Sulforaphane protects rodent retinas against ischemia-reperfusion injury through the activation of the Nrf2/HO-1 antioxidant pathway

PLoS ONE

Volumn 9, Issue 12, 2014, Pages

  Pan, Hong ^a,b,c   He, Meihua ^a,c   Liu, Ruixing ^a,c   Brecha, Nicholas C ^d,e   Yu, Albert Cheung Hoi ^a   Pu, Mingliang ^a,c  

^a PEKING UNIVERSITY HEALTH SCIENCE CENTER   (China)

^b BINZHOU MEDICAL UNIVERSITY   (China)

^c PEKING UNIVERSITY   (China)

^d UNIVERSITY OF CALIFORNIA   (United States)

^e VETERANS AFFAIRS MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

HEME OXYGENASE 1; PROTOPORPHYRIN ZINC; REACTIVE OXYGEN METABOLITE; SULFORAPHANE; TRANSCRIPTION FACTOR NRF2; ANTIOXIDANT; ISOTHIOCYANIC ACID DERIVATIVE; PROTECTIVE AGENT; SULFORAFAN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CELL SURVIVAL; CONTROLLED STUDY; INTRAOCULAR PRESSURE; MALE; NEUROPROTECTION; NONHUMAN; OXIDATIVE STRESS; PROTEIN EXPRESSION; RAT; REPERFUSION INJURY; RETINA AMACRINE CELL; RETINA GANGLION CELL; RETINA INNER NUCLEAR LAYER; RETINA ISCHEMIA; RETINITIS; SIGNAL TRANSDUCTION; ANIMAL; CYTOLOGY; DISEASE MODEL; DRUG EFFECTS; INFLAMMATION; INTRAPERITONEAL DRUG ADMINISTRATION; METABOLISM; PATHOLOGY; PHYSIOLOGY; RETINA; SPRAGUE DAWLEY RAT; UPREGULATION;

AMACRINE CELLS; ANIMALS; ANTIOXIDANTS; APOPTOSIS; DISEASE MODELS, ANIMAL; HEME OXYGENASE-1; INFLAMMATION; INJECTIONS, INTRAPERITONEAL; INTRAOCULAR PRESSURE; ISOTHIOCYANATES; MALE; NF-E2-RELATED FACTOR 2; PROTECTIVE AGENTS; RATS; RATS, SPRAGUE-DAWLEY; REACTIVE OXYGEN SPECIES; REPERFUSION INJURY; RETINA; RETINAL GANGLION CELLS; UP-REGULATION;

EID: 84932639745     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0114186     Document Type: Article

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