Grape seed and tea extracts and catechin 3-gallates are potent inhibitors of α-amylase and α-glucosidase activity

Journal of Agricultural and Food Chemistry

Volumn 60, Issue 36, 2012, Pages 8924-8929

  Yilmazer Musa, Meltem ^a   Griffith, Anneke M ^a   Michels, Alexander J ^a   Schneider, Erik ^b   Frei, Balz ^a  

^a OREGON STATE UNIVERSITY   (United States)

^b USANA Health Sciences Inc   (United States)

Author keywords

amylase; glucosidase; catechins; diabetes; enzyme inhibition; grape seed extract; tea

Indexed keywords

ACARBOSE; AMYLASE ACTIVITY; CATECHINS; EPIGALLOCATECHIN GALLATE; FLAVAN-3-OLS; GLUCOSIDASE; GLUCOSIDASE ACTIVITY; GRAPE SEED EXTRACT; GRAPE SEEDS; GREEN TEA; INHIBITORY EFFECT; POTENT INHIBITOR; PROCYANIDINS; TEA; TEA EXTRACTS;

AMYLASES; ENZYME INHIBITION; FRUITS; MEDICAL PROBLEMS; ORGANIC COMPOUNDS; PLANT EXTRACTS; SEED; VITAMINS;

PHENOLS;

ALPHA GLUCOSIDASE; AMYLASE; CATECHIN; CATECHIN GALLATE; DRUG DERIVATIVE; ENZYME INHIBITOR; FUNGAL PROTEIN; PLANT EXTRACT;

CHEMISTRY; CONFERENCE PAPER; DRUG ANTAGONISM; ENZYMOLOGY; HUMAN; KINETICS; PLANT SEED; SACCHAROMYCETALES; SALIVA; TEA; VITIS;

ALPHA-AMYLASES; ALPHA-GLUCOSIDASES; CAMELLIA SINENSIS; CATECHIN; ENZYME INHIBITORS; FUNGAL PROTEINS; HUMANS; KINETICS; PLANT EXTRACTS; SACCHAROMYCETALES; SALIVA; SEEDS; VITIS;

VITACEAE;

EID: 84866359037     PISSN: 00218561     EISSN: 15205118     Source Type: Journal    
DOI: 10.1021/jf301147n     Document Type: Conference Paper

References (33)

1. Skyler, J. S.; Bergenstal, R.; Bonow, R. O.; Buse, J.; Deedwania, P.; Gale, E. A.; Howard, B. V.; Kirkman, M. S.; Kosiborod, M.; Reaven, P.; Sherwin, R. S. Intensive glycemic control and the prevention of cardiovascular events: implications of the ACCORD, ADVANCE, and VA diabetes trials: a position statement of the American Diabetes Association and a scientific statement of the American College of Cardiology Foundation and the American Heart Association Circulation 2009, 119, 351-357
2. Blonde, L. Benefits and risks for intensive glycemic control in patients with diabetes mellitus Am. J. Med. Sci. 2012, 343, 17-20
3. Bolen, S.; Feldman, L.; Vassy, J.; Wilson, L.; Yeh, H. C.; Marinopoulos, S.; Wiley, C.; Selvin, E.; Wilson, R.; Bass, E. B.; Brancati, F. L. Systematic review: comparative effectiveness and safety of oral medications for type 2 diabetes mellitus Ann. Intern. Med. 2007, 147, 386-399
4. Lebovitz, H. E. α-Glucosidase inhibitors Endocrinol. Metab. Clin. North Am. 1997, 26, 539-551
5. Fujisawa, T.; Ikegami, H.; Inoue, K.; Kawabata, Y.; Ogihara, T. Effect of two α-glucosidase inhibitors, voglibose and acarbose, on postprandial hyperglycemia correlates with subjective abdominal symptoms Metabolism 2005, 54, 387-390
6. Neuser, D.; Benson, A.; Bruckner, A.; Goldberg, R. B.; Hoogwerf, B. J.; Petzinna, D. Safety and tolerability of acarbose in the treatment of type 1 and type 2 diabetes mellitus Clin. Drug Invest. 2005, 25, 579-587
7. Said, O.; Fulder, S.; Khalil, K.; Azaizeh, H.; Kassis, E.; Saad, B. Maintaining a physiological blood glucose level with 'glucolevel', a combination of four anti-diabetes plants used in the traditional arab herbal medicine Evidence-Based Complement. Altern. Med. 2008, 5, 421-8
8. Bhat, M.; Zinjarde, S. S.; Bhargava, S. Y.; Kumar, A. R.; Joshi, B. N. Antidiabetic Indian plants: a good source of potent amylase inhibitors Evidence-Based Complement. Altern. Med. 2011, 2011, 810207
9. Benalla, W.; Bellahcen, S.; Bnouham, M. Antidiabetic medicinal plants as a source of α-glucosidase inhibitors Curr. Diabetes Rev. 2010, 6, 247-254
10. Kamiyama, O.; Sanae, F.; Ikeda, K.; Higashi, Y.; Minami, Y.; Asano, N.; Adachi, I.; Kato, A. In vitro inhibition of α-glucosidases and glycogen phosphorylase by catechin gallates in green tea Food Chem. 2010, 122, 1061-1066
11. Li, Y. Q.; Zhou, F. C.; Gao, F.; Bian, J. S.; Shan, F. Comparative evaluation of quercetin, isoquercetin and rutin as inhibitors of α-glucosidase J. Agric. Food Chem. 2009, 57, 11463-11468
12. McDougall, G. J.; Shpiro, F.; Dobson, P.; Smith, P.; Blake, A.; Stewart, D. Different polyphenolic components of soft fruits inhibit α-amylase and α-glucosidase J. Agric. Food Chem. 2005, 53, 2760-2766
13. Wolfram, S. Effects of green tea and EGCG on cardiovascular and metabolic health J. Am. Coll. Nutr. 2007, 26, 373S-388S
14. Nahas, R.; Moher, M. Complementary and alternative medicine for the treatment of type 2 diabetes Can. Fam. Physician 2009, 55, 591-596
15. Kar, P.; Laight, D.; Rooprai, H. K.; Shaw, K. M.; Cummings, M. Effects of grape seed extract in type 2 diabetic subjects at high cardiovascular risk: a double blind randomized placebo controlled trial examining metabolic markers, vascular tone, inflammation, oxidative stress and insulin sensitivity Diabetes Med. 2009, 26, 526-531
16. Montagut, G.; Blade, C.; Blay, M.; Fernandez-Larrea, J.; Pujadas, G.; Salvado, M. J.; Arola, L.; Pinent, M.; Ardevol, A. Effects of a grapeseed procyanidin extract (GSPE) on insulin resistance J. Nutr. Biochem. 2010, 21, 961-967
17. Yan, J.; Zhao, Y.; Suo, S.; Liu, Y.; Zhao, B. Green tea catechins ameliorate adipose insulin resistance by improving oxidative stress Free Radical Biol. Med. 2012, 52, 1648-1657
18. Park, J. H.; Jin, J. Y.; Baek, W. K.; Park, S. H.; Sung, H. Y.; Kim, Y. K.; Lee, J.; Song, D. K. Ambivalent role of gallated catechins in glucose tolerance in humans: a novel insight into non-absorbable gallated catechin-derived inhibitors of glucose absorption J. Physiol. Pharmacol. 2009, 60, 101-109
19. Mandic, A. I.; Dcrossilas, S. M.; Ćetković, G. S.; Čanadanović-Brunet, J. M.; Tumbas, V. T. Polyphenolic composition and antioxidant activities of grape seed extract Int. J. Food Prop. 2008, 11, 713-726
20. Khanal, R. C.; Howard, L. R.; Prior, R. L. Procyanidin content of grape seed and pomace, and total anthocyanin content of grape pomace as affected by extrusion processing J. Food Sci. 2009, 74, H174-H182
21. Soares, S.; Mateus, N.; Freitas, V. Interaction of different polyphenols with bovine serum albumin (BSA) and human salivary α-amylase (HSA) by fluorescence quenching J. Agric. Food Chem. 2007, 55, 6726-6735
22. Gamberucci, A.; Konta, L.; Colucci, A.; Giunti, R.; Magyar, J. E.; Mandl, J.; Banhegyi, G.; Benedetti, A.; Csala, M. Green tea flavonols inhibit glucosidase II Biochem. Pharmacol. 2006, 72, 640-646
23. Koh, L. W.; Wong, L. L.; Loo, Y. Y.; Kasapis, S.; Huang, D. Evaluation of different teas against starch digestibility by mammalian glycosidases J. Agric. Food. Chem. 2010, 58, 148-154
24. Tadera, K.; Minami, Y.; Takamatsu, K.; Matsuoka, T. Inhibition of α-glucosidase and α-amylase by flavonoids J. Nutr. Sci. Vitaminol. (Tokyo) 2006, 52, 149-153
25. de Freitas, V.; Mateus, N. Structural features of procyanidin interactions with salivary proteins J. Agric. Food Chem. 2001, 49, 940-945
26. Lo Piparo, E.; Scheib, H.; Frei, N.; Williamson, G.; Grigorov, M.; Chou, C. J. Flavonoids for controlling starch digestion: structural requirements for inhibiting human α-amylase J. Med. Chem. 2008, 51, 3555-3561
27. Deutschlander, M. S.; van de Venter, M.; Roux, S.; Louw, J.; Lall, N. Hypoglycaemic activity of four plant extracts traditionally used in South Africa for diabetes J. Ethnopharmacol. 2009, 124, 619-624
28. Zhao, Y.; Chen, P.; Lin, L.; Harnly, J. M.; Yu, L.; Li, Z. Tentative identification, quantitation, and principal component analysis of green pu-erh, green, and white teas using UPLC/DAD/MS Food Chem. 2011, 126, 1269-1277
29. Mateus, N.; Pinto, R.; Ruão, P.; de Freitas, V. Influence of the addition of grape seed procyanidins to Port wines in the resulting reactivity with human salivary proteins Food Chem. 2004, 84, 195-200
30. Truscheit, E.; Frommer, W.; Junge, B.; Müller, L.; Schmidt, D. D.; Wingender, W. Chemistry and biochemistry of microbial α-glucosidase inhibitors Angew. Chem., Int. Ed. 1981, 20, 744-761
31. Rios, L.; Benett, R.; Lazarus, S.; Rémésy, C.; Scalbert, A.; Williamson, G. Cocoa procyanidins are stable during gastric transit in humans Am. J. Clin. Nutr. 2002, 76, 1106-1110
32. Serra, A.; Maciá, A.; Romero, M.; Valls, J.; Bladé, C.; Arola, L.; Motilva, M. Bioavailability of procyanidin dimers and trimers and matrix food effects in in vitro and in vivo models Brit. J. Nutr. 2009, 103, 944-952
33. Manach, C.; Williamson, G.; Morand, C.; Scalbert, A.; Rémésy, C. Bioavailability and bioefficacy of polyphenols in humans. I. Review of 97 bioavailability studies Am. J. Clin. Nutr. 2005, 81, 230S-242S