-
4
-
-
84893831480
-
The promise and challenge of high-throughput sequencing of the antibody repertoire
-
Georgiou G, Ippolito GC, Beausang J, Busse CE, Wardemann H, Quake SR. The promise and challenge of high-throughput sequencing of the antibody repertoire. Nat Biotech. 2014;32:158–168.
-
(2014)
Nat Biotech
, vol.32
, pp. 158-168
-
-
Georgiou, G.1
Ippolito, G.C.2
Beausang, J.3
Busse, C.E.4
Wardemann, H.5
Quake, S.R.6
-
5
-
-
44449118948
-
Rapid cloning of high-affinity human monoclonal antibodies against influenza virus
-
Wrammert J, Smith K, Miller J, et al. Rapid cloning of high-affinity human monoclonal antibodies against influenza virus. Nature. 2008;453:667–671.
-
(2008)
Nature
, vol.453
, pp. 667-671
-
-
Wrammert, J.1
Smith, K.2
Miller, J.3
-
6
-
-
84900844918
-
Reconstructing a B-cell clonal lineage. II. Mutation, selection, and affinity maturation
-
Kepler TB, Munshaw S, Wiehe K, et al. Reconstructing a B-cell clonal lineage. II. Mutation, selection, and affinity maturation. Front Immunol. 2014;5:170.
-
(2014)
Front Immunol
, vol.5
, pp. 170
-
-
Kepler, T.B.1
Munshaw, S.2
Wiehe, K.3
-
7
-
-
85000360533
-
Reconstructing a B-cell clonal lineage. I. Statistical inference of unobserved ancestors
-
Kepler TB. Reconstructing a B-cell clonal lineage. I. Statistical inference of unobserved ancestors. F1000 Res. 2013;2:103.
-
(2013)
F1000 Res
, vol.2
, pp. 103
-
-
Kepler, T.B.1
-
9
-
-
84907681865
-
Immunoglobulin gene insertions and deletions in the affinity maturation of HIV-1 broadly reactive neutralizing antibodies
-
Kepler TB, Liao H-X, Alam SM, et al. Immunoglobulin gene insertions and deletions in the affinity maturation of HIV-1 broadly reactive neutralizing antibodies. Host Cell Microbe. 2014;16:304–313.
-
(2014)
Host Cell Microbe
, vol.16
, pp. 304-313
-
-
Kepler, T.B.1
Liao, H.-X.2
Alam, S.M.3
-
10
-
-
77951949737
-
SoDA2: A Hidden Markov Model approach for identification of immunoglobulin rearrangements
-
Munshaw S, Kepler TB. SoDA2: A Hidden Markov Model approach for identification of immunoglobulin rearrangements. Bioinformatics. 2010;26:867–872.
-
(2010)
Bioinformatics
, vol.26
, pp. 867-872
-
-
Munshaw, S.1
Kepler, T.B.2
-
11
-
-
77955975654
-
Robustness of ancestral sequence reconstruction to phylogenetic uncertainty
-
Hanson-Smith V, Kolaczkowski B, Thornton JW. Robustness of ancestral sequence reconstruction to phylogenetic uncertainty. Mol Biol Evol. 2010;27:1988–1999.
-
(2010)
Mol Biol Evol
, vol.27
, pp. 1988-1999
-
-
Hanson-Smith, V.1
Kolaczkowski, B.2
Thornton, J.W.3
-
12
-
-
84892365659
-
Prevalence of broadly neutralizing antibody responses during chronic HIV-1 infection
-
Hraber P, Seaman MS, Bailer RT, Mascola JR, Montefiori DC, Korber BT. Prevalence of broadly neutralizing antibody responses during chronic HIV-1 infection. AIDS. 2014;28:163–169.
-
(2014)
AIDS
, vol.28
, pp. 163-169
-
-
Hraber, P.1
Seaman, M.S.2
Bailer, R.T.3
Mascola, J.R.4
Montefiori, D.C.5
Korber, B.T.6
-
13
-
-
84863774072
-
Broadly neutralizing antibodies present new prospects to counter highly antigenically diverse viruses
-
Burton DR, Poignard P, Stanfield RL, Wilson IA. Broadly neutralizing antibodies present new prospects to counter highly antigenically diverse viruses. Science. 2012;337:183–186.
-
(2012)
Science
, vol.337
, pp. 183-186
-
-
Burton, D.R.1
Poignard, P.2
Stanfield, R.L.3
Wilson, I.A.4
-
14
-
-
84879302728
-
HIV-1 neutralizing antibodies: Understanding nature's pathways
-
Mascola JR, Haynes BF. HIV-1 neutralizing antibodies: Understanding nature's pathways. Immunol Rev. 2013;254:225–244.
-
(2013)
Immunol Rev
, vol.254
, pp. 225-244
-
-
Mascola, J.R.1
Haynes, B.F.2
-
15
-
-
84866495323
-
Human antibodies that neutralize HIV-1: Identification, structures, and B cell ontogenies
-
Kwong PD, Mascola JR. Human antibodies that neutralize HIV-1: Identification, structures, and B cell ontogenies. Immunity. 2012;37:412–425.
-
(2012)
Immunity
, vol.37
, pp. 412-425
-
-
Kwong, P.D.1
Mascola, J.R.2
-
16
-
-
0013890286
-
[On the possibilities of preventing remote sequelae of viral heptatitis]
-
Macchioro G, Zucconi V, Magris D. [On the possibilities of preventing remote sequelae of viral heptatitis]. Epatologia. 1966;12:281–287.
-
(1966)
Epatologia
, vol.12
, pp. 281-287
-
-
Macchioro, G.1
Zucconi, V.2
Magris, D.3
-
18
-
-
84984802096
-
Minimally mutated HIV-1 broadly neutralizing antibodies to guide reductionist vaccine design
-
Jardine JG, Sok D, Julien JP, et al. Minimally mutated HIV-1 broadly neutralizing antibodies to guide reductionist vaccine design. PLoS Pathog. 2016;12:e1005815.
-
(2016)
PLoS Pathog
, vol.12
-
-
Jardine, J.G.1
Sok, D.2
Julien, J.P.3
-
19
-
-
77958115264
-
A limited number of antibody specificities mediate broad and potent serum neutralization in selected HIV-1 infected individuals
-
Walker LM, Simek MD, Priddy F, et al. A limited number of antibody specificities mediate broad and potent serum neutralization in selected HIV-1 infected individuals. PLoS Pathog. 2010;6:e1001028.
-
(2010)
PLoS Pathog
, vol.6
-
-
Walker, L.M.1
Simek, M.D.2
Priddy, F.3
-
20
-
-
84876797103
-
Co-evolution of a broadly neutralizing HIV-1 antibody and founder virus
-
Liao HX, Lynch R, Zhou T, et al. Co-evolution of a broadly neutralizing HIV-1 antibody and founder virus. Nature. 2013;496:469–476.
-
(2013)
Nature
, vol.496
, pp. 469-476
-
-
Liao, H.X.1
Lynch, R.2
Zhou, T.3
-
21
-
-
84899991983
-
Developmental pathway for potent V1V2-directed HIV-neutralizing antibodies
-
Doria-Rose NA, Schramm CA, Gorman J, et al. Developmental pathway for potent V1V2-directed HIV-neutralizing antibodies. Nature. 2014;509:55–62.
-
(2014)
Nature
, vol.509
, pp. 55-62
-
-
Doria-Rose, N.A.1
Schramm, C.A.2
Gorman, J.3
-
22
-
-
84869155712
-
Evolution of an HIV glycan-dependent broadly neutralizing antibody epitope through immune escape
-
Moore PL, Gray ES, Wibmer CK, et al. Evolution of an HIV glycan-dependent broadly neutralizing antibody epitope through immune escape. Nat Med. 2012;18:1688–1692.
-
(2012)
Nat Med
, vol.18
, pp. 1688-1692
-
-
Moore, P.L.1
Gray, E.S.2
Wibmer, C.K.3
-
23
-
-
79551518897
-
Characteristics of the earliest cross-neutralizing antibody response to HIV-1
-
Mikell I, Sather DN, Kalams SA, Altfeld M, Alter G, Stamatatos L. Characteristics of the earliest cross-neutralizing antibody response to HIV-1. PLoS Pathog. 2011;7:e1001251.
-
(2011)
PLoS Pathog
, vol.7
-
-
Mikell, I.1
Sather, D.N.2
Kalams, S.A.3
Altfeld, M.4
Alter, G.5
Stamatatos, L.6
-
24
-
-
77954943648
-
Structural basis for broad and potent neutralization of HIV-1 by antibody VRC01
-
Zhou T, Georgiev I, Wu X, et al. Structural basis for broad and potent neutralization of HIV-1 by antibody VRC01. Science. 2010;329:811–817.
-
(2010)
Science
, vol.329
, pp. 811-817
-
-
Zhou, T.1
Georgiev, I.2
Wu, X.3
-
25
-
-
80052942203
-
Focused evolution of HIV-1 neutralizing antibodies revealed by structures and deep sequencing
-
Wu X, Zhou T, Zhu J, et al. Focused evolution of HIV-1 neutralizing antibodies revealed by structures and deep sequencing. Science. 2011;333:1593–1602.
-
(2011)
Science
, vol.333
, pp. 1593-1602
-
-
Wu, X.1
Zhou, T.2
Zhu, J.3
-
27
-
-
0027499308
-
Passenger transgenes reveal intrinsic specificity of the antibody hypermutation mechanism: Clustering, polarity, and specific hot spots
-
Betz AG, Rada C, Pannell R, Milstein C, Neuberger MS. Passenger transgenes reveal intrinsic specificity of the antibody hypermutation mechanism: Clustering, polarity, and specific hot spots. Proc Natl Acad Sci USA. 1993;90:2385–2388.
-
(1993)
Proc Natl Acad Sci USA
, vol.90
, pp. 2385-2388
-
-
Betz, A.G.1
Rada, C.2
Pannell, R.3
Milstein, C.4
Neuberger, M.S.5
-
28
-
-
0028794835
-
Hypermutation generating the sheep immunoglobulin repertoire is an antigen-independent process
-
Reynaud CA, Garcia C, Hein WR, Weill JC. Hypermutation generating the sheep immunoglobulin repertoire is an antigen-independent process. Cell. 1995;80:115–125.
-
(1995)
Cell
, vol.80
, pp. 115-125
-
-
Reynaud, C.A.1
Garcia, C.2
Hein, W.R.3
Weill, J.C.4
-
30
-
-
0031456649
-
Clone: A Monte-Carlo computer simulation of B cell clonal expansion, somatic mutation, and antigen-driven selection
-
Shlomchik MJ, Watts P, Weigert MG, Litwin S. Clone: A Monte-Carlo computer simulation of B cell clonal expansion, somatic mutation, and antigen-driven selection. Curr Top Microbiol Immunol. 1998;229:173–197.
-
(1998)
Curr Top Microbiol Immunol
, vol.229
, pp. 173-197
-
-
Shlomchik, M.J.1
Watts, P.2
Weigert, M.G.3
Litwin, S.4
-
31
-
-
84904361849
-
Affinity maturation in an HIV broadly neutralizing B-cell lineage through reorientation of variable domains
-
Fera D, Schmidt AG, Haynes BF, et al. Affinity maturation in an HIV broadly neutralizing B-cell lineage through reorientation of variable domains. Proc Natl Acad Sci USA. 2014;111:10275–10280.
-
(2014)
Proc Natl Acad Sci USA
, vol.111
, pp. 10275-10280
-
-
Fera, D.1
Schmidt, A.G.2
Haynes, B.F.3
-
32
-
-
84905369598
-
Cooperation of B cell lineages in induction of HIV-1-broadly neutralizing antibodies
-
Gao F, Bonsignori M, Liao HX, et al. Cooperation of B cell lineages in induction of HIV-1-broadly neutralizing antibodies. Cell. 2014;158:481–491.
-
(2014)
Cell
, vol.158
, pp. 481-491
-
-
Gao, F.1
Bonsignori, M.2
Liao, H.X.3
-
33
-
-
84875759341
-
Somatic mutations of the immunoglobulin framework are generally required for broad and potent HIV-1 neutralization
-
Klein F, Diskin R, Scheid JF, et al. Somatic mutations of the immunoglobulin framework are generally required for broad and potent HIV-1 neutralization. Cell. 2013;153:126–138.
-
(2013)
Cell
, vol.153
, pp. 126-138
-
-
Klein, F.1
Diskin, R.2
Scheid, J.F.3
-
34
-
-
84893352067
-
Antibodies VRC01 and 10E8 neutralize HIV-1 with high breadth and potency even with Ig-framework regions substantially reverted to germline
-
Georgiev IS, Rudicell RS, Saunders KO, et al. Antibodies VRC01 and 10E8 neutralize HIV-1 with high breadth and potency even with Ig-framework regions substantially reverted to germline. J Immunol. 2014;192:1100–1106.
-
(2014)
J Immunol
, vol.192
, pp. 1100-1106
-
-
Georgiev, I.S.1
Rudicell, R.S.2
Saunders, K.O.3
-
35
-
-
84951574208
-
Structural analysis of the unmutated ancestor of the HIV-1 envelope V2 region antibody CH58 isolated from an RV144 vaccine efficacy trial vaccinee
-
Nicely NI, Wiehe K, Kepler TB, et al. Structural analysis of the unmutated ancestor of the HIV-1 envelope V2 region antibody CH58 isolated from an RV144 vaccine efficacy trial vaccinee. EBioMedicine. 2015;2:713–722.
-
(2015)
EBioMedicine
, vol.2
, pp. 713-722
-
-
Nicely, N.I.1
Wiehe, K.2
Kepler, T.B.3
-
36
-
-
84872809067
-
Vaccine induction of antibodies against a structurally heterogeneous site of immune pressure within HIV-1 envelope protein variable regions 1 and 2
-
Liao HX, Bonsignori M, Alam SM, et al. Vaccine induction of antibodies against a structurally heterogeneous site of immune pressure within HIV-1 envelope protein variable regions 1 and 2. Immunity. 2013;38:176–186.
-
(2013)
Immunity
, vol.38
, pp. 176-186
-
-
Liao, H.X.1
Bonsignori, M.2
Alam, S.M.3
-
37
-
-
73349094086
-
Vaccination with ALVAC and AIDSVAX to prevent HIV-1 infection in Thailand
-
Rerks-Ngarm S, Pitisuttithum P, Nitayaphan S, et al. Vaccination with ALVAC and AIDSVAX to prevent HIV-1 infection in Thailand. N Engl J Med. 2009;361:2209–2220.
-
(2009)
N Engl J Med
, vol.361
, pp. 2209-2220
-
-
Rerks-Ngarm, S.1
Pitisuttithum, P.2
Nitayaphan, S.3
-
38
-
-
84859393693
-
Immune-correlates analysis of an HIV-1 vaccine efficacy trial
-
Haynes BF, Gilbert PB, McElrath MJ, et al. Immune-correlates analysis of an HIV-1 vaccine efficacy trial. N Engl J Med. 2012;366:1275–1286.
-
(2012)
N Engl J Med
, vol.366
, pp. 1275-1286
-
-
Haynes, B.F.1
Gilbert, P.B.2
McElrath, M.J.3
-
39
-
-
84867653590
-
Increased HIV-1 vaccine efficacy against viruses with genetic signatures in Env V2
-
Rolland M, Edlefsen PT, Larsen BB, et al. Increased HIV-1 vaccine efficacy against viruses with genetic signatures in Env V2. Nature. 2012;490:417–420.
-
(2012)
Nature
, vol.490
, pp. 417-420
-
-
Rolland, M.1
Edlefsen, P.T.2
Larsen, B.B.3
-
40
-
-
0036902235
-
Close-range electrostatic interactions in proteins
-
Kumar S, Nussinov R. Close-range electrostatic interactions in proteins. ChemBioChem. 2002;3:604–617.
-
(2002)
ChemBioChem
, vol.3
, pp. 604-617
-
-
Kumar, S.1
Nussinov, R.2
-
41
-
-
0027943261
-
Conformational isomerism and the diversity of antibodies
-
Foote J, Milstein C. Conformational isomerism and the diversity of antibodies. Proc Natl Acad Sci USA. 1994;91:10370–10374.
-
(1994)
Proc Natl Acad Sci USA
, vol.91
, pp. 10370-10374
-
-
Foote, J.1
Milstein, C.2
-
42
-
-
0033634681
-
Maturation of an antibody response is governed by modulations in flexibility of the antigen-combining site
-
Manivel V, Sahoo NC, Salunke DM, Rao KV. Maturation of an antibody response is governed by modulations in flexibility of the antigen-combining site. Immunity. 2000;13:611–620.
-
(2000)
Immunity
, vol.13
, pp. 611-620
-
-
Manivel, V.1
Sahoo, N.C.2
Salunke, D.M.3
Rao, K.V.4
-
43
-
-
0037373997
-
Thermodynamic and kinetic aspects of antibody evolution during the immune response to hapten
-
Sagawa T, Oda M, Ishimura M, Furukawa K, Azuma T. Thermodynamic and kinetic aspects of antibody evolution during the immune response to hapten. Mol Immunol. 2003;39:801–808.
-
(2003)
Mol Immunol
, vol.39
, pp. 801-808
-
-
Sagawa, T.1
Oda, M.2
Ishimura, M.3
Furukawa, K.4
Azuma, T.5
-
44
-
-
34547460183
-
Molecular evolution of affinity and flexibility in the immune system
-
Thorpe IF, Brooks CL 3rd. Molecular evolution of affinity and flexibility in the immune system. Proc Natl Acad Sci USA. 2007;104:8821–8826.
-
(2007)
Proc Natl Acad Sci USA
, vol.104
, pp. 8821-8826
-
-
Thorpe, I.F.1
Brooks, C.L.2
-
45
-
-
84871994029
-
Preconfiguration of the antigen-binding site during affinity maturation of a broadly neutralizing influenza virus antibody
-
Schmidt AG, Xu H, Khan AR, et al. Preconfiguration of the antigen-binding site during affinity maturation of a broadly neutralizing influenza virus antibody. Proc Natl Acad Sci USA. 2013;110:264–269.
-
(2013)
Proc Natl Acad Sci USA
, vol.110
, pp. 264-269
-
-
Schmidt, A.G.1
Xu, H.2
Khan, A.R.3
-
46
-
-
84962253716
-
Structural basis for germline antibody recognition of HIV-1 immunogens
-
Scharf L, West AP, Sievers SA, et al. Structural basis for germline antibody recognition of HIV-1 immunogens. Elife. 2016;5:1–24.
-
(2016)
Elife
, vol.5
, pp. 1-24
-
-
Scharf, L.1
West, A.P.2
Sievers, S.A.3
-
47
-
-
84918548024
-
Antibody light-chain-restricted recognition of the site of immune pressure in the RV144 HIV-1 vaccine trial is phylogenetically conserved
-
Wiehe K, Easterhoff D, Luo K, et al. Antibody light-chain-restricted recognition of the site of immune pressure in the RV144 HIV-1 vaccine trial is phylogenetically conserved. Immunity. 2014;41:909–918.
-
(2014)
Immunity
, vol.41
, pp. 909-918
-
-
Wiehe, K.1
Easterhoff, D.2
Luo, K.3
-
48
-
-
84979741951
-
Somatic hypermutation-induced changes in the structure and dynamics of HIV-1 broadly neutralizing antibodies
-
Davenport TM, Gorman J, Joyce MG, et al. Somatic hypermutation-induced changes in the structure and dynamics of HIV-1 broadly neutralizing antibodies. Structure. 2016;1346–1357.
-
(2016)
Structure
, pp. 1346-1357
-
-
Davenport, T.M.1
Gorman, J.2
Joyce, M.G.3
-
49
-
-
84969835812
-
Broadly neutralizing antibodies to HIV and their role in vaccine design
-
Burton DR, Hangartner L. Broadly neutralizing antibodies to HIV and their role in vaccine design. Annu Rev Immunol. 2016;34:635–659.
-
(2016)
Annu Rev Immunol
, vol.34
, pp. 635-659
-
-
Burton, D.R.1
Hangartner, L.2
-
50
-
-
84921606536
-
Insights into the trimeric HIV-1 envelope glycoprotein structure
-
Ward AB, Wilson IA. Insights into the trimeric HIV-1 envelope glycoprotein structure. Trends Biochem Sci. 2015;40:101–107.
-
(2015)
Trends Biochem Sci
, vol.40
, pp. 101-107
-
-
Ward, A.B.1
Wilson, I.A.2
-
51
-
-
84909640954
-
Structure and immune recognition of trimeric pre-fusion HIV-1 Env
-
Pancera M, Zhou T, Druz A, et al. Structure and immune recognition of trimeric pre-fusion HIV-1 Env. Nature. 2014;514:455–461.
-
(2014)
Nature
, vol.514
, pp. 455-461
-
-
Pancera, M.1
Zhou, T.2
Druz, A.3
-
52
-
-
84963936310
-
Trimeric HIV-1-Env structures define glycan shields from clades A, B, and G
-
Stewart-Jones GB, Soto C, Lemmin T, et al. Trimeric HIV-1-Env structures define glycan shields from clades A, B, and G. Cell. 2016;165:813–826.
-
(2016)
Cell
, vol.165
, pp. 813-826
-
-
Stewart-Jones, G.B.1
Soto, C.2
Lemmin, T.3
-
53
-
-
70450182950
-
Structural basis of immune evasion at the site of CD4 attachment on HIV-1 gp120
-
Chen L, Kwon YD, Zhou T, et al. Structural basis of immune evasion at the site of CD4 attachment on HIV-1 gp120. Science. 2009;326:1123–1127.
-
(2009)
Science
, vol.326
, pp. 1123-1127
-
-
Chen, L.1
Kwon, Y.D.2
Zhou, T.3
-
54
-
-
84930418589
-
Structural repertoire of HIV-1-neutralizing antibodies targeting the CD4 supersite in 14 donors
-
Zhou T, Lynch RM, Chen L, et al. Structural repertoire of HIV-1-neutralizing antibodies targeting the CD4 supersite in 14 donors. Cell. 2015;161:1280–1292.
-
(2015)
Cell
, vol.161
, pp. 1280-1292
-
-
Zhou, T.1
Lynch, R.M.2
Chen, L.3
-
55
-
-
84867427047
-
Structural insights into key sites of vulnerability on HIV-1 Env and influenza HA
-
Julien JP, Lee PS, Wilson IA. Structural insights into key sites of vulnerability on HIV-1 Env and influenza HA. Immunol Rev. 2012;250:180–198.
-
(2012)
Immunol Rev
, vol.250
, pp. 180-198
-
-
Julien, J.P.1
Lee, P.S.2
Wilson, I.A.3
-
56
-
-
84959296091
-
Maturation pathway from germline to broad HIV-1 neutralizer of a CD4-mimic antibody
-
Bonsignori M, Zhou T, Sheng Z, et al. Maturation pathway from germline to broad HIV-1 neutralizer of a CD4-mimic antibody. Cell. 2016;165:449–463.
-
(2016)
Cell
, vol.165
, pp. 449-463
-
-
Bonsignori, M.1
Zhou, T.2
Sheng, Z.3
-
57
-
-
84937761089
-
Maturation and diversity of the VRC01-antibody lineage over 15 years of chronic HIV-1 infection
-
Wu X, Zhang Z, Schramm CA, et al. Maturation and diversity of the VRC01-antibody lineage over 15 years of chronic HIV-1 infection. Cell. 2015;161:470–485.
-
(2015)
Cell
, vol.161
, pp. 470-485
-
-
Wu, X.1
Zhang, Z.2
Schramm, C.A.3
-
58
-
-
84963620358
-
Affinity maturation of a potent family of HIV antibodies is primarily focused on accommodating or avoiding glycans
-
Garces F, Lee JH, de Val N, et al. Affinity maturation of a potent family of HIV antibodies is primarily focused on accommodating or avoiding glycans. Immunity. 2015;43:1053–1063.
-
(2015)
Immunity
, vol.43
, pp. 1053-1063
-
-
Garces, F.1
Lee, J.H.2
de Val, N.3
-
59
-
-
84880161438
-
Supersite of immune vulnerability on the glycosylated face of HIV-1 envelope glycoprotein gp120
-
Kong L, Lee JH, Doores KJ, et al. Supersite of immune vulnerability on the glycosylated face of HIV-1 envelope glycoprotein gp120. Nat Struct Mol Biol. 2013;20:796–803.
-
(2013)
Nat Struct Mol Biol
, vol.20
, pp. 796-803
-
-
Kong, L.1
Lee, J.H.2
Doores, K.J.3
-
60
-
-
84869831194
-
Complex-type N-glycan recognition by potent broadly neutralizing HIV antibodies
-
Mouquet H, Scharf L, Euler Z, et al. Complex-type N-glycan recognition by potent broadly neutralizing HIV antibodies. Proc Natl Acad Sci USA. 2012;109:E3268–E3277.
-
(2012)
Proc Natl Acad Sci USA
, vol.109
, pp. E3268-E3277
-
-
Mouquet, H.1
Scharf, L.2
Euler, Z.3
-
61
-
-
82255179322
-
A potent and broad neutralizing antibody recognizes and penetrates the HIV glycan shield
-
Pejchal R, Doores KJ, Walker LM, et al. A potent and broad neutralizing antibody recognizes and penetrates the HIV glycan shield. Science. 2011;334:1097–1103.
-
(2011)
Science
, vol.334
, pp. 1097-1103
-
-
Pejchal, R.1
Doores, K.J.2
Walker, L.M.3
-
62
-
-
80053132436
-
Broad neutralization coverage of HIV by multiple highly potent antibodies
-
Walker LM, Huber M, Doores KJ, et al. Broad neutralization coverage of HIV by multiple highly potent antibodies. Nature. 2011;477:466–470.
-
(2011)
Nature
, vol.477
, pp. 466-470
-
-
Walker, L.M.1
Huber, M.2
Doores, K.J.3
-
63
-
-
84967148279
-
Early antibody lineage diversification and independent limb maturation lead to broad HIV-1 neutralization targeting the Env high-mannose patch
-
MacLeod DT, Choi NM, Briney B, et al. Early antibody lineage diversification and independent limb maturation lead to broad HIV-1 neutralization targeting the Env high-mannose patch. Immunity. 2016;44:1215–1226.
-
(2016)
Immunity
, vol.44
, pp. 1215-1226
-
-
MacLeod, D.T.1
Choi, N.M.2
Briney, B.3
-
64
-
-
84956714697
-
Broadly neutralizing antibody responses in a large longitudinal sub-saharan HIV primary infection cohort
-
Landais E, Huang X, Havenar-Daughton C, et al. Broadly neutralizing antibody responses in a large longitudinal sub-saharan HIV primary infection cohort. PLoS Pathog. 2016;12:e1005369.
-
(2016)
PLoS Pathog
, vol.12
-
-
Landais, E.1
Huang, X.2
Havenar-Daughton, C.3
-
65
-
-
21344434534
-
Cardiolipin polyspecific autoreactivity in two broadly neutralizing HIV-1 antibodies
-
Haynes BF, Fleming J, St Clair EW, et al. Cardiolipin polyspecific autoreactivity in two broadly neutralizing HIV-1 antibodies. Science. 2005;308:1906–1908.
-
(2005)
Science
, vol.308
, pp. 1906-1908
-
-
Haynes, B.F.1
Fleming, J.2
St Clair, E.W.3
-
66
-
-
84919430580
-
Polyreactivity and autoreactivity among HIV-1 antibodies
-
Liu M, Yang G, Wiehe K, et al. Polyreactivity and autoreactivity among HIV-1 antibodies. J Virol. 2015;89:784–798.
-
(2015)
J Virol
, vol.89
, pp. 784-798
-
-
Liu, M.1
Yang, G.2
Wiehe, K.3
-
67
-
-
84874562109
-
Identification of autoantigens recognized by the 2F5 and 4E10 broadly neutralizing HIV-1 antibodies
-
Yang G, Holl TM, Liu Y, et al. Identification of autoantigens recognized by the 2F5 and 4E10 broadly neutralizing HIV-1 antibodies. J Exp Med. 2013;210:241–256.
-
(2013)
J Exp Med
, vol.210
, pp. 241-256
-
-
Yang, G.1
Holl, T.M.2
Liu, Y.3
-
68
-
-
73949133588
-
Role of HIV membrane in neutralization by two broadly neutralizing antibodies
-
Alam SM, Morelli M, Dennison SM, et al. Role of HIV membrane in neutralization by two broadly neutralizing antibodies. Proc Natl Acad Sci USA. 2009;106:20234–20239.
-
(2009)
Proc Natl Acad Sci USA
, vol.106
, pp. 20234-20239
-
-
Alam, S.M.1
Morelli, M.2
Dennison, S.M.3
-
69
-
-
33947635198
-
The role of antibody polyspecificity and lipid reactivity in binding of broadly neutralizing anti-HIV-1 envelope human monoclonal antibodies 2F5 and 4E10 to glycoprotein 41 membrane proximal envelope epitopes
-
Alam SM, McAdams M, Boren D, et al. The role of antibody polyspecificity and lipid reactivity in binding of broadly neutralizing anti-HIV-1 envelope human monoclonal antibodies 2F5 and 4E10 to glycoprotein 41 membrane proximal envelope epitopes. J Immunol. 2007;178:4424–4435.
-
(2007)
J Immunol
, vol.178
, pp. 4424-4435
-
-
Alam, S.M.1
McAdams, M.2
Boren, D.3
-
70
-
-
76249083814
-
Autoreactivity in an HIV-1 broadly reactive neutralizing antibody variable region heavy chain induces immunologic tolerance
-
Verkoczy L, Diaz M, Holl TM, et al. Autoreactivity in an HIV-1 broadly reactive neutralizing antibody variable region heavy chain induces immunologic tolerance. Proc Natl Acad Sci USA. 2010;107:181–186.
-
(2010)
Proc Natl Acad Sci USA
, vol.107
, pp. 181-186
-
-
Verkoczy, L.1
Diaz, M.2
Holl, T.M.3
-
71
-
-
84880667257
-
Common tolerance mechanisms, but distinct cross-reactivities associated with gp41 and lipids, limit production of HIV-1 broad neutralizing antibodies 2F5 and 4E10
-
Chen Y, Zhang J, Hwang KK, et al. Common tolerance mechanisms, but distinct cross-reactivities associated with gp41 and lipids, limit production of HIV-1 broad neutralizing antibodies 2F5 and 4E10. J Immunol. 2013;191:1260–1275.
-
(2013)
J Immunol
, vol.191
, pp. 1260-1275
-
-
Chen, Y.1
Zhang, J.2
Hwang, K.K.3
-
72
-
-
84964837055
-
Initiation of immune tolerance-controlled HIV gp41 neutralizing B cell lineages
-
Zhang R, Verkoczy L, Wiehe K, et al. Initiation of immune tolerance-controlled HIV gp41 neutralizing B cell lineages. Sci Transl Med. 2016;8:336ra362.
-
(2016)
Sci Transl Med
, vol.8
, pp. 336ra362
-
-
Zhang, R.1
Verkoczy, L.2
Wiehe, K.3
-
73
-
-
77649132440
-
Relationship between antibody 2F5 neutralization of HIV-1 and hydrophobicity of its heavy chain third complementarity-determining region
-
Ofek G, McKee K, Yang Y, et al. Relationship between antibody 2F5 neutralization of HIV-1 and hydrophobicity of its heavy chain third complementarity-determining region. J Virol. 2010;84:2955–2962.
-
(2010)
J Virol
, vol.84
, pp. 2955-2962
-
-
Ofek, G.1
McKee, K.2
Yang, Y.3
-
74
-
-
84883348588
-
Induction of HIV-1 broad neutralizing antibodies in 2F5 knock-in mice: Selection against membrane proximal external region-associated autoreactivity limits T-dependent responses
-
Verkoczy L, Chen Y, Zhang J, et al. Induction of HIV-1 broad neutralizing antibodies in 2F5 knock-in mice: Selection against membrane proximal external region-associated autoreactivity limits T-dependent responses. J Immunol. 2013;191:2538–2550.
-
(2013)
J Immunol
, vol.191
, pp. 2538-2550
-
-
Verkoczy, L.1
Chen, Y.2
Zhang, J.3
-
75
-
-
84903459040
-
Redemption of autoantibodies on anergic B cells by variable-region glycosylation and mutation away from self-reactivity
-
Sabouri Z, Schofield P, Horikawa K, et al. Redemption of autoantibodies on anergic B cells by variable-region glycosylation and mutation away from self-reactivity. Proc Natl Acad Sci USA. 2014;111:E2567–E2575.
-
(2014)
Proc Natl Acad Sci USA
, vol.111
, pp. E2567-E2575
-
-
Sabouri, Z.1
Schofield, P.2
Horikawa, K.3
-
76
-
-
84959932564
-
Composition and antigenic effects of individual glycan sites of a trimeric HIV-1 envelope glycoprotein
-
Behrens AJ, Vasiljevic S, Pritchard LK, et al. Composition and antigenic effects of individual glycan sites of a trimeric HIV-1 envelope glycoprotein. Cell Rep. 2016;14:2695–2706.
-
(2016)
Cell Rep
, vol.14
, pp. 2695-2706
-
-
Behrens, A.J.1
Vasiljevic, S.2
Pritchard, L.K.3
-
77
-
-
34247636624
-
Exploiting the defensive sugars of HIV-1 for drug and vaccine design
-
Scanlan CN, Offer J, Zitzmann N, Dwek RA. Exploiting the defensive sugars of HIV-1 for drug and vaccine design. Nature. 2007;446:1038–1045.
-
(2007)
Nature
, vol.446
, pp. 1038-1045
-
-
Scanlan, C.N.1
Offer, J.2
Zitzmann, N.3
Dwek, R.A.4
-
78
-
-
84924787042
-
Targeting host-derived glycans on enveloped viruses for antibody-based vaccine design
-
Crispin M, Doores KJ. Targeting host-derived glycans on enveloped viruses for antibody-based vaccine design. Curr Opin Virol. 2015;11:63–69.
-
(2015)
Curr Opin Virol
, vol.11
, pp. 63-69
-
-
Crispin, M.1
Doores, K.J.2
-
79
-
-
0037393393
-
HIV-1: Nature's master of disguise
-
Mascola JR, Montefiori DC. HIV-1: Nature's master of disguise. Nat Med. 2003;9:393–394.
-
(2003)
Nat Med
, vol.9
, pp. 393-394
-
-
Mascola, J.R.1
Montefiori, D.C.2
-
80
-
-
79961184231
-
Characterization of glycosylation profiles of HIV-1 transmitted/founder envelopes by mass spectrometry
-
Go EP, Hewawasam G, Liao HX, et al. Characterization of glycosylation profiles of HIV-1 transmitted/founder envelopes by mass spectrometry. J Virol. 2011;85:8270–8284.
-
(2011)
J Virol
, vol.85
, pp. 8270-8284
-
-
Go, E.P.1
Hewawasam, G.2
Liao, H.X.3
-
81
-
-
84870562234
-
HIV therapy by a combination of broadly neutralizing antibodies in humanized mice
-
Klein F, Halper-Stromberg A, Horwitz JA, et al. HIV therapy by a combination of broadly neutralizing antibodies in humanized mice. Nature. 2012;492:118–122.
-
(2012)
Nature
, vol.492
, pp. 118-122
-
-
Klein, F.1
Halper-Stromberg, A.2
Horwitz, J.A.3
-
82
-
-
84956639986
-
Mechanisms of escape from the PGT128 family of anti-HIV broadly neutralizing antibodies
-
Krumm SA, Mohammed H, Le KM, et al. Mechanisms of escape from the PGT128 family of anti-HIV broadly neutralizing antibodies. Retrovirology. 2016;13:8.
-
(2016)
Retrovirology
, vol.13
, pp. 8
-
-
Krumm, S.A.1
Mohammed, H.2
Le, K.M.3
-
83
-
-
84878519611
-
Broadly neutralizing antibody PGT121 allosterically modulates CD4 binding via recognition of the HIV-1 gp120 V3 base and multiple surrounding glycans
-
Julien JP, Sok D, Khayat R, et al. Broadly neutralizing antibody PGT121 allosterically modulates CD4 binding via recognition of the HIV-1 gp120 V3 base and multiple surrounding glycans. PLoS Pathog. 2013;9:e1003342.
-
(2013)
PLoS Pathog
, vol.9
-
-
Julien, J.P.1
Sok, D.2
Khayat, R.3
-
84
-
-
84887626950
-
Therapeutic efficacy of potent neutralizing HIV-1-specific monoclonal antibodies in SHIV-infected rhesus monkeys
-
Barouch DH, Whitney JB, Moldt B, et al. Therapeutic efficacy of potent neutralizing HIV-1-specific monoclonal antibodies in SHIV-infected rhesus monkeys. Nature. 2013;503:224–228.
-
(2013)
Nature
, vol.503
, pp. 224-228
-
-
Barouch, D.H.1
Whitney, J.B.2
Moldt, B.3
-
85
-
-
84888251984
-
The effects of somatic hypermutation on neutralization and binding in the PGT121 family of broadly neutralizing HIV antibodies
-
Sok D, Laserson U, Laserson J, et al. The effects of somatic hypermutation on neutralization and binding in the PGT121 family of broadly neutralizing HIV antibodies. PLoS Pathog. 2013;9:e1003754.
-
(2013)
PLoS Pathog
, vol.9
-
-
Sok, D.1
Laserson, U.2
Laserson, J.3
-
86
-
-
84907527916
-
Structural evolution of glycan recognition by a family of potent HIV antibodies
-
Garces F, Sok D, Kong L, et al. Structural evolution of glycan recognition by a family of potent HIV antibodies. Cell. 2014;159:69–79.
-
(2014)
Cell
, vol.159
, pp. 69-79
-
-
Garces, F.1
Sok, D.2
Kong, L.3
-
87
-
-
84907681865
-
Immunoglobulin gene insertions and deletions in the affinity maturation of HIV-1 broadly reactive neutralizing antibodies
-
Kepler TB, Liao HX, Alam SM, et al. Immunoglobulin gene insertions and deletions in the affinity maturation of HIV-1 broadly reactive neutralizing antibodies. Cell Host Microbe. 2014;16:304–313.
-
(2014)
Cell Host Microbe
, vol.16
, pp. 304-313
-
-
Kepler, T.B.1
Liao, H.X.2
Alam, S.M.3
-
88
-
-
84882589754
-
Multidonor analysis reveals structural elements, genetic determinants, and maturation pathway for HIV-1 neutralization by VRC01-class antibodies
-
Zhou T, Zhu J, Wu X, et al. Multidonor analysis reveals structural elements, genetic determinants, and maturation pathway for HIV-1 neutralization by VRC01-class antibodies. Immunity. 2013;39:245–258.
-
(2013)
Immunity
, vol.39
, pp. 245-258
-
-
Zhou, T.1
Zhu, J.2
Wu, X.3
-
89
-
-
82755184131
-
Increasing the potency and breadth of an HIV antibody by using structure-based rational design
-
Diskin R, Scheid JF, Marcovecchio PM, et al. Increasing the potency and breadth of an HIV antibody by using structure-based rational design. Science. 2011;334:1289–1293.
-
(2011)
Science
, vol.334
, pp. 1289-1293
-
-
Diskin, R.1
Scheid, J.F.2
Marcovecchio, P.M.3
-
90
-
-
84878626061
-
Engineering HIV envelope protein to activate germline B cell receptors of broadly neutralizing anti-CD4 binding site antibodies
-
McGuire AT, Hoot S, Dreyer AM, et al. Engineering HIV envelope protein to activate germline B cell receptors of broadly neutralizing anti-CD4 binding site antibodies. J Exp Med. 2013;210:655–663.
-
(2013)
J Exp Med
, vol.210
, pp. 655-663
-
-
McGuire, A.T.1
Hoot, S.2
Dreyer, A.M.3
-
91
-
-
84920771783
-
Two classes of broadly neutralizing antibodies within a single lineage directed to the high-mannose patch of HIV envelope
-
Doores KJ, Kong L, Krumm SA, et al. Two classes of broadly neutralizing antibodies within a single lineage directed to the high-mannose patch of HIV envelope. J Virol. 2015;89:1105–1118.
-
(2015)
J Virol
, vol.89
, pp. 1105-1118
-
-
Doores, K.J.1
Kong, L.2
Krumm, S.A.3
-
92
-
-
84941363719
-
Broadly neutralizing antibody 8ANC195 recognizes closed and open states of HIV-1 Env
-
Scharf L, Wang H, Gao H, Chen S, McDowall AW, Bjorkman PJ. Broadly neutralizing antibody 8ANC195 recognizes closed and open states of HIV-1 Env. Cell. 2015;162:1379–1390.
-
(2015)
Cell
, vol.162
, pp. 1379-1390
-
-
Scharf, L.1
Wang, H.2
Gao, H.3
Chen, S.4
McDowall, A.W.5
Bjorkman, P.J.6
-
93
-
-
84921607768
-
Broad and potent HIV-1 neutralization by a human antibody that binds the gp41-gp120 interface
-
Huang J, Kang BH, Pancera M, et al. Broad and potent HIV-1 neutralization by a human antibody that binds the gp41-gp120 interface. Nature. 2014;515:138–142.
-
(2014)
Nature
, vol.515
, pp. 138-142
-
-
Huang, J.1
Kang, B.H.2
Pancera, M.3
-
94
-
-
84883755842
-
Secondary mechanisms of diversification in the human antibody repertoire
-
Briney BS, Jr JE. Secondary mechanisms of diversification in the human antibody repertoire. Front Immunol. 2013;4:42.
-
(2013)
Front Immunol
, vol.4
, pp. 42
-
-
Briney, B.S.1
Jr, J.E.2
-
95
-
-
84986296891
-
Tailored immunogens direct affinity maturation toward HIV neutralizing antibodies
-
Briney B, Sok D, Jardine JG, et al. Tailored immunogens direct affinity maturation toward HIV neutralizing antibodies. Cell. 2016;166(1459–1470):e1411.
-
(2016)
Cell
, vol.166
, Issue.1459-1470
-
-
Briney, B.1
Sok, D.2
Jardine, J.G.3
-
96
-
-
84986313440
-
Sequential immunization elicits broadly neutralizing anti-HIV-1 antibodies in Ig knockin mice
-
Escolano A, Steichen JM, Dosenovic P, et al. Sequential immunization elicits broadly neutralizing anti-HIV-1 antibodies in Ig knockin mice. Cell. 2016;166(1445–1458):e1412.
-
(2016)
Cell
, vol.166
, Issue.1445-1458
-
-
Escolano, A.1
Steichen, J.M.2
Dosenovic, P.3
-
97
-
-
84986300672
-
Induction of HIV neutralizing antibody lineages in mice with diverse precursor repertoires
-
Tian M, Cheng C, Chen X, et al. Induction of HIV neutralizing antibody lineages in mice with diverse precursor repertoires. Cell. 2016;166(1471–1484):e1418.
-
(2016)
Cell
, vol.166
, Issue.1471-1484
-
-
Tian, M.1
Cheng, C.2
Chen, X.3
-
98
-
-
84876051105
-
Structural basis for HIV-1 gp120 recognition by a germ-line version of a broadly neutralizing antibody
-
Scharf L, West AP Jr, Gao H, et al. Structural basis for HIV-1 gp120 recognition by a germ-line version of a broadly neutralizing antibody. Proc Natl Acad Sci USA. 2013;110:6049–6054.
-
(2013)
Proc Natl Acad Sci USA
, vol.110
, pp. 6049-6054
-
-
Scharf, L.1
West, A.P.2
Gao, H.3
-
99
-
-
84877609579
-
Rational HIV immunogen design to target specific germline B cell receptors
-
Jardine J, Julien JP, Menis S, et al. Rational HIV immunogen design to target specific germline B cell receptors. Science. 2013;340:711–716.
-
(2013)
Science
, vol.340
, pp. 711-716
-
-
Jardine, J.1
Julien, J.P.2
Menis, S.3
-
100
-
-
84976349128
-
Developmental pathway of the MPER-directed HIV-1-neutralizing antibody 10E8
-
Soto C, Ofek G, Joyce MG, et al. Developmental pathway of the MPER-directed HIV-1-neutralizing antibody 10E8. PLoS ONE. 2016;11:e0157409.
-
(2016)
PLoS ONE
, vol.11
-
-
Soto, C.1
Ofek, G.2
Joyce, M.G.3
|