메뉴 건너뛰기




Volumn 400, Issue , 2017, Pages 149-168

Gastric organoids: An emerging model system to study Helicobacter pylori pathogenesis

Author keywords

[No Author keywords available]

Indexed keywords

ADULT STEM CELL; BACTERIAL VIRULENCE; CELL DIFFERENTIATION; CELL SELF-RENEWAL; EPIGENETICS; EPITHELIAL MESENCHYMAL TRANSITION; HELICOBACTER PYLORI; HUMAN; NONHUMAN; PATHOGENESIS; PLURIPOTENT STEM CELL; STEM CELL CULTURE; STEM CELL EXPANSION; STEM CELL NICHE; STOMACH EPITHELIUM; ANIMAL; BIOLOGICAL MODEL; CELL CULTURE TECHNIQUE; CYTOPLASM; GROWTH, DEVELOPMENT AND AGING; HELICOBACTER INFECTION; MICROBIOLOGY; PHYSIOLOGY; STOMACH;

EID: 85010908780     PISSN: 0070217X     EISSN: 21969965     Source Type: Book Series    
DOI: 10.1007/978-3-319-50520-6_7     Document Type: Chapter
Times cited : (48)

References (91)
  • 1
    • 48249087613 scopus 로고    scopus 로고
    • Correlation of T cell response and bacterial clearance in human volunteers challenged with Helicobacter pylori revealed by randomised controlled vaccination with Ty21a-based Salmonella vaccines
    • Aebischer T, Bumann D, Epple HJ et al (2008) Correlation of T cell response and bacterial clearance in human volunteers challenged with Helicobacter pylori revealed by randomised controlled vaccination with Ty21a-based Salmonella vaccines. Gut 57:1065–1072. doi:10.1136/gut.2007.145839.
    • (2008) Gut , vol.57 , pp. 1065-1072
    • Aebischer, T.1    Bumann, D.2    Epple, H.J.3
  • 2
    • 84905968839 scopus 로고    scopus 로고
    • A video protocol of retroviral infection in primary intestinal organoid culture
    • Andersson-Rolf A, Fink J, Mustata RC, Koo B-K (2014) A video protocol of retroviral infection in primary intestinal organoid culture. J Vis Exp. doi:10.3791/51765.
    • (2014) J Vis Exp
    • Andersson-Rolf, A.1    Fink, J.2    Mustata, R.C.3    Koo, B.-K.4
  • 3
    • 80053914464 scopus 로고    scopus 로고
    • Sox2+ adult stem and progenitor cells are important for tissue regeneration and survival of mice
    • Arnold K, Sarkar A, Yram MA et al (2011) Sox2+ adult stem and progenitor cells are important for tissue regeneration and survival of mice. Cell Stem Cell 9:317–329. doi:10.1016/j.stem.2011.09.001.
    • (2011) Cell Stem Cell , vol.9 , pp. 317-329
    • Arnold, K.1    Sarkar, A.2    Yram, M.A.3
  • 4
    • 77958165564 scopus 로고    scopus 로고
    • What a disorder: Proinflammatory signaling pathways induced by Helicobacter pylori
    • Backert S, Naumann M (2010) What a disorder: proinflammatory signaling pathways induced by Helicobacter pylori. Trends Microbiol 18(11):479–486. doi:10.1016/j.tim.2010.08.003.
    • (2010) Trends Microbiol , vol.18 , Issue.11 , pp. 479-486
    • Backert, S.1    Naumann, M.2
  • 5
    • 0034042694 scopus 로고    scopus 로고
    • Translocation of the Helicobacter pylori CagA protein in gastric epithelial cells by a type IV secretion apparatus
    • Backert S, Ziska E, Brinkmann V et al (2000) Translocation of the Helicobacter pylori CagA protein in gastric epithelial cells by a type IV secretion apparatus. Cell Microbiol 2:155–164. doi:10.1046/j.1462-5822.2000.00043.x
    • (2000) Cell Microbiol , vol.2 , pp. 155-164
    • Backert, S.1    Ziska, E.2    Brinkmann, V.3
  • 6
    • 84930981461 scopus 로고    scopus 로고
    • Composition, structure and function of the Helicobacter pylori cag pathogenicity island encoded type IV secretion system
    • Backert S, Tegtmeyer N, Fischer W (2015) Composition, structure and function of the Helicobacter pylori cag pathogenicity island encoded type IV secretion system. Future Microbiol 10(6):955–965. doi:10.2217/fmb.15.32.
    • (2015) Future Microbiol , vol.10 , Issue.6 , pp. 955-965
    • Backert, S.1    Tegtmeyer, N.2    Fischer, W.3
  • 7
    • 73049116186 scopus 로고    scopus 로고
    • +ve stem cells drive self-renewal in the stomach and build long-lived gastric units in vitro
    • +ve stem cells drive self-renewal in the stomach and build long-lived gastric units in vitro. Cell Stem Cell 6:25–36. doi:10.1016/j.stem.2009.11.013.
    • (2010) Cell Stem Cell , vol.6 , pp. 25-36
    • Barker, N.1    Huch, M.2    Kujala, P.3
  • 8
    • 84949431975 scopus 로고    scopus 로고
    • Organoids as model for infectious diseases: Culture of human and murine stomach organoids and microinjection of Helicobacter pylori
    • Bartfeld S, Clevers H (2015) Organoids as model for infectious diseases: culture of human and murine stomach organoids and microinjection of Helicobacter pylori. J Vis Exp. doi:10.3791/53359.
    • (2015) J Vis Exp
    • Bartfeld, S.1    Clevers, H.2
  • 9
    • 77951166289 scopus 로고    scopus 로고
    • High-throughput and single-cell imaging of NF-kappaB oscillations using monoclonal cell lines
    • Bartfeld S, Hess S, Bauer B et al (2010) High-throughput and single-cell imaging of NF-kappaB oscillations using monoclonal cell lines. BMC Cell Biol 11:21. doi:10.1186/1471-2121-11-21.
    • (2010) BMC Cell Biol , vol.11 , pp. 21
    • Bartfeld, S.1    Hess, S.2    Bauer, B.3
  • 10
    • 84922875352 scopus 로고    scopus 로고
    • In vitro expansion of human gastric epithelial stem cells and their responses to bacterial infection
    • Bartfeld S, Bayram T, van de Wetering M et al (2015) In vitro expansion of human gastric epithelial stem cells and their responses to bacterial infection. Gastroenterology 148(126–136): e6. doi:10.1053/j.gastro.2014.09.042.
    • (2015) Gastroenterology , vol.148 , Issue.126-136
    • Bartfeld, S.1    Bayram, T.2    van de Wetering, M.3
  • 11
    • 85007560110 scopus 로고    scopus 로고
    • Adult gastric stem cells and their niches
    • Bartfeld S, Koo BK (2016). Adult gastric stem cells and their niches. WIREs Dev Biol. doi:10.1002/wdev.261.
    • (2016) Wires Dev Biol
    • Bartfeld, S.1    Koo, B.K.2
  • 12
    • 84924365664 scopus 로고    scopus 로고
    • CD44 plays a functional role in Helicobacter pylori-induced epithelial cell proliferation
    • Bertaux-Skeirik N, Feng R, Schumacher MA et al (2015) CD44 plays a functional role in Helicobacter pylori-induced epithelial cell proliferation. PLoS Pathog 11:e1004663. doi:10.1371/journal.ppat.1004663.
    • (2015) Plos Pathog , pp. 11
    • Bertaux-Skeirik, N.1    Feng, R.2    Schumacher, M.A.3
  • 13
    • 0033587779 scopus 로고    scopus 로고
    • Dynamics of Helicobacter pylori colonization in relation to the host response
    • Blaser MJ, Kirschner D (1999) Dynamics of Helicobacter pylori colonization in relation to the host response. Proc Natl Acad Sci 96:8359–8364. doi:10.1073/pnas.96.15.8359.
    • (1999) Proc Natl Acad Sci , vol.96 , pp. 8359-8364
    • Blaser, M.J.1    Kirschner, D.2
  • 14
    • 0029043658 scopus 로고
    • Infection with Helicobacter pylori strains possessing cagA is associated with an increased risk of developing adenocarcinoma of the stomach
    • Blaser MJ, Perez-Perez GI, Kleanthous H et al (1995) Infection with Helicobacter pylori strains possessing cagA is associated with an increased risk of developing adenocarcinoma of the stomach. Cancer Res 55:2111–2115.
    • (1995) Cancer Res , vol.55 , pp. 2111-2115
    • Blaser, M.J.1    Perez-Perez, G.I.2    Kleanthous, H.3
  • 15
    • 84920983131 scopus 로고    scopus 로고
    • Organoid models of human and mouse ductal pancreatic cancer
    • Boj SF, Hwang C-I, Baker LA et al (2015) Organoid models of human and mouse ductal pancreatic cancer. Cell 160:324–338. doi:10.1016/j.cell.2014.12.021.
    • (2015) Cell , vol.160 , pp. 324-338
    • Boj, S.F.1    Hwang, C.-I.2    Baker, L.A.3
  • 16
    • 0031408931 scopus 로고    scopus 로고
    • Isolation and culturing of highly polarized primary epithelial cells from normal human stomach (Antrum) as spheroid-like vesicles
    • Boxberger H-J, Sessler MJ, Grausam MC et al (1997) Isolation and culturing of highly polarized primary epithelial cells from normal human stomach (antrum) as spheroid-like vesicles. Methods Cell Sci 19:169–178. doi:10.1023/A:1009751913391.
    • (1997) Methods Cell Sci , vol.19 , pp. 169-178
    • Boxberger, H.-J.1    Sessler, M.J.2    Grausam, M.C.3
  • 17
    • 57849111930 scopus 로고    scopus 로고
    • The gastric epithelial progenitor cell niche and differentiation of the zymogenic (Chief) cell lineage
    • Bredemeyer AJ, Geahlen JH, Weis VG et al (2009) The gastric epithelial progenitor cell niche and differentiation of the zymogenic (chief) cell lineage. Dev Biol 325:211–224. doi:10.1016/j.ydbio.2008.10.025.
    • (2009) Dev Biol , vol.325 , pp. 211-224
    • Bredemeyer, A.J.1    Geahlen, J.H.2    Weis, V.G.3
  • 18
    • 84893196064 scopus 로고    scopus 로고
    • Cell lineage distribution atlas of the human stomach reveals heterogeneous gland populations in the gastric antrum
    • Choi E, Roland JT, Barlow BJ et al (2014) Cell lineage distribution atlas of the human stomach reveals heterogeneous gland populations in the gastric antrum. Gut 63:1711–1720. doi:10.1136/gutjnl-2013-305964.
    • (2014) Gut , vol.63 , pp. 1711-1720
    • Choi, E.1    Roland, J.T.2    Barlow, B.J.3
  • 19
    • 0037732638 scopus 로고    scopus 로고
    • Helicobacter pylori CagA protein targets the c-Met receptor and enhances the motogenic response
    • Churin Y, Al-Ghoul L, Kepp O et al (2003) Helicobacter pylori CagA protein targets the c-Met receptor and enhances the motogenic response. J Cell Biol 161:249–255. doi:10.1083/jcb. 200208039.
    • (2003) J Cell Biol , vol.161 , pp. 249-255
    • Churin, Y.1    Al-Ghoul, L.2    Kepp, O.3
  • 20
    • 0027173990 scopus 로고
    • Molecular characterization of the 128-kDa immunodominant antigen of Helicobacter pylori associated with cytotoxicity and duodenal ulcer
    • Covacci A, Censini S, Bugnoli M et al (1993) Molecular characterization of the 128-kDa immunodominant antigen of Helicobacter pylori associated with cytotoxicity and duodenal ulcer. Proc Natl Acad Sci 90:5791–5795.
    • (1993) Proc Natl Acad Sci , vol.90 , pp. 5791-5795
    • Covacci, A.1    Censini, S.2    Bugnoli, M.3
  • 21
    • 84964317107 scopus 로고    scopus 로고
    • Organoid models of human gastrointestinal development and disease
    • Dedhia PH, Bertaux-Skeirik N, Zavros Y, Spence JR (2016) Organoid models of human gastrointestinal development and disease. Gastroenterology 150:1098–1112. doi:10.1053/j.gastro.2015.12.042.
    • (2016) Gastroenterology , vol.150 , pp. 1098-1112
    • Dedhia, P.H.1    Bertaux-Skeirik, N.2    Zavros, Y.3    Spence, J.R.4
  • 22
    • 84944442090 scopus 로고    scopus 로고
    • Notch signaling regulates gastric antral LGR5 stem cell function
    • Demitrack ES, Gifford GB, Keeley TM et al (2015) Notch signaling regulates gastric antral LGR5 stem cell function. EMBO J 34:2522–2536. doi:10.15252/embj.201490583.
    • (2015) EMBO J , vol.34 , pp. 2522-2536
    • Demitrack, E.S.1    Gifford, G.B.2    Keeley, T.M.3
  • 23
    • 84929103936 scopus 로고    scopus 로고
    • Sequential cancer mutations in cultured human intestinal stem cells
    • Drost J, van Jaarsveld RH, Ponsioen B et al (2015) Sequential cancer mutations in cultured human intestinal stem cells. Nature 521:43–47. doi:10.1038/nature14415.
    • (2015) Nature , vol.521 , pp. 43-47
    • Drost, J.1    van Jaarsveld, R.H.2    Ponsioen, B.3
  • 24
    • 84959357347 scopus 로고    scopus 로고
    • Organoids as an in vitro model of human development and disease
    • Fatehullah A, Tan SH, Barker N (2016) Organoids as an in vitro model of human development and disease. Nat Cell Biol 18:246–254. doi:10.1038/ncb3312.
    • (2016) Nat Cell Biol , vol.18 , pp. 246-254
    • Fatehullah, A.1    Tan, S.H.2    Barker, N.3
  • 25
    • 84906938767 scopus 로고    scopus 로고
    • Indian hedgehog mediates gastrin-induced proliferation in stomach of adult mice
    • Feng R, Aihara E, Kenny S et al (2014) Indian hedgehog mediates gastrin-induced proliferation in stomach of adult mice. Gastroenterology 147(655–666):e9. doi:10.1053/j.gastro.2014.05.006.
    • (2014) Gastroenterology , vol.147 , Issue.655-666 , pp. 9
    • Feng, R.1    Aihara, E.2    Kenny, S.3
  • 26
    • 84971516758 scopus 로고    scopus 로고
    • A colorectal tumor organoid library demonstrates progressive loss of niche factor requirements during tumorigenesis
    • Fujii M, Shimokawa M, Date S et al (2016) A colorectal tumor organoid library demonstrates progressive loss of niche factor requirements during tumorigenesis. Cell Stem Cell. doi:10.1016/j.stem.2016.04.003.
    • (2016) Cell Stem Cell
    • Fujii, M.1    Shimokawa, M.2    Date, S.3
  • 27
    • 0023493924 scopus 로고
    • Proliferative effects of urogastrone-EGF on the intestinal epithelium
    • Goodlad RA, Wilson TJ, Lenton W et al (1987) Proliferative effects of urogastrone-EGF on the intestinal epithelium. Gut 28:37–43.
    • (1987) Gut , vol.28 , pp. 37-43
    • Goodlad, R.A.1    Wilson, T.J.2    Lenton, W.3
  • 28
    • 84954214835 scopus 로고    scopus 로고
    • Mist1 expressing gastric stem cells maintain the normal and neoplastic gastric epithelium and are supported by a perivascular stem cell niche
    • Hayakawa Y, Ariyama H, Stancikova J et al (2015a) Mist1 expressing gastric stem cells maintain the normal and neoplastic gastric epithelium and are supported by a perivascular stem cell niche. Cancer Cell 28:800–814. doi:10.1016/j.ccell.2015.10.003.
    • (2015) Cancer Cell , vol.28 , pp. 800-814
    • Hayakawa, Y.1    Ariyama, H.2    Stancikova, J.3
  • 29
    • 84924371079 scopus 로고    scopus 로고
    • CCK2R identifies and regulates gastric antral stem cell states and carcinogenesis
    • Hayakawa Y, Jin G, Wang H et al (2015b) CCK2R identifies and regulates gastric antral stem cell states and carcinogenesis. Gut 64:544–553. doi:10.1136/gutjnl-2014-307190.
    • (2015) Gut , vol.64 , pp. 544-553
    • Hayakawa, Y.1    Jin, G.2    Wang, H.3
  • 30
    • 0025343810 scopus 로고
    • Bacterial adhesion and disease activity in Helicobacter associated chronic gastritis
    • Hessey SJ, Spencer J, Wyatt JI et al (1990) Bacterial adhesion and disease activity in Helicobacter associated chronic gastritis. Gut 31:134–138.
    • (1990) Gut , vol.31 , pp. 134-138
    • Hessey, S.J.1    Spencer, J.2    Wyatt, J.I.3
  • 31
    • 84942991269 scopus 로고    scopus 로고
    • Chemodetection and destruction of host urea allows Helicobacter pylori to locate the epithelium
    • Huang JY, Sweeney EG, Sigal M et al (2015) Chemodetection and destruction of host urea allows Helicobacter pylori to locate the epithelium. Cell Host Microbe 18:147–156. doi:10.1016/j. chom.2015.07.002.
    • (2015) Cell Host Microbe , vol.18 , pp. 147-156
    • Huang, J.Y.1    Sweeney, E.G.2    Sigal, M.3
  • 32
    • 84942121762 scopus 로고    scopus 로고
    • Modeling mouse and human development using organoid cultures
    • Huch M, Koo B-K (2015) Modeling mouse and human development using organoid cultures. Dev Camb Engl 142:3113–3125. doi:10.1242/dev.118570.
    • (2015) Dev Camb Engl , vol.142 , pp. 3113-3125
    • Huch, M.1    Koo, B.-K.2
  • 33
    • 84885846800 scopus 로고    scopus 로고
    • Unlimited in vitro expansion of adult bi-potent pancreas progenitors through the Lgr5/R-spondin axis
    • Huch M, Bonfanti P, Boj SF et al (2013) Unlimited in vitro expansion of adult bi-potent pancreas progenitors through the Lgr5/R-spondin axis. EMBO J 32:2708–2721. doi:10.1038/emboj.2013.204.
    • (2013) EMBO J , vol.32 , pp. 2708-2721
    • Huch, M.1    Bonfanti, P.2    Boj, S.F.3
  • 34
    • 0027263559 scopus 로고
    • Dynamics of epithelial cells in the corpus of the mouse stomach. IV. Bidirectional migration of parietal cells ending in their gradual degeneration and loss
    • Karam SM (1993) Dynamics of epithelial cells in the corpus of the mouse stomach. IV. Bidirectional migration of parietal cells ending in their gradual degeneration and loss. Anat Rec 236:314–332. doi:10.1002/ar.1092360205.
    • (1993) Anat Rec , vol.236 , pp. 314-332
    • Karam, S.M.1
  • 35
    • 0027174442 scopus 로고
    • Dynamics of epithelial cells in the corpus of the mouse stomach. III. Inward migration of neck cells followed by progressive transformation into zymogenic cells
    • Karam SM, Leblond CP (1993a) Dynamics of epithelial cells in the corpus of the mouse stomach. III. Inward migration of neck cells followed by progressive transformation into zymogenic cells. Anat Rec 236:297–313. doi:10.1002/ar.1092360204.
    • (1993) Anat Rec , vol.236 , pp. 297-313
    • Karam, S.M.1    Leblond, C.P.2
  • 36
    • 0027195468 scopus 로고
    • Dynamics of epithelial cells in the corpus of the mouse stomach. II. Outward migration of pit cells
    • Karam SM, Leblond CP (1993b) Dynamics of epithelial cells in the corpus of the mouse stomach. II. Outward migration of pit cells. Anat Rec 236:280–296. doi:10.1002/ar.1092360203.
    • (1993) Anat Rec , vol.236 , pp. 280-296
    • Karam, S.M.1    Leblond, C.P.2
  • 37
    • 84907552531 scopus 로고    scopus 로고
    • Identification of multipotent luminal progenitor cells in human prostate organoid cultures
    • Karthaus WR, Iaquinta PJ, Drost J et al (2014) Identification of multipotent luminal progenitor cells in human prostate organoid cultures. Cell 159:163–175. doi:10.1016/j.cell.2014.08.017.
    • (2014) Cell , vol.159 , pp. 163-175
    • Karthaus, W.R.1    Iaquinta, P.J.2    Drost, J.3
  • 38
    • 84875554273 scopus 로고    scopus 로고
    • Establishment of a long-term three-dimensional primary culture of mouse glandular stomach epithelial cells within the stem cell niche
    • Katano T, Ootani A, Mizoshita T et al (2013) Establishment of a long-term three-dimensional primary culture of mouse glandular stomach epithelial cells within the stem cell niche. Biochem Biophys Res Commun 432:558–563. doi:10.1016/j.bbrc.2013.02.051.
    • (2013) Biochem Biophys Res Commun , vol.432 , pp. 558-563
    • Katano, T.1    Ootani, A.2    Mizoshita, T.3
  • 39
    • 84949504069 scopus 로고    scopus 로고
    • The Notch and Wnt pathways regulate stemness and differentiation in human fallopian tube organoids
    • Kessler M, Hoffmann K, Brinkmann V et al (2015) The Notch and Wnt pathways regulate stemness and differentiation in human fallopian tube organoids. Nat Commun 6:8989. doi:10.1038/ncomms9989.
    • (2015) Nat Commun , vol.6 , pp. 8989
    • Kessler, M.1    Hoffmann, K.2    Brinkmann, V.3
  • 40
    • 84856490464 scopus 로고    scopus 로고
    • Controlled gene expression in primary Lgr5 organoid cultures
    • Koo B-K, Stange DE, Sato T et al (2012) Controlled gene expression in primary Lgr5 organoid cultures. Nat Methods 9:81–83. doi:10.1038/nmeth.1802.
    • (2012) Nat Methods , vol.9 , pp. 81-83
    • Koo, B.-K.1    Stange, D.E.2    Sato, T.3
  • 41
    • 84856090845 scopus 로고    scopus 로고
    • Lineage tracing
    • Kretzschmar K, Watt FM (2012) Lineage tracing. Cell 148:33–45. doi:10.1016/j.cell.2012.01.002.
    • (2012) Cell , vol.148 , pp. 33-45
    • Kretzschmar, K.1    Watt, F.M.2
  • 42
    • 84904396621 scopus 로고    scopus 로고
    • Organogenesis in a dish: Modeling development and disease using organoid technologies
    • Lancaster MA, Knoblich JA (2014) Organogenesis in a dish: modeling development and disease using organoid technologies. Science 345:1247125. doi:10.1126/science.1247125.
    • (2014) Science , vol.345
    • Lancaster, M.A.1    Knoblich, J.A.2
  • 43
    • 0031905670 scopus 로고    scopus 로고
    • Animal models for host-pathogen interaction studies
    • Lee A (1998) Animal models for host-pathogen interaction studies. Br Med Bull 54:163–173.
    • (1998) Br Med Bull , vol.54 , pp. 163-173
    • Lee, A.1
  • 44
    • 0021966480 scopus 로고
    • Dynamic histology of the antral epithelium in the mouse stomach: IV. Ultrastructure and renewal of gland cells
    • Lee ER, Leblond CP (1985a) Dynamic histology of the antral epithelium in the mouse stomach: IV. Ultrastructure and renewal of gland cells. Am J Anat 172:241–259.
    • (1985) Am J Anat , vol.172 , pp. 241-259
    • Lee, E.R.1    Leblond, C.P.2
  • 45
    • 0021957288 scopus 로고
    • Dynamic histology of the antral epithelium in the mouse stomach: II. Ultrastructure and renewal of isthmal cells
    • Lee ER, Leblond CP (1985b) Dynamic histology of the antral epithelium in the mouse stomach: II. Ultrastructure and renewal of isthmal cells. Am J Anat 172:205–224. doi:10.1002/aja.1001720304.
    • (1985) Am J Anat , vol.172 , pp. 205-224
    • Lee, E.R.1    Leblond, C.P.2
  • 46
    • 0020071305 scopus 로고
    • Division of the mouse gastric mucosa into zymogenic and mucous regions on the basis of gland features
    • Lee ER, Trasler J, Dwivedi S, Leblond CP (1982) Division of the mouse gastric mucosa into zymogenic and mucous regions on the basis of gland features. Am J Anat 164:187–207. doi:10.1002/aja.1001640302.
    • (1982) Am J Anat , vol.164 , pp. 187-207
    • Lee, E.R.1    Trasler, J.2    Dwivedi, S.3    Leblond, C.P.4
  • 47
    • 84861972831 scopus 로고    scopus 로고
    • Wnt signaling through inhibition of b-Catenin degradation in an intact Axin1 complex
    • Li VSW, Ng SS, Boersema PJ et al (2012) Wnt signaling through inhibition of b-Catenin degradation in an intact Axin1 complex. Cell 149:1245–1256. doi:10.1016/j.cell.2012.05.002.
    • (2012) Cell , vol.149 , pp. 1245-1256
    • Li, V.1    Ng, S.S.2    Boersema, P.J.3
  • 48
    • 84904066077 scopus 로고    scopus 로고
    • Oncogenic transformation of diverse gastrointestinal tissues in primary organoid culture
    • Li X, Nadauld L, Ootani A et al (2014) Oncogenic transformation of diverse gastrointestinal tissues in primary organoid culture. Nat Med 20:769–777. doi:10.1038/nm.3585.
    • (2014) Nat Med , vol.20 , pp. 769-777
    • Li, X.1    Nadauld, L.2    Ootani, A.3
  • 50
    • 84924422753 scopus 로고    scopus 로고
    • Modeling colorectal cancer using CRISPR-Cas9-mediated engineering of human intestinal organoids
    • Matano M, Date S, Shimokawa M et al (2015) Modeling colorectal cancer using CRISPR-Cas9-mediated engineering of human intestinal organoids. Nat Med. doi:10.1038/nm.3802.
    • (2015) Nat Med
    • Matano, M.1    Date, S.2    Shimokawa, M.3
  • 51
    • 80955137949 scopus 로고    scopus 로고
    • Generating human intestinal tissue from pluripotent stem cells in vitro
    • McCracken KW, Howell JC, Wells JM, Spence JR (2011) Generating human intestinal tissue from pluripotent stem cells in vitro. Nat Protoc 6:1920–1928. doi:10.1038/nprot.2011.410.
    • (2011) Nat Protoc , vol.6 , pp. 1920-1928
    • McCracken, K.W.1    Howell, J.C.2    Wells, J.M.3    Spence, J.R.4
  • 52
    • 84918561297 scopus 로고    scopus 로고
    • Modelling human development and disease in pluripotent stem-cell-derived gastric organoids
    • McCracken KW, Catá EM, Crawford CM et al (2014) Modelling human development and disease in pluripotent stem-cell-derived gastric organoids. Nature 516:400–404. doi:10.1038/nature13863.
    • (2014) Nature , vol.516 , pp. 400-404
    • McCracken, K.W.1    Catá, E.M.2    Crawford, C.M.3
  • 53
    • 84937574058 scopus 로고    scopus 로고
    • Reserve stem cells: Differentiated cells reprogram to fuel repair, metaplasia, and neoplasia in the adult gastrointestinal tract
    • Mills JC, Sansom OJ (2015) Reserve stem cells: differentiated cells reprogram to fuel repair, metaplasia, and neoplasia in the adult gastrointestinal tract. Sci Signal 8:re8. doi:10.1126/scisignal.aaa7540.
    • (2015) Sci Signal , vol.8
    • Mills, J.C.1    Sansom, O.J.2
  • 54
    • 84859717291 scopus 로고    scopus 로고
    • C-Src and c-Abl kinases control hierarchic phosphorylation and function of the CagA effector protein in Western and East Asian Helicobacter pylori strains
    • Mueller D, Tegtmeyer N, Brandt S, Yamaoka Y, De Poire E, Sgouras D, Wessler S, Torres J, Smolka A, Backert S (2012) c-Src and c-Abl kinases control hierarchic phosphorylation and function of the CagA effector protein in Western and East Asian Helicobacter pylori strains. J Clin Invest 122:1553–1566. doi:10.1172/JCI61143.
    • (2012) J Clin Invest , vol.122 , pp. 1553-1566
    • Mueller, D.1    Tegtmeyer, N.2    Brandt, S.3    Yamaoka, Y.4    de Poire, E.5    Sgouras, D.6    Wessler, S.7    Torres, J.8    Smolka, A.9    Backert, S.10
  • 55
    • 84938700713 scopus 로고    scopus 로고
    • Generation of stomach tissue from mouse embryonic stem cells
    • Noguchi TK, Ninomiya N, Sekine M et al (2015) Generation of stomach tissue from mouse embryonic stem cells. Nat Cell Biol 17:984–993. doi:10.1038/ncb3200.
    • (2015) Nat Cell Biol , vol.17 , pp. 984-993
    • Noguchi, T.K.1    Ninomiya, N.2    Sekine, M.3
  • 56
    • 84990068792 scopus 로고    scopus 로고
    • The Mongolian Gerbil: A robust model of Helicobacter pylori-induced gastric inflammation and cancer
    • Noto JM, Romero-Gallo J, Piazuelo MB, Peek RM (2016) The Mongolian Gerbil: a robust model of Helicobacter pylori-induced gastric inflammation and cancer. Methods Mol Biol Clifton NJ 1422:263–280. doi:10.1007/978-1-4939-3603-8_24.
    • (2016) Methods Mol Biol Clifton NJ , vol.1422 , pp. 263-280
    • Noto, J.M.1    Romero-Gallo, J.2    Piazuelo, M.B.3    Peek, R.M.4
  • 57
    • 33846910009 scopus 로고    scopus 로고
    • FGF10 signaling controls stomach morphogenesis
    • Nyeng P, Norgaard GA, Kobberup S, Jensen J (2007) FGF10 signaling controls stomach morphogenesis. Dev Biol 303:295–310. doi:10.1016/j.ydbio.2006.11.017.
    • (2007) Dev Biol , vol.303 , pp. 295-310
    • Nyeng, P.1    Norgaard, G.A.2    Kobberup, S.3    Jensen, J.4
  • 58
    • 0034685651 scopus 로고    scopus 로고
    • An air-liquid interface promotes the differentiation of gastric surface mucous cells (GSM06) in culture
    • Ootani A, Toda S, Fujimoto K, Sugihara H (2000) An air-liquid interface promotes the differentiation of gastric surface mucous cells (GSM06) in culture. Biochem Biophys Res Commun 271:741–746. doi:10.1006/bbrc.2000.2673.
    • (2000) Biochem Biophys Res Commun , vol.271 , pp. 741-746
    • Ootani, A.1    Toda, S.2    Fujimoto, K.3    Sugihara, H.4
  • 59
    • 0037906431 scopus 로고    scopus 로고
    • Foveolar differentiation of mouse gastric mucosa in vitro
    • Ootani A, Toda S, Fujimoto K, Sugihara H (2003) Foveolar differentiation of mouse gastric mucosa in vitro. Am J Pathol 162:1905–1912. doi:10.1016/S0002-9440(10)64324-6.
    • (2003) Am J Pathol , vol.162 , pp. 1905-1912
    • Ootani, A.1    Toda, S.2    Fujimoto, K.3    Sugihara, H.4
  • 60
    • 67349157318 scopus 로고    scopus 로고
    • Sustained in vitro intestinal epithelial culture within a Wnt-dependent stem cell niche
    • Ootani A, Li X, Sangiorgi E et al (2009) Sustained in vitro intestinal epithelial culture within a Wnt-dependent stem cell niche. Nat Med 15:701–706. doi:10.1038/nm.1951.
    • (2009) Nat Med , vol.15 , pp. 701-706
    • Ootani, A.1    Li, X.2    Sangiorgi, E.3
  • 61
    • 84884996155 scopus 로고    scopus 로고
    • The functional interplay of Helicobacter pylori factors with gastric epithelial cells induces a multi-step process in pathogenesis
    • Posselt G, Backert S, Wessler S (2013) The functional interplay of Helicobacter pylori factors with gastric epithelial cells induces a multi-step process in pathogenesis. Cell Commun Signal CCS 11:77. doi:10.1186/1478-811x-11-77.
    • (2013) Cell Commun Signal CCS , vol.11 , pp. 77
    • Posselt, G.1    Backert, S.2    Wessler, S.3
  • 62
    • 36549009168 scopus 로고    scopus 로고
    • Prospective identification of a multilineage progenitor in murine stomach epithelium
    • Qiao XT, Ziel JW, McKimpson W et al (2007) Prospective identification of a multilineage progenitor in murine stomach epithelium. Gastroenterology 133(1989–1998):e3. doi:10.1053/j.gastro.2007.09.031.
    • (2007) Gastroenterology , vol.133 , Issue.1989-1998
    • Qiao, X.T.1    Ziel, J.W.2    McKimpson, W.3
  • 63
    • 84876688065 scopus 로고    scopus 로고
    • Acute WNT signalling activation perturbs differentiation within the adult stomach and rapidly leads to tumour formation
    • Radulescu S, Ridgway RA, Cordero J et al (2013) Acute WNT signalling activation perturbs differentiation within the adult stomach and rapidly leads to tumour formation. Oncogene 32:2048–2057. doi:10.1038/onc.2012.224.
    • (2013) Oncogene , vol.32 , pp. 2048-2057
    • Radulescu, S.1    Ridgway, R.A.2    Cordero, J.3
  • 64
    • 0031656148 scopus 로고    scopus 로고
    • Helicobacter pylori-infected human antral primary cell cultures: Effect on gastrin cell function
    • Richter-Dahlfors A, Heczko U, Meloche RM et al (1998) Helicobacter pylori-infected human antral primary cell cultures: effect on gastrin cell function. Am J Physiol 275:G393–G401.
    • (1998) Am J Physiol , vol.275 , pp. G393-G401
    • Richter-Dahlfors, A.1    Heczko, U.2    Meloche, R.M.3
  • 65
    • 84878760040 scopus 로고    scopus 로고
    • Growing self-organizing mini-guts from a single intestinal stem cell: Mechanism and applications
    • Sato T, Clevers H (2013) Growing self-organizing mini-guts from a single intestinal stem cell: mechanism and applications. Science 340:1190–1194. doi:10.1126/science.1234852.
    • (2013) Science , vol.340 , pp. 1190-1194
    • Sato, T.1    Clevers, H.2
  • 66
    • 67349123408 scopus 로고    scopus 로고
    • Single Lgr5 stem cells build crypt villus structures in vitro without a mesenchymal niche
    • Sato T, Vries RG, Snippert HJ et al (2009) Single Lgr5 stem cells build crypt villus structures in vitro without a mesenchymal niche. Nature 459:262–265. doi:10.1038/nature07935.
    • (2009) Nature , vol.459 , pp. 262-265
    • Sato, T.1    Vries, R.G.2    Snippert, H.J.3
  • 67
    • 80054857419 scopus 로고    scopus 로고
    • Long-term expansion of epithelial organoids from human colon, adenoma, adenocarcinoma, and barrett’s epithelium
    • Sato T, Stange DE, Ferrante M et al (2011) Long-term expansion of epithelial organoids from human colon, adenoma, adenocarcinoma, and barrett’s epithelium. Gastroenterology 141:1762–1772. doi:10.1053/j.gastro.2011.07.050.
    • (2011) Gastroenterology , vol.141 , pp. 1762-1772
    • Sato, T.1    Stange, D.E.2    Ferrante, M.3
  • 68
    • 84930016564 scopus 로고    scopus 로고
    • Salmonella manipulation of host signaling pathways provokes cellular transformation associated with gallbladder carcinoma
    • Scanu T, Spaapen RM, Bakker JM et al (2015) Salmonella manipulation of host signaling pathways provokes cellular transformation associated with gallbladder carcinoma. Cell Host Microbe 17:763–774. doi:10.1016/j.chom.2015.05.002.
    • (2015) Cell Host Microbe , vol.17 , pp. 763-774
    • Scanu, T.1    Spaapen, R.M.2    Bakker, J.M.3
  • 69
    • 84958987439 scopus 로고    scopus 로고
    • A novel human gastric primary cell culture system for modelling Helicobacter pylori infection in vitro
    • Schlaermann P, Toelle B, Berger H et al (2016) A novel human gastric primary cell culture system for modelling Helicobacter pylori infection in vitro. Gut. doi:10.1136/gutjnl-2014-307949.
    • (2016) Gut
    • Schlaermann, P.1    Toelle, B.2    Berger, H.3
  • 70
    • 1842788063 scopus 로고    scopus 로고
    • The spatial orientation of Helicobacter pylori in the gastric mucus
    • Schreiber S, Konradt M, Groll C et al (2004) The spatial orientation of Helicobacter pylori in the gastric mucus. Proc Natl Acad Sci USA 101:5024–5029. doi:10.1073/pnas.0308386101.
    • (2004) Proc Natl Acad Sci USA , vol.101 , pp. 5024-5029
    • Schreiber, S.1    Konradt, M.2    Groll, C.3
  • 71
    • 84927690290 scopus 로고    scopus 로고
    • The use of murine-derived fundic organoids in studies of gastric physiology: The use of fundic organoids
    • Schumacher MA, Aihara E, Feng R, et al (2015a) The use of murine-derived fundic organoids in studies of gastric physiology: the use of fundic organoids. J Physiol. doi:10.1113/jphysiol.2014.283028.
    • (2015) J Physiol
    • Schumacher, M.A.1    Aihara, E.2    Feng, R.3
  • 72
    • 84920877107 scopus 로고    scopus 로고
    • Helicobacter pylori-induced sonic hedgehog expression is regulated by NFjB pathway activation: The use of a novel in vitro model to study epithelial response to infection
    • Schumacher MA, Feng R, Aihara E et al (2015b) Helicobacter pylori-induced sonic hedgehog expression is regulated by NFjB pathway activation: the use of a novel in vitro model to study epithelial response to infection. Helicobacter 20:19–28. doi:10.1111/hel.12152.
    • (2015) Helicobacter , vol.20 , pp. 19-28
    • Schumacher, M.A.1    Feng, R.2    Aihara, E.3
  • 73
    • 84885773392 scopus 로고    scopus 로고
    • Generation of BAC transgenic epithelial organoids
    • Schwank G, Andersson-Rolf A, Koo B-K et al (2013a) Generation of BAC transgenic epithelial organoids. PLoS ONE 8:e76871. doi:10.1371/journal.pone.0076871.
    • (2013) Plos ONE , pp. 8
    • Schwank, G.1    Ersson-Rolf, A.2    Koo, B.-K.3
  • 74
    • 84890033064 scopus 로고    scopus 로고
    • Functional repair of CFTR by CRISPR/Cas9 in intestinal stem cell organoids of cystic fibrosis patients
    • Schwank G, Koo B-K, Sasselli V et al (2013b) Functional repair of CFTR by CRISPR/Cas9 in intestinal stem cell organoids of cystic fibrosis patients. Cell Stem Cell 13:653–658. doi:10.1016/j.stem.2013.11.002.
    • (2013) Cell Stem Cell , vol.13 , pp. 653-658
    • Schwank, G.1    Koo, B.-K.2    Sasselli, V.3
  • 75
    • 0036510363 scopus 로고    scopus 로고
    • Src is the kinase of the Helicobacter pylori CagA protein in vitro and in vivo
    • Selbach M, Moese S, Hauck CR, Meyer TF, Backert S (2002) Src is the kinase of the Helicobacter pylori CagA protein in vitro and in vivo. J Biol Chem 277:6775–6778. doi:10.1074/jbc.C100754200.
    • (2002) J Biol Chem , vol.277 , pp. 6775-6778
    • Selbach, M.1    Moese, S.2    Hauck, C.R.3    Meyer, T.F.4    Backert, S.5
  • 76
    • 0031816886 scopus 로고    scopus 로고
    • Bacterial factors and immune pathogenesis in Helicobacter pylori infection
    • Shimoyama T, Crabtree J (1998) Bacterial factors and immune pathogenesis in Helicobacter pylori infection. Gut 43:S2–S5.
    • (1998) Gut , vol.43 , pp. S2-S5
    • Shimoyama, T.1    Crabtree, J.2
  • 77
    • 84928393314 scopus 로고    scopus 로고
    • Bending gradients: How the intestinal stem cell gets its home
    • Shyer AE, Huycke TR, Lee C et al (2015) Bending gradients: how the intestinal stem cell gets its home. Cell 161:569–580. doi:10.1016/j.cell.2015.03.041.
    • (2015) Cell , vol.161 , pp. 569-580
    • Shyer, A.E.1    Huycke, T.R.2    Lee, C.3
  • 78
    • 84887613180 scopus 로고    scopus 로고
    • Helicobacter pylori induces type 4 secretion system-dependent, but CagA-independent activation of IjBs and NF-jB/RelA at early time points
    • Sokolova O, Borgmann M, Rieke C et al (2013) Helicobacter pylori induces type 4 secretion system-dependent, but CagA-independent activation of IjBs and NF-jB/RelA at early time points. Int J Med Microbiol 303:548–552. doi:10.1016/j.ijmm.2013.07.008.
    • (2013) Int J Med Microbiol , vol.303 , pp. 548-552
    • Sokolova, O.1    Borgmann, M.2    Rieke, C.3
  • 80
    • 84885672388 scopus 로고    scopus 로고
    • Differentiated Troy+ chief cells act as reserve stem cells to generate all lineages of the stomach epithelium
    • Stange DE, Koo B-K, Huch M et al (2013) Differentiated Troy+ chief cells act as reserve stem cells to generate all lineages of the stomach epithelium. Cell 155:357–368. doi:10.1016/j.cell.2013.09.008.
    • (2013) Cell , vol.155 , pp. 357-368
    • Stange, D.E.1    Koo, B.-K.2    Huch, M.3
  • 81
    • 78751560396 scopus 로고    scopus 로고
    • High-throughput 3D spheroid culture and drug testing using a 384 hanging drop array
    • Tung Y-C, Hsiao AY, Allen SG et al (2011) High-throughput 3D spheroid culture and drug testing using a 384 hanging drop array. The Analyst 136:473–478. doi:10.1039/c0an00609b
    • (2011) The Analyst , vol.136 , pp. 473-478
    • Tung, Y.-C.1    Hsiao, A.Y.2    Allen, S.G.3
  • 82
    • 84928974420 scopus 로고    scopus 로고
    • Prospective derivation of a living organoid biobank of colorectal cancer patients
    • Van de Wetering M, Francies HE, Francis JM et al (2015) Prospective derivation of a living organoid biobank of colorectal cancer patients. Cell 161:933–945. doi:10.1016/j.cell.2015.03.053.
    • (2015) Cell , vol.161 , pp. 933-945
    • van De Wetering, M.1    Francies, H.E.2    Francis, J.M.3
  • 83
    • 0034907949 scopus 로고    scopus 로고
    • Sonic hedgehog regulates gastric gland morphogenesis in man and mouse
    • Van Den Brink GR, Hardwick JCH, Peppelenbosch MP et al (2001) Sonic hedgehog regulates gastric gland morphogenesis in man and mouse. Gastroenterology 121:317–328. doi:10.1053/gast.2001.26261.
    • (2001) Gastroenterology , vol.121 , pp. 317-328
    • Van Den Brink, G.R.1    Hardwick, J.2    Peppelenbosch, M.P.3
  • 84
    • 84934985095 scopus 로고    scopus 로고
    • Development of an enhanced human gastrointestinal epithelial culture system to facilitate patient-based assays
    • VanDussen KL, Marinshaw JM, Shaikh N et al (2015) Development of an enhanced human gastrointestinal epithelial culture system to facilitate patient-based assays. Gut 64:911–920. doi:10.1136/gutjnl-2013-306651.
    • (2015) Gut , vol.64 , pp. 911-920
    • Vandussen, K.L.1    Marinshaw, J.M.2    Shaikh, N.3
  • 85
    • 0029861301 scopus 로고    scopus 로고
    • Processing and proliferative effects of human progastrin in transgenic mice
    • Wang TC, Koh TJ, Varro A et al (1996) Processing and proliferative effects of human progastrin in transgenic mice. J Clin Invest 98:1918–1929. doi:10.1172/JCI118993.
    • (1996) J Clin Invest , vol.98 , pp. 1918-1929
    • Wang, T.C.1    Koh, T.J.2    Varro, A.3
  • 86
    • 84920247287 scopus 로고
    • Unidentified curved bacilli on gastric epithelium in active chronic gastritis
    • Warren JR, Marshall B (1983) Unidentified curved bacilli on gastric epithelium in active chronic gastritis. The Lancet 321:1273–1275. doi:10.1016/S0140-6736(83)92719-8.
    • (1983) The Lancet , vol.321 , pp. 1273-1275
    • Warren, J.R.1    Marshall, B.2
  • 87
    • 84893283877 scopus 로고    scopus 로고
    • How to make an intestine
    • Wells JM, Spence JR (2014) How to make an intestine. Development 141:752–760. doi:10.1242/dev.097386.
    • (2014) Development , vol.141 , pp. 752-760
    • Wells, J.M.1    Spence, J.R.2
  • 88
    • 85013211780 scopus 로고    scopus 로고
    • Organoids as model systems for gastrointestinal diseases: Tissue engineering meets genetic engineering
    • Werner K, Weitz J, Stange DE (2016) Organoids as model systems for gastrointestinal diseases: tissue engineering meets genetic engineering. Curr Pathobiol Rep 4:1–9. doi:10.1007/s40139-016-0100-z
    • (2016) Curr Pathobiol Rep , vol.4 , pp. 1-9
    • Werner, K.1    Weitz, J.2    Stange, D.E.3
  • 89
    • 84929660818 scopus 로고    scopus 로고
    • Helicobacter pylori targets cancer-associated apical-junctional constituents in gastroids and gastric epithelial cells
    • Wroblewski LE, Piazuelo MB, Chaturvedi R et al (2014) Helicobacter pylori targets cancer-associated apical-junctional constituents in gastroids and gastric epithelial cells. Gut. doi:10.1136/gutjnl-2014-307650.
    • (2014) Gut
    • Wroblewski, L.E.1    Piazuelo, M.B.2    Chaturvedi, R.3
  • 90
    • 34250205971 scopus 로고    scopus 로고
    • AGS and other tissue culture cells can unknowingly be persistently infected with PIV5; a virus that blocks interferon signalling by degrading STAT1
    • Young DF, Carlos TS, Hagmaier K et al (2007) AGS and other tissue culture cells can unknowingly be persistently infected with PIV5; a virus that blocks interferon signalling by degrading STAT1. Virology 365:238–240. doi:10.1016/j.virol.2007.03.061.
    • (2007) Virology , vol.365 , pp. 238-240
    • Young, D.F.1    Carlos, T.S.2    Hagmaier, K.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.