-
1
-
-
84880161438
-
Supersite of immune vulnerability on the glycosylated face of HIV-1 envelope glycoprotein gp120
-
Kong L, Lee JH, Doores KJ, Murin CD, Julien JP, McBride R, Liu Y, Marozsan A, Cupo A, Klasse PJ, Hoffenberg S, Caulfield M, King CR, Hua Y, Le KM, Khayat R, Deller MC, Clayton T, Tien H, Feizi T, Sanders RW, Paulson JC, Moore JP, Stanfield RL, Burton DR, Ward AB, Wilson IA. 2013. Supersite of immune vulnerability on the glycosylated face of HIV-1 envelope glycoprotein gp120. Nat Struct Mol Biol 20:796-803. http://dx.doi.org/10.1038/nsmb.2594.
-
(2013)
Nat Struct Mol Biol
, vol.20
, pp. 796-803
-
-
Kong, L.1
Lee, J.H.2
Doores, K.J.3
Murin, C.D.4
Julien, J.P.5
McBride, R.6
Liu, Y.7
Marozsan, A.8
Cupo, A.9
Klasse, P.J.10
Hoffenberg, S.11
Caulfield, M.12
King, C.R.13
Hua, Y.14
Le, K.M.15
Khayat, R.16
Deller, M.C.17
Clayton, T.18
Tien, H.19
Feizi, T.20
Sanders, R.W.21
Paulson, J.C.22
Moore, J.P.23
Stanfield, R.L.24
Burton, D.R.25
Ward, A.B.26
Wilson, I.A.27
more..
-
2
-
-
84869831194
-
Complex-type N-glycan recognition by potent broadly neutralizing HIV antibodies
-
Mouquet H, Scharf L, Euler Z, Liu Y, Eden C, Scheid JF, Halper-Stromberg A, Gnanapragasam PN, Spencer DI, Seaman MS, Schuitemaker H, Feizi T, Nussenzweig MC, Bjorkman PJ. 2012. Complex-type N-glycan recognition by potent broadly neutralizing HIV antibodies. Proc Natl Acad Sci USA 109:E3268-E3277. http://dx.doi.org/10.1073/pnas.1217207109.
-
(2012)
Proc Natl Acad Sci USA
, vol.109
, pp. E3268-E3277
-
-
Mouquet, H.1
Scharf, L.2
Euler, Z.3
Liu, Y.4
Eden, C.5
Scheid, J.F.6
Halper-Stromberg, A.7
Gnanapragasam, P.N.8
Spencer, D.I.9
Seaman, M.S.10
Schuitemaker, H.11
Feizi, T.12
Nussenzweig, M.C.13
Bjorkman, P.J.14
-
3
-
-
80053132436
-
Broad neutralization coverage of HIV by multiple highly potent antibodies
-
Walker LM, Huber M, Doores KJ, Falkowska E, Pejchal R, Julien JP, Wang SK, Ramos A, Chan-Hui PY, Moyle M, Mitcham JL, Hammond PW, Olsen OA, Phung P, Fling S, Wong CH, Phogat S, Wrin T, Simek MD, Koff WC, Wilson IA, Burton DR, Poignard P. 2011. Broad neutralization coverage of HIV by multiple highly potent antibodies. Nature 477:466-470. http://dx.doi.org/10.1038/nature10373.
-
(2011)
Nature
, vol.477
, pp. 466-470
-
-
Walker, L.M.1
Huber, M.2
Doores, K.J.3
Falkowska, E.4
Pejchal, R.5
Julien, J.P.6
Wang, S.K.7
Ramos, A.8
Chan-Hui, P.Y.9
Moyle, M.10
Mitcham, J.L.11
Hammond, P.W.12
Olsen, O.A.13
Phung, P.14
Fling, S.15
Wong, C.H.16
Phogat, S.17
Wrin, T.18
Simek, M.D.19
Koff, W.C.20
Wilson, I.A.21
Burton, D.R.22
Poignard, P.23
more..
-
4
-
-
77958115264
-
A limited number of antibody specificities mediate broad and potent serum neutralization in selected HIV-1 infected individuals
-
Walker LM, Simek MD, Priddy F, Gach JS, Wagner D, Zwick MB, Phogat SK, Poignard P, Burton DR. 2010. A limited number of antibody specificities mediate broad and potent serum neutralization in selected HIV-1 infected individuals. PLoS Pathog 6:e1001028. http://dx.doi.org/10.1371/journal.ppat.1001028.
-
(2010)
PLoS Pathog
, vol.6
-
-
Walker, L.M.1
Simek, M.D.2
Priddy, F.3
Gach, J.S.4
Wagner, D.5
Zwick, M.B.6
Phogat, S.K.7
Poignard, P.8
Burton, D.R.9
-
5
-
-
84869155712
-
Evolution of an HIV glycan-dependent broadly neutralizing antibody epitope through immune escape
-
Moore PL, Gray ES, Wibmer CK, Bhiman JN, Nonyane M, Sheward DJ, Hermanus T, Bajimaya S, Tumba NL, Abrahams MR, Lambson BE, Ranchobe N, Ping L, Ngandu N, Abdool Karim Q, Abdool Karim SS, Swanstrom RI, Seaman MS, Williamson C, Morris L. 2012. Evolution of an HIV glycan-dependent broadly neutralizing antibody epitope through immune escape. Nat Med 18:1688-1692. http://dx.doi.org/10.1038/nm.2985.
-
(2012)
Nat Med
, vol.18
, pp. 1688-1692
-
-
Moore, P.L.1
Gray, E.S.2
Wibmer, C.K.3
Bhiman, J.N.4
Nonyane, M.5
Sheward, D.J.6
Hermanus, T.7
Bajimaya, S.8
Tumba, N.L.9
Abrahams, M.R.10
Lambson, B.E.11
Ranchobe, N.12
Ping, L.13
Ngandu, N.14
Abdool Karim, Q.15
Abdool Karim, S.S.16
Swanstrom, R.I.17
Seaman, M.S.18
Williamson, C.19
Morris, L.20
more..
-
6
-
-
84055181327
-
Rapid development of glycan-specific, broad, and potent anti-HIV-1 gp120 neutralizing antibodies in an R5 SIV/HIV chimeric virus infected macaque
-
Walker LM, Sok D, Nishimura Y, Donau O, Sadjadpour R, Gautam R, Shingai M, Pejchal R, Ramos A, Simek MD, Geng Y, Wilson IA, Poignard P, Martin MA, Burton DR. 2011. Rapid development of glycan-specific, broad, and potent anti-HIV-1 gp120 neutralizing antibodies in an R5 SIV/HIV chimeric virus infected macaque. Proc Natl Acad Sci USA 108:20125-20129. http://dx.doi.org/10.1073/pnas.1117531108.
-
(2011)
Proc Natl Acad Sci USA
, vol.108
, pp. 20125-20129
-
-
Walker, L.M.1
Sok, D.2
Nishimura, Y.3
Donau, O.4
Sadjadpour, R.5
Gautam, R.6
Shingai, M.7
Pejchal, R.8
Ramos, A.9
Simek, M.D.10
Geng, Y.11
Wilson, I.A.12
Poignard, P.13
Martin, M.A.14
Burton, D.R.15
-
7
-
-
79955389756
-
The neutralization breadth of HIV-1 develops incrementally over four years and is associated with CD4+ T cell decline and high viral load during acute infection
-
Gray ES, Madiga MC, Hermanus T, Moore PL, Wibmer CK, Tumba NL, Werner L, Mlisana K, Sibeko S, Williamson C, Abdool Karim SS, Morris L. 2011. The neutralization breadth of HIV-1 develops incrementally over four years and is associated with CD4+ T cell decline and high viral load during acute infection. J Virol 85:4828-4840. http://dx.doi.org/10.1128/JVI.00198-11.
-
(2011)
J Virol
, vol.85
, pp. 4828-4840
-
-
Gray, E.S.1
Madiga, M.C.2
Hermanus, T.3
Moore, P.L.4
Wibmer, C.K.5
Tumba, N.L.6
Werner, L.7
Mlisana, K.8
Sibeko, S.9
Williamson, C.10
Abdool Karim, S.S.11
Morris, L.12
-
8
-
-
80051677678
-
The glycan shield of HIV is predominantly oligomannose independently of production system or viral clade
-
Bonomelli C, Doores KJ, Dunlop DC, Thaney V, Dwek RA, Burton DR, Crispin M, Scanlan CN. 2011. The glycan shield of HIV is predominantly oligomannose independently of production system or viral clade. PLoS One 6:e23521. http://dx.doi.org/10.1371/journal.pone.0023521.
-
(2011)
PLoS One
, vol.6
-
-
Bonomelli, C.1
Doores, K.J.2
Dunlop, D.C.3
Thaney, V.4
Dwek, R.A.5
Burton, D.R.6
Crispin, M.7
Scanlan, C.N.8
-
9
-
-
77956385205
-
Envelope glycans of immunodeficiency virions are almost entirely oligomannose antigens
-
Doores KJ, Bonomelli C, Harvey DJ, Vasiljevic S, Dwek RA, Burton DR, Crispin M, Scanlan CN. 2010. Envelope glycans of immunodeficiency virions are almost entirely oligomannose antigens. Proc Natl Acad Sci USA 107:13800-13805. http://dx.doi.org/10.1073/pnas.1006498107.
-
(2010)
Proc Natl Acad Sci USA
, vol.107
, pp. 13800-13805
-
-
Doores, K.J.1
Bonomelli, C.2
Harvey, D.J.3
Vasiljevic, S.4
Dwek, R.A.5
Burton, D.R.6
Crispin, M.7
Scanlan, C.N.8
-
10
-
-
0023811767
-
Carbohydrates of human immunodeficiency virus. Structures of oligosaccharides linked to the envelope glycoprotein 120
-
Geyer H, Holschbach C, Hunsmann G, Schneider J. 1988. Carbohydrates of human immunodeficiency virus. Structures of oligosaccharides linked to the envelope glycoprotein 120. J Biol Chem 263:11760-11767.
-
(1988)
J Biol Chem
, vol.263
, pp. 11760-11767
-
-
Geyer, H.1
Holschbach, C.2
Hunsmann, G.3
Schneider, J.4
-
11
-
-
0025292252
-
Assignment of intrachain disulfide bonds and characterization of potential glycosylation sites of the type 1 recombinant human immunodeficiency virus envelope glycoprotein (gp120) expressed in Chinese hamster ovary cells
-
Leonard CK, Spellman MW, Riddle L, Harris RJ, Thomas JN, Gregory TJ. 1990. Assignment of intrachain disulfide bonds and characterization of potential glycosylation sites of the type 1 recombinant human immunodeficiency virus envelope glycoprotein (gp120) expressed in Chinese hamster ovary cells. J Biol Chem 265:10373-10382.
-
(1990)
J Biol Chem
, vol.265
, pp. 10373-10382
-
-
Leonard, C.K.1
Spellman, M.W.2
Riddle, L.3
Harris, R.J.4
Thomas, J.N.5
Gregory, T.J.6
-
12
-
-
0034687168
-
Mass spectrometric characterization of the glycosylation pattern of HIV-gp120 expressed in CHO cells
-
Zhu X, Borchers C, Bienstock RJ, Tomer KB. 2000. Mass spectrometric characterization of the glycosylation pattern of HIV-gp120 expressed in CHO cells. Biochemistry 39:11194-11204. http://dx.doi.org/10.1021/bi000432m.
-
(2000)
Biochemistry
, vol.39
, pp. 11194-11204
-
-
Zhu, X.1
Borchers, C.2
Bienstock, R.J.3
Tomer, K.B.4
-
13
-
-
84869232528
-
Highly potent HIV-specific antibody neutralization in vitro translates into effective protection against mucosal SHIV challenge in vivo
-
Moldt B, Rakasz EG, Schultz N, Chan-Hui PY, Swiderek K, Weisgrau KL, Piaskowski SM, Bergman Z, Watkins DI, Poignard P, Burton DR. 2012. Highly potent HIV-specific antibody neutralization in vitro translates into effective protection against mucosal SHIV challenge in vivo. Proc Natl Acad Sci USA 109:18921-18925. http://dx.doi.org/10.1073/pnas.1214785109.
-
(2012)
Proc Natl Acad Sci USA
, vol.109
, pp. 18921-18925
-
-
Moldt, B.1
Rakasz, E.G.2
Schultz, N.3
Chan-Hui, P.Y.4
Swiderek, K.5
Weisgrau, K.L.6
Piaskowski, S.M.7
Bergman, Z.8
Watkins, D.I.9
Poignard, P.10
Burton, D.R.11
-
14
-
-
84887626950
-
Therapeutic efficacy of potent neutralizing HIV-1-specific monoclonal antibodies in SHIVinfected rhesus monkeys
-
Barouch DH, Whitney JB, Moldt B, Klein F, Oliveira TY, Liu J, Stephenson KE, Chang HW, Shekhar K, Gupta S, Nkolola JP, Seaman MS, Smith KM, Borducchi EN, Cabral C, Smith JY, Blackmore S, Sanisetty S, Perry JR, Beck M, Lewis MG, Rinaldi W, Chakraborty AK, Poignard P, Nussenzweig MC, Burton DR. 2013. Therapeutic efficacy of potent neutralizing HIV-1-specific monoclonal antibodies in SHIVinfected rhesus monkeys. Nature 503:224-228. http://dx.doi.org/10.1038/nature12744.
-
(2013)
Nature
, vol.503
, pp. 224-228
-
-
Barouch, D.H.1
Whitney, J.B.2
Moldt, B.3
Klein, F.4
Oliveira, T.Y.5
Liu, J.6
Stephenson, K.E.7
Chang, H.W.8
Shekhar, K.9
Gupta, S.10
Nkolola, J.P.11
Seaman, M.S.12
Smith, K.M.13
Borducchi, E.N.14
Cabral, C.15
Smith, J.Y.16
Blackmore, S.17
Sanisetty, S.18
Perry, J.R.19
Beck, M.20
Lewis, M.G.21
Rinaldi, W.22
Chakraborty, A.K.23
Poignard, P.24
Nussenzweig, M.C.25
Burton, D.R.26
more..
-
15
-
-
82255179322
-
A potent and broad neutralizing antibody recognizes and penetrates the HIV glycan shield
-
Pejchal R, Doores KJ, Walker LM, Khayat R, Huang PS, Wang SK, Stanfield RL, Julien JP, Ramos A, Crispin M, Depetris R, Katpally U, Marozsan A, Cupo A, Maloveste S, Liu Y, McBride R, Ito Y, Sanders RW, Ogohara C, Paulson JC, Feizi T, Scanlan CN, Wong CH, Moore JP, Olson WC, Ward AB, Poignard P, Schief WR, Burton DR, Wilson IA. 2011. A potent and broad neutralizing antibody recognizes and penetrates the HIV glycan shield. Science 334:1097-1103. http://dx.doi.org/10.1126/science.1213256.
-
(2011)
Science
, vol.334
, pp. 1097-1103
-
-
Pejchal, R.1
Doores, K.J.2
Walker, L.M.3
Khayat, R.4
Huang, P.S.5
Wang, S.K.6
Stanfield, R.L.7
Julien, J.P.8
Ramos, A.9
Crispin, M.10
Depetris, R.11
Katpally, U.12
Marozsan, A.13
Cupo, A.14
Maloveste, S.15
Liu, Y.16
McBride, R.17
Ito, Y.18
Sanders, R.W.19
Ogohara, C.20
Paulson, J.C.21
Feizi, T.22
Scanlan, C.N.23
Wong, C.H.24
Moore, J.P.25
Olson, W.C.26
Ward, A.B.27
Poignard, P.28
Schief, W.R.29
Burton, D.R.30
Wilson, I.A.31
more..
-
16
-
-
84878519611
-
Broadly neutralizing antibody PGT121 allosterically modulates CD4 binding via recognition of the HIV-1 gp120 V3 base and multiple surrounding glycans
-
Julien JP, Sok D, Khayat R, Lee JH, Doores KJ, Walker LM, Ramos A, Diwanji DC, Pejchal R, Cupo A, Katpally U, Depetris RS, Stanfield RL, McBride R, Marozsan AJ, Paulson JC, Sanders RW, Moore JP, Burton DR, Poignard P, Ward AB, Wilson IA. 2013. Broadly neutralizing antibody PGT121 allosterically modulates CD4 binding via recognition of the HIV-1 gp120 V3 base and multiple surrounding glycans. PLoS Pathog 9:e1003342. http://dx.doi.org/10.1371/journal.ppat.1003342.
-
(2013)
PLoS Pathog
, vol.9
-
-
Julien, J.P.1
Sok, D.2
Khayat, R.3
Lee, J.H.4
Doores, K.J.5
Walker, L.M.6
Ramos, A.7
Diwanji, D.C.8
Pejchal, R.9
Cupo, A.10
Katpally, U.11
Depetris, R.S.12
Stanfield, R.L.13
McBride, R.14
Marozsan, A.J.15
Paulson, J.C.16
Sanders, R.W.17
Moore, J.P.18
Burton, D.R.19
Poignard, P.20
Ward, A.B.21
Wilson, I.A.22
more..
-
17
-
-
84890858459
-
Crystal structure of a soluble cleaved HIV-1 envelope trimer
-
Julien JP, Cupo A, Sok D, Stanfield RL, Lyumkis D, Deller MC, Klasse PJ, Burton DR, Sanders RW, Moore JP, Ward AB, Wilson IA. 2013. Crystal structure of a soluble cleaved HIV-1 envelope trimer. Science 342: 1477-1483. http://dx.doi.org/10.1126/science.1245625.
-
(2013)
Science
, vol.342
, pp. 1477-1483
-
-
Julien, J.P.1
Cupo, A.2
Sok, D.3
Stanfield, R.L.4
Lyumkis, D.5
Deller, M.C.6
Klasse, P.J.7
Burton, D.R.8
Sanders, R.W.9
Moore, J.P.10
Ward, A.B.11
Wilson, I.A.12
-
18
-
-
84901236516
-
Promiscuous glycan site recognition by antibodies to the high-mannose patch of gp120 broadens neutralization of HIV
-
Sok D, Doores KJ, Briney B, Le KM, Saye-Francisco KL, Ramos A, Kulp DW, Julien JP, Menis S, Wickramasinghe L, Seaman MS, Schief WR, Wilson IA, Poignard P, Burton DR. 2014. Promiscuous glycan site recognition by antibodies to the high-mannose patch of gp120 broadens neutralization of HIV. Sci Transl Med 6:236ra63. http://dx.doi.org/10.1126/scitranslmed.3008104.
-
(2014)
Sci Transl Med
, vol.6
-
-
Sok, D.1
Doores, K.J.2
Briney, B.3
Le, K.M.4
Saye-Francisco, K.L.5
Ramos, A.6
Kulp, D.W.7
Julien, J.P.8
Menis, S.9
Wickramasinghe, L.10
Seaman, M.S.11
Schief, W.R.12
Wilson, I.A.13
Poignard, P.14
Burton, D.R.15
-
19
-
-
84874203056
-
N332-directed broadly neutralizing antibodies use diverse modes of HIV-1 recognition: inferences from heavy-light chain complementation of function
-
Pancera M, Yang Y, Louder MK, Gorman J, Lu G, McLellan JS, Stuckey J, Zhu J, Burton DR, Koff WC, Mascola JR, Kwong PD. 2013. N332-directed broadly neutralizing antibodies use diverse modes of HIV-1 recognition: inferences from heavy-light chain complementation of function. PLoS One 8:e55701. http://dx.doi.org/10.1371/journal.pone.0055701.
-
(2013)
PLoS One
, vol.8
-
-
Pancera, M.1
Yang, Y.2
Louder, M.K.3
Gorman, J.4
Lu, G.5
McLellan, J.S.6
Stuckey, J.7
Zhu, J.8
Burton, D.R.9
Koff, W.C.10
Mascola, J.R.11
Kwong, P.D.12
-
20
-
-
84888251984
-
The effects of somatic hypermutation on neutralization and binding in the PGT121 family of broadly neutralizing HIV antibodies
-
Sok D, Laserson U, Laserson J, Liu Y, Vigneault F, Julien JP, Briney B, Ramos A, Saye KF, Le K, Mahan A, Wang S, Kardar M, Yaari G, Walker LM, Simen BB, St. John EP, Chan-Hui PY, Swiderek K, Kleinstein SH, Alter G, Seaman MS, Chakraborty AK, Koller D, Wilson IA, Church GM, Burton DR, Poignard P. 2013. The effects of somatic hypermutation on neutralization and binding in the PGT121 family of broadly neutralizing HIV antibodies. PLoS Pathog 9:e1003754. http://dx.doi.org/10.1371/journal.ppat.1003754.
-
(2013)
PLoS Pathog
, vol.9
-
-
Sok, D.1
Laserson, U.2
Laserson, J.3
Liu, Y.4
Vigneault, F.5
Julien, J.P.6
Briney, B.7
Ramos, A.8
Saye, K.F.9
Le, K.10
Mahan, A.11
Wang, S.12
Kardar, M.13
Yaari, G.14
Walker, L.M.15
Simen, B.B.16
St John, E.P.17
Chan-Hui, P.Y.18
Swiderek, K.19
Kleinstein, S.H.20
Alter, G.21
Seaman, M.S.22
Chakraborty, A.K.23
Koller, D.24
Wilson, I.A.25
Church, G.M.26
Burton, D.R.27
Poignard, P.28
more..
-
21
-
-
67650453747
-
Human immunodeficiency virus type 1 elite neutralizers: individuals with broad and potent neutralizing activity identified by using a high-throughput neutralization assay together with an analytical selection algorithm
-
Simek MD, Rida W, Priddy FH, Pung P, Carrow E, Laufer DS, Lehrman JK, Boaz M, Tarragona-Fiol T, Miiro G, Birungi J, Pozniak A, McPhee DA, Manigart O, Karita E, Inwoley A, Jaoko W, Dehovitz J, Bekker LG, Pitisuttithum P, Paris R, Walker LM, Poignard P, Wrin T, Fast PE, Burton DR, Koff WC. 2009. Human immunodeficiency virus type 1 elite neutralizers: individuals with broad and potent neutralizing activity identified by using a high-throughput neutralization assay together with an analytical selection algorithm. J Virol 83:7337-7348. http://dx.doi.org/10.1128/JVI.00110-09.
-
(2009)
J Virol
, vol.83
, pp. 7337-7348
-
-
Simek, M.D.1
Rida, W.2
Priddy, F.H.3
Pung, P.4
Carrow, E.5
Laufer, D.S.6
Lehrman, J.K.7
Boaz, M.8
Tarragona-Fiol, T.9
Miiro, G.10
Birungi, J.11
Pozniak, A.12
McPhee, D.A.13
Manigart, O.14
Karita, E.15
Inwoley, A.16
Jaoko, W.17
Dehovitz, J.18
Bekker, L.G.19
Pitisuttithum, P.20
Paris, R.21
Walker, L.M.22
Poignard, P.23
Wrin, T.24
Fast, P.E.25
Burton, D.R.26
Koff, W.C.27
more..
-
22
-
-
63149142646
-
B cells in HIV infection and disease
-
Moir S, Fauci AS. 2009. B cells in HIV infection and disease. Nat Rev Immunol 9:235-245. http://dx.doi.org/10.1038/nri2524.
-
(2009)
Nat Rev Immunol
, vol.9
, pp. 235-245
-
-
Moir, S.1
Fauci, A.S.2
-
23
-
-
77957198704
-
Variable loop glycan dependency of the broad and potent HIV-1-neutralizing antibodies PG9 and PG16
-
Doores KJ, Burton DR. 2010. Variable loop glycan dependency of the broad and potent HIV-1-neutralizing antibodies PG9 and PG16. J Virol 84:10510-10521. http://dx.doi.org/10.1128/JVI.00552-10.
-
(2010)
J Virol
, vol.84
, pp. 10510-10521
-
-
Doores, K.J.1
Burton, D.R.2
-
24
-
-
36849031722
-
Efficient generation of monoclonal antibodies from single human B cells by single cell RT-PCR and expression vector cloning
-
Tiller T, Meffre E, Yurasov S, Tsuiji M, Nussenzweig MC, Wardemann H. 2008. Efficient generation of monoclonal antibodies from single human B cells by single cell RT-PCR and expression vector cloning. J Immunol Methods 329:112-124. http://dx.doi.org/10.1016/j.jim.2007.09.017.
-
(2008)
J Immunol Methods
, vol.329
, pp. 112-124
-
-
Tiller, T.1
Meffre, E.2
Yurasov, S.3
Tsuiji, M.4
Nussenzweig, M.C.5
Wardemann, H.6
-
25
-
-
18344375268
-
An approach to rapid protein crystallization using nanodroplets
-
Santarsiero BD, Yegian DT, Lee CC, Spraggon G, Gu J, Scheibe D, Uber DC, Cornell EW, Nordmeyer RA, Kolbe WF, Jin J, Jones AL, Jaklevic JM, Schultz PG, Stevens RC. 2002. An approach to rapid protein crystallization using nanodroplets. J Appl Cryst 35:278-281. http://dx.doi.org/10.1107/S0021889802001474.
-
(2002)
J Appl Cryst
, vol.35
, pp. 278-281
-
-
Santarsiero, B.D.1
Yegian, D.T.2
Lee, C.C.3
Spraggon, G.4
Gu, J.5
Scheibe, D.6
Uber, D.C.7
Cornell, E.W.8
Nordmeyer, R.A.9
Kolbe, W.F.10
Jin, J.11
Jones, A.L.12
Jaklevic, J.M.13
Schultz, P.G.14
Stevens, R.C.15
-
26
-
-
0037015054
-
Structural genomics of the Thermotoga maritima proteome implemented in a highthroughput structure determination pipeline
-
Lesley SA, Kuhn P, Godzik A, Deacon AM, Mathews I, Kreusch A, Spraggon G, Klock HE, McMullan D, Shin T, Vincent J, Robb A, Brinen LS, Miller MD, McPhillips TM, Miller MA, Scheibe D, Canaves JM, Guda C, Jaroszewski L, Selby TL, Elsliger MA, Wooley J, Taylor SS, Hodgson KO, Wilson IA, Schultz PG, Stevens RC. 2002. Structural genomics of the Thermotoga maritima proteome implemented in a highthroughput structure determination pipeline. Proc Natl Acad Sci USA 99:11664-11669. http://dx.doi.org/10.1073/pnas.142413399.
-
(2002)
Proc Natl Acad Sci USA
, vol.99
, pp. 11664-11669
-
-
Lesley, S.A.1
Kuhn, P.2
Godzik, A.3
Deacon, A.M.4
Mathews, I.5
Kreusch, A.6
Spraggon, G.7
Klock, H.E.8
McMullan, D.9
Shin, T.10
Vincent, J.11
Robb, A.12
Brinen, L.S.13
Miller, M.D.14
McPhillips, T.M.15
Miller, M.A.16
Scheibe, D.17
Canaves, J.M.18
Guda, C.19
Jaroszewski, L.20
Selby, T.L.21
Elsliger, M.A.22
Wooley, J.23
Taylor, S.S.24
Hodgson, K.O.25
Wilson, I.A.26
Schultz, P.G.27
Stevens, R.C.28
more..
-
27
-
-
0031059866
-
Processing of X-ray diffraction data collected in oscillation mode
-
Otwinowski Z, Minor W. 1997. Processing of X-ray diffraction data collected in oscillation mode. Methods Enzymol 276:307-326. http://dx.doi.org/10.1016/S0076-6879(97)76066-X.
-
(1997)
Methods Enzymol
, vol.276
, pp. 307-326
-
-
Otwinowski, Z.1
Minor, W.2
-
28
-
-
34447508216
-
Phaser crystallographic software
-
McCoy AJ, Grosse-Kunstleve RW, Adams PD, Winn MD, Storoni LC, Read RJ. 2007. Phaser crystallographic software. J Appl Crystallogr 40: 658-674. http://dx.doi.org/10.1107/S0021889807021206.
-
(2007)
J Appl Crystallogr
, vol.40
, pp. 658-674
-
-
McCoy, A.J.1
Grosse-Kunstleve, R.W.2
Adams, P.D.3
Winn, M.D.4
Storoni, L.C.5
Read, R.J.6
-
30
-
-
76449098262
-
PHENIX: a comprehensive Python-based system for macromolecular structure solution
-
Adams PD, Afonine PV, Bunkoczi G, Chen VB, Davis IW, Echols N, Headd JJ, Hung LW, Kapral GJ, Grosse-Kunstleve RW, McCoy AJ, Moriarty NW, Oeffner R, Read RJ, Richardson DC, Richardson JS, Terwilliger TC, Zwart PH. 2010. PHENIX: a comprehensive Python-based system for macromolecular structure solution. Acta Crystallogr D Biol Crystallogr 66: 213-221. http://dx.doi.org/10.1107/S0907444909052925.
-
(2010)
Acta Crystallogr D Biol Crystallogr
, vol.66
, pp. 213-221
-
-
Adams, P.D.1
Afonine, P.V.2
Bunkoczi, G.3
Chen, V.B.4
Davis, I.W.5
Echols, N.6
Headd, J.J.7
Hung, L.W.8
Kapral, G.J.9
Grosse-Kunstleve, R.W.10
McCoy, A.J.11
Moriarty, N.W.12
Oeffner, R.13
Read, R.J.14
Richardson, D.C.15
Richardson, J.S.16
Terwilliger, T.C.17
Zwart, P.H.18
-
31
-
-
84868597004
-
Anti-HIV B cell lines as candidate vaccine biosensors
-
Ota T, Doyle-Cooper C, Cooper AB, Huber M, Falkowska E, Doores KJ, Hangartner L, Le K, Sok D, Jardine J, Lifson J, Wu X, Mascola JR, Poignard P, Binley JM, Chakrabarti BK, Schief WR, Wyatt RT, Burton DR, Nemazee D. 2012. Anti-HIV B cell lines as candidate vaccine biosensors. J Immunol 189:4814-4824. http://dx.doi.org/10.4049/jimmunol.1202165.
-
(2012)
J Immunol
, vol.189
, pp. 4814-4824
-
-
Ota, T.1
Doyle-Cooper, C.2
Cooper, A.B.3
Huber, M.4
Falkowska, E.5
Doores, K.J.6
Hangartner, L.7
Le, K.8
Sok, D.9
Jardine, J.10
Lifson, J.11
Wu, X.12
Mascola, J.R.13
Poignard, P.14
Binley, J.M.15
Chakrabarti, B.K.16
Schief, W.R.17
Wyatt, R.T.18
Burton, D.R.19
Nemazee, D.20
more..
-
32
-
-
84896690177
-
Diverse recombinant HIV-1 Envs fail to activate B cells expressing the germline B cell receptors of the broadly neutralizing anti-HIV-1 antibodies PG9 and 447-52D
-
McGuire AT, Glenn JA, Lippy A, Stamatatos L. 2014. Diverse recombinant HIV-1 Envs fail to activate B cells expressing the germline B cell receptors of the broadly neutralizing anti-HIV-1 antibodies PG9 and 447-52D. J Virol 88:2645-2657. http://dx.doi.org/10.1128/JVI.03228-13.
-
(2014)
J Virol
, vol.88
, pp. 2645-2657
-
-
McGuire, A.T.1
Glenn, J.A.2
Lippy, A.3
Stamatatos, L.4
-
33
-
-
84877609579
-
Rational HIV immunogen design to target specific germline B cell receptors
-
Jardine J, Julien JP, Menis S, Ota T, Kalyuzhniy O, McGuire A, Sok D, Huang PS, MacPherson S, Jones M, Nieusma T, Mathison J, Baker D, Ward AB, Burton DR, Stamatatos L, Nemazee D, Wilson IA, Schief WR. 2013. Rational HIV immunogen design to target specific germline B cell receptors. Science 340:711-716. http://dx.doi.org/10.1126/science.1234150.
-
(2013)
Science
, vol.340
, pp. 711-716
-
-
Jardine, J.1
Julien, J.P.2
Menis, S.3
Ota, T.4
Kalyuzhniy, O.5
McGuire, A.6
Sok, D.7
Huang, P.S.8
MacPherson, S.9
Jones, M.10
Nieusma, T.11
Mathison, J.12
Baker, D.13
Ward, A.B.14
Burton, D.R.15
Stamatatos, L.16
Nemazee, D.17
Wilson, I.A.18
Schief, W.R.19
-
34
-
-
70449701456
-
Germline-like predecessors of broadly neutralizing antibodies lack measurable binding to HIV-1 envelope glycoproteins: implications for evasion of immune responses and design of vaccine immunogens
-
Xiao X, Chen W, Feng Y, Zhu Z, Prabakaran P, Wang Y, Zhang MY, Longo NS, Dimitrov DS. 2009. Germline-like predecessors of broadly neutralizing antibodies lack measurable binding to HIV-1 envelope glycoproteins: implications for evasion of immune responses and design of vaccine immunogens. Biochem Biophys Res Commun 390:404-409. http://dx.doi.org/10.1016/j.bbrc.2009.09.029.
-
(2009)
Biochem Biophys Res Commun
, vol.390
, pp. 404-409
-
-
Xiao, X.1
Chen, W.2
Feng, Y.3
Zhu, Z.4
Prabakaran, P.5
Wang, Y.6
Zhang, M.Y.7
Longo, N.S.8
Dimitrov, D.S.9
-
35
-
-
77957201600
-
Very few substitutions in a germ line antibody are required to initiate significant domain exchange
-
Huber M, Le KM, Doores KJ, Fulton Z, Stanfield RL, Wilson IA, Burton DR. 2010. Very few substitutions in a germ line antibody are required to initiate significant domain exchange. J Virol 84:10700-10707. http://dx.doi.org/10.1128/JVI.01111-10.
-
(2010)
J Virol
, vol.84
, pp. 10700-10707
-
-
Huber, M.1
Le, K.M.2
Doores, K.J.3
Fulton, Z.4
Stanfield, R.L.5
Wilson, I.A.6
Burton, D.R.7
-
36
-
-
84904327067
-
Conservation, compensation, and evolution of Nlinked glycans in the HIV-1 group M subtypes and circulating recombinant forms
-
823605
-
Travers SA. 2012. Conservation, compensation, and evolution of Nlinked glycans in the HIV-1 group M subtypes and circulating recombinant forms. ISRN AIDS 2012:823605. http://dx.doi.org/10.5402/2012/823605.
-
(2012)
ISRN AIDS
, vol.2012
-
-
Travers, S.A.1
-
37
-
-
84875034460
-
Asymmetric recognition of the HIV-1 trimer by broadly neutralizing antibody PG9
-
Julien JP, Lee JH, Cupo A, Murin CD, Derking R, Hoffenberg S, Caulfield MJ, King CR, Marozsan AJ, Klasse PJ, Sanders RW, Moore JP, Wilson IA, Ward AB. 2013. Asymmetric recognition of the HIV-1 trimer by broadly neutralizing antibody PG9. Proc Natl Acad Sci USA 110:4351-4356. http://dx.doi.org/10.1073/pnas.1217537110.
-
(2013)
Proc Natl Acad Sci USA
, vol.110
, pp. 4351-4356
-
-
Julien, J.P.1
Lee, J.H.2
Cupo, A.3
Murin, C.D.4
Derking, R.5
Hoffenberg, S.6
Caulfield, M.J.7
King, C.R.8
Marozsan, A.J.9
Klasse, P.J.10
Sanders, R.W.11
Moore, J.P.12
Wilson, I.A.13
Ward, A.B.14
-
38
-
-
0030589039
-
Structural families in loops of homologous proteins: automatic classification, modelling and application to antibodies
-
Martin AC, Thornton JM. 1996. Structural families in loops of homologous proteins: automatic classification, modelling and application to antibodies. J Mol Biol 263:800-815. http://dx.doi.org/10.1006/jmbi.1996.0617.
-
(1996)
J Mol Biol
, vol.263
, pp. 800-815
-
-
Martin, A.C.1
Thornton, J.M.2
-
39
-
-
84879302728
-
HIV-1 neutralizing antibodies: understanding nature's pathways
-
Mascola JR, Haynes BF. 2013. HIV-1 neutralizing antibodies: understanding nature's pathways. Immunol Rev 254:225-244. http://dx.doi.org/10.1111/imr.12075.
-
(2013)
Immunol Rev
, vol.254
, pp. 225-244
-
-
Mascola, J.R.1
Haynes, B.F.2
-
40
-
-
80052942203
-
Focused evolution of HIV-1 neutralizing antibodies revealed by structures and deep sequencing
-
Wu X, Zhou T, Zhu J, Zhang B, Georgiev I, Wang C, Chen X, Longo NS, Louder M, McKee K, O'Dell S, Perfetto S, Schmidt SD, Shi W, Wu L, Yang Y, Yang ZY, Yang Z, Zhang Z, Bonsignori M, Crump JA, Kapiga SH, Sam NE, Haynes BF, Simek M, Burton DR, Koff WC, Doria-Rose NA, Connors M, Mullikin JC, Nabel GJ, Roederer M, Shapiro L, Kwong PD, Mascola JR. 2011. Focused evolution of HIV-1 neutralizing antibodies revealed by structures and deep sequencing. Science 333:1593-1602. http://dx.doi.org/10.1126/science.1207532.
-
(2011)
Science
, vol.333
, pp. 1593-1602
-
-
Wu, X.1
Zhou, T.2
Zhu, J.3
Zhang, B.4
Georgiev, I.5
Wang, C.6
Chen, X.7
Longo, N.S.8
Louder, M.9
McKee, K.10
O'Dell, S.11
Perfetto, S.12
Schmidt, S.D.13
Shi, W.14
Wu, L.15
Yang, Y.16
Yang, Z.Y.17
Yang, Z.18
Zhang, Z.19
Bonsignori, M.20
Crump, J.A.21
Kapiga, S.H.22
Sam, N.E.23
Haynes, B.F.24
Simek, M.25
Burton, D.R.26
Koff, W.C.27
Doria-Rose, N.A.28
Connors, M.29
Mullikin, J.C.30
Nabel, G.J.31
Roederer, M.32
Shapiro, L.33
Kwong, P.D.34
Mascola, J.R.35
more..
-
41
-
-
84899991983
-
Developmental pathway for potent V1V2-directed HIV-neutralizing antibodies
-
Doria-Rose NA, Schramm CA, Gorman J, Moore PL, Bhiman JN, DeKosky BJ, Ernandes MJ, Georgiev IS, Kim HJ, Pancera M, Staupe RP, Altae-Tran HR, Bailer RT, Crooks ET, Cupo A, Druz A, Garrett NJ, Hoi KH, Kong R, Louder MK, Longo NS, McKee K, Nonyane M, O'Dell S, Roark RS, Rudicell RS, Schmidt SD, Sheward DJ, Soto C, Wibmer CK, Yang Y, Zhang Z, Mullikin JC, Binley JM, Sanders RW, Wilson IA, Moore JP, Ward AB, Georgiou G, Williamson C, Abdool Karim SS, Morris L, Kwong PD, Shapiro L, Mascola JR. 2014. Developmental pathway for potent V1V2-directed HIV-neutralizing antibodies. Nature 509:55-62. http://dx.doi.org/10.1038/nature13036.
-
(2014)
Nature
, vol.509
, pp. 55-62
-
-
Doria-Rose, N.A.1
Schramm, C.A.2
Gorman, J.3
Moore, P.L.4
Bhiman, J.N.5
DeKosky, B.J.6
Ernandes, M.J.7
Georgiev, I.S.8
Kim, H.J.9
Pancera, M.10
Staupe, R.P.11
Altae-Tran, H.R.12
Bailer, R.T.13
Crooks, E.T.14
Cupo, A.15
Druz, A.16
Garrett, N.J.17
Hoi, K.H.18
Kong, R.19
Louder, M.K.20
Longo, N.S.21
McKee, K.22
Nonyane, M.23
O'Dell, S.24
Roark, R.S.25
Rudicell, R.S.26
Schmidt, S.D.27
Sheward, D.J.28
Soto, C.29
Wibmer, C.K.30
Yang, Y.31
Zhang, Z.32
Mullikin, J.C.33
Binley, J.M.34
Sanders, R.W.35
Wilson, I.A.36
Moore, J.P.37
Ward, A.B.38
Georgiou, G.39
Williamson, C.40
Abdool Karim, S.S.41
Morris, L.42
Kwong, P.D.43
Shapiro, L.44
Mascola, J.R.45
more..
-
42
-
-
84887270287
-
Viral escape from HIV-1 neutralizing antibodies drives increased plasma neutralization breadth through sequential recognition of multiple epitopes and immunotypes
-
Wibmer CK, Bhiman JN, Gray ES, Tumba N, Abdool Karim SS, Williamson C, Morris L, Moore PL. 2013. Viral escape from HIV-1 neutralizing antibodies drives increased plasma neutralization breadth through sequential recognition of multiple epitopes and immunotypes. PLoS Pathog 9:e1003738. http://dx.doi.org/10.1371/journal.ppat.1003738.
-
(2013)
PLoS Pathog
, vol.9
-
-
Wibmer, C.K.1
Bhiman, J.N.2
Gray, E.S.3
Tumba, N.4
Abdool Karim, S.S.5
Williamson, C.6
Morris, L.7
Moore, P.L.8
-
43
-
-
84905369598
-
Cooperation of B cell lineages in induction of HIV-1-broadly neutralizing antibodies
-
Gao F, Bonsignori M, Liao HX, Kumar A, Xia SM, Lu X, Cai F, Hwang KK, Song H, Zhou T, Lynch RM, Alam SM, Moody MA, Ferrari G, Berrong M, Kelsoe G, Shaw GM, Hahn BH, Montefiori DC, Kamanga G, Cohen MS, Hraber P, Kwong PD, Korber BT, Mascola JR, Kepler TB, Haynes BF. 2014. Cooperation of B cell lineages in induction of HIV-1-broadly neutralizing antibodies. Cell 158:481-491. http://dx.doi.org/10.1016/j.cell.2014.06.022.
-
(2014)
Cell
, vol.158
, pp. 481-491
-
-
Gao, F.1
Bonsignori, M.2
Liao, H.X.3
Kumar, A.4
Xia, S.M.5
Lu, X.6
Cai, F.7
Hwang, K.K.8
Song, H.9
Zhou, T.10
Lynch, R.M.11
Alam, S.M.12
Moody, M.A.13
Ferrari, G.14
Berrong, M.15
Kelsoe, G.16
Shaw, G.M.17
Hahn, B.H.18
Montefiori, D.C.19
Kamanga, G.20
Cohen, M.S.21
Hraber, P.22
Kwong, P.D.23
Korber, B.T.24
Mascola, J.R.25
Kepler, T.B.26
Haynes, B.F.27
more..
-
44
-
-
77954943648
-
Structural basis for broad and potent neutralization of HIV-1 by antibody VRC01
-
Zhou T, Georgiev I, Wu X, Yang ZY, Dai K, Finzi A, Kwon YD, Scheid JF, Shi W, Xu L, Yang Y, Zhu J, Nussenzweig MC, Sodroski J, Shapiro L, Nabel GJ, Mascola JR, Kwong PD. 2010. Structural basis for broad and potent neutralization of HIV-1 by antibody VRC01. Science 329:811-817. http://dx.doi.org/10.1126/science.1192819.
-
(2010)
Science
, vol.329
, pp. 811-817
-
-
Zhou, T.1
Georgiev, I.2
Wu, X.3
Yang, Z.Y.4
Dai, K.5
Finzi, A.6
Kwon, Y.D.7
Scheid, J.F.8
Shi, W.9
Xu, L.10
Yang, Y.11
Zhu, J.12
Nussenzweig, M.C.13
Sodroski, J.14
Shapiro, L.15
Nabel, G.J.16
Mascola, J.R.17
Kwong, P.D.18
-
45
-
-
82755184131
-
Increasing the potency and breadth of an HIV antibody by using structure-based rational design
-
Diskin R, Scheid JF, Marcovecchio PM, West AP, Jr, Klein F, Gao H, Gnanapragasam PN, Abadir A, Seaman MS, Nussenzweig MC, Bjorkman PJ. 2011. Increasing the potency and breadth of an HIV antibody by using structure-based rational design. Science 334:1289-1293. http://dx.doi.org/10.1126/science.1213782.
-
(2011)
Science
, vol.334
, pp. 1289-1293
-
-
Diskin, R.1
Scheid, J.F.2
Marcovecchio, P.M.3
West, A.P.4
Klein, F.5
Gao, H.6
Gnanapragasam, P.N.7
Abadir, A.8
Seaman, M.S.9
Nussenzweig, M.C.10
Bjorkman, P.J.11
-
46
-
-
84899909771
-
Antibody 8ANC195 reveals a site of broad vulnerability on the HIV-1 envelope spike
-
Scharf L, Scheid JF, Lee JH, West AP, Jr, Chen C, Gao H, Gnanapragasam PN, Mares R, Seaman MS, Ward AB, Nussenzweig MC, Bjorkman PJ. 2014. Antibody 8ANC195 reveals a site of broad vulnerability on the HIV-1 envelope spike. Cell Rep 7:785-795. http://dx.doi.org/10.1016/j.celrep.2014.04.001.
-
(2014)
Cell Rep
, vol.7
, pp. 785-795
-
-
Scharf, L.1
Scheid, J.F.2
Lee, J.H.3
West, A.P.4
Chen, C.5
Gao, H.6
Gnanapragasam, P.N.7
Mares, R.8
Seaman, M.S.9
Ward, A.B.10
Nussenzweig, M.C.11
Bjorkman, P.J.12
-
47
-
-
84894173514
-
Structural insights on the role of antibodies in HIV-1 vaccine and therapy
-
West AP, Jr, Scharf L, Scheid JF, Klein F, Bjorkman PJ, Nussenzweig MC. 2014. Structural insights on the role of antibodies in HIV-1 vaccine and therapy. Cell 156:633-648. http://dx.doi.org/10.1016/j.cell.2014.01.052.
-
(2014)
Cell
, vol.156
, pp. 633-648
-
-
West, A.P.1
Scharf, L.2
Scheid, J.F.3
Klein, F.4
Bjorkman, P.J.5
Nussenzweig, M.C.6
|