3H-1,2-Dithiole-3-thione as a novel therapeutic agent for the treatment of ischemic stroke through Nrf2 defense pathway

Brain, Behavior, and Immunity

Volumn 62, Issue , 2017, Pages 180-192

  Kuo, Ping Chang ^a   Yu, I Chen ^a   Scofield, Barbara A ^a   Brown, Dennis A ^b   Curfman, Eric T ^a   Paraiso, Hallel C ^c   Chang, Fen Lei ^a   Yen, Jui Hung ^a  

^a INDIANA UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b MANCHESTER UNIVERSITY   (United States)

^c INDIANA UNIVERSITY PURDUE UNIVERSITY FORT WAYNE   (United States)

Author keywords

D3T; HO 1; Ischemic stroke; Microglia; Neuroinflammation; Nrf2

Indexed keywords

1,2 DITHIOLE 3 THIONE DERIVATIVE; 3H 1,2 DITHIOLE 3 THIONE; TRANSCRIPTION FACTOR NRF2; UNCLASSIFIED DRUG; 1,2-DITHIOL-3-THIONE; ANTIOXIDANT; REACTIVE OXYGEN METABOLITE; THIOKETONE; THIOPHENE DERIVATIVE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIINFLAMMATORY ACTIVITY; ANTIOXIDANT ACTIVITY; ARTICLE; BLOOD BRAIN BARRIER; BRAIN EDEMA; BRAIN INFARCTION SIZE; BRAIN INJURY; BRAIN ISCHEMIA; CELL ACTIVATION; CENTRAL NERVOUS SYSTEM; CONTROLLED STUDY; CYTOKINE PRODUCTION; DRUG EFFICACY; DRUG MECHANISM; IMMUNOCOMPETENT CELL; INFLAMMATORY INFILTRATE; MALE; METABOLIC INHIBITION; MICROGLIA; MIDDLE CEREBRAL ARTERY OCCLUSION; MOUSE; NEUROLOGIC DISEASE; NONHUMAN; PROTECTION; PROTEIN INDUCTION; SIGNAL TRANSDUCTION; ANIMAL; CEREBRAL ARTERY DISEASE; CEREBROVASCULAR ACCIDENT; DISEASE MODEL; DRUG EFFECT; METABOLISM;

ANIMALS; ANTIOXIDANTS; BRAIN ISCHEMIA; DISEASE MODELS, ANIMAL; INFARCTION, MIDDLE CEREBRAL ARTERY; MICE; NF-E2-RELATED FACTOR 2; REACTIVE OXYGEN SPECIES; SIGNAL TRANSDUCTION; STROKE; THIONES; THIOPHENES;

EID: 85011556615     PISSN: 08891591     EISSN: 10902139     Source Type: Journal    
DOI: 10.1016/j.bbi.2017.01.018     Document Type: Article

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