3H-1,2-dithiole-3-thione protects retinal pigment epithelium cells against Ultra-violet radiation via activation of Akt-mTORC1-dependent Nrf2-HO-1 signaling

Scientific Reports

Volumn 6, Issue , 2016, Pages

  Li, Ke Ran ^a,b   Yang, Su Qing ^a   Gong, Yi Qing ^b   Yang, Hong ^b   Li, Xiu Miao ^b   Zhao, Yu Xia ^b   Yao, Jin ^b   Jiang, Qin ^b   Cao, Cong ^a  

^a SOOCHOW UNIVERSITY   (China)

^b NANJING MEDICAL UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

1,2-DITHIOL-3-THIONE; HEME OXYGENASE 1; HMOX1 PROTEIN, MOUSE; MAMMALIAN TARGET OF RAPAMYCIN COMPLEX 1; MEMBRANE PROTEIN; NFE2L2 PROTEIN, MOUSE; PROTEIN KINASE B; RADIOPROTECTIVE AGENT; REACTIVE OXYGEN METABOLITE; THIOKETONE; THIOPHENE DERIVATIVE; TRANSCRIPTION FACTOR NRF2;

ANIMAL; APOPTOSIS; C57BL MOUSE; CELL CULTURE; HUMAN; METABOLISM; RADIATION RESPONSE; RETINAL PIGMENT EPITHELIUM; SIGNAL TRANSDUCTION; ULTRAVIOLET RADIATION;

ANIMALS; APOPTOSIS; CELLS, CULTURED; HEME OXYGENASE-1; HUMANS; MECHANISTIC TARGET OF RAPAMYCIN COMPLEX 1; MEMBRANE PROTEINS; MICE, INBRED C57BL; NF-E2-RELATED FACTOR 2; PROTO-ONCOGENE PROTEINS C-AKT; RADIATION-PROTECTIVE AGENTS; REACTIVE OXYGEN SPECIES; RETINAL PIGMENT EPITHELIUM; SIGNAL TRANSDUCTION; THIONES; THIOPHENES; ULTRAVIOLET RAYS;

EID: 84967185340     PISSN: None     EISSN: 20452322     Source Type: Journal    
DOI: 10.1038/srep25525     Document Type: Article

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