Activation drives PD-1 expression during vaccine-specific proliferation and following lentiviral infection in macaques

European Journal of Immunology

Volumn 38, Issue 5, 2008, Pages 1435-1445

  Hokey, David A ^a   Johnson, F Brad ^a   Smith, Jasmine ^a   Weber, Joshua L ^a   Yan, Jian ^a   Hirao, Lauren ^a   Boyer, Jean D ^a   Lewis, Mark G ^b   Makedonas, George ^a   Betts, Michael R ^a   Weiner, David B ^a  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

^b BIOQUAL INC   (United States)

Author keywords

Exhaustion; HIV; PD 1; SIV; Vaccine

Indexed keywords

CD3 ANTIGEN; CELL PROTEIN; DNA VACCINE; GAMMA INTERFERON; PROTEIN PD 1; UNCLASSIFIED DRUG; APOPTOSIS REGULATORY PROTEIN; BACTERIAL ANTIGEN; CD28 ANTIGEN; ENTEROTOXIN; FAS ANTIGEN; INTERLEUKIN 2; PEPTIDE FRAGMENT; POL PROTEIN; STAPHYLOCOCCUS ENTEROTOXIN B; TUMOR NECROSIS FACTOR ALPHA; VIRUS ENVELOPE PROTEIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIGEN SPECIFICITY; ARTICLE; CD8+ T LYMPHOCYTE; CELLULAR IMMUNITY; CONTROLLED STUDY; CYTOKINE RELEASE; DNA IMMUNIZATION; EX VIVO STUDY; LYMPHOCYTE ACTIVATION; LYMPHOCYTE PROLIFERATION; MACACA; MEMORY T LYMPHOCYTE; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; PROTEIN LOCALIZATION; REGULATORY MECHANISM; RETROVIRUS INFECTION; T LYMPHOCYTE; TELOMERE; ANIMAL; CD4+ T LYMPHOCYTE; CELL PROLIFERATION; CHEMISTRY; GENETICS; IMMUNOLOGY; METABOLISM; MONKEY DISEASE; SIMIAN IMMUNODEFICIENCY VIRUS; T LYMPHOCYTE SUBPOPULATION;

ANIMALS; ANTIGENS, BACTERIAL; ANTIGENS, CD28; ANTIGENS, CD3; ANTIGENS, CD95; APOPTOSIS REGULATORY PROTEINS; CD4-POSITIVE T-LYMPHOCYTES; CD8-POSITIVE T-LYMPHOCYTES; CELL PROLIFERATION; ENTEROTOXINS; GENE PRODUCTS, ENV; GENE PRODUCTS, POL; INTERFERON TYPE II; INTERLEUKIN-2; LYMPHOCYTE ACTIVATION; MACACA FASCICULARIS; MACACA MULATTA; PEPTIDE FRAGMENTS; SIMIAN ACQUIRED IMMUNODEFICIENCY SYNDROME; SIMIAN IMMUNODEFICIENCY VIRUS; T-LYMPHOCYTE SUBSETS; T-LYMPHOCYTES; TELOMERE; TUMOR NECROSIS FACTOR-ALPHA; VACCINES, DNA;

EID: 47049083508     PISSN: 00142980     EISSN: None     Source Type: Journal    
DOI: 10.1002/eji.200737857     Document Type: Article

References (33)

1. Barber, D. L., Wherry, E. J., Masopust, D., Zhu, B., Allison, J. P., Sharpe, A. H., Freeman, G. J. et al., Restoring function in exhausted CD8 T cells during chronic viral infection. Nature 2006. 439: 682-687.
2. Day, C. L., Kaufmann, D. E., Kiepiela, P., Brown, J. A., Moodley, E. S., Reddy, S., Mackey, E. W. et al., PD-1 expression on HIV-specific T cells is associated with T-cell exhaustion and disease progression. Nature 2006. 443: 350-354.
3. + T cell survival in HIV infection. J. Exp. Med. 2006. 203: 2281-2292.
4. + T cells leads to reversible immune dysfunction. Nat. Med. 2006. 12: 1198-1202.
5. Hokey, D. A. and Weiner, D. B., DNA vaccines for HIV: Challenges and opportunities. Springer Semin. Immunopathol. 2006. 28: 267-279.
6. + T cells express high levels of PD1 and cytokines but have impaired proliferative capacity in acute and chronic SIVmac251 infection. Blood 2007. 110: 928-936.
7. Velu, V., Kannanganat, S., Ibegbu, C., Chennareddi, L., Villinger, F., Freeman, G. J., Ahmed, R. et al., Elevated expression levels of inhibitory receptor programmed death 1 on simian immunodeficiency virus-specific CD8 T cells during chronic infection but not after vaccination. J. Virol. 2007. 81: 5819-5828.
8. Vibhakar, R., Juan, G., Traganos, F., Darzynkiewicz, Z. and Finger, L. R., Activation-induced expression of human programmed death-1 gene in T-lymphocytes. Exp. Cell Res. 1997. 232: 25-28.
9. Nam, K., Akari, H., Terao, K., Shibata, H., Kawamura, S. and Yoshikawa, Y., Peripheral blood extrathymic CD4(+)CD8(+) T cells with high cytotoxic activity are from the same lineage as CD4(+)CD8(-) T cells in cynomolgus monkeys. Int. Immunol. 2000. 12: 1095-1103.
10. Nascimbeni, M., Shin, E. C., Chiriboga, L., Kleiner, D. E. and Rehermann, B., Peripheral CD4(+)CD8(+) T cells are differentiated effector memory cells with antiviral functions. Blood 2004. 104: 478-486.
11. + T cells are highly activated memory cells with an increased capacity to produce cytokines. Eur. J. Immunol. 2006. 36: 583-592.
12. Suni, M. A., Ghanekar, S. A., Houck, D. W., Maecker, H. T., Wormsley, S. B., Picker, L. J., Moss, R. B. et al., CD4(+)CD8(dim) T lymphocytes exhibit enhanced cytokine expression, proliferation and cytotoxic activity in response to HCMV and HIV-1 antigens. Eur. J. Immunol. 2001. 31: 2512-2520.
13. Zuckermann, F. A., Extrathymic CD4/CD8 double positive T cells. Vet. Immunol. Immunopathol. 1999. 72: 55-66.
14. Jankovic, V., Messaoudi, I. and Nikolich-Zugich, J., Phenotypic and functional T-cell aging in rhesus macaques (Macaca mulatta): Differential behavior of CD4 and CD8 subsets. Blood 2003. 102: 3244-3251.
15. Pitcher, C. J., Hagen, S. I., Walker, J. M., Lum, R., Mitchell, B. L., Maino, V. C., Axthelm, M. K. et al., Development and homeostasis of T cell memory in rhesus macaque. J. Immunol. 2002. 168: 29-43.
16. Weng, N. P., Levine, B. L., June, C. H. and Hodes, R. J., Human naive and memory T lymphocytes differ in telomeric length and replicative potential. Proc. Natl. Acad. Sci. USA 1995. 92: 11091-11094.
17. Herbig, U., Ferreira, M., Condel, L., Carey, D. and Sedivy, J. M., Cellular senescence in aging primates. Science 2006. 311: 1257.
18. Takai, H., Smogorzewska, A. and de Lange, T., DNA damage foci at dysfunctional telomeres. Curr. Biol. 2003. 13: 1549-1556.
19. Chen, L., Co-inhibitory molecules of the B7-CD28 family in the control of T-cell immunity. Nat. Rev. Immunol. 2004. 4: 336-347.
20. Greenwald, R. J., Freeman, G. J. and Sharpe, A. H., The B7 family revisited. Annu. Rev. Immunol. 2005. 23: 515-548.
21. Okazaki, T., Iwai, Y. and Honjo, T., New regulatory co-receptors: Inducible co-stimulator and PD-1. Curr. Opin. Immunol. 2002. 14: 779-782.
22. Okazaki, T. and Wang, J., PD-1/PD-L pathway and autoimmunity. Autoimmunity 2005. 38: 353-357.
23. Parry, R. V., Chemnitz, J. M., Frauwirth, K. A., Lanfranco, A. R., Braunstein, I., Kobayashi, S. V., Linsley, P. S. et al., CTLA-4 and PD-1 receptors inhibit T-cell activation by distinct mechanisms. Mol. Cell. Biol. 2005. 25: 9543-9553.
24. Sandner, S. E., Clarkson, M. R., Salama, A. D., Sanchez-Fueyo, A., Domenig, C., Habicht, A., Najafian, N. et al., Role of the programmed death-1 pathway in regulation of alloimmune responses in vivo. J. Immunol. 2005. 174: 3408-3415.
25. Ito, T., Ueno, T., Clarkson, M. R., Yuan, X., Jurewicz, M. M., Yagita, H., Azuma, M. et al., Analysis of the role of negative T cell costimulatory pathways in CD4 and CD8 T cell-mediated alloimmune responses in vivo. J. Immunol. 2005. 174: 6648-6656.
26. + T cell tolerance through PD-1 and CTLA-4. Nat. Immunol. 2005. 6: 280-286.
27. + T cell exhaustion
28. Freeman, G. J., Wherry, E. J., Ahmed, R. and Sharpe, A. H., Reinvigorating exhausted HIV-specific Tcells via PD-1-PD-1 ligand blockade. J. Exp. Med. 2006. 203: 2223-2227.
29. del Rio, M. L., Penuelas-Rivas, G., Dominguez-Perles, R., Ramirez, P., Parrilla, P. and Rodriguez-Barbosa, J. I., Antibody-mediated signaling through PD-1 costimulates T cells and enhances CD28-dependent proliferation. Eur. J. Immunol. 2005. 35: 3545-3560.
30. + T lymphocytes that express cytotoxicity-associated molecules and are committed to produce interferon-gamma and tumor necrosis factor-alpha. J. Infect. Dis. 1998. 178: 1158-1162.
31. + cell subset in HIV disease implicate replicative senescence in HIV pathogenesis. Aids 1996. 10: F17-F22.
32. Valenzuela, H. F. and Effros, R. B., Divergent telomerase and CD28 expression patterns in human CD4 and CD8 T cells following repeated encounters with the same antigenic stimulus. Clin. Immunol. 2002. 105: 117-125.
33. Steinert, S., White, D. M., Zou, Y., Shay, J.W. and Wright, W. E., Telomere biology and cellular aging in nonhuman primate cells. Exp. Cell Res. 2002. 272: 146-152.