메뉴 건너뛰기




Volumn 119, Issue 25, 2012, Pages 6089-6098

Inhibition of Bcl-2 antiapoptotic members by obatoclax potently enhances sorafenib-induced apoptosis in human myeloid leukemia cells through a Bim-dependent process

Author keywords

[No Author keywords available]

Indexed keywords

BIM PROTEIN; CD34 ANTIGEN; GREEN FLUORESCENT PROTEIN; OBATOCLAX; PROTEIN BCL 2; PROTEIN BCL XL; PROTEIN MCL 1; SHORT HAIRPIN RNA; SORAFENIB;

EID: 84862737555     PISSN: 00064971     EISSN: 15280020     Source Type: Journal    
DOI: 10.1182/blood-2011-09-378141     Document Type: Article
Times cited : (97)

References (50)
  • 3
    • 33644954099 scopus 로고    scopus 로고
    • Loss of the tissue-specific proapoptotic BH3-only protein Nbk/Bik is a unifying feature of renal cell carcinoma
    • Sturm I, Stephan C, Gillissen B, et al. Loss of the tissue-specific proapoptotic BH3-only protein Nbk/Bik is a unifying feature of renal cell carcinoma. Cell Death Differ. 2006;13(4):619-627.
    • (2006) Cell Death Differ , vol.13 , Issue.4 , pp. 619-627
    • Sturm, I.1    Stephan, C.2    Gillissen, B.3
  • 4
    • 37649023004 scopus 로고    scopus 로고
    • Small molecule obatoclax (GX15-070) antagonizes MCL-1 and overcomes MCL-1-mediated resistance to apoptosis
    • Nguyen M, Marcellus RC, Roulston A, et al. Small molecule obatoclax (GX15-070) antagonizes MCL-1 and overcomes MCL-1-mediated resistance to apoptosis. Proc Natl Acad Sci U S A. 2007;104(49):19512-19517.
    • (2007) Proc Natl Acad Sci U S A , vol.104 , Issue.49 , pp. 19512-19517
    • Nguyen, M.1    Marcellus, R.C.2    Roulston, A.3
  • 5
    • 44849133234 scopus 로고    scopus 로고
    • Mechanisms of antileukemic activity of the novel Bcl-2 homology domain-3 mimetic GX15-070 (obatoclax)
    • Konopleva M, Watt J, Contractor R, et al. Mechanisms of antileukemic activity of the novel Bcl-2 homology domain-3 mimetic GX15-070 (obatoclax). Cancer Res. 2008;68(9):3413-3420.
    • (2008) Cancer Res , vol.68 , Issue.9 , pp. 3413-3420
    • Konopleva, M.1    Watt, J.2    Contractor, R.3
  • 6
    • 34249982915 scopus 로고    scopus 로고
    • Preclinical studies of the pan-Bcl inhibitor obatoclax (GX015-070) in multiple myeloma
    • DOI 10.1182/blood-2006-10-047951
    • Trudel S, Li ZH, Rauw J, et al. Preclinical studies of the pan-Bcl inhibitor obatoclax (GX015-070) in multiple myeloma. Blood. 2007;109(12):5430- 5438. (Pubitemid 46890566)
    • (2007) Blood , vol.109 , Issue.12 , pp. 5430-5438
    • Trudel, S.1    Zhi, H.L.2    Rauw, J.3    Tiedemann, R.E.4    Xiao, Y.W.5    Stewart, A.K.6
  • 7
    • 58149340656 scopus 로고    scopus 로고
    • A phase I study of the pan bcl-2 family inhibitor obatoclax mesylate in patients with advanced hematologic malignancies
    • Schimmer AD, O'Brien S, Kantarjian H, et al. A phase I study of the pan bcl-2 family inhibitor obatoclax mesylate in patients with advanced hematologic malignancies. Clin Cancer Res. 2008; 14(24):8295-8301.
    • (2008) Clin Cancer Res , vol.14 , Issue.24 , pp. 8295-8301
    • Schimmer, A.D.1    O'Brien, S.2    Kantarjian, H.3
  • 8
    • 77957029255 scopus 로고    scopus 로고
    • Phase II study of obatoclax mesylate (GX15- 070), a small-molecule BCL-2 family antagonist, for patients with myelofibrosis
    • Parikh SA, Kantarjian H, Schimmer A, et al. Phase II study of obatoclax mesylate (GX15- 070), a small-molecule BCL-2 family antagonist, for patients with myelofibrosis. Clin Lymphoma Myeloma Leuk. 2010;10(4):285-289.
    • (2010) Clin Lymphoma Myeloma Leuk , vol.10 , Issue.4 , pp. 285-289
    • Parikh, S.A.1    Kantarjian, H.2    Schimmer, A.3
  • 9
    • 58849086028 scopus 로고    scopus 로고
    • BH3 mimetic obatoclax enhances TRAIL-mediated apoptosis in human pancreatic cancer cells
    • Huang S, Okumura K, Sinicrope FA. BH3 mimetic obatoclax enhances TRAIL-mediated apoptosis in human pancreatic cancer cells. Clin Cancer Res. 2009;15(1):150-159.
    • (2009) Clin Cancer Res , vol.15 , Issue.1 , pp. 150-159
    • Huang, S.1    Okumura, K.2    Sinicrope, F.A.3
  • 10
    • 79959774131 scopus 로고    scopus 로고
    • Obatoclax induces Atg7-dependent autophagy independent of beclin-1 and BAX/BAK
    • McCoy F, Hurwitz J, McTavish N, et al. Obatoclax induces Atg7-dependent autophagy independent of beclin-1 and BAX/BAK. Cell Death Dis. 2010; 1(12):e108.
    • (2010) Cell Death Dis , vol.1 , Issue.12
    • McCoy, F.1    Hurwitz, J.2    McTavish, N.3
  • 11
    • 77951171023 scopus 로고    scopus 로고
    • Induction of autophagy-dependent necroptosis is required for childhood acute lymphoblastic leukemia cells to overcome glucocorticoid resistance
    • Bonapace L, Bornhauser BC, Schmitz M, et al. Induction of autophagy-dependent necroptosis is required for childhood acute lymphoblastic leukemia cells to overcome glucocorticoid resistance. J Clin Invest. 2010;120(4):1310-1323.
    • (2010) J Clin Invest , vol.120 , Issue.4 , pp. 1310-1323
    • Bonapace, L.1    Bornhauser, B.C.2    Schmitz, M.3
  • 13
    • 55749088393 scopus 로고    scopus 로고
    • Preclinical overview of sorafenib, a multikinase inhibitor that targets both Raf and VEGF and PDGF receptor tyrosine kinase signaling
    • Wilhelm SM, Adnane L, Newell P, et al. Preclinical overview of sorafenib, a multikinase inhibitor that targets both Raf and VEGF and PDGF receptor tyrosine kinase signaling. Mol Cancer Ther. 2008; 7(10):3129-3140.
    • (2008) Mol Cancer Ther , vol.7 , Issue.10 , pp. 3129-3140
    • Wilhelm, S.M.1    Adnane, L.2    Newell, P.3
  • 14
    • 33847195060 scopus 로고    scopus 로고
    • Antitumor activity of sorafenib in FLT3-driven leukemic cells
    • Auclair D, Miller D, Yatsula V, et al. Antitumor activity of sorafenib in FLT3-driven leukemic cells. Leukemia. 2007;21(3):439-445.
    • (2007) Leukemia , vol.21 , Issue.3 , pp. 439-445
    • Auclair, D.1    Miller, D.2    Yatsula, V.3
  • 16
    • 27444436166 scopus 로고    scopus 로고
    • Apoptosis induced by the kinase inhibitor BAY 43-9006 in human leukemia cells involves down-regulation of Mcl-1 through inhibition of translation
    • DOI 10.1074/jbc.M506551200
    • Rahmani M, Davis EM, Bauer C, Dent P, Grant S. Apoptosis induced by the kinase inhibitor BAY 43-9006 in human leukemia cells involves downregulation of Mcl-1 through inhibition of translation. J Biol Chem. 2005;280(42):35217-35227. (Pubitemid 41532709)
    • (2005) Journal of Biological Chemistry , vol.280 , Issue.42 , pp. 35217-35227
    • Rahmani, M.1    Davis, E.M.2    Bauer, C.3    Dent, P.4    Grant, S.5
  • 17
    • 27144502652 scopus 로고    scopus 로고
    • The role of Mcl-1 downregulation in the proapoptotic activity of the multikinase inhibitor BAY 43-9006
    • DOI 10.1038/sj.onc.1208841, PII 1208841
    • Yu C, Bruzek LM, Meng XW, et al. The role of Mcl-1 downregulation in the proapoptotic activity of the multikinase inhibitor BAY 43-9006. Oncogene. 2005;24(46):6861-6869. (Pubitemid 41509409)
    • (2005) Oncogene , vol.24 , Issue.46 , pp. 6861-6869
    • Yu, C.1    Bruzek, L.M.2    Xue, W.M.3    Gores, G.J.4    Carter, C.A.5    Kaufmann, S.H.6    Adjei, A.A.7
  • 18
    • 33846212284 scopus 로고    scopus 로고
    • Sorafenib blocks the RAF/MEK/ERK pathway, inhibits tumor angiogenesis, and induces tumor cell apoptosis in hepatocellular carcinoma model PLC/PRF/5
    • DOI 10.1158/0008-5472.CAN-06-1377
    • Liu L, Cao Y, Chen C, et al. Sorafenib blocks the RAF/MEK/ERK pathway, inhibits tumor angiogenesis, and induces tumor cell apoptosis in hepatocellular carcinoma model PLC/PRF/5. Cancer Res. 2006;66(24):11851-11858. (Pubitemid 46094197)
    • (2006) Cancer Research , vol.66 , Issue.24 , pp. 11851-11858
    • Liu, L.1    Cao, Y.2    Chen, C.3    Zhang, X.4    McNabola, A.5    Wilkie, D.6    Wilhelm, S.7    Lynch, M.8    Carter, C.9
  • 19
    • 35148900795 scopus 로고    scopus 로고
    • L down-regulation
    • DOI 10.1158/0008-5472.CAN-07-0598
    • Rosato RR, Almenara JA, Coe S, Grant S. The multikinase inhibitor sorafenib potentiates TRAIL lethality in human leukemia cells in association with Mcl-1 and cFLIPL down-regulation. Cancer Res. 2007;67(19):9490-9500. (Pubitemid 47535939)
    • (2007) Cancer Research , vol.67 , Issue.19 , pp. 9490-9500
    • Rosato, R.R.1    Almenara, J.A.2    Coe, S.3    Grant, S.4
  • 22
    • 79955809893 scopus 로고    scopus 로고
    • Sorafenib induces cell death in chronic lymphocytic leukemia by translational downregulation of Mcl-1
    • Huber S, Oelsner M, Decker T, et al. Sorafenib induces cell death in chronic lymphocytic leukemia by translational downregulation of Mcl-1. Leukemia. 2011;25(5):838-847.
    • (2011) Leukemia , vol.25 , Issue.5 , pp. 838-847
    • Huber, S.1    Oelsner, M.2    Decker, T.3
  • 23
    • 67650786255 scopus 로고    scopus 로고
    • BCL-2 family inhibitors enhance histone deacetylase inhibitor and sorafenib lethality via autophagy and overcome blockade of the extrinsic pathway to facilitate killing
    • Martin AP, Park MA, Mitchell C, et al. BCL-2 family inhibitors enhance histone deacetylase inhibitor and sorafenib lethality via autophagy and overcome blockade of the extrinsic pathway to facilitate killing. Mol Pharmacol. 2009;76(2):327-341.
    • (2009) Mol Pharmacol , vol.76 , Issue.2 , pp. 327-341
    • Martin, A.P.1    Park, M.A.2    Mitchell, C.3
  • 24
    • 77951620660 scopus 로고    scopus 로고
    • The let-7 family of microRNAs inhibits Bcl-xL expression and potentiates sorafenib-induced apoptosis in human hepatocellular carcinoma
    • Shimizu S, Takehara T, Hikita H, et al. The let-7 family of microRNAs inhibits Bcl-xL expression and potentiates sorafenib-induced apoptosis in human hepatocellular carcinoma. J Hepatol. 2010;52(5):698-704.
    • (2010) J Hepatol , vol.52 , Issue.5 , pp. 698-704
    • Shimizu, S.1    Takehara, T.2    Hikita, H.3
  • 25
    • 73349137309 scopus 로고    scopus 로고
    • The BH3-only protein Bim plays a critical role in leukemia cell death triggered by concomitant inhibition of the PI3K/Akt and MEK/ERK1/2 pathways
    • Rahmani M, Anderson A, Habibi JR, et al. The BH3-only protein Bim plays a critical role in leukemia cell death triggered by concomitant inhibition of the PI3K/Akt and MEK/ERK1/2 pathways. Blood. 2009;114(20):4507-4516.
    • (2009) Blood , vol.114 , Issue.20 , pp. 4507-4516
    • Rahmani, M.1    Anderson, A.2    Habibi, J.R.3
  • 26
    • 34547197343 scopus 로고    scopus 로고
    • The kinase inhibitor sorafenib induces cell death through a process involving induction of endoplasmic reticulum stress
    • DOI 10.1128/MCB.01080-06
    • Rahmani M, Davis EM, Crabtree TR, et al. The kinase inhibitor sorafenib induces cell death through a process involving induction of endoplasmic reticulum stress. Mol Cell Biol. 2007; 27(15):5499-5513. (Pubitemid 47124402)
    • (2007) Molecular and Cellular Biology , vol.27 , Issue.15 , pp. 5499-5513
    • Rahmani, M.1    Davis, E.M.2    Crabtree, T.R.3    Habibi, J.R.4    Nguyen, T.K.5    Dent, P.6    Grant, S.7
  • 27
    • 78649911452 scopus 로고    scopus 로고
    • Melanoma differentiation associated gene-7/interleukin-24 potently induces apoptosis in human myeloid leukemia cells through a process regulated by endoplasmic reticulum stress
    • Rahmani M, Mayo M, Dash R, et al. Melanoma differentiation associated gene-7/interleukin-24 potently induces apoptosis in human myeloid leukemia cells through a process regulated by endoplasmic reticulum stress. Mol Pharmacol. 2010; 78(6):1096-1104.
    • (2010) Mol Pharmacol , vol.78 , Issue.6 , pp. 1096-1104
    • Rahmani, M.1    Mayo, M.2    Dash, R.3
  • 28
    • 34548412863 scopus 로고    scopus 로고
    • + human leukemia cells in association with signal transducer and activator of transcription 5 inhibition and myeloid cell leukemia-1 down-regulation
    • DOI 10.1124/mol.106.033308
    • Rahmani M, Nguyen TK, Dent P, Grant S. The multikinase inhibitor sorafenib induces apoptosis in highly imatinib mesylate-resistant bcr/abl+ human leukemia cells in association with signal transducer and activator of transcription 5 inhibition and myeloid cell leukemia-1 down-regulation. Mol Pharmacol. 2007;72(3):788-795. (Pubitemid 47351213)
    • (2007) Molecular Pharmacology , vol.72 , Issue.3 , pp. 788-795
    • Rahmani, M.1    Nguyen, T.K.2    Dent, P.3    Grant, S.4
  • 29
    • 0036347348 scopus 로고    scopus 로고
    • The histone deacetylase inhibitor sodium butyrate interacts synergistically with phorbol myristate acetate (PMA) to induce mitochondrial damage and apoptosis in human myeloid leukemia cells through a tumor necrosis factor-alpha-mediated process
    • DOI 10.1006/excr.2002.5548
    • Rahmani M, Dai Y, Grant S. The histone deacetylase inhibitor sodium butyrate interacts synergistically with phorbol myristate acetate (PMA) to induce mitochondrial damage and apoptosis in human myeloid leukemia cells through a tumor necrosis factor-alpha-mediated process. Exp Cell Res. 2002;277(1):31-47. (Pubitemid 34948338)
    • (2002) Experimental Cell Research , vol.277 , Issue.1 , pp. 31-47
    • Rahmani, M.1    Dai, Y.2    Grant, S.3
  • 31
    • 0021118703 scopus 로고
    • Quantitative analysis of dose-effect relationships: The combined effects of multiple drugs or enzyme inhibitors
    • Chou TC, Talalay P. Quantitative analysis of dose-effect relationships: the combined effects of multiple drugs or enzyme inhibitors. Adv Enzyme Regul. 1984;22:27-55.
    • (1984) Adv Enzyme Regul , vol.22 , pp. 27-55
    • Chou, T.C.1    Talalay, P.2
  • 32
    • 0842281645 scopus 로고    scopus 로고
    • Cell Death: Critical Control Points
    • DOI 10.1016/S0092-8674(04)00046-7
    • Danial NN, Korsmeyer SJ. Cell death: critical control points. Cell. 2004;116(2):205-219. (Pubitemid 38167313)
    • (2004) Cell , vol.116 , Issue.2 , pp. 205-219
    • Danial, N.N.1    Korsmeyer, S.J.2
  • 33
    • 38149102519 scopus 로고    scopus 로고
    • GSK- 3beta inhibition enhances sorafenib-induced apoptosis in melanoma cell lines
    • Panka DJ, Cho DC, Atkins MB, Mier JW. GSK- 3beta inhibition enhances sorafenib-induced apoptosis in melanoma cell lines. J Biol Chem. 2008; 283(2):726-732.
    • (2008) J Biol Chem , vol.283 , Issue.2 , pp. 726-732
    • Panka, D.J.1    Cho, D.C.2    Atkins, M.B.3    Mier, J.W.4
  • 35
    • 34248362003 scopus 로고    scopus 로고
    • The BH3-mimetic GX15-070 synergizes with bortezomib in mantle cell lymphoma by enhancing Noxa-mediated activation of Bak
    • DOI 10.1182/blood-2006-07-034173
    • Perez-Galan P, Roue G, Villamor N, Campo E, Colomer D. The BH3-mimetic GX15-070 synergizes with bortezomib in mantle cell lymphoma by enhancing Noxa-mediated activation of Bak. Blood. 2007;109(10):4441-4449. (Pubitemid 46743414)
    • (2007) Blood , vol.109 , Issue.10 , pp. 4441-4449
    • Perez-Galan, P.1    Roue, G.2    Villamor, N.3    Campo, E.4    Colomer, D.5
  • 36
    • 69249139451 scopus 로고    scopus 로고
    • Human melanoma cells under endoplasmic reticulum stress are more susceptible to apoptosis induced by the BH3 mimetic obatoclax
    • Jiang CC, Wroblewski D, Yang F, Hersey P, Zhang XD. Human melanoma cells under endoplasmic reticulum stress are more susceptible to apoptosis induced by the BH3 mimetic obatoclax. Neoplasia. 2009;11(9):945-955.
    • (2009) Neoplasia , vol.11 , Issue.9 , pp. 945-955
    • Jiang, C.C.1    Wroblewski, D.2    Yang, F.3    Hersey, P.4    Zhang, X.D.5
  • 37
    • 79955961530 scopus 로고    scopus 로고
    • Defective regulation of autophagy upon leucine deprivation reveals a targetable liability of human melanoma cells in vitro and in vivo
    • Sheen JH, Zoncu R, Kim D, Sabatini DM. Defective regulation of autophagy upon leucine deprivation reveals a targetable liability of human melanoma cells in vitro and in vivo. Cancer Cell. 2011;19(5):613-628.
    • (2011) Cancer Cell , vol.19 , Issue.5 , pp. 613-628
    • Sheen, J.H.1    Zoncu, R.2    Kim, D.3    Sabatini, D.M.4
  • 38
    • 77951249136 scopus 로고    scopus 로고
    • Lysosome dysfunction triggers Atg7-dependent neural apoptosis
    • Walls KC, Ghosh AP, Franklin AV, et al. Lysosome dysfunction triggers Atg7-dependent neural apoptosis. J Biol Chem. 2010;285(14):10497-10507.
    • (2010) J Biol Chem , vol.285 , Issue.14 , pp. 10497-10507
    • Walls, K.C.1    Ghosh, A.P.2    Franklin, A.V.3
  • 39
    • 65949114300 scopus 로고    scopus 로고
    • Sorafenib induces apoptosis specifically in cells expressing BCR/ABL by inhibiting its kinase activity to activate the intrinsic mitochondrial pathway
    • Kurosu T, Ohki M, Wu N, Kagechika H, Miura O. Sorafenib induces apoptosis specifically in cells expressing BCR/ABL by inhibiting its kinase activity to activate the intrinsic mitochondrial pathway. Cancer Res. 2009;69(9):3927-3936.
    • (2009) Cancer Res , vol.69 , Issue.9 , pp. 3927-3936
    • Kurosu, T.1    Ohki, M.2    Wu, N.3    Kagechika, H.4    Miura, O.5
  • 40
    • 3142683869 scopus 로고    scopus 로고
    • MCL1 is phosphorylated in the PEST region and stabilized upon ERK activation in viable cells, and at additional sites with cytotoxic okadaic acid or taxol
    • DOI 10.1038/sj.onc.1207692
    • Domina AM, Vrana JA, Gregory MA, Hann SR, Craig RW. MCL1 is phosphorylated in the PEST region and stabilized upon ERK activation in viable cells, and at additional sites with cytotoxic okadaic acid or taxol. Oncogene. 2004;23(31): 5301-5315. (Pubitemid 39005806)
    • (2004) Oncogene , vol.23 , Issue.31 , pp. 5301-5315
    • Domina, A.M.1    Vrana, J.A.2    Gregory, M.A.3    Hann, S.R.4    Craig, R.W.5
  • 42
    • 0034283981 scopus 로고    scopus 로고
    • Apoptosis is rapidly triggered by antisense depletion of MCL-1 in differentiating U937 cells
    • Moulding DA, Giles RV, Spiller DG, et al. Apoptosis is rapidly triggered by antisense depletion of MCL-1 in differentiating U937 cells. Blood. 2000; 96(5):1756-1763. (Pubitemid 30661059)
    • (2000) Blood , vol.96 , Issue.5 , pp. 1756-1763
    • Moulding, D.A.1    Giles, R.V.2    Spiller, D.G.3    White, M.R.H.4    Tidd, D.M.5    Edwards, S.W.6
  • 43
    • 0038046166 scopus 로고    scopus 로고
    • Elimination of Mcl-1 is required for the initiation of apoptosis following ultraviolet irradiation
    • DOI 10.1101/gad.1093903
    • Nijhawan D, Fang M, Traer E, et al. Elimination of Mcl-1 is required for the initiation of apoptosis following ultraviolet irradiation. Genes Dev. 2003; 17(12):1475-1486. (Pubitemid 36734705)
    • (2003) Genes and Development , vol.17 , Issue.12 , pp. 1475-1486
    • Nijhawan, D.1    Fang, M.2    Traer, E.3    Zhong, Q.4    Gao, W.5    Du, F.6    Wang, X.7
  • 44
    • 84984559474 scopus 로고    scopus 로고
    • Sorafenib overcomes TRAIL resistance of hepatocellular carcinoma cells through the inhibition of STAT3
    • Chen KF, Tai WT, Liu TH, et al. Sorafenib overcomes TRAIL resistance of hepatocellular carcinoma cells through the inhibition of STAT3. Clin Cancer Res. 2010;16(21):5189-5199.
    • (2010) Clin Cancer Res , vol.16 , Issue.21 , pp. 5189-5199
    • Chen, K.F.1    Tai, W.T.2    Liu, T.H.3
  • 45
    • 15844422694 scopus 로고    scopus 로고
    • L and Bcl-2 on mitochondria in human B cells
    • DOI 10.1002/eji.200425878
    • Gomez-Bougie P, Bataille R, Amiot M. Endogenous association of Bim BH3-only protein with Mcl-1, Bcl-xL and Bcl-2 on mitochondria in human B cells. Eur J Immunol. 2005;35(3):971-976. (Pubitemid 40425553)
    • (2005) European Journal of Immunology , vol.35 , Issue.3 , pp. 971-976
    • Gomez-Bougie, P.1    Bataille, R.2    Amiot, M.3
  • 48
    • 34147193472 scopus 로고    scopus 로고
    • Cell biology: Autophagy and cancer
    • DOI 10.1038/446745a, PII 446745A
    • Levine B. Cell biology: autophagy and cancer. Nature. 2007;446(7137):745-747. (Pubitemid 46582063)
    • (2007) Nature , vol.446 , Issue.7137 , pp. 745-747
    • Levine, B.1
  • 50
    • 34250900953 scopus 로고    scopus 로고
    • LC3, an autophagosome marker, can be incorporated into protein aggregates independent of autophagy: Caution in the interpretation of LC3 localization
    • Kuma A, Matsui M, Mizushima N. LC3, an autophagosome marker, can be incorporated into protein aggregates independent of autophagy: caution in the interpretation of LC3 localization. Autophagy. 2007;3(4):323-328. (Pubitemid 46986336)
    • (2007) Autophagy , vol.3 , Issue.4 , pp. 323-328
    • Kuma, A.1    Matsui, M.2    Mizushima, N.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.