cells expressing myelin oligodendrocyte glycoprotein peptide along with TRAIL or programmed death-1 ligand. J Immunol 174(4):1888-1897.
    • (2005) J Immunol , vol.174 , Issue.4 , pp. 1888-1897
    • Hirata, S.1
  • 22
    • 73949088551 scopus 로고    scopus 로고
    • PD-L1 regulates the development, maintenance, and function of induced regulatory T cells
    • Francisco LM, et al. (2009) PD-L1 regulates the development, maintenance, and function of induced regulatory T cells. J Exp Med 206(13):3015-3029.
    • (2009) J Exp Med , vol.206 , Issue.13 , pp. 3015-3029
    • Francisco, L.M.1
  • 23
    • 84927084465 scopus 로고    scopus 로고
    • Differential control of CD4(+) T-cell subsets by the PD-1/PDL1 axis in a mouse model of allergic asthma
    • McAlees JW, et al. (2015) Differential control of CD4(+) T-cell subsets by the PD-1/PDL1 axis in a mouse model of allergic asthma. Eur J Immunol 45(4):1019-1029.
    • (2015) Eur J Immunol , vol.45 , Issue.4 , pp. 1019-1029
    • McAlees, J.W.1
  • 24
    • 1642459098 scopus 로고    scopus 로고
    • Activation of arterial wall dendritic cells and breakdown of self-Tolerance in giant cell arteritis
    • Ma-Krupa W, et al. (2004) Activation of arterial wall dendritic cells and breakdown of self-Tolerance in giant cell arteritis. J Exp Med 199(2):173-183.
    • (2004) J Exp Med , vol.199 , Issue.2 , pp. 173-183
    • Ma-Krupa, W.1
  • 25
    • 33745505948 scopus 로고    scopus 로고
    • Vascular dendritic cells in giant cell arteritis
    • Weyand CM, et al. (2005) Vascular dendritic cells in giant cell arteritis. Ann N Y Acad Sci 1062:195-208.
    • (2005) Ann N Y Acad Sci , vol.1062 , pp. 195-208
    • Weyand, C.M.1
  • 26
    • 84971309786 scopus 로고    scopus 로고
    • NADPH oxidase deficiency underlies dysfunction of aged CD8+ Tregs
    • Wen Z, et al. (2016) NADPH oxidase deficiency underlies dysfunction of aged CD8+ Tregs. J Clin Invest 126(5):1953-1967.
    • (2016) J Clin Invest , vol.126 , Issue.5 , pp. 1953-1967
    • Wen, Z.1
  • 27
    • 79251563204 scopus 로고    scopus 로고
    • Blocking the NOTCH pathway inhibits vascular inflammation in large-vessel vasculitis
    • Piggott K, et al. (2011) Blocking the NOTCH pathway inhibits vascular inflammation in large-vessel vasculitis. Circulation 123(3):309-318.
    • (2011) Circulation , vol.123 , Issue.3 , pp. 309-318
    • Piggott, K.1
  • 28
    • 0029980187 scopus 로고    scopus 로고
    • Interferongamma- producing T cells in giant cell vasculitis represent a minority of tissue-infiltrating cells and are located distant from the site of pathology
    • Wagner AD, Björnsson J, Bartley GB, Goronzy JJ, Weyand CM (1996) Interferongamma- producing T cells in giant cell vasculitis represent a minority of tissue-infiltrating cells and are located distant from the site of pathology. Am J Pathol 148(6): 1925-1933.
    • (1996) Am J Pathol , vol.148 , Issue.6 , pp. 1925-1933
    • Wagner, A.D.1    Björnsson, J.2    Bartley, G.B.3    Goronzy, J.J.4    Weyand, C.M.5
  • 29
    • 34547661982 scopus 로고    scopus 로고
    • Biopsy-negative giant cell arteritis: Does anti-CD83 immunohistochemistry advance the diagnosis?
    • Slobodin G, et al. (2007) Biopsy-negative giant cell arteritis: Does anti-CD83 immunohistochemistry advance the diagnosis? Eur J Intern Med 18(5):405-408.
    • (2007) Eur J Intern Med , vol.18 , Issue.5 , pp. 405-408
    • Slobodin, G.1
  • 30
    • 0034596948 scopus 로고    scopus 로고
    • Engagement of the PD-1 immunoinhibitory receptor by a novel B7 family member leads to negative regulation of lymphocyte activation
    • Freeman GJ, et al. (2000) Engagement of the PD-1 immunoinhibitory receptor by a novel B7 family member leads to negative regulation of lymphocyte activation. J Exp Med 192(7):1027-1034.
    • (2000) J Exp Med , vol.192 , Issue.7 , pp. 1027-1034
    • Freeman, G.J.1
  • 31
    • 18544380239 scopus 로고    scopus 로고
    • Tumor-Associated B7-H1 promotes T-cell apoptosis: A potential mechanism of immune evasion
    • Dong H, et al. (2002) Tumor-Associated B7-H1 promotes T-cell apoptosis: A potential mechanism of immune evasion. Nat Med 8(8):793-800.
    • (2002) Nat Med , vol.8 , Issue.8 , pp. 793-800
    • Dong, H.1
  • 32
    • 0037307930 scopus 로고    scopus 로고
    • Blockade of programmed death-1 ligands on dendritic cells enhances T cell activation and cytokine production
    • Brown JA, et al. (2003) Blockade of programmed death-1 ligands on dendritic cells enhances T cell activation and cytokine production. J Immunol 170(3):1257-1266.
    • (2003) J Immunol , vol.170 , Issue.3 , pp. 1257-1266
    • Brown, J.A.1
  • 33
    • 84891166519 scopus 로고    scopus 로고
    • Immune mechanisms in medium and large-vessel vasculitis
    • Weyand CM, Goronzy JJ (2013) Immune mechanisms in medium and large-vessel vasculitis. Nat Rev Rheumatol 9(12):731-740.
    • (2013) Nat Rev Rheumatol , vol.9 , Issue.12 , pp. 731-740
    • Weyand, C.M.1    Goronzy, J.J.2
  • 34
    • 0031901492 scopus 로고    scopus 로고
    • Platelet-derived growth factor, intimal hyperplasia, and ischemic complications in giant cell arteritis
    • Kaiser M, Weyand CM, Björnsson J, Goronzy JJ (1998) Platelet-derived growth factor, intimal hyperplasia, and ischemic complications in giant cell arteritis. Arthritis Rheum 41(4):623-633.
    • (1998) Arthritis Rheum , vol.41 , Issue.4 , pp. 623-633
    • Kaiser, M.1    Weyand, C.M.2    Björnsson, J.3    Goronzy, J.J.4
  • 35
    • 54349106248 scopus 로고    scopus 로고
    • Imatinib mesylate inhibits in vitro and ex vivo biological responses related to vascular occlusion in giant cell arteritis
    • Lozano E, Segarra M, García-Martínez A, Hernández-Rodríguez J, Cid MC (2008) Imatinib mesylate inhibits in vitro and ex vivo biological responses related to vascular occlusion in giant cell arteritis. Ann Rheum Dis 67(11):1581-1588.
    • (2008) Ann Rheum Dis , vol.67 , Issue.11 , pp. 1581-1588
    • Lozano, E.1    Segarra, M.2    García-Martínez, A.3    Hernández-Rodríguez, J.4    Cid, M.C.5
  • 36
    • 0032885563 scopus 로고    scopus 로고
    • Formation of new vasa vasorum in vasculitis. Production of angiogenic cytokines by multinucleated giant cells
    • Kaiser M, Younge B, Björnsson J, Goronzy JJ, Weyand CM (1999) Formation of new vasa vasorum in vasculitis. Production of angiogenic cytokines by multinucleated giant cells. Am J Pathol 155(3):765-774.
    • (1999) Am J Pathol , vol.155 , Issue.3 , pp. 765-774
    • Kaiser, M.1    Younge, B.2    Björnsson, J.3    Goronzy, J.J.4    Weyand, C.M.5
  • 37
    • 43049180068 scopus 로고    scopus 로고
    • Is intimal hyperplasia a marker of neuro-ophthalmic complications of giant cell arteritis?
    • Oxford
    • Makkuni D, et al. (2008) Is intimal hyperplasia a marker of neuro-ophthalmic complications of giant cell arteritis? Rheumatology (Oxford) 47(4):488-490.
    • (2008) Rheumatology , vol.47 , Issue.4 , pp. 488-490
    • Makkuni, D.1
  • 38
    • 0028791059 scopus 로고
    • Lymphoproliferative disorders with early lethality in mice deficient in Ctla-4
    • Waterhouse P, et al. (1995) Lymphoproliferative disorders with early lethality in mice deficient in Ctla-4. Science 270(5238):985-988.
    • (1995) Science , vol.270 , Issue.5238 , pp. 985-988
    • Waterhouse, P.1
  • 39
    • 1642306942 scopus 로고    scopus 로고
    • B7-H1 determines accumulation and deletion of intrahepatic CD8(+) T lymphocytes
    • Dong H, et al. (2004) B7-H1 determines accumulation and deletion of intrahepatic CD8(+) T lymphocytes. Immunity 20(3):327-336.
    • (2004) Immunity , vol.20 , Issue.3 , pp. 327-336
    • Dong, H.1
  • 40
    • 84863840695 scopus 로고    scopus 로고
    • Aberrant expression of the negative costimulator PD-1 on T cells in granulomatosis with polyangiitis
    • Oxford
    • Wilde B, et al. (2012) Aberrant expression of the negative costimulator PD-1 on T cells in granulomatosis with polyangiitis. Rheumatology (Oxford) 51(7):1188-1197.
    • (2012) Rheumatology , vol.51 , Issue.7 , pp. 1188-1197
    • Wilde, B.1
  • 41
    • 84896290367 scopus 로고    scopus 로고
    • Drug-Associated polymyalgia rheumatica/giant cell arteritis occurring in two patients after treatment with ipilimumab, an antagonist of ctla-4
    • Goldstein BL, Gedmintas L, Todd DJ (2014) Drug-Associated polymyalgia rheumatica/giant cell arteritis occurring in two patients after treatment with ipilimumab, an antagonist of ctla-4. Arthritis Rheumatol 66(3):768-769.
    • (2014) Arthritis Rheumatol , vol.66 , Issue.3 , pp. 768-769
    • Goldstein, B.L.1    Gedmintas, L.2    Todd, D.J.3
  • 42
    • 84858760109 scopus 로고    scopus 로고
    • Combining immunotherapy and targeted therapies in cancer treatment
    • Vanneman M, Dranoff G (2012) Combining immunotherapy and targeted therapies in cancer treatment. Nat Rev Cancer 12(4):237-251.
    • (2012) Nat Rev Cancer , vol.12 , Issue.4 , pp. 237-251
    • Vanneman, M.1    Dranoff, G.2
  • 43
    • 47049083508 scopus 로고    scopus 로고
    • Activation drives PD-1 expression during vaccine-specific proliferation and following lentiviral infection in macaques
    • Hokey DA, et al. (2008) Activation drives PD-1 expression during vaccine-specific proliferation and following lentiviral infection in macaques. Eur J Immunol 38(5): 1435-1445.
    • (2008) Eur J Immunol , vol.38 , Issue.5 , pp. 1435-1445
    • Hokey, D.A.1
  • 44
    • 84861798801 scopus 로고    scopus 로고
    • Interleukin-21 modulates Th1 and Th17 responses in giant cell arteritis
    • Terrier B, et al. (2012) Interleukin-21 modulates Th1 and Th17 responses in giant cell arteritis. Arthritis Rheum 64(6):2001-2011.
    • (2012) Arthritis Rheum , vol.64 , Issue.6 , pp. 2001-2011
    • Terrier, B.1
  • 45
    • 77953747963 scopus 로고    scopus 로고
    • The PD-1 pathway in tolerance and autoimmunity
    • Francisco LM, Sage PT, Sharpe AH (2010) The PD-1 pathway in tolerance and autoimmunity. Immunol Rev 236:219-242.
    • (2010) Immunol Rev , vol.236 , pp. 219-242
    • Francisco, L.M.1    Sage, P.T.2    Sharpe, A.H.3
  • 46
    • 27144496045 scopus 로고    scopus 로고
    • CTLA-4 and PD-1 receptors inhibit T-cell activation by distinct mechanisms
    • Parry RV, et al. (2005) CTLA-4 and PD-1 receptors inhibit T-cell activation by distinct mechanisms. Mol Cell Biol 25(21):9543-9553.
    • (2005) Mol Cell Biol , vol.25 , Issue.21 , pp. 9543-9553
    • Parry, R.V.1
  • 47
    • 0035923535 scopus 로고    scopus 로고
    • PD-1 immunoreceptor inhibits B cell receptor-mediated signaling by recruiting src homology 2-domain-containing tyrosine phosphatase 2 to phosphotyrosine
    • Okazaki T, Maeda A, Nishimura H, Kurosaki T, Honjo T (2001) PD-1 immunoreceptor inhibits B cell receptor-mediated signaling by recruiting src homology 2-domain-containing tyrosine phosphatase 2 to phosphotyrosine. Proc Natl Acad Sci USA 98(24):13866-13871.
    • (2001) Proc Natl Acad Sci USA , vol.98 , Issue.24 , pp. 13866-13871
    • Okazaki, T.1    Maeda, A.2    Nishimura, H.3    Kurosaki, T.4    Honjo, T.5
  • 48
    • 66949173728 scopus 로고    scopus 로고
    • The mTOR kinase differentially regulates effector and regulatory T cell lineage commitment
    • Delgoffe GM, et al. (2009) The mTOR kinase differentially regulates effector and regulatory T cell lineage commitment. Immunity 30(6):832-844.
    • (2009) Immunity , vol.30 , Issue.6 , pp. 832-844
    • Delgoffe, G.M.1
  • 49
    • 84860237060 scopus 로고    scopus 로고
    • Regulation and function of mTOR signalling in T cell fate decisions
    • Chi H (2012) Regulation and function of mTOR signalling in T cell fate decisions. Nat Rev Immunol 12(5):325-338.
    • (2012) Nat Rev Immunol , vol.12 , Issue.5 , pp. 325-338
    • Chi, H.1
  • 50
    • 84897521932 scopus 로고    scopus 로고
    • TGF-β signaling mediates endothelial-To-mesenchymal transition (EndMT) during vein graft remodeling
    • Cooley BC, et al. (2014) TGF-β signaling mediates endothelial-To-mesenchymal transition (EndMT) during vein graft remodeling. Sci Transl Med 6(227):227ra34.
    • (2014) Sci Transl Med , vol.6 , Issue.227 , pp. 227ra34
    • Cooley, B.C.1
  • 51
    • 84855912001 scopus 로고    scopus 로고
    • Pericyte depletion results in hypoxia-Associated epithelial-Tomesenchymal transition and metastasis mediated by met signaling pathway
    • Cooke VG, et al. (2012) Pericyte depletion results in hypoxia-Associated epithelial-Tomesenchymal transition and metastasis mediated by met signaling pathway. Cancer Cell 21(1):66-81.
    • (2012) Cancer Cell , vol.21 , Issue.1 , pp. 66-81
    • Cooke, V.G.1
  • 52
    • 32544459770 scopus 로고    scopus 로고
    • Restoring function in exhausted CD8 T cells during chronic viral infection
    • Barber DL, et al. (2006) Restoring function in exhausted CD8 T cells during chronic viral infection. Nature 439(7077):682-687.
    • (2006) Nature , vol.439 , Issue.7077 , pp. 682-687
    • Barber, D.L.1
  • 53
    • 33748947326 scopus 로고    scopus 로고
    • PD-1 expression on HIV-specific T cells is associated with T-cell exhaustion and disease progression
    • Day CL, et al. (2006) PD-1 expression on HIV-specific T cells is associated with T-cell exhaustion and disease progression. Nature 443(7109):350-354.
    • (2006) Nature , vol.443 , Issue.7109 , pp. 350-354
    • Day, C.L.1
  • 54
    • 84938397867 scopus 로고    scopus 로고
    • T-cell exhaustion, co-stimulation and clinical outcome in autoimmunity and infection
    • McKinney EF, Lee JC, Jayne DR, Lyons PA, Smith KG (2015) T-cell exhaustion, co-stimulation and clinical outcome in autoimmunity and infection. Nature 523(7562):612-616.
    • (2015) Nature , vol.523 , Issue.7562 , pp. 612-616
    • McKinney, E.F.1    Lee, J.C.2    Jayne, D.R.3    Lyons, P.A.4    Smith, K.G.5
  • 55
    • 49249089425 scopus 로고    scopus 로고
    • Control of peripheral T-cell tolerance and autoimmunity via the CTLA-4 and PD-1 pathways
    • Fife BT, Bluestone JA (2008) Control of peripheral T-cell tolerance and autoimmunity via the CTLA-4 and PD-1 pathways. Immunol Rev 224:166-182.
    • (2008) Immunol Rev , vol.224 , pp. 166-182
    • Fife, B.T.1    Bluestone, J.A.2
  • 56
    • 33748098860 scopus 로고    scopus 로고
    • PD-L1 is induced in hepatocytes by viral infection and by interferon-Alpha and -gamma and mediates T cell apoptosis
    • Mühlbauer M, et al. (2006) PD-L1 is induced in hepatocytes by viral infection and by interferon-Alpha and -gamma and mediates T cell apoptosis. J Hepatol 45(4):520-528.
    • (2006) J Hepatol , vol.45 , Issue.4 , pp. 520-528
    • Mühlbauer, M.1
  • 57
    • 4444355857 scopus 로고    scopus 로고
    • Interferon-beta enhances monocyte and dendritic cell expression of B7-H1 (PD-L1), a strong inhibitor of autologous T-cell activation: Relevance for the immune modulatory effect in multiple sclerosis
    • Schreiner B, et al. (2004) Interferon-beta enhances monocyte and dendritic cell expression of B7-H1 (PD-L1), a strong inhibitor of autologous T-cell activation: Relevance for the immune modulatory effect in multiple sclerosis. J Neuroimmunol 155(1-2):172-182.
    • (2004) J Neuroimmunol , vol.155 , Issue.1-2 , pp. 172-182
    • Schreiner, B.1
  • 58
    • 0036785604 scopus 로고    scopus 로고
    • B7-H1 is expressed by human endothelial cells and suppresses T cell cytokine synthesis
    • Mazanet MM, Hughes CC (2002) B7-H1 is expressed by human endothelial cells and suppresses T cell cytokine synthesis. J Immunol 169(7):3581-3588.
    • (2002) J Immunol , vol.169 , Issue.7 , pp. 3581-3588
    • Mazanet, M.M.1    Hughes, C.C.2
  • 59
    • 58149191881 scopus 로고    scopus 로고
    • The common gamma-chain cytokines IL-2, IL-7, IL-15, and IL-21 induce the expression of programmed death-1 and its ligands
    • Kinter AL, et al. (2008) The common gamma-chain cytokines IL-2, IL-7, IL-15, and IL-21 induce the expression of programmed death-1 and its ligands. J Immunol 181(10): 6738-6746.
    • (2008) J Immunol , vol.181 , Issue.10 , pp. 6738-6746
    • Kinter, A.L.1
  • 60
    • 0031030254 scopus 로고    scopus 로고
    • Disease patterns and tissue cytokine profiles in giant cell arteritis
    • Weyand CM, et al. (1997) Disease patterns and tissue cytokine profiles in giant cell arteritis. Arthritis Rheum 40(1):19-26.
    • (1997) Arthritis Rheum , vol.40 , Issue.1 , pp. 19-26
    • Weyand, C.M.1
  • 61
    • 0038790045 scopus 로고    scopus 로고
    • Medium-And large-vessel vasculitis
    • Weyand CM, Goronzy JJ (2003) Medium-And large-vessel vasculitis. N Engl J Med 349(2):160-169.
    • (2003) N Engl J Med , vol.349 , Issue.2 , pp. 160-169
    • Weyand, C.M.1    Goronzy, J.J.2
  • 63
    • 84961226298 scopus 로고    scopus 로고
    • The glycolytic enzyme PKM2 bridges metabolic and inflammatory dysfunction in coronary artery disease
    • Shirai T, et al. (2016) The glycolytic enzyme PKM2 bridges metabolic and inflammatory dysfunction in coronary artery disease. J Exp Med 213(3):337-354.
    • (2016) J Exp Med , vol.213 , Issue.3 , pp. 337-354
    • Shirai, T.1


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