-
1
-
-
78049485263
-
Estimates of worldwide burden of cancer in 2008: GLOBOCAN 2008
-
21351269
-
Ferlay J, Shin HR, Bray F, Forman D, Mathers C, Parkin DM. Estimates of worldwide burden of cancer in 2008:GLOBOCAN 2008. Int J Cancer 2010; 127:2893-917; PMID:21351269; http://dx.doi.org/10.1002/ijc.25516
-
(2010)
Int J Cancer
, vol.127
, pp. 2893-2917
-
-
Ferlay, J.1
Shin, H.R.2
Bray, F.3
Forman, D.4
Mathers, C.5
Parkin, D.M.6
-
2
-
-
84920837701
-
Cancer statistics, 2015
-
25559415
-
Siegel RL, Miller KD, Jemal A. Cancer statistics, 2015. CA Cancer J Clin 2015; 65:5-29; PMID:25559415; http://dx.doi.org/10.3322/caac.21254
-
(2015)
CA Cancer J Clin
, vol.65
, pp. 5-29
-
-
Siegel, R.L.1
Miller, K.D.2
Jemal, A.3
-
3
-
-
84864246454
-
Endometrial cancer
-
22825101
-
Sorosky JI. Endometrial cancer. Obstet Gynecol 2012; 120:383-97; PMID:22825101; http://dx.doi.org/10.1097/AOG.0b013e3182605bf1
-
(2012)
Obstet Gynecol
, vol.120
, pp. 383-397
-
-
Sorosky, J.I.1
-
4
-
-
0020660717
-
Two pathogenetic types of endometrial carcinoma
-
6822361
-
Bokhman JV. Two pathogenetic types of endometrial carcinoma. Gynecol Oncol 1983; 15:10-7; PMID:6822361; http://dx.doi.org/10.1016/0090-8258(83)90111-7
-
(1983)
Gynecol Oncol
, vol.15
, pp. 10-17
-
-
Bokhman, J.V.1
-
5
-
-
84877254190
-
Integrated genomic characterization of endometrial carcinoma
-
Benz CC
-
Kandoth C, Schultz N, Cherniack AD, Akbani R, Liu Y, Shen H, Robertson AG, Pashtan I, Shen R, Benz CC. Integrated genomic characterization of endometrial carcinoma. Nature 2013; 497:67-73.
-
(2013)
Nature
, vol.497
, pp. 67-73
-
-
Kandoth, C.1
Schultz, N.2
Cherniack, A.D.3
Akbani, R.4
Liu, Y.5
Shen, H.6
Robertson, A.G.7
Pashtan, I.8
Shen, R.9
-
6
-
-
77649130174
-
Vaginal brachytherapy versus pelvic external beam radiotherapy for patients with endometrial cancer of high-intermediate risk (PORTEC-2): an open-label, non-inferiority, randomised trial
-
20206777
-
Nout RA, Smit VT, Putter H, Jurgenliemk-Schulz IM, Jobsen JJ, Lutgens LC, van der Steen-Banasik EM, Mens JW, Slot A, Kroese MC, et al. Vaginal brachytherapy versus pelvic external beam radiotherapy for patients with endometrial cancer of high-intermediate risk (PORTEC-2):an open-label, non-inferiority, randomised trial. Lancet 2010; 375:816-23; PMID:20206777; http://dx.doi.org/10.1016/S0140-6736(09)62163-2
-
(2010)
Lancet
, vol.375
, pp. 816-823
-
-
Nout, R.A.1
Smit, V.T.2
Putter, H.3
Jurgenliemk-Schulz, I.M.4
Jobsen, J.J.5
Lutgens, L.C.6
van der Steen-Banasik, E.M.7
Mens, J.W.8
Slot, A.9
Kroese, M.C.10
-
7
-
-
58149186453
-
Adjuvant external beam radiotherapy in the treatment of endometrial cancer (MRC ASTEC and NCIC CTG EN.5 randomised trials): pooled trial results, systematic review, and meta-analysis
-
19070891
-
Blake P, Swart AM, Orton J, Kitchener H, Whelan T, Lukka H, Eisenhauer E, Bacon M, Tu D, Parmar MK. Adjuvant external beam radiotherapy in the treatment of endometrial cancer (MRC ASTEC and NCIC CTG EN.5 randomised trials):pooled trial results, systematic review, and meta-analysis. Lancet 2009; 373:137-46; PMID:19070891; http://dx.doi.org/10.1016/S0140-6736(08)61767-5
-
(2009)
Lancet
, vol.373
, pp. 137-146
-
-
Blake, P.1
Swart, A.M.2
Orton, J.3
Kitchener, H.4
Whelan, T.5
Lukka, H.6
Eisenhauer, E.7
Bacon, M.8
Tu, D.9
Parmar, M.K.10
-
8
-
-
82955186386
-
Adjuvant chemotherapy for endometrial cancer
-
21697679
-
Tangjitgamol S, See HT, Kavanagh J. Adjuvant chemotherapy for endometrial cancer. Int J Gynecol Cancer 2011; 21:885-95; PMID:21697679; http://dx.doi.org/10.1097/IGC.0b013e3182169239
-
(2011)
Int J Gynecol Cancer
, vol.21
, pp. 885-895
-
-
Tangjitgamol, S.1
See, H.T.2
Kavanagh, J.3
-
9
-
-
34447536870
-
Systemic chemotherapy for uterine carcinoma: metastatic and adjuvant
-
17617530
-
Fleming GF. Systemic chemotherapy for uterine carcinoma:metastatic and adjuvant. J Clin Oncol 2007; 25:2983-90; PMID:17617530; http://dx.doi.org/10.1200/JCO.2007.10.8431
-
(2007)
J Clin Oncol
, vol.25
, pp. 2983-2990
-
-
Fleming, G.F.1
-
10
-
-
2342591455
-
The discovery of receptor tyrosine kinases: targets for cancer therapy
-
15122207
-
Gschwind A, Fischer OM, Ullrich A. The discovery of receptor tyrosine kinases:targets for cancer therapy. Nat Rev Cancer 2004; 4:361-70; PMID:15122207; http://dx.doi.org/10.1038/nrc1360
-
(2004)
Nat Rev Cancer
, vol.4
, pp. 361-370
-
-
Gschwind, A.1
Fischer, O.M.2
Ullrich, A.3
-
11
-
-
0032577051
-
The Croonian Lecture 1997. The phosphorylation of proteins on tyrosine: its role in cell growth and disease
-
9602534
-
Hunter T. The Croonian Lecture 1997. The phosphorylation of proteins on tyrosine:its role in cell growth and disease. Philos Trans R Soc Lond B Biol Sci 1998; 353:583-605; PMID:9602534; http://dx.doi.org/10.1098/rstb.1998.0228
-
(1998)
Philos Trans R Soc Lond B Biol Sci
, vol.353
, pp. 583-605
-
-
Hunter, T.1
-
12
-
-
75149130051
-
Targeting the cancer kinome through polypharmacology
-
20094047
-
Knight ZA, Lin H, Shokat KM. Targeting the cancer kinome through polypharmacology. Nat Rev Cancer 2010; 10:130-7; PMID:20094047; http://dx.doi.org/10.1038/nrc2787
-
(2010)
Nat Rev Cancer
, vol.10
, pp. 130-137
-
-
Knight, Z.A.1
Lin, H.2
Shokat, K.M.3
-
13
-
-
79952231921
-
Management of hepatocellular carcinoma: an update
-
21374666
-
Bruix J, Sherman M. Management of hepatocellular carcinoma:an update. Hepatology 2011; 53:1020-2; PMID:21374666; http://dx.doi.org/10.1002/hep.24199
-
(2011)
Hepatology
, vol.53
, pp. 1020-1022
-
-
Bruix, J.1
Sherman, M.2
-
14
-
-
33846148701
-
Sorafenib in advanced clear-cell renal-cell carcinoma
-
17215530
-
Escudier B, Eisen T, Stadler WM, Szczylik C, Oudard S, Siebels M, Negrier S, Chevreau C, Solska E, Desai AA, et al. Sorafenib in advanced clear-cell renal-cell carcinoma. N Engl J Med 2007; 356:125-34; PMID:17215530; http://dx.doi.org/10.1056/NEJMoa060655
-
(2007)
N Engl J Med
, vol.356
, pp. 125-134
-
-
Escudier, B.1
Eisen, T.2
Stadler, W.M.3
Szczylik, C.4
Oudard, S.5
Siebels, M.6
Negrier, S.7
Chevreau, C.8
Solska, E.9
Desai, A.A.10
-
15
-
-
4944249117
-
BAY 43-9006 exhibits broad spectrum oral antitumor activity and targets the RAF/MEK/ERK pathway and receptor tyrosine kinases involved in tumor progression and angiogenesis
-
15466206
-
Wilhelm SM, Carter C, Tang L, Wilkie D, McNabola A, Rong H, Chen C, Zhang X, Vincent P, McHugh M, et al. BAY 43-9006 exhibits broad spectrum oral antitumor activity and targets the RAF/MEK/ERK pathway and receptor tyrosine kinases involved in tumor progression and angiogenesis. Cancer Res 2004; 64:7099-109; PMID:15466206; http://dx.doi.org/10.1158/0008-5472.CAN-04-1443
-
(2004)
Cancer Res
, vol.64
, pp. 7099-7109
-
-
Wilhelm, S.M.1
Carter, C.2
Tang, L.3
Wilkie, D.4
McNabola, A.5
Rong, H.6
Chen, C.7
Zhang, X.8
Vincent, P.9
McHugh, M.10
-
16
-
-
33749238553
-
Discovery and development of sorafenib: a multikinase inhibitor for treating cancer
-
17016424
-
Wilhelm S, Carter C, Lynch M, Lowinger T, Dumas J, Smith RA, Schwartz B, Simantov R, Kelley S. Discovery and development of sorafenib:a multikinase inhibitor for treating cancer. Nat Rev Drug Discov 2006; 5:835-44; PMID:17016424; http://dx.doi.org/10.1038/nrd2130
-
(2006)
Nat Rev Drug Discov
, vol.5
, pp. 835-844
-
-
Wilhelm, S.1
Carter, C.2
Lynch, M.3
Lowinger, T.4
Dumas, J.5
Smith, R.A.6
Schwartz, B.7
Simantov, R.8
Kelley, S.9
-
17
-
-
37549006796
-
Clinical and biological significance of vascular endothelial growth factor in endometrial cancer
-
18094433
-
Kamat AA, Merritt WM, Coffey D, Lin YG, Patel PR, Broaddus R, Nugent E, Han LY, Landen CN, Jr, Spannuth WA, et al. Clinical and biological significance of vascular endothelial growth factor in endometrial cancer. Clin Cancer Res 2007; 13:7487-95; PMID:18094433; http://dx.doi.org/10.1158/1078-0432.CCR-07-1017
-
(2007)
Clin Cancer Res
, vol.13
, pp. 7487-7495
-
-
Kamat, A.A.1
Merritt, W.M.2
Coffey, D.3
Lin, Y.G.4
Patel, P.R.5
Broaddus, R.6
Nugent, E.7
Han, L.Y.8
Landen, C.N.9
Spannuth, W.A.10
-
18
-
-
34247128217
-
A phase II trial of thalidomide in patients with refractory endometrial cancer and correlation with angiogenesis biomarkers: a Gynecologic Oncology Group study
-
17306350
-
McMeekin DS, Sill MW, Benbrook D, Darcy KM, Stearns-Kurosawa DJ, Eaton L, Yamada SD, Gynecologic Oncology Group. A phase II trial of thalidomide in patients with refractory endometrial cancer and correlation with angiogenesis biomarkers:a Gynecologic Oncology Group study. Gynecol Oncol 2007; 105:508-16; PMID:17306350; http://dx.doi.org/10.1016/j.ygyno.2007.01.019
-
(2007)
Gynecol Oncol
, vol.105
, pp. 508-516
-
-
McMeekin, D.S.1
Sill, M.W.2
Benbrook, D.3
Darcy, K.M.4
Stearns-Kurosawa, D.J.5
Eaton, L.6
Yamada, S.D.7
-
19
-
-
16544390524
-
K-Ras and H-Ras activation promote distinct consequences on endometrial cell survival
-
15087391
-
Ninomiya Y, Kato K, Takahashi A, Ueoka Y, Kamikihara T, Arima T, Matsuda T, Kato H, Nishida J, Wake N. K-Ras and H-Ras activation promote distinct consequences on endometrial cell survival. Cancer Res 2004; 64:2759-65; PMID:15087391; http://dx.doi.org/10.1158/0008-5472.CAN-3487-2
-
(2004)
Cancer Res
, vol.64
, pp. 2759-2765
-
-
Ninomiya, Y.1
Kato, K.2
Takahashi, A.3
Ueoka, Y.4
Kamikihara, T.5
Arima, T.6
Matsuda, T.7
Kato, H.8
Nishida, J.9
Wake, N.10
-
20
-
-
77949337347
-
A phase II study of sorafenib in advanced uterine carcinoma/carcinosarcoma: a trial of the Chicago, PMH, and California Phase II Consortia
-
20117828
-
Nimeiri HS, Oza AM, Morgan RJ, Huo D, Elit L, Knost JA, Wade JL, 3rd, Agamah E, Vokes EE, Fleming GF. A phase II study of sorafenib in advanced uterine carcinoma/carcinosarcoma:a trial of the Chicago, PMH, and California Phase II Consortia. Gynecol Oncol 2010; 117:37-40; PMID:20117828; http://dx.doi.org/10.1016/j.ygyno.2010.01.013
-
(2010)
Gynecol Oncol
, vol.117
, pp. 37-40
-
-
Nimeiri, H.S.1
Oza, A.M.2
Morgan, R.J.3
Huo, D.4
Elit, L.5
Knost, J.A.6
Wade, J.L.7
Agamah, E.8
Vokes, E.E.9
Fleming, G.F.10
-
21
-
-
38049097938
-
Identification of genotype-correlated sensitivity to selective kinase inhibitors by using high-throughput tumor cell line profiling
-
18077425
-
McDermott U, Sharma SV, Dowell L, Greninger P, Montagut C, Lamb J, Archibald H, Raudales R, Tam A, Lee D, et al. Identification of genotype-correlated sensitivity to selective kinase inhibitors by using high-throughput tumor cell line profiling. Proc Natl Acad Sci U S A 2007; 104:19936-41; PMID:18077425; http://dx.doi.org/10.1073/pnas.0707498104
-
(2007)
Proc Natl Acad Sci U S A
, vol.104
, pp. 19936-19941
-
-
McDermott, U.1
Sharma, S.V.2
Dowell, L.3
Greninger, P.4
Montagut, C.5
Lamb, J.6
Archibald, H.7
Raudales, R.8
Tam, A.9
Lee, D.10
-
22
-
-
27344435774
-
Gene set enrichment analysis: a knowledge-based approach for interpreting genome-wide expression profiles
-
16199517
-
Subramanian A, Tamayo P, Mootha VK, Mukherjee S, Ebert BL, Gillette MA, Paulovich A, Pomeroy SL, Golub TR, Lander ES, et al. Gene set enrichment analysis:a knowledge-based approach for interpreting genome-wide expression profiles. Proc Natl Acad Sci U S A 2005; 102:15545-50; PMID:16199517; http://dx.doi.org/10.1073/pnas.0506580102
-
(2005)
Proc Natl Acad Sci U S A
, vol.102
, pp. 15545-15550
-
-
Subramanian, A.1
Tamayo, P.2
Mootha, V.K.3
Mukherjee, S.4
Ebert, B.L.5
Gillette, M.A.6
Paulovich, A.7
Pomeroy, S.L.8
Golub, T.R.9
Lander, E.S.10
-
23
-
-
27444436166
-
Apoptosis induced by the kinase inhibitor BAY 43-9006 in human leukemia cells involves down-regulation of Mcl-1 through inhibition of translation
-
16109713
-
Rahmani M, Davis EM, Bauer C, Dent P, Grant S. Apoptosis induced by the kinase inhibitor BAY 43-9006 in human leukemia cells involves down-regulation of Mcl-1 through inhibition of translation. J Biol Chem 2005; 280:35217-27; PMID:16109713; http://dx.doi.org/10.1074/jbc.M506551200
-
(2005)
J Biol Chem
, vol.280
, pp. 35217-35227
-
-
Rahmani, M.1
Davis, E.M.2
Bauer, C.3
Dent, P.4
Grant, S.5
-
24
-
-
33846212284
-
Sorafenib blocks the RAF/MEK/ERK pathway, inhibits tumor angiogenesis, and induces tumor cell apoptosis in hepatocellular carcinoma model PLC/PRF/5
-
17178882
-
Liu L, Cao Y, Chen C, Zhang X, McNabola A, Wilkie D, Wilhelm S, Lynch M, Carter C. Sorafenib blocks the RAF/MEK/ERK pathway, inhibits tumor angiogenesis, and induces tumor cell apoptosis in hepatocellular carcinoma model PLC/PRF/5. Cancer Res 2006; 66:11851-8; PMID:17178882; http://dx.doi.org/10.1158/0008-5472.CAN-06-1377
-
(2006)
Cancer Res
, vol.66
, pp. 11851-11858
-
-
Liu, L.1
Cao, Y.2
Chen, C.3
Zhang, X.4
McNabola, A.5
Wilkie, D.6
Wilhelm, S.7
Lynch, M.8
Carter, C.9
-
25
-
-
67649715548
-
Sorafenib and rapamycin induce growth suppression in mouse models of hepatocellular carcinoma
-
19220580
-
Huynh H, Ngo VC, Koong HN, Poon D, Choo SP, Thng CH, Chow P, Ong HS, Chung A, Soo KC. Sorafenib and rapamycin induce growth suppression in mouse models of hepatocellular carcinoma. J Cell Mol Med 2009; 13:2673-83; PMID:19220580; http://dx.doi.org/10.1111/j.1582-4934.2009.00692.x
-
(2009)
J Cell Mol Med
, vol.13
, pp. 2673-2683
-
-
Huynh, H.1
Ngo, V.C.2
Koong, H.N.3
Poon, D.4
Choo, S.P.5
Thng, C.H.6
Chow, P.7
Ong, H.S.8
Chung, A.9
Soo, K.C.10
-
26
-
-
84867531311
-
Sorafenib inhibits hypoxia-inducible factor-1alpha synthesis: implications for antiangiogenic activity in hepatocellular carcinoma
-
22929805
-
Liu LP, Ho RL, Chen GG, Lai PB. Sorafenib inhibits hypoxia-inducible factor-1alpha synthesis:implications for antiangiogenic activity in hepatocellular carcinoma. Clin Cancer Res 2012; 18:5662-71; PMID:22929805; http://dx.doi.org/10.1158/1078-0432.CCR-12-0552
-
(2012)
Clin Cancer Res
, vol.18
, pp. 5662-5671
-
-
Liu, L.P.1
Ho, R.L.2
Chen, G.G.3
Lai, P.B.4
-
27
-
-
35148900795
-
The multikinase inhibitor sorafenib potentiates TRAIL lethality in human leukemia cells in association with Mcl-1 and cFLIPL down-regulation
-
17909059
-
Rosato RR, Almenara JA, Coe S, Grant S. The multikinase inhibitor sorafenib potentiates TRAIL lethality in human leukemia cells in association with Mcl-1 and cFLIPL down-regulation. Cancer Res 2007; 67:9490-500; PMID:17909059; http://dx.doi.org/10.1158/0008-5472.CAN-07-0598
-
(2007)
Cancer Res
, vol.67
, pp. 9490-9500
-
-
Rosato, R.R.1
Almenara, J.A.2
Coe, S.3
Grant, S.4
-
28
-
-
34547197343
-
The kinase inhibitor sorafenib induces cell death through a process involving induction of endoplasmic reticulum stress
-
17548474
-
Rahmani M, Davis EM, Crabtree TR, Habibi JR, Nguyen TK, Dent P, Grant S. The kinase inhibitor sorafenib induces cell death through a process involving induction of endoplasmic reticulum stress. Mol Cell Biol 2007; 27:5499-513; PMID:17548474; http://dx.doi.org/10.1128/MCB.01080-06
-
(2007)
Mol Cell Biol
, vol.27
, pp. 5499-5513
-
-
Rahmani, M.1
Davis, E.M.2
Crabtree, T.R.3
Habibi, J.R.4
Nguyen, T.K.5
Dent, P.6
Grant, S.7
-
29
-
-
34548412863
-
The multikinase inhibitor sorafenib induces apoptosis in highly imatinib mesylate-resistant bcr/abl+ human leukemia cells in association with signal transducer and activator of transcription 5 inhibition and myeloid cell leukemia-1 down-regulation
-
17595328
-
Rahmani M, Nguyen TK, Dent P, Grant S. The multikinase inhibitor sorafenib induces apoptosis in highly imatinib mesylate-resistant bcr/abl+ human leukemia cells in association with signal transducer and activator of transcription 5 inhibition and myeloid cell leukemia-1 down-regulation. Mol Pharmacol 2007; 72:788-95; PMID:17595328; http://dx.doi.org/10.1124/mol.106.033308
-
(2007)
Mol Pharmacol
, vol.72
, pp. 788-795
-
-
Rahmani, M.1
Nguyen, T.K.2
Dent, P.3
Grant, S.4
-
30
-
-
76249092117
-
The multikinase inhibitor Sorafenib induces apoptosis and sensitises endometrial cancer cells to TRAIL by different mechanisms
-
20071162
-
Llobet D, Eritja N, Yeramian A, Pallares J, Sorolla A, Domingo M, Santacana M, Gonzalez-Tallada FJ, Matias-Guiu X, Dolcet X. The multikinase inhibitor Sorafenib induces apoptosis and sensitises endometrial cancer cells to TRAIL by different mechanisms. Eur J Cancer 2010; 46:836-50; PMID:20071162; http://dx.doi.org/10.1016/j.ejca.2009.12.025
-
(2010)
Eur J Cancer
, vol.46
, pp. 836-850
-
-
Llobet, D.1
Eritja, N.2
Yeramian, A.3
Pallares, J.4
Sorolla, A.5
Domingo, M.6
Santacana, M.7
Gonzalez-Tallada, F.J.8
Matias-Guiu, X.9
Dolcet, X.10
-
31
-
-
84879142881
-
Sorafenib induces endometrial carcinoma apoptosis by inhibiting Elk-1-dependent Mcl-1 transcription and inducing Akt/GSK3beta-dependent protein degradation
-
23463670
-
Sun NK, Huang SL, Chang TC, Chao CC. Sorafenib induces endometrial carcinoma apoptosis by inhibiting Elk-1-dependent Mcl-1 transcription and inducing Akt/GSK3beta-dependent protein degradation. J Cell Biochem 2013; 114:1819-31; PMID:23463670; http://dx.doi.org/10.1002/jcb.24530
-
(2013)
J Cell Biochem
, vol.114
, pp. 1819-1831
-
-
Sun, N.K.1
Huang, S.L.2
Chang, T.C.3
Chao, C.C.4
-
32
-
-
77957954881
-
The Bcl-xL inhibitor, ABT-737, efficiently induces apoptosis and suppresses growth of hepatoma cells in combination with sorafenib
-
20799354
-
Hikita H, Takehara T, Shimizu S, Kodama T, Shigekawa M, Iwase K, Hosui A, Miyagi T, Tatsumi T, Ishida H, et al. The Bcl-xL inhibitor, ABT-737, efficiently induces apoptosis and suppresses growth of hepatoma cells in combination with sorafenib. Hepatology 2010; 52:1310-21; PMID:20799354; http://dx.doi.org/10.1002/hep.23836
-
(2010)
Hepatology
, vol.52
, pp. 1310-1321
-
-
Hikita, H.1
Takehara, T.2
Shimizu, S.3
Kodama, T.4
Shigekawa, M.5
Iwase, K.6
Hosui, A.7
Miyagi, T.8
Tatsumi, T.9
Ishida, H.10
-
33
-
-
84862737555
-
Inhibition of Bcl-2 antiapoptotic members by obatoclax potently enhances sorafenib-induced apoptosis in human myeloid leukemia cells through a Bim-dependent process
-
22446485
-
Rahmani M, Aust MM, Attkisson E, Williams DC, Jr., Ferreira-Gonzalez A, Grant S. Inhibition of Bcl-2 antiapoptotic members by obatoclax potently enhances sorafenib-induced apoptosis in human myeloid leukemia cells through a Bim-dependent process. Blood 2012; 119:6089-98; PMID:22446485; http://dx.doi.org/10.1182/blood-2011-09-378141
-
(2012)
Blood
, vol.119
, pp. 6089-6098
-
-
Rahmani, M.1
Aust, M.M.2
Attkisson, E.3
Williams, D.C.4
Ferreira-Gonzalez, A.5
Grant, S.6
-
34
-
-
84859169877
-
The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity
-
22460905
-
Barretina J, Caponigro G, Stransky N, Venkatesan K, Margolin AA, Kim S, Wilson CJ, Lehár J, Kryukov GV, Sonkin D, et al. The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity. Nature 2012; 483:603-7; PMID:22460905; http://dx.doi.org/10.1038/nature11003
-
(2012)
Nature
, vol.483
, pp. 603-607
-
-
Barretina, J.1
Caponigro, G.2
Stransky, N.3
Venkatesan, K.4
Margolin, A.A.5
Kim, S.6
Wilson, C.J.7
Lehár, J.8
Kryukov, G.V.9
Sonkin, D.10
-
35
-
-
84876812269
-
Signals from the lysosome: a control centre for cellular clearance and energy metabolism
-
23609508
-
Settembre C, Fraldi A, Medina DL, Ballabio A. Signals from the lysosome:a control centre for cellular clearance and energy metabolism. Nat Rev Mol Cell Biol 2013; 14:283-96; PMID:23609508; http://dx.doi.org/10.1038/nrm3565
-
(2013)
Nat Rev Mol Cell Biol
, vol.14
, pp. 283-296
-
-
Settembre, C.1
Fraldi, A.2
Medina, D.L.3
Ballabio, A.4
-
36
-
-
84883182637
-
Disrupting proton dynamics and energy metabolism for cancer therapy
-
23969692
-
Parks SK, Chiche J, Pouyssegur J. Disrupting proton dynamics and energy metabolism for cancer therapy. Nat Rev Cancer 2013; 13:611-23; PMID:23969692; http://dx.doi.org/10.1038/nrc3579
-
(2013)
Nat Rev Cancer
, vol.13
, pp. 611-623
-
-
Parks, S.K.1
Chiche, J.2
Pouyssegur, J.3
-
37
-
-
25444440875
-
The role of autophagy in cancer development and response to therapy
-
16148885
-
Kondo Y, Kanzawa T, Sawaya R, Kondo S. The role of autophagy in cancer development and response to therapy. Nat Rev Cancer 2005; 5:726-34; PMID:16148885; http://dx.doi.org/10.1038/nrc1692
-
(2005)
Nat Rev Cancer
, vol.5
, pp. 726-734
-
-
Kondo, Y.1
Kanzawa, T.2
Sawaya, R.3
Kondo, S.4
-
38
-
-
80053420059
-
Targeting autophagy enhances sorafenib lethality for hepatocellular carcinoma via ER stress-related apoptosis
-
21691147
-
Shi YH, Ding ZB, Zhou J, Hui B, Shi GM, Ke AW, Wang XY, Dai Z, Peng YF, Gu CY, et al. Targeting autophagy enhances sorafenib lethality for hepatocellular carcinoma via ER stress-related apoptosis. Autophagy 2011; 7:1159-72; PMID:21691147; http://dx.doi.org/10.4161/auto.7.10.16818
-
(2011)
Autophagy
, vol.7
, pp. 1159-1172
-
-
Shi, Y.H.1
Ding, Z.B.2
Zhou, J.3
Hui, B.4
Shi, G.M.5
Ke, A.W.6
Wang, X.Y.7
Dai, Z.8
Peng, Y.F.9
Gu, C.Y.10
-
39
-
-
84976598271
-
PSMD10/Gankyrin induces autophagy to promote tumor progression through cytoplasmic interaction with ATG7 and nuclear transactivation of ATG7 expression
-
Luo T, Fu J, Xu A, Su B, Ren Y, Li N, et al. PSMD10/Gankyrin induces autophagy to promote tumor progression through cytoplasmic interaction with ATG7 and nuclear transactivation of ATG7 expression. Autophagy 2016; 12:1355-71; PMID:25905985; http://dx.doi.org/10.1080/15548627.2015.1034405
-
Autophagy 2016; 12:1355-71; PMID:25905985
-
-
Luo, T.1
Fu, J.2
Xu, A.3
Su, B.4
Ren, Y.5
Li, N.6
-
40
-
-
79960410571
-
Sorafenib enhances pemetrexed cytotoxicity through an autophagy-dependent mechanism in cancer cells
-
21622715
-
Bareford MD, Park MA, Yacoub A, Hamed HA, Tang Y, Cruickshanks N, Eulitt P, Hubbard N, Tye G, Burow ME, et al. Sorafenib enhances pemetrexed cytotoxicity through an autophagy-dependent mechanism in cancer cells. Cancer Res 2011; 71:4955-67; PMID:21622715; http://dx.doi.org/10.1158/0008-5472.CAN-11-0898
-
(2011)
Cancer Res
, vol.71
, pp. 4955-4967
-
-
Bareford, M.D.1
Park, M.A.2
Yacoub, A.3
Hamed, H.A.4
Tang, Y.5
Cruickshanks, N.6
Eulitt, P.7
Hubbard, N.8
Tye, G.9
Burow, M.E.10
-
41
-
-
84983718691
-
Mcl-1-dependent activation of Beclin 1 mediates autophagic cell death induced by sorafenib and SC-59 in hepatocellular carcinoma cells
-
23392173
-
Tai WT, Shiau CW, Chen HL, Liu CY, Lin CS, Cheng AL, Chen PJ, Chen KF. Mcl-1-dependent activation of Beclin 1 mediates autophagic cell death induced by sorafenib and SC-59 in hepatocellular carcinoma cells. Cell Death Dis 2013; 4:e485; PMID:23392173; http://dx.doi.org/10.1038/cddis.2013.18
-
(2013)
Cell Death Dis
, vol.4
, pp. e485
-
-
Tai, W.T.1
Shiau, C.W.2
Chen, H.L.3
Liu, C.Y.4
Lin, C.S.5
Cheng, A.L.6
Chen, P.J.7
Chen, K.F.8
-
42
-
-
84902659100
-
Inhibition of Akt reverses the acquired resistance to sorafenib by switching protective autophagy to autophagic cell death in hepatocellular carcinoma
-
24705351
-
Zhai B, Hu F, Jiang X, Xu J, Zhao D, Liu B, Pan S, Dong X, Tan G, Wei Z, et al. Inhibition of Akt reverses the acquired resistance to sorafenib by switching protective autophagy to autophagic cell death in hepatocellular carcinoma. Mol Cancer Ther 2014; 13:1589-98; PMID:24705351; http://dx.doi.org/10.1158/1535-7163.MCT-13-1043
-
(2014)
Mol Cancer Ther
, vol.13
, pp. 1589-1598
-
-
Zhai, B.1
Hu, F.2
Jiang, X.3
Xu, J.4
Zhao, D.5
Liu, B.6
Pan, S.7
Dong, X.8
Tan, G.9
Wei, Z.10
-
43
-
-
84862295360
-
Guidelines for the use and interpretation of assays for monitoring autophagy
-
22966490
-
Klionsky DJ, Abdalla FC, Abeliovich H, Abraham RT, Acevedo-Arozena A, Adeli K, Agholme L, Agnello M, Agostinis P, Aguirre-Ghiso JA, et al. Guidelines for the use and interpretation of assays for monitoring autophagy. Autophagy 2012; 8:445-544; PMID:22966490; http://dx.doi.org/10.4161/auto.19496
-
(2012)
Autophagy
, vol.8
, pp. 445-544
-
-
Klionsky, D.J.1
Abdalla, F.C.2
Abeliovich, H.3
Abraham, R.T.4
Acevedo-Arozena, A.5
Adeli, K.6
Agholme, L.7
Agnello, M.8
Agostinis, P.9
Aguirre-Ghiso, J.A.10
-
44
-
-
23844483152
-
The apoptosis/autophagy paradox: autophagic vacuolization before apoptotic death
-
15985464
-
Gonzalez-Polo RA, Boya P, Pauleau AL, Jalil A, Larochette N, Souquere S, Eskelinen EL, Pierron G, Saftig P, Kroemer G. The apoptosis/autophagy paradox:autophagic vacuolization before apoptotic death. J Cell Sci 2005; 118:3091-102; PMID:15985464; http://dx.doi.org/10.1242/jcs.02447
-
(2005)
J Cell Sci
, vol.118
, pp. 3091-3102
-
-
Gonzalez-Polo, R.A.1
Boya, P.2
Pauleau, A.L.3
Jalil, A.4
Larochette, N.5
Souquere, S.6
Eskelinen, E.L.7
Pierron, G.8
Saftig, P.9
Kroemer, G.10
-
45
-
-
34548077575
-
Dissection of the autophagosome maturation process by a novel reporter protein, tandem fluorescent-tagged LC3
-
17534139
-
Kimura S, Noda T, Yoshimori T. Dissection of the autophagosome maturation process by a novel reporter protein, tandem fluorescent-tagged LC3. Autophagy 2007; 3:452-60; PMID:17534139; http://dx.doi.org/10.4161/auto.4451
-
(2007)
Autophagy
, vol.3
, pp. 452-460
-
-
Kimura, S.1
Noda, T.2
Yoshimori, T.3
-
46
-
-
84867887350
-
Deconstructing the third dimension: how 3D culture microenvironments alter cellular cues
-
22797912
-
Baker BM, Chen CS. Deconstructing the third dimension:how 3D culture microenvironments alter cellular cues. J Cell Sci 2012; 125:3015-24; PMID:22797912; http://dx.doi.org/10.1242/jcs.079509
-
(2012)
J Cell Sci
, vol.125
, pp. 3015-3024
-
-
Baker, B.M.1
Chen, C.S.2
-
47
-
-
84941968109
-
The epithelial polarity regulator LGALS9/galectin-9 induces fatal frustrated autophagy in KRAS mutant colon carcinoma that depends on elevated basal autophagic flux
-
26086204
-
Wiersma VR, de Bruyn M, Wei Y, van Ginkel RJ, Hirashima M, Niki T, Nishi N, Zhou J, Pouwels SD, Samplonius DF, et al. The epithelial polarity regulator LGALS9/galectin-9 induces fatal frustrated autophagy in KRAS mutant colon carcinoma that depends on elevated basal autophagic flux. Autophagy 2015; 11:1373-88; PMID:26086204; http://dx.doi.org/10.1080/15548627.2015.1063767
-
(2015)
Autophagy
, vol.11
, pp. 1373-1388
-
-
Wiersma, V.R.1
de Bruyn, M.2
Wei, Y.3
van Ginkel, R.J.4
Hirashima, M.5
Niki, T.6
Nishi, N.7
Zhou, J.8
Pouwels, S.D.9
Samplonius, D.F.10
-
48
-
-
84055190769
-
Sorafenib increases endoplasmic reticulum (ER) stress in concert with vorinostat
-
22095133
-
Inamoto T, Azuma H. Sorafenib increases endoplasmic reticulum (ER) stress in concert with vorinostat. Cancer Biol Ther 2011; 12:1018; PMID:22095133; http://dx.doi.org/10.4161/cbt.12.12.18135
-
(2011)
Cancer Biol Ther
, vol.12
, pp. 1018
-
-
Inamoto, T.1
Azuma, H.2
-
49
-
-
84923195554
-
UPR, autophagy, and mitochondria crosstalk underlies the ER stress response
-
25656104
-
Senft D, Ronai ZA. UPR, autophagy, and mitochondria crosstalk underlies the ER stress response. Trends Biochem Sci 2015; 40:141-8; PMID:25656104; http://dx.doi.org/10.1016/j.tibs.2015.01.002
-
(2015)
Trends Biochem Sci
, vol.40
, pp. 141-148
-
-
Senft, D.1
Ronai, Z.A.2
-
50
-
-
84931405749
-
Dictyopteris undulata extract induces apoptosis via induction of endoplasmic reticulum stress in human colon cancer cells
-
25337580
-
Kang KA, Kim JK, Jeong YJ, Na SY, Hyun JW. Dictyopteris undulata extract induces apoptosis via induction of endoplasmic reticulum stress in human colon cancer cells. J Cancer Prev 2014; 19:118-24; PMID:25337580; http://dx.doi.org/10.15430/JCP.2014.19.2.118
-
(2014)
J Cancer Prev
, vol.19
, pp. 118-124
-
-
Kang, K.A.1
Kim, J.K.2
Jeong, Y.J.3
Na, S.Y.4
Hyun, J.W.5
-
51
-
-
33645294370
-
3,3′-diindolylmethane (DIM) and its derivatives induce apoptosis in pancreatic cancer cells through endoplasmic reticulum stress-dependent upregulation of DR5
-
16332727
-
Abdelrahim M, Newman K, Vanderlaag K, Samudio I, Safe S. 3,3′-diindolylmethane (DIM) and its derivatives induce apoptosis in pancreatic cancer cells through endoplasmic reticulum stress-dependent upregulation of DR5. Carcinogenesis 2006; 27:717-28; PMID:16332727; http://dx.doi.org/10.1093/carcin/bgi270
-
(2006)
Carcinogenesis
, vol.27
, pp. 717-728
-
-
Abdelrahim, M.1
Newman, K.2
Vanderlaag, K.3
Samudio, I.4
Safe, S.5
-
52
-
-
77958512943
-
Protective mechanism of KIOM-4 in streptozotocin-induced pancreatic beta-cells damage is involved in the inhibition of endoplasmic reticulum stress
-
Zhang R, Kim JS, Kang KA, Piao MJ, Kim KC, Hyun JW. Protective mechanism of KIOM-4 in streptozotocin-induced pancreatic beta-cells damage is involved in the inhibition of endoplasmic reticulum stress. Evid Based Complement Alternat Med 2011; 2011.
-
(2011)
Evid Based Complement Alternat Med
, vol.2011
-
-
Zhang, R.1
Kim, J.S.2
Kang, K.A.3
Piao, M.J.4
Kim, K.C.5
Hyun, J.W.6
-
53
-
-
84885455062
-
The eIF2alpha/ATF4 pathway is essential for stress-induced autophagy gene expression
-
23804767
-
B'Chir W, Maurin AC, Carraro V, Averous J, Jousse C, Muranishi Y, Parry L, Stepien G, Fafournoux P, Bruhat A. The eIF2alpha/ATF4 pathway is essential for stress-induced autophagy gene expression. Nucleic Acids Res 2013; 41:7683-99; PMID:23804767; http://dx.doi.org/10.1093/nar/gkt563
-
(2013)
Nucleic Acids Res
, vol.41
, pp. 7683-7699
-
-
B'Chir, W.1
Maurin, A.C.2
Carraro, V.3
Averous, J.4
Jousse, C.5
Muranishi, Y.6
Parry, L.7
Stepien, G.8
Fafournoux, P.9
Bruhat, A.10
-
54
-
-
84879607395
-
Stress-induced self-cannibalism: on the regulation of autophagy by endoplasmic reticulum stress
-
23052213
-
Deegan S, Saveljeva S, Gorman AM, Samali A. Stress-induced self-cannibalism:on the regulation of autophagy by endoplasmic reticulum stress. Cell Mol Life Sci 2013; 70:2425-41; PMID:23052213; http://dx.doi.org/10.1007/s00018-012-1173-4
-
(2013)
Cell Mol Life Sci
, vol.70
, pp. 2425-2441
-
-
Deegan, S.1
Saveljeva, S.2
Gorman, A.M.3
Samali, A.4
-
55
-
-
0034723235
-
Coupling of stress in the ER to activation of JNK protein kinases by transmembrane protein kinase IRE1
-
10650002
-
Urano F, Wang X, Bertolotti A, Zhang Y, Chung P, Harding HP, Ron D. Coupling of stress in the ER to activation of JNK protein kinases by transmembrane protein kinase IRE1. Science 2000; 287:664-6; PMID:10650002; http://dx.doi.org/10.1126/science.287.5453.664
-
(2000)
Science
, vol.287
, pp. 664-666
-
-
Urano, F.1
Wang, X.2
Bertolotti, A.3
Zhang, Y.4
Chung, P.5
Harding, H.P.6
Ron, D.7
-
56
-
-
84862027112
-
Activation of JNK and high expression level of CD133 predict a poor response to sorafenib in hepatocellular carcinoma
-
22596232
-
Hagiwara S, Kudo M, Nagai T, Inoue T, Ueshima K, Nishida N, Watanabe T, Sakurai T. Activation of JNK and high expression level of CD133 predict a poor response to sorafenib in hepatocellular carcinoma. Br J Cancer 2012; 106:1997-2003; PMID:22596232; http://dx.doi.org/10.1038/bjc.2012.145
-
(2012)
Br J Cancer
, vol.106
, pp. 1997-2003
-
-
Hagiwara, S.1
Kudo, M.2
Nagai, T.3
Inoue, T.4
Ueshima, K.5
Nishida, N.6
Watanabe, T.7
Sakurai, T.8
-
57
-
-
84884318201
-
Targeting mixed lineage kinases in ER-positive breast cancer cells leads to G2/M cell cycle arrest and apoptosis
-
23902710
-
Wang L, Gallo KA, Conrad SE. Targeting mixed lineage kinases in ER-positive breast cancer cells leads to G2/M cell cycle arrest and apoptosis. Oncotarget 2013; 4:1158-71; PMID:23902710; http://dx.doi.org/10.18632/oncotarget.1093
-
(2013)
Oncotarget
, vol.4
, pp. 1158-1171
-
-
Wang, L.1
Gallo, K.A.2
Conrad, S.E.3
-
58
-
-
78751671550
-
ACS chemical neuroscience spotlight on CEP-1347
-
22778853
-
Sweeney ZK, Lewcock JW. ACS chemical neuroscience spotlight on CEP-1347. ACS Chem Neurosci 2011; 2:3-4; PMID:22778853; http://dx.doi.org/10.1021/cn1000793
-
(2011)
ACS Chem Neurosci
, vol.2
, pp. 3-4
-
-
Sweeney, Z.K.1
Lewcock, J.W.2
-
59
-
-
68149139456
-
The autophagy effector Beclin 1: a novel BH3-only protein
-
19641499
-
Sinha S, Levine B. The autophagy effector Beclin 1:a novel BH3-only protein. Oncogene 2008; 27 Suppl 1:S137-48; PMID:19641499; http://dx.doi.org/10.1038/onc.2009.51
-
(2008)
Oncogene
, vol.27
, pp. S137-S148
-
-
Sinha, S.1
Levine, B.2
-
60
-
-
80052606545
-
High Beclin 1 expression defines a poor prognosis in endometrial adenocarcinomas
-
21741077
-
Giatromanolaki A, Koukourakis MI, Koutsopoulos A, Chloropoulou P, Liberis V, Sivridis E. High Beclin 1 expression defines a poor prognosis in endometrial adenocarcinomas. Gynecol Oncol 2011; 123:147-51; PMID:21741077; http://dx.doi.org/10.1016/j.ygyno.2011.06.023
-
(2011)
Gynecol Oncol
, vol.123
, pp. 147-151
-
-
Giatromanolaki, A.1
Koukourakis, M.I.2
Koutsopoulos, A.3
Chloropoulou, P.4
Liberis, V.5
Sivridis, E.6
-
61
-
-
84890850438
-
Autophagy inhibition suppresses pulmonary metastasis of HCC in mice via impairing anoikis resistance and colonization of HCC cells
-
24157892
-
Peng YF, Shi YH, Ding ZB, Ke AW, Gu CY, Hui B, Zhou J, Qiu SJ, Dai Z, Fan J. Autophagy inhibition suppresses pulmonary metastasis of HCC in mice via impairing anoikis resistance and colonization of HCC cells. Autophagy 2013; 9:2056-68; PMID:24157892; http://dx.doi.org/10.4161/auto.26398
-
(2013)
Autophagy
, vol.9
, pp. 2056-2068
-
-
Peng, Y.F.1
Shi, Y.H.2
Ding, Z.B.3
Ke, A.W.4
Gu, C.Y.5
Hui, B.6
Zhou, J.7
Qiu, S.J.8
Dai, Z.9
Fan, J.10
-
62
-
-
79959968916
-
The novel estrogen-induced gene EIG121 regulates autophagy and promotes cell survival under stress
-
21072319
-
Deng L, Feng J, Broaddus RR. The novel estrogen-induced gene EIG121 regulates autophagy and promotes cell survival under stress. Cell Death Dis 2010; 1:e32; PMID:21072319; http://dx.doi.org/10.1038/cddis.2010.9
-
(2010)
Cell Death Dis
, vol.1
, pp. e32
-
-
Deng, L.1
Feng, J.2
Broaddus, R.R.3
-
63
-
-
84901001901
-
Involvement of autophagy in cervical, endometrial and ovarian cancer
-
24122662
-
Orfanelli T, Jeong JM, Doulaveris G, Holcomb K, Witkin SS. Involvement of autophagy in cervical, endometrial and ovarian cancer. Int J Cancer 2014; 135:519-28; PMID:24122662; http://dx.doi.org/10.1002/ijc.28524
-
(2014)
Int J Cancer
, vol.135
, pp. 519-528
-
-
Orfanelli, T.1
Jeong, J.M.2
Doulaveris, G.3
Holcomb, K.4
Witkin, S.S.5
-
64
-
-
84953877584
-
Cross-cancer profiling of molecular alterations within the human autophagy interaction network
-
Lebovitz CB, Robertson AG, Goya R, Jones SJ, Morin RD, Marra MA, et al. Cross-cancer profiling of molecular alterations within the human autophagy interaction network. Autophagy 2015; 11:1668-87; PMID:26208877; http://dx.doi.org/10.1080/15548627.2015.1067362
-
Autophagy 2015; 11:1668-87; PMID:26208877
-
-
Lebovitz, C.B.1
Robertson, A.G.2
Goya, R.3
Jones, S.J.4
Morin, R.D.5
Marra, M.A.6
-
65
-
-
78650825936
-
Autophagy in endometrial carcinomas and prognostic relevance of ‘stone-like’ structures (SLS): what is destined for the atypical endometrial hyperplasia?
-
21099253
-
Sivridis E, Giatromanolaki A, Liberis V, Koukourakis MI. Autophagy in endometrial carcinomas and prognostic relevance of ‘stone-like’ structures (SLS):what is destined for the atypical endometrial hyperplasia? Autophagy 2011; 7:74-82; PMID:21099253; http://dx.doi.org/10.4161/auto.7.1.13947
-
(2011)
Autophagy
, vol.7
, pp. 74-82
-
-
Sivridis, E.1
Giatromanolaki, A.2
Liberis, V.3
Koukourakis, M.I.4
-
66
-
-
2042458747
-
Relationships between drug activity in NCI preclinical in vitro and in vivo models and early clinical trials
-
11355958
-
Johnson JI, Decker S, Zaharevitz D, Rubinstein LV, Venditti JM, Schepartz S, Kalyandrug S, Christian M, Arbuck S, Hollingshead M, et al. Relationships between drug activity in NCI preclinical in vitro and in vivo models and early clinical trials. Br J Cancer 2001; 84:1424-31; PMID:11355958; http://dx.doi.org/10.1054/bjoc.2001.1796
-
(2001)
Br J Cancer
, vol.84
, pp. 1424-1431
-
-
Johnson, J.I.1
Decker, S.2
Zaharevitz, D.3
Rubinstein, L.V.4
Venditti, J.M.5
Schepartz, S.6
Kalyandrug, S.7
Christian, M.8
Arbuck, S.9
Hollingshead, M.10
-
67
-
-
84906895091
-
Patient-derived xenograft models: an emerging platform for translational cancer research
-
25185190
-
Hidalgo M, Amant F, Biankin AV, Budinska E, Byrne AT, Caldas C, Clarke RB, de Jong S, Jonkers J, Mælandsmo GM, et al. Patient-derived xenograft models:an emerging platform for translational cancer research. Cancer Discov 2014; 4:998-1013; PMID:25185190; http://dx.doi.org/10.1158/2159-8290.CD-14-0001
-
(2014)
Cancer Discov
, vol.4
, pp. 998-1013
-
-
Hidalgo, M.1
Amant, F.2
Biankin, A.V.3
Budinska, E.4
Byrne, A.T.5
Caldas, C.6
Clarke, R.B.7
de Jong, S.8
Jonkers, J.9
Mælandsmo, G.M.10
-
68
-
-
84904855170
-
Sorafenib in radioactive iodine-refractory, locally advanced or metastatic differentiated thyroid cancer: a randomised, double-blind, phase 3 trial
-
24768112
-
Brose MS, Nutting CM, Jarzab B, Elisei R, Siena S, Bastholt L, de la Fouchardiere C, Pacini F, Paschke R, Shong YK, et al. Sorafenib in radioactive iodine-refractory, locally advanced or metastatic differentiated thyroid cancer:a randomised, double-blind, phase 3 trial. Lancet 2014; 384:319-28; PMID:24768112; http://dx.doi.org/10.1016/S0140-6736(14)60421-9
-
(2014)
Lancet
, vol.384
, pp. 319-328
-
-
Brose, M.S.1
Nutting, C.M.2
Jarzab, B.3
Elisei, R.4
Siena, S.5
Bastholt, L.6
de la Fouchardiere, C.7
Pacini, F.8
Paschke, R.9
Shong, Y.K.10
-
69
-
-
57349191046
-
Sorafenib in advanced hepatocellular carcinoma
-
18650514
-
Llovet JM, Ricci S, Mazzaferro V, Hilgard P, Gane E, Blanc JF, de Oliveira AC, Santoro A, Raoul JL, Forner A, et al. Sorafenib in advanced hepatocellular carcinoma. N Engl J Med 2008; 359:378-90; PMID:18650514; http://dx.doi.org/10.1056/NEJMoa0708857
-
(2008)
N Engl J Med
, vol.359
, pp. 378-390
-
-
Llovet, J.M.1
Ricci, S.2
Mazzaferro, V.3
Hilgard, P.4
Gane, E.5
Blanc, J.F.6
de Oliveira, A.C.7
Santoro, A.8
Raoul, J.L.9
Forner, A.10
-
70
-
-
84868237540
-
Experience with sorafenib in the treatment of advanced renal cell carcinoma
-
23205057
-
Procopio G, Verzoni E, Testa I, Nicolai N, Salvioni R, Debraud F. Experience with sorafenib in the treatment of advanced renal cell carcinoma. Ther Adv Urol 2012; 4:303-13; PMID:23205057; http://dx.doi.org/10.1177/1756287212457216
-
(2012)
Ther Adv Urol
, vol.4
, pp. 303-313
-
-
Procopio, G.1
Verzoni, E.2
Testa, I.3
Nicolai, N.4
Salvioni, R.5
Debraud, F.6
-
71
-
-
84884327551
-
Mechanisms of resistance to sorafenib and the corresponding strategies in hepatocellular carcinoma
-
23898367
-
Zhai B, Sun XY. Mechanisms of resistance to sorafenib and the corresponding strategies in hepatocellular carcinoma. World J Hepatol 2013; 5:345-52; PMID:23898367; http://dx.doi.org/10.4254/wjh.v5.i7.345
-
(2013)
World J Hepatol
, vol.5
, pp. 345-352
-
-
Zhai, B.1
Sun, X.Y.2
-
72
-
-
84857698541
-
Inhibition of autophagy potentiates the antitumor effect of the multikinase inhibitor sorafenib in hepatocellular carcinoma
-
21858812
-
Shimizu S, Takehara T, Hikita H, Kodama T, Tsunematsu H, Miyagi T, Hosui A, Ishida H, Tatsumi T, Kanto T, et al. Inhibition of autophagy potentiates the antitumor effect of the multikinase inhibitor sorafenib in hepatocellular carcinoma. Int J Cancer 2012; 131:548-57; PMID:21858812; http://dx.doi.org/10.1002/ijc.26374
-
(2012)
Int J Cancer
, vol.131
, pp. 548-557
-
-
Shimizu, S.1
Takehara, T.2
Hikita, H.3
Kodama, T.4
Tsunematsu, H.5
Miyagi, T.6
Hosui, A.7
Ishida, H.8
Tatsumi, T.9
Kanto, T.10
-
73
-
-
84880743543
-
Sorafenib enhances proteasome inhibitor-mediated cytotoxicity via inhibition of unfolded protein response and keratin phosphorylation
-
23727131
-
Honma Y, Harada M. Sorafenib enhances proteasome inhibitor-mediated cytotoxicity via inhibition of unfolded protein response and keratin phosphorylation. Exp Cell Res 2013; 319:2166-78; PMID:23727131; http://dx.doi.org/10.1016/j.yexcr.2013.05.023
-
(2013)
Exp Cell Res
, vol.319
, pp. 2166-2178
-
-
Honma, Y.1
Harada, M.2
-
74
-
-
37649005234
-
Autophagy in the pathogenesis of disease
-
18191218
-
Levine B, Kroemer G. Autophagy in the pathogenesis of disease. Cell 2008; 132:27-42; PMID:18191218; http://dx.doi.org/10.1016/j.cell.2007.12.018
-
(2008)
Cell
, vol.132
, pp. 27-42
-
-
Levine, B.1
Kroemer, G.2
-
75
-
-
84929517189
-
Autophagy is upregulated in ovarian endometriosis: a possible interplay with p53 and heme oxygenase-1
-
Allavena G, Carrarelli P, Del Bello B, Luisi S, Petraglia F, Maellaro E. Autophagy is upregulated in ovarian endometriosis:a possible interplay with p53 and heme oxygenase-1. Fertil Steril 2015; 103:1244-51e1; http://dx.doi.org/10.1016/j.fertnstert.2015.02.007
-
(2015)
Fertil Steril
, vol.103
, pp. 51e1-1244
-
-
Allavena, G.1
Carrarelli, P.2
Del Bello, B.3
Luisi, S.4
Petraglia, F.5
Maellaro, E.6
-
76
-
-
84860628759
-
The role of autophagy in human endometrium
-
22088918
-
Choi J, Jo M, Lee E, Oh YK, Choi D. The role of autophagy in human endometrium. Biol Reprod 2012; 86:70; PMID:22088918; http://dx.doi.org/10.1095/biolreprod.111.096206
-
(2012)
Biol Reprod
, vol.86
, pp. 70
-
-
Choi, J.1
Jo, M.2
Lee, E.3
Oh, Y.K.4
Choi, D.5
-
77
-
-
84922516153
-
The expression of the autophagy gene beclin-1 mRNA and protein in ectopic and eutopic endometrium of patients with endometriosis
-
25780525
-
Zhang L, Liu Y, Xu Y, Wu H, Wei Z, Cao Y. The expression of the autophagy gene beclin-1 mRNA and protein in ectopic and eutopic endometrium of patients with endometriosis. Int J Fertil Steril 2015; 8:429-36; PMID:25780525
-
(2015)
Int J Fertil Steril
, vol.8
, pp. 429-436
-
-
Zhang, L.1
Liu, Y.2
Xu, Y.3
Wu, H.4
Wei, Z.5
Cao, Y.6
-
78
-
-
44949237240
-
JNK1-mediated phosphorylation of Bcl-2 regulates starvation-induced autophagy
-
18570871
-
Wei Y, Pattingre S, Sinha S, Bassik M, Levine B. JNK1-mediated phosphorylation of Bcl-2 regulates starvation-induced autophagy. Mol Cell 2008; 30:678-88; PMID:18570871; http://dx.doi.org/10.1016/j.molcel.2008.06.001
-
(2008)
Mol Cell
, vol.30
, pp. 678-688
-
-
Wei, Y.1
Pattingre, S.2
Sinha, S.3
Bassik, M.4
Levine, B.5
-
79
-
-
84864942148
-
Bim inhibits autophagy by recruiting Beclin 1 to microtubules
-
22742832
-
Luo S, Garcia-Arencibia M, Zhao R, Puri C, Toh PP, Sadiq O, Rubinsztein DC. Bim inhibits autophagy by recruiting Beclin 1 to microtubules. Mol Cell 2012; 47:359-70; PMID:22742832; http://dx.doi.org/10.1016/j.molcel.2012.05.040
-
(2012)
Mol Cell
, vol.47
, pp. 359-370
-
-
Luo, S.1
Garcia-Arencibia, M.2
Zhao, R.3
Puri, C.4
Toh, P.P.5
Sadiq, O.6
Rubinsztein, D.C.7
-
80
-
-
77951212660
-
Autophagy and metastasis: another double-edged sword
-
19945838
-
Kenific CM, Thorburn A, Debnath J. Autophagy and metastasis:another double-edged sword. Curr Opin Cell Biol 2010; 22:241-5; PMID:19945838; http://dx.doi.org/10.1016/j.ceb.2009.10.008
-
(2010)
Curr Opin Cell Biol
, vol.22
, pp. 241-245
-
-
Kenific, C.M.1
Thorburn, A.2
Debnath, J.3
-
81
-
-
84944076036
-
Metabolic reprogramming induces resistance to anti-NOTCH1 therapies in T cell acute lymphoblastic leukemia
-
26390244
-
Herranz D, Ambesi-Impiombato A, Sudderth J, Sanchez-Martin M, Belver L, Tosello V, Xu L, Wendorff AA, Castillo M, Haydu JE, et al. Metabolic reprogramming induces resistance to anti-NOTCH1 therapies in T cell acute lymphoblastic leukemia. Nat Med 2015; 21:1182-9; PMID:26390244; http://dx.doi.org/10.1038/nm.3955
-
(2015)
Nat Med
, vol.21
, pp. 1182-1189
-
-
Herranz, D.1
Ambesi-Impiombato, A.2
Sudderth, J.3
Sanchez-Martin, M.4
Belver, L.5
Tosello, V.6
Xu, L.7
Wendorff, A.A.8
Castillo, M.9
Haydu, J.E.10
-
82
-
-
40449086885
-
Blocked autophagy sensitizes resistant carcinoma cells to radiation therapy
-
18316613
-
Apel A, Herr I, Schwarz H, Rodemann HP, Mayer A. Blocked autophagy sensitizes resistant carcinoma cells to radiation therapy. Cancer Res 2008; 68:1485-94; PMID:18316613; http://dx.doi.org/10.1158/0008-5472.CAN-07-0562
-
(2008)
Cancer Res
, vol.68
, pp. 1485-1494
-
-
Apel, A.1
Herr, I.2
Schwarz, H.3
Rodemann, H.P.4
Mayer, A.5
-
83
-
-
66449122303
-
Targeting autophagy potentiates tyrosine kinase inhibitor-induced cell death in Philadelphia chromosome-positive cells, including primary CML stem cells
-
19363292
-
Bellodi C, Lidonnici MR, Hamilton A, Helgason GV, Soliera AR, Ronchetti M, Galavotti S, Young KW, Selmi T, Yacobi R, et al. Targeting autophagy potentiates tyrosine kinase inhibitor-induced cell death in Philadelphia chromosome-positive cells, including primary CML stem cells. J Clin Invest 2009; 119:1109-23; PMID:19363292; http://dx.doi.org/10.1172/JCI35660
-
(2009)
J Clin Invest
, vol.119
, pp. 1109-1123
-
-
Bellodi, C.1
Lidonnici, M.R.2
Hamilton, A.3
Helgason, G.V.4
Soliera, A.R.5
Ronchetti, M.6
Galavotti, S.7
Young, K.W.8
Selmi, T.9
Yacobi, R.10
-
84
-
-
66349119373
-
Stage-specific effect of inhibition of autophagy on chemotherapy-induced cytotoxicity
-
19270491
-
Shingu T, Fujiwara K, Bogler O, Akiyama Y, Moritake K, Shinojima N, Tamada Y, Yokoyama T, Kondo S. Stage-specific effect of inhibition of autophagy on chemotherapy-induced cytotoxicity. Autophagy 2009; 5:537-9; PMID:19270491; http://dx.doi.org/10.4161/auto.5.4.8164
-
(2009)
Autophagy
, vol.5
, pp. 537-539
-
-
Shingu, T.1
Fujiwara, K.2
Bogler, O.3
Akiyama, Y.4
Moritake, K.5
Shinojima, N.6
Tamada, Y.7
Yokoyama, T.8
Kondo, S.9
-
85
-
-
67650885510
-
Autophagy facilitates the development of breast cancer resistance to the anti-HER2 monoclonal antibody trastuzumab
-
19606230
-
Vazquez-Martin A, Oliveras-Ferraros C, Menendez JA. Autophagy facilitates the development of breast cancer resistance to the anti-HER2 monoclonal antibody trastuzumab. PLoS One 2009; 4:e6251; PMID:19606230; http://dx.doi.org/10.1371/journal.pone.0006251
-
(2009)
PLoS One
, vol.4
, pp. e6251
-
-
Vazquez-Martin, A.1
Oliveras-Ferraros, C.2
Menendez, J.A.3
-
86
-
-
80052470635
-
Tumor engraftment in nude mice and enrichment in stroma- related gene pathways predict poor survival and resistance to gemcitabine in patients with pancreatic cancer
-
21742805
-
Garrido-Laguna I, Uson M, Rajeshkumar NV, Tan AC, de Oliveira E, Karikari C, Villaroel MC, Salomon A, Taylor G, Sharma R, et al. Tumor engraftment in nude mice and enrichment in stroma- related gene pathways predict poor survival and resistance to gemcitabine in patients with pancreatic cancer. Clin Cancer Res 2011; 17:5793-800; PMID:21742805; http://dx.doi.org/10.1158/1078-0432.CCR-11-0341
-
(2011)
Clin Cancer Res
, vol.17
, pp. 5793-5800
-
-
Garrido-Laguna, I.1
Uson, M.2
Rajeshkumar, N.V.3
Tan, A.C.4
de Oliveira, E.5
Karikari, C.6
Villaroel, M.C.7
Salomon, A.8
Taylor, G.9
Sharma, R.10
-
87
-
-
34447123764
-
A new model of patient tumor-derived breast cancer xenografts for preclinical assays
-
17606733
-
Marangoni E, Vincent-Salomon A, Auger N, Degeorges A, Assayag F, de Cremoux P, de Plater L, Guyader C, De Pinieux G, Judde JG, et al. A new model of patient tumor-derived breast cancer xenografts for preclinical assays. Clin Cancer Res 2007; 13:3989-98; PMID:17606733; http://dx.doi.org/10.1158/1078-0432.CCR-07-0078
-
(2007)
Clin Cancer Res
, vol.13
, pp. 3989-3998
-
-
Marangoni, E.1
Vincent-Salomon, A.2
Auger, N.3
Degeorges, A.4
Assayag, F.5
de Cremoux, P.6
de Plater, L.7
Guyader, C.8
De Pinieux, G.9
Judde, J.G.10
-
88
-
-
80051588648
-
A pilot clinical study of treatment guided by personalized tumorgrafts in patients with advanced cancer
-
21673092
-
Hidalgo M, Bruckheimer E, Rajeshkumar NV, Garrido-Laguna I, De Oliveira E, Rubio-Viqueira B, Strawn S, Wick MJ, Martell J, Sidransky D. A pilot clinical study of treatment guided by personalized tumorgrafts in patients with advanced cancer. Mol Cancer Ther 2011; 10:1311-6; PMID:21673092; http://dx.doi.org/10.1158/1535-7163.MCT-11-0233
-
(2011)
Mol Cancer Ther
, vol.10
, pp. 1311-1316
-
-
Hidalgo, M.1
Bruckheimer, E.2
Rajeshkumar, N.V.3
Garrido-Laguna, I.4
De Oliveira, E.5
Rubio-Viqueira, B.6
Strawn, S.7
Wick, M.J.8
Martell, J.9
Sidransky, D.10
-
89
-
-
77953198644
-
A novel three-dimensional culture system of polarized epithelial cells to study endometrial carcinogenesis
-
20395448
-
Eritja N, Llobet D, Domingo M, Santacana M, Yeramian A, Matias-Guiu X, Dolcet X. A novel three-dimensional culture system of polarized epithelial cells to study endometrial carcinogenesis. Am J Pathol 2010; 176:2722-31; PMID:20395448; http://dx.doi.org/10.2353/ajpath.2010.090974
-
(2010)
Am J Pathol
, vol.176
, pp. 2722-2731
-
-
Eritja, N.1
Llobet, D.2
Domingo, M.3
Santacana, M.4
Yeramian, A.5
Matias-Guiu, X.6
Dolcet, X.7
-
90
-
-
84866002291
-
The cBio cancer genomics portal: an open platform for exploring multidimensional cancer genomics data
-
22588877
-
Cerami E, Gao J, Dogrusoz U, Gross BE, Sumer SO, Aksoy BA, Jacobsen A, Byrne CJ, Heuer ML, Larsson E, et al. The cBio cancer genomics portal:an open platform for exploring multidimensional cancer genomics data. Cancer Discov 2012; 2:401-4; PMID:22588877; http://dx.doi.org/10.1158/2159-8290.CD-12-0095
-
(2012)
Cancer Discov
, vol.2
, pp. 401-404
-
-
Cerami, E.1
Gao, J.2
Dogrusoz, U.3
Gross, B.E.4
Sumer, S.O.5
Aksoy, B.A.6
Jacobsen, A.7
Byrne, C.J.8
Heuer, M.L.9
Larsson, E.10
-
91
-
-
84875740314
-
Integrative analysis of complex cancer genomics and clinical profiles using the cBioPortal
-
23550210
-
Gao J, Aksoy BA, Dogrusoz U, Dresdner G, Gross B, Sumer SO, Sun Y, Jacobsen A, Sinha R, Larsson E, et al. Integrative analysis of complex cancer genomics and clinical profiles using the cBioPortal. Sci Signal 2013; 6:pl1; PMID:23550210; http://dx.doi.org/10.1126/scisignal.2004088
-
(2013)
Sci Signal
, vol.6
, pp. pl1
-
-
Gao, J.1
Aksoy, B.A.2
Dogrusoz, U.3
Dresdner, G.4
Gross, B.5
Sumer, S.O.6
Sun, Y.7
Jacobsen, A.8
Sinha, R.9
Larsson, E.10
-
92
-
-
0036947892
-
Robust estimators for expression analysis
-
12490442
-
Hubbell E, Liu WM, Mei R. Robust estimators for expression analysis. Bioinformatics 2002; 18:1585-92; PMID:12490442; http://dx.doi.org/10.1093/bioinformatics/18.12.1585
-
(2002)
Bioinformatics
, vol.18
, pp. 1585-1592
-
-
Hubbell, E.1
Liu, W.M.2
Mei, R.3
-
93
-
-
0034069495
-
Gene ontology: tool for the unification of biology. The Gene Ontology Consortium
-
10802651
-
Ashburner M, Ball CA, Blake JA, Botstein D, Butler H, Cherry JM, Davis AP, Dolinski K, Dwight SS, Eppig JT, et al. Gene ontology:tool for the unification of biology. The Gene Ontology Consortium. Nat Genet 2000; 25:25-9; PMID:10802651; http://dx.doi.org/10.1038/75556
-
(2000)
Nat Genet
, vol.25
, pp. 25-29
-
-
Ashburner, M.1
Ball, C.A.2
Blake, J.A.3
Botstein, D.4
Butler, H.5
Cherry, J.M.6
Davis, A.P.7
Dolinski, K.8
Dwight, S.S.9
Eppig, J.T.10
-
94
-
-
77955458622
-
Loss of human Greatwall results in G2 arrest and multiple mitotic defects due to deregulation of the cyclin B-Cdc2/PP2A balance
-
20538976
-
Burgess A, Vigneron S, Brioudes E, Labbe JC, Lorca T, Castro A. Loss of human Greatwall results in G2 arrest and multiple mitotic defects due to deregulation of the cyclin B-Cdc2/PP2A balance. Proc Natl Acad Sci U S A 2010; 107:12564-9; PMID:20538976; http://dx.doi.org/10.1073/pnas.0914191107
-
(2010)
Proc Natl Acad Sci U S A
, vol.107
, pp. 12564-12569
-
-
Burgess, A.1
Vigneron, S.2
Brioudes, E.3
Labbe, J.C.4
Lorca, T.5
Castro, A.6
-
95
-
-
84899714028
-
Partial inhibition of Cdk1 in G 2 phase overrides the SAC and decouples mitotic events
-
24626186
-
McCloy RA, Rogers S, Caldon CE, Lorca T, Castro A, Burgess A. Partial inhibition of Cdk1 in G 2 phase overrides the SAC and decouples mitotic events. Cell Cycle 2014; 13:1400-12; PMID:24626186; http://dx.doi.org/10.4161/cc.28401
-
(2014)
Cell Cycle
, vol.13
, pp. 1400-1412
-
-
McCloy, R.A.1
Rogers, S.2
Caldon, C.E.3
Lorca, T.4
Castro, A.5
Burgess, A.6
|