CCK2R identifies and regulates gastric antral stem cell states and carcinogenesis

Gut

Volumn 64, Issue 4, 2015, Pages 544-553

  Hayakawa, Yoku ^a   Jin, Guangchun ^a   Wang, Hongshan ^a   Chen, Xiaowei ^a   Westphalen, Christoph B ^a,b   Asfaha, Samuel ^a   Renz, Bernhard W ^a   Ariyama, Hiroshi ^a   Dubeykovskaya, Zinaida A ^a   Takemoto, Yoshihiro ^a   Lee, Yoomi ^a   Muley, Ashlesha ^a   Tailor, Yagnesh ^a   Chen, Duan ^c   Muthupalani, Sureshkumar ^d   Fox, James G ^d   Shulkes, Arthur ^e   Worthley, Daniel L ^a   Takaishi, Shigeo ^a,f   Wang, Timothy C ^a  

^a NewYork Presbyterian Hospital   (United States)

^b LUDWIG MAXIMILIANS UNIVERSITY   (Germany)

^c NORWEGIAN UNIVERSITY OF SCIENCE AND TECHNOLOGY   (Norway)

^d MASSACHUSETTS INSTITUTE OF TECHNOLOGY   (United States)

^e UNIVERSITY OF MELBOURNE   (Australia)

^f KYUSHU UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

CELL PROTEIN; CHOLECYSTOKININ B RECEPTOR; LGR5 PROTEIN; METHYLNITROSOUREA; PROGASTRIN; UNCLASSIFIED DRUG; GASTRIN; PROTEIN PRECURSOR;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CARCINOGENESIS; CELL ACTIVATION; CELL COUNT; CELL LINEAGE; CELL POPULATION; CROSS BREEDING; GASTRIC ANTRAL STEM CELL; HORMONAL REGULATION; IN VITRO STUDY; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN LOCALIZATION; STEM CELL; STEM CELL CULTURE; STEM CELL EXPANSION; STOMACH ANTRUM; ANIMAL; CELL CULTURE; CYTOLOGY; PHYSIOLOGY;

ANIMALS; CARCINOGENESIS; CELLS, CULTURED; GASTRINS; MICE; PROTEIN PRECURSORS; PYLORIC ANTRUM; RECEPTOR, CHOLECYSTOKININ B; STEM CELLS;

EID: 84924371079     PISSN: 00175749     EISSN: 14683288     Source Type: Journal    
DOI: 10.1136/gutjnl-2014-307190     Document Type: Article

References (50)

1. Jemal A, Siegel R, Ward E, et al. Cancer statistics, 2008. CA Cancer J Clin 2008;58:71-96.
2. Fox JG, Wang TC. Inflammation, atrophy, and gastric cancer. J Clin Invest 2007;117:60-9.
3. Lauren P. The Two Histological Main Types of Gastric Carcinoma: Diffuse and So-Called Intestinal-Type Carcinoma. An Attempt at a Histo-Clinical Classification. Acta pathologica et microbiologica Scandinavica 1965;64:31-49.
4. Fuchs CS, Mayer RJ. Gastric carcinoma. N Engl J Med 1995;333:32-41.
5. Blot WJ, Devesa SS, Kneller RW, et al. Rising incidence of adenocarcinoma of the esophagus and gastric cardia. JAMA 1991;265:1287-9.
6. Devesa SS, Blot WJ, Fraumeni JF Jr. Changing patterns in the incidence of esophageal and gastric carcinoma in the United States. Cancer 1998;83:2049-53.
7. Tatematsu M, Yamamoto M, Iwata H, et al. Induction of glandular stomach cancers in C3H mice treated with N-methyl-N-nitrosourea in the drinking water. Jpn J Cancer Res 1993;84:1258-64.
8. Barker N, Huch M, Kujala P, et al . Lgr5(+ve) stem cells drive self-renewal in the stomach and build long-lived gastric units in vitro. Cell Stem Cell 2010;6:25-36.
9. Arnold K, Sarkar A, Yram MA, et al. Sox2(+) adult stem and progenitor cells are important for tissue regeneration and survival of mice. Cell Stem Cell 2011;9:317-29.
10. Leushacke M, Ng A, Galle J, et al. Lgr5+ Gastric Stem Cells Divide Symmetrically to Effect Epithelial Homeostasis in the Pylorus. Cell Reports 2013;5:349-56.
11. Sato T, Vries RG, Snippert HJ, et al. Single Lgr5 stem cells build crypt-villus structures in vitro without a mesenchymal niche. Nature 2009;459:262-5.
12. Sato T, Stange DE, Ferrante M, et al. Long-term expansion of epithelial organoids from human colon, adenoma, adenocarcinoma, and Barrett's epithelium. Gastroenterology 2011;141:1762-72.
13. Stange DE, Koo BK, Huch M, et al. Differentiated troy(+) chief cells act as reserve stem cells to generate all lineages of the stomach epithelium. Cell 2013;155:357-68.
14. Kopin A, Lee Y, McBride E, et al. Expression cloning and characterization of the canine parietal cell gastrin receptor. Proc Natl Acad Sci U S A 1992;89: 3605-9.
15. Nakajima T, Konda Y, Izumi Y, et al. Gastrin stimulates the growth of pit cell precursors by inducing its own receptors. Am J Physiol Gastrointest Liver Physiol 2002;282:G359-66.
16. Kopin AS, Lee YM, McBride EW, et al. Expression cloning and characterization of the canine parietal cell gastrin receptor. Proc Natl Acad Sci U S A 1992;89:3605-9.
17. Kazumori H, Ishihara S, Kawashima K, et al. Analysis of gastrin receptor gene expression in proliferating cells in the neck zone of gastric fundic glands using laser capture microdissection. FEBS Lett 2001;489:208-14.
18. Nagata A, Ito M, Iwata N, et al. G protein-coupled cholecystokinin-B/gastrin receptors are responsible for physiological cell growth of the stomach mucosa in vivo. Proc Natl Acad Sci USA 1996;93:11825-30.
19. Langhans N, Rindi G, Chiu M, et al. Abnormal gastric histology and decreased acid production in cholecystokinin-B/gastrin receptor-de ficient mice. Gastroenterology 1997;112:280-6.
20. Wang TC, Dangler CA, Chen D, et al. Synergistic interaction between hypergastrinemia and Helicobacter infection in a mouse model of gastric cancer. Gastroenterology 2000;118:36-47.
21. Koh TJ, Goldenring JR, Ito S, et al. Gastrin deficiency results in altered gastric differentiation and decreased colonic proliferation in mice. Gastroenterology 1997;113:1015-25.
22. Dockray GJ, Varro A, Dimaline R, et al. The gastrins: their production and biological activities. Annual review of physiology 2001;63:119-39.
23. Wang TC, Koh TJ, Varro A, et al. Processing and proliferative effects of human progastrin in transgenic mice. J Clin Invest 1996;98:1918-29.
24. Singh P, Velasco M, Given R, et al. Progastrin expression predisposes mice to colon carcinomas and adenomas in response to a chemical carcinogen. Gastroenterology 2000;119:162-71.
25. Jin G, Ramanathan V, Quante M, et al. Inactivating cholecystokinin-2 receptor inhibits progastrin-dependent colonic crypt fi ssion, proliferation, and colorectal cancer in mice. J Clin Invest 2009;119:2691-701.
26. Jin G, Westphalen C, Hayakawa Y, et al. Progastrin stimulates colonic proliferation via CCK2R- and beta-arrestin-dependent suppression of BMP2. Gastroenterology 2013;145:820-30.
27. Wang TC, Bonner-Weir S, Oates PS, et al. Pancreatic gastrin stimulates islet differentiation of transforming growth factor alpha-induced ductular precursor cells. J Clin Invest 1993;92:1349-56.
28. Barker N, van Es JH, Kuipers J, et al. Identification of stem cells in small intestine and colon by marker gene Lgr5. Nature 2007;449:1003-7.
29. Gong S, Zheng C, Doughty ML, et al. A gene expression atlas of the central nervous system based on bacterial artificial chromosomes. Nature 2003;425:917-25.
30. Quante M, Marrache F, Goldenring JR, et al. TFF2 mRNA transcript expression marks a gland progenitor cell of the gastric oxyntic mucosa. Gastroenterology 2010;139:2018-27 e2.
31. Takaishi S, Shibata W, Tomita H, et al. In vivo analysis of mouse gastrin gene regulation in enhanced GFP-BAC transgenic mice. Am J Physiol Gastrointest Liver Physiol 2011;300:G334-44.
32. Jin G, Westphalen CB, Hayakawa Y, et al. Progastrin Stimulates Colonic Cell Proliferation via CCKBR- and beta-Arrestin-Dependent Suppression of BMP2. Gastroenterology 2013;145:820-30.e10.
33. Sato T, van Es JH, Snippert HJ, et al. Paneth cells constitute the niche for Lgr5 stem cells in intestinal crypts. Nature 2011;469:415-18.
34. Tatematsu M, Ogawa K, Hoshiya T, et al. Induction of adenocarcinomas in the glandular stomach of BALB/c mice treated with N-methyl-N-nitrosourea. Jpn J Cancer Res 1992;83:915-18.
35. He XC, Yin T, Grindley JC, et al. PTEN-deficient intestinal stem cells initiate intestinal polyposis. Nat Genet 2007;39:189-98.
36. Hayakawa Y, Fox J, Gonda T, et al . Mouse Models of Gastric Cancer. Cancers 2013;5:92-130.
37. Fuchs E. The tortoise and the hair: slow-cycling cells in the stem cell race. Cell 2009;137:811-19.
38. Potten CS, Owen G, Booth D. Intestinal stem cells protect their genome by selective segregation of template DNA strands. J Cell Sci 2002;115:2381-8.
39. Ritsma L, Ellenbroek SI, Zomer A, et al . Intestinal crypt homeostasis revealed at single-stem-cell level by in vivo live imaging. Nature 2014;507:362-5.
40. Sangiorgi E, Capecchi MR. Bmi1 is expressed in vivo in intestinal stem cells. Nat Genet 2008;40:915-20.
41. Takeda N, Jain R, LeBoeuf MR, et al. Interconversion between intestinal stem cell populations in distinct niches. Science 2011;334:1420-4.
42. Montgomery RK, Carlone DL, Richmond CA, et al. Mouse telomerase reverse transcriptase (mTert) expression marks slowly cycling intestinal stem cells. Proc Natl Acad Sci USA 2011;108:179-84.
43. Leblond CP, Stevens CE, Bogoroch R. Histological Localization of Newly-formed Desoxyribonucleic Acid. Science 1948;108:531-3.
44. Lee ER, Leblond CP. Dynamic histology of the antral epithelium in the mouse stomach: II. Ultrastructure and renewal of isthmal cells. Am J Anat 1985;172:205-24.
45. Lee ER. Dynamic histology of the antral epithelium in the mouse stomach: I. Architecture of antral units. Am J Anat 1985;172:187-204.
46. Buczacki SJ, Zecchini HI, Nicholson AM, et al. Intestinal label-retaining cells are secretory precursors expressing Lgr5. Nature 2013;495:65-9.
47. van Es JH, Sato T, van de Wetering M, et al. Dll1+ secretory progenitor cells revert to stem cells upon crypt damage. Nat Cell Biol 2012;14: 1099-104.
48. Ramanathan V, Jin G, Westphalen CB, et al. P53 gene mutation increases progastrin dependent colonic proliferation and colon cancer formation in mice. Cancer Invest 2012;30:275-86.
49. Konturek PC, Konturek SJ, Bielanski W, et al. Influence of COX-2 inhibition by rofecoxib on serum and tumor progastrin and gastrin levels and expression of PPARgamma and apoptosis-related proteins in gastric cancer patients. Dig Dis Sci 2003;48:2005-17.
50. Tomita H, Takaishi S, Menheniott TR, et al. Inhibition of gastric carcinogenesis by the hormone gastrin is mediated by suppression of TFF1 epigenetic silencing. Gastroenterology 2011;140:879-91.