-
1
-
-
84973867039
-
DNA polymerases divide the labor of genome replication
-
Lujan, S.A., Williams, J.S., Kunkel, T.A. DNA polymerases divide the labor of genome replication. Trends Cell Biol. 2016, 26, 640-654.
-
(2016)
Trends Cell Biol
, vol.26
, pp. 640-654
-
-
Lujan, S.A.1
Williams, J.S.2
Kunkel, T.A.3
-
2
-
-
84962510070
-
The eukaryotic replisome goes under the microscope
-
O’Donnell, M., Li, H. The eukaryotic replisome goes under the microscope. Curr. Biol. 2016, 26, R247-256.
-
(2016)
Curr. Biol
, vol.26
, pp. R247-R256
-
-
O’Donnell, M.1
Li, H.2
-
3
-
-
84891301320
-
Causes and consequences of replication stress
-
Zeman, M.K., Cimprich, K.A. Causes and consequences of replication stress. Nat. Cell Biol. 2014, 16, 2-9.
-
(2014)
Nat. Cell Biol
, vol.16
, pp. 2-9
-
-
Zeman, M.K.1
Cimprich, K.A.2
-
4
-
-
84869026790
-
Senataxin associates with replication forks to protect fork integrity across RNA-polymerase-II-transcribed genes
-
Alzu, A., Bermejo, R., Begnis, M., Lucca, C., Piccini, D., Carotenuto, W., Saponaro, M., Brambati, A., Cocito, A., Foiani, M., et al. Senataxin associates with replication forks to protect fork integrity across RNA-polymerase-II-transcribed genes. Cell 2012, 151, 835-846.
-
(2012)
Cell
, vol.151
, pp. 835-846
-
-
Alzu, A.1
Bermejo, R.2
Begnis, M.3
Lucca, C.4
Piccini, D.5
Carotenuto, W.6
Saponaro, M.7
Brambati, A.8
Cocito, A.9
Foiani, M.10
-
5
-
-
84860338675
-
R loops: From transcription byproducts to threats to genome stability
-
Aguilera, A., Garcia-Muse, T. R loops: From transcription byproducts to threats to genome stability. Mol. Cell 2012, 46, 115-124.
-
(2012)
Mol. Cell
, vol.46
, pp. 115-124
-
-
Aguilera, A.1
Garcia-Muse, T.2
-
6
-
-
79959345878
-
Human senataxin resolves RNA/DNA hybrids formed at transcriptional pause sites to promote Xrn2-dependent termination
-
Skourti-Stathaki, K., Proudfoot, N.J., Gromak, N. Human senataxin resolves RNA/DNA hybrids formed at transcriptional pause sites to promote Xrn2-dependent termination. Mol. Cell 2011, 42, 794-805.
-
(2011)
Mol. Cell
, vol.42
, pp. 794-805
-
-
Skourti-Stathaki, K.1
Proudfoot, N.J.2
Gromak, N.3
-
7
-
-
84859087611
-
R-loop formation is a distinctive characteristic of unmethylated human cpg island promoters
-
Ginno, P.A., Lott, P.L., Christensen, H.C., Korf, I., Chedin, F. R-loop formation is a distinctive characteristic of unmethylated human cpg island promoters. Mol. Cell 2012, 45, 814-825.
-
(2012)
Mol. Cell
, vol.45
, pp. 814-825
-
-
Ginno, P.A.1
Lott, P.L.2
Christensen, H.C.3
Korf, I.4
Chedin, F.5
-
8
-
-
84978536132
-
Prevalent, dynamic, and conserved R-loop structures associate with specific epigenomic signatures in mammals
-
Sanz, L.A., Hartono, S.R., Lim, Y.W., Steyaert, S., Rajpurkar, A., Ginno, P.A., Xu, X., Chedin, F. Prevalent, dynamic, and conserved R-loop structures associate with specific epigenomic signatures in mammals. Mol. Cell 2016, 63, 167-178.
-
(2016)
Mol. Cell
, vol.63
, pp. 167-178
-
-
Sanz, L.A.1
Hartono, S.R.2
Lim, Y.W.3
Steyaert, S.4
Rajpurkar, A.5
Ginno, P.A.6
Xu, X.7
Chedin, F.8
-
9
-
-
84885081625
-
Gc skew at the 50 and 30 ends of human genes links R-loop formation to epigenetic regulation and transcription termination
-
Ginno, P.A., Lim, Y.W., Lott, P.L., Korf, I.F., Chedin, F. Gc skew at the 50 and 30 ends of human genes links R-loop formation to epigenetic regulation and transcription termination. Genome Res. 2013, 23, 1590-1600.
-
(2013)
Genome Res
, vol.23
, pp. 1590-1600
-
-
Ginno, P.A.1
Lim, Y.W.2
Lott, P.L.3
Korf, I.F.4
Chedin, F.5
-
10
-
-
84974623814
-
S1-drip-seq identifies high expression and polya tracts as major contributors to R-loop formation
-
Wahba, L., Costantino, L., Tan, F.J., Zimmer, A., Koshland, D. S1-drip-seq identifies high expression and polya tracts as major contributors to R-loop formation. Genes Dev. 2016, 30, 1327-1338.
-
(2016)
Genes Dev
, vol.30
, pp. 1327-1338
-
-
Wahba, L.1
Costantino, L.2
Tan, F.J.3
Zimmer, A.4
Koshland, D.5
-
11
-
-
84878870169
-
The rs of biology: R-loops and the regulation of regulators
-
Wahba, L., Koshland, D. The rs of biology: R-loops and the regulation of regulators. Mol. Cell 2013, 50, 611-612.
-
(2013)
Mol. Cell
, vol.50
, pp. 611-612
-
-
Wahba, L.1
Koshland, D.2
-
12
-
-
84902081933
-
The contribution of co-transcriptional RNA:DNA hybrid structures to DNA damage and genome instability
-
Hamperl, S., Cimprich, K.A. The contribution of co-transcriptional RNA:DNA hybrid structures to DNA damage and genome instability. DNA Repair 2014, 19, 84-94.
-
(2014)
DNA Repair
, vol.19
, pp. 84-94
-
-
Hamperl, S.1
Cimprich, K.A.2
-
13
-
-
84974698796
-
Transcription as a threat to genome integrity
-
Gaillard, H., Aguilera, A. Transcription as a threat to genome integrity. Annu. Rev. Biochem. 2016, 85, 291-317.
-
(2016)
Annu. Rev. Biochem
, vol.85
, pp. 291-317
-
-
Gaillard, H.1
Aguilera, A.2
-
14
-
-
79952266545
-
Aid induces double-strand breaks at immunoglobulin switch regions and c-myc causing chromosomal translocations in yeast tho mutants
-
Ruiz, J.F., Gomez-Gonzalez, B., Aguilera, A. Aid induces double-strand breaks at immunoglobulin switch regions and c-myc causing chromosomal translocations in yeast tho mutants. PLoS Genet. 2011, 7, e1002009.
-
(2011)
Plos Genet
, vol.7
-
-
Ruiz, J.F.1
Gomez-Gonzalez, B.2
Aguilera, A.3
-
15
-
-
84918791689
-
Transcription-coupled nucleotide excision repair factors promote R-loop-induced genome instability
-
Sollier, J., Stork, C.T., Garcia-Rubio, M.L., Paulsen, R.D., Aguilera, A., Cimprich, K.A. Transcription-coupled nucleotide excision repair factors promote R-loop-induced genome instability. Mol. Cell 2014, 56, 777-785.
-
(2014)
Mol. Cell
, vol.56
, pp. 777-785
-
-
Sollier, J.1
Stork, C.T.2
Garcia-Rubio, M.L.3
Paulsen, R.D.4
Aguilera, A.5
Cimprich, K.A.6
-
16
-
-
84994802487
-
Fancd2 facilitates replication through common fragile sites
-
Madireddy, A., Kosiyatrakul, S.T., Boisvert, R.A., Herrera-Moyano, E., Garcia-Rubio, M.L., Gerhardt, J., Vuono, E.A., Owen, N., Yan, Z., Olson, S., et al. Fancd2 facilitates replication through common fragile sites. Mol. Cell 2016, 64, 388-404.
-
(2016)
Mol. Cell
, vol.64
, pp. 388-404
-
-
Madireddy, A.1
Kosiyatrakul, S.T.2
Boisvert, R.A.3
Herrera-Moyano, E.4
Garcia-Rubio, M.L.5
Gerhardt, J.6
Vuono, E.A.7
Owen, N.8
Yan, Z.9
Olson, S.10
-
17
-
-
84901474570
-
Mechanisms of genome instability induced by RNA-processing defects
-
Chan, Y.A., Hieter, P., Stirling, P.C. Mechanisms of genome instability induced by RNA-processing defects. Trends Genet. 2014, 30, 245-253.
-
(2014)
Trends Genet
, vol.30
, pp. 245-253
-
-
Chan, Y.A.1
Hieter, P.2
Stirling, P.C.3
-
18
-
-
61349102407
-
Ribonuclease H: The enzymes in eukaryotes
-
Cerritelli, S.M., Crouch, R.J. Ribonuclease H: The enzymes in eukaryotes. FEBS J. 2009, 276, 1494-1505.
-
(2009)
FEBS J
, vol.276
, pp. 1494-1505
-
-
Cerritelli, S.M.1
Crouch, R.J.2
-
19
-
-
78650727733
-
Yeast sen1 helicase protects the genome from transcription-associated instability
-
Mischo, H.E., Gomez-Gonzalez, B., Grzechnik, P., Rondon, A.G., Wei, W., Steinmetz, L., Aguilera, A., Proudfoot, N.J. Yeast sen1 helicase protects the genome from transcription-associated instability. Mol. Cell 2011, 41, 21-32.
-
(2011)
Mol. Cell
, vol.41
, pp. 21-32
-
-
Mischo, H.E.1
Gomez-Gonzalez, B.2
Grzechnik, P.3
Rondon, A.G.4
Wei, W.5
Steinmetz, L.6
Aguilera, A.7
Proudfoot, N.J.8
-
20
-
-
84899887504
-
Periodic DNA patrolling underlies diverse functions of pif1 on R-loops and g-rich DNA
-
Zhou, R., Zhang, J., Bochman, M.L., Zakian, V.A., Ha, T. Periodic DNA patrolling underlies diverse functions of pif1 on R-loops and g-rich DNA. Elife 2014, 3, e02190.
-
(2014)
Elife
, vol.3
-
-
Zhou, R.1
Zhang, J.2
Bochman, M.L.3
Zakian, V.A.4
Ha, T.5
-
21
-
-
79957813857
-
Human DHX9 helicase preferentially unwinds RNA-containing displacement loops (R-loops) and G-quadruplexes
-
Chakraborty, P., Grosse, F. Human DHX9 helicase preferentially unwinds RNA-containing displacement loops (R-loops) and G-quadruplexes. DNA Repair 2011, 10, 654-665.
-
(2011)
DNA Repair
, vol.10
, pp. 654-665
-
-
Chakraborty, P.1
Grosse, F.2
-
22
-
-
23744455164
-
Inactivation of the SR protein splicing factor ASF/SF2 results in genomic instability
-
Li, X., Manley, J.L. Inactivation of the SR protein splicing factor ASF/SF2 results in genomic instability. Cell 2005, 122, 365-378.
-
(2005)
Cell
, vol.122
, pp. 365-378
-
-
Li, X.1
Manley, J.L.2
-
23
-
-
0141819093
-
Cotranscriptionally formed DNA:RNA hybrids mediate transcription elongation impairment and transcription-associated recombination
-
Huertas, P., Aguilera, A. Cotranscriptionally formed DNA:RNA hybrids mediate transcription elongation impairment and transcription-associated recombination. Mol. Cell 2003, 12, 711-721.
-
(2003)
Mol. Cell
, vol.12
, pp. 711-721
-
-
Huertas, P.1
Aguilera, A.2
-
24
-
-
79961031438
-
Genome-wide function of THO/TREX in active genes prevents R-loop-dependent replication obstacles
-
Gomez-Gonzalez, B., Garcia-Rubio, M., Bermejo, R., Gaillard, H., Shirahige, K., Marin, A., Foiani, M., Aguilera, A. Genome-wide function of THO/TREX in active genes prevents R-loop-dependent replication obstacles. EMBO J. 2011, 30, 3106-3119.
-
(2011)
EMBO J
, vol.30
, pp. 3106-3119
-
-
Gomez-Gonzalez, B.1
Garcia-Rubio, M.2
Bermejo, R.3
Gaillard, H.4
Shirahige, K.5
Marin, A.6
Foiani, M.7
Aguilera, A.8
-
25
-
-
84255177502
-
RNaseHandmultiple RNA biogenesis factors cooperate to prevent RNA:DNA hybrids from generating genome instability
-
Wahba, L., Amon, J.D., Koshland, D., Vuica-Ross, M. RNaseHandmultiple RNA biogenesis factors cooperate to prevent RNA:DNA hybrids from generating genome instability. Mol. Cell 2011, 44, 978-988.
-
(2011)
Mol. Cell
, vol.44
, pp. 978-988
-
-
Wahba, L.1
Amon, J.D.2
Koshland, D.3
Vuica-Ross, M.4
-
26
-
-
84856253456
-
R-loop-mediated genome instability in mRNA cleavage and polyadenylation mutants
-
Stirling, P.C., Chan, Y.A., Minaker, S.W., Aristizabal, M.J., Barrett, I., Sipahimalani, P., Kobor, M.S., Hieter, P. R-loop-mediated genome instability in mRNA cleavage and polyadenylation mutants. Genes Dev. 2012, 26, 163-175.
-
(2012)
Genes Dev
, vol.26
, pp. 163-175
-
-
Stirling, P.C.1
Chan, Y.A.2
Minaker, S.W.3
Aristizabal, M.J.4
Barrett, I.5
Sipahimalani, P.6
Kobor, M.S.7
Hieter, P.8
-
27
-
-
85031774921
-
Canonical DNA repair pathways influence R-loop-driven genome instability
-
Stirling, P.C., Hieter, P. Canonical DNA repair pathways influence R-loop-driven genome instability. J. Mol. Biol. 2016.
-
(2016)
J. Mol. Biol
-
-
Stirling, P.C.1
Hieter, P.2
-
28
-
-
70449522304
-
Topoisomerase I suppresses genomic instability by preventing interference between replication and transcription
-
Tuduri, S., Crabbe, L., Conti, C., Tourriere, H., Holtgreve-Grez, H., Jauch, A., Pantesco, V., De Vos, J., Thomas, A., Theillet, C., et al. Topoisomerase I suppresses genomic instability by preventing interference between replication and transcription. Nat. Cell Biol. 2009, 11, 1315-1324.
-
(2009)
Nat. Cell Biol
, vol.11
, pp. 1315-1324
-
-
Tuduri, S.1
Crabbe, L.2
Conti, C.3
Tourriere, H.4
Holtgreve-Grez, H.5
Jauch, A.6
Pantesco, V.7
De Vos, J.8
Thomas, A.9
Theillet, C.10
-
29
-
-
77954841539
-
Loss of topoisomerase I leads to R-loop-mediated transcriptional blocks during ribosomal RNA synthesis
-
El Hage, A., French, S.L., Beyer, A.L., Tollervey, D. Loss of topoisomerase I leads to R-loop-mediated transcriptional blocks during ribosomal RNA synthesis. Genes Dev. 2010, 24, 1546-1558.
-
(2010)
Genes Dev
, vol.24
, pp. 1546-1558
-
-
El Hage, A.1
French, S.L.2
Beyer, A.L.3
Tollervey, D.4
-
30
-
-
80051823466
-
Guanine repeat-containing sequences confer transcription-dependent instability in an orientation-specific manner in yeast
-
Kim, N., Jinks-Robertson, S. Guanine repeat-containing sequences confer transcription-dependent instability in an orientation-specific manner in yeast. DNA Repair 2011, 10, 953-960.
-
(2011)
DNA Repair
, vol.10
, pp. 953-960
-
-
Kim, N.1
Jinks-Robertson, S.2
-
31
-
-
84882781833
-
R-loop formation at Snord116 mediates topotecan inhibition of Ube3a-antisense and allele-specific chromatin decondensation
-
Powell, W.T., Coulson, R.L., Gonzales, M.L., Crary, F.K., Wong, S.S., Adams, S., Ach, R.A., Tsang, P., Yamada, N.A., Yasui, D.H., et al. R-loop formation at Snord116 mediates topotecan inhibition of Ube3a-antisense and allele-specific chromatin decondensation. Proc. Natl. Acad. Sci. USA 2013, 110, 13938-13943.
-
(2013)
Proc. Natl. Acad. Sci. USA
, vol.110
, pp. 13938-13943
-
-
Powell, W.T.1
Coulson, R.L.2
Gonzales, M.L.3
Crary, F.K.4
Wong, S.S.5
Adams, S.6
Ach, R.A.7
Tsang, P.8
Yamada, N.A.9
Yasui, D.H.10
-
32
-
-
84984908043
-
A checkpoint-related function of the MCM replicative helicase is required to avert accumulation of RNA:DNA hybrids during S-phase and ensuing DSBs during G2/M
-
Vijayraghavan, S., Tsai, F.L., Schwacha, A. A checkpoint-related function of the MCM replicative helicase is required to avert accumulation of RNA:DNA hybrids during S-phase and ensuing DSBs during G2/M. PLoS Genet. 2016, 12, e1006277.
-
(2016)
Plos Genet
, vol.12
-
-
Vijayraghavan, S.1
Tsai, F.L.2
Schwacha, A.3
-
33
-
-
84929397329
-
MCM2-7 is an active player in the DNA replication checkpoint signaling cascade via proposed modulation of its DNA gate
-
Tsai, F.L., Vijayraghavan, S., Prinz, J., MacAlpine, H.K., MacAlpine, D.M., Schwacha, A. MCM2-7 is an active player in the DNA replication checkpoint signaling cascade via proposed modulation of its DNA gate. Mol. Cell Biol. 2015, 35, 2131-2143.
-
(2015)
Mol. Cell Biol
, vol.35
, pp. 2131-2143
-
-
Tsai, F.L.1
Vijayraghavan, S.2
Prinz, J.3
Macalpine, H.K.4
Macalpine, D.M.5
Schwacha, A.6
-
34
-
-
33748752207
-
The replicative helicases of bacteria, archaea, and eukarya can unwind RNA-DNA hybrid substrates
-
Shin, J.H., Kelman, Z. The replicative helicases of bacteria, archaea, and eukarya can unwind RNA-DNA hybrid substrates. J. Biol. Chem. 2006, 281, 26914-26921.
-
(2006)
J. Biol. Chem
, vol.281
, pp. 26914-26921
-
-
Shin, J.H.1
Kelman, Z.2
-
35
-
-
84901408644
-
RECQL5 controls transcript elongation and suppresses genome instability associated with transcription stress
-
Saponaro, M., Kantidakis, T., Mitter, R., Kelly, G.P., Heron, M., Williams, H., Soding, J., Stewart, A., Svejstrup, J.Q. RECQL5 controls transcript elongation and suppresses genome instability associated with transcription stress. Cell 2014, 157, 1037-1049.
-
(2014)
Cell
, vol.157
, pp. 1037-1049
-
-
Saponaro, M.1
Kantidakis, T.2
Mitter, R.3
Kelly, G.P.4
Heron, M.5
Williams, H.6
Soding, J.7
Stewart, A.8
Svejstrup, J.Q.9
-
36
-
-
77958595004
-
RECQ5 helicase associates with the C-terminal repeat domain of RNA polymerase II during productive elongation phase of transcription
-
Kanagaraj, R., Huehn, D., MacKellar, A., Menigatti, M., Zheng, L., Urban, V., Shevelev, I., Greenleaf, A.L., Janscak, P. RECQ5 helicase associates with the C-terminal repeat domain of RNA polymerase II during productive elongation phase of transcription. Nucleic Acids Res. 2010, 38, 8131-8140.
-
(2010)
Nucleic Acids Res
, vol.38
, pp. 8131-8140
-
-
Kanagaraj, R.1
Huehn, D.2
Mackellar, A.3
Menigatti, M.4
Zheng, L.5
Urban, V.6
Shevelev, I.7
Greenleaf, A.L.8
Janscak, P.9
-
37
-
-
33750980979
-
Human RECQ5beta helicase promotes strand exchange on synthetic DNA structures resembling a stalled replication fork
-
Kanagaraj, R., Saydam, N., Garcia, P.L., Zheng, L., Janscak, P. Human RECQ5beta helicase promotes strand exchange on synthetic DNA structures resembling a stalled replication fork. Nucleic Acids Res. 2006, 34, 5217-5231.
-
(2006)
Nucleic Acids Res
, vol.34
, pp. 5217-5231
-
-
Kanagaraj, R.1
Saydam, N.2
Garcia, P.L.3
Zheng, L.4
Janscak, P.5
-
38
-
-
63049125856
-
RECQLl5 plays an important role in DNA replication and cell survival after camptothecin treatment
-
Hu, Y., Lu, X., Zhou, G., Barnes, E.L., Luo, G. RECQLl5 plays an important role in DNA replication and cell survival after camptothecin treatment. Mol. Biol. Cell 2009, 20, 114-123.
-
(2009)
Mol. Biol. Cell
, vol.20
, pp. 114-123
-
-
Hu, Y.1
Lu, X.2
Zhou, G.3
Barnes, E.L.4
Luo, G.5
-
39
-
-
84926631633
-
RECQ5-dependent SUMOoylation of DNA topoisomerase I prevents transcription-associated genome instability
-
Li, M., Pokharel, S., Wang, J.T., Xu, X., Liu, Y. RECQ5-dependent SUMOoylation of DNA topoisomerase I prevents transcription-associated genome instability. Nat. Commun. 2015.
-
(2015)
Nat. Commun
-
-
Li, M.1
Pokharel, S.2
Wang, J.T.3
Xu, X.4
Liu, Y.5
-
40
-
-
84983271796
-
RECQ5 helicase promotes resolution of conflicts between replication and transcription in human cells
-
Urban, V., Dobrovolna, J., Huhn, D., Fryzelkova, J., Bartek, J., Janscak, P. RECQ5 helicase promotes resolution of conflicts between replication and transcription in human cells. J. Cell Biol. 2016, 214, 401-415.
-
(2016)
J. Cell Biol
, vol.214
, pp. 401-415
-
-
Urban, V.1
Dobrovolna, J.2
Huhn, D.3
Fryzelkova, J.4
Bartek, J.5
Janscak, P.6
-
41
-
-
78649837330
-
BRCA2 acts as a RAD51 loader to facilitate telomere replication and capping
-
Badie, S., Escandell, J.M., Bouwman, P., Carlos, A.R., Thanasoula, M., Gallardo, M.M., Suram, A., Jaco, I., Benitez, J., Herbig, U., et al. BRCA2 acts as a RAD51 loader to facilitate telomere replication and capping. Nat. Struct. Mol. Biol. 2010, 17, 1461-1469.
-
(2010)
Nat. Struct. Mol. Biol
, vol.17
, pp. 1461-1469
-
-
Badie, S.1
Escandell, J.M.2
Bouwman, P.3
Carlos, A.R.4
Thanasoula, M.5
Gallardo, M.M.6
Suram, A.7
Jaco, I.8
Benitez, J.9
Herbig, U.10
-
42
-
-
84863753191
-
A distinct replication fork protection pathway connects fanconi anemia tumor suppressors to RAD51-BRCA1/2
-
Schlacher, K., Wu, H., Jasin, M. A distinct replication fork protection pathway connects fanconi anemia tumor suppressors to RAD51-BRCA1/2. Cancer Cell 2012, 22, 106-116.
-
(2012)
Cancer Cell
, vol.22
, pp. 106-116
-
-
Schlacher, K.1
Wu, H.2
Jasin, M.3
-
43
-
-
84904459138
-
BRCA2 prevents R-loop accumulation and associates with TREX-2 mRNA export factor PCID2
-
Bhatia, V., Barroso, S.I., Garcia-Rubio, M.L., Tumini, E., Herrera-Moyano, E., Aguilera, A. BRCA2 prevents R-loop accumulation and associates with TREX-2 mRNA export factor PCID2. Nature 2014, 511, 362-365.
-
(2014)
Nature
, vol.511
, pp. 362-365
-
-
Bhatia, V.1
Barroso, S.I.2
Garcia-Rubio, M.L.3
Tumini, E.4
Herrera-Moyano, E.5
Aguilera, A.6
-
44
-
-
84963657302
-
Interplay between fanconi anemia and homologous recombination pathways in genome integrity
-
Michl, J., Zimmer, J., Tarsounas, M. Interplay between fanconi anemia and homologous recombination pathways in genome integrity. EMBO J. 2016, 35, 909-923.
-
(2016)
EMBO J
, vol.35
, pp. 909-923
-
-
Michl, J.1
Zimmer, J.2
Tarsounas, M.3
-
45
-
-
33749000596
-
The role of BRCA1 in transcriptional regulation and cell cycle control
-
Mullan, P.B., Quinn, J.E., Harkin, D.P. The role of BRCA1 in transcriptional regulation and cell cycle control. Oncogene 2006, 25, 5854-5863.
-
(2006)
Oncogene
, vol.25
, pp. 5854-5863
-
-
Mullan, P.B.1
Quinn, J.E.2
Harkin, D.P.3
-
46
-
-
84923848772
-
BRCA1 recruitment to transcriptional pause sites is required for R-loop-driven DNA damage repair
-
Hatchi, E., Skourti-Stathaki, K., Ventz, S., Pinello, L., Yen, A., Kamieniarz-Gdula, K., Dimitrov, S., Pathania, S., McKinney, K.M., Eaton, M.L., et al. BRCA1 recruitment to transcriptional pause sites is required for R-loop-driven DNA damage repair. Mol. Cell 2015, 57, 636-647.
-
(2015)
Mol. Cell
, vol.57
, pp. 636-647
-
-
Hatchi, E.1
Skourti-Stathaki, K.2
Ventz, S.3
Pinello, L.4
Yen, A.5
Kamieniarz-Gdula, K.6
Dimitrov, S.7
Pathania, S.8
McKinney, K.M.9
Eaton, M.L.10
-
47
-
-
34548759123
-
Emergence of a DNA-damage response network consisting of Fanconi anaemia and BRCA proteins
-
Wang, W. Emergence of a DNA-damage response network consisting of Fanconi anaemia and BRCA proteins. Nat. Rev. Genet. 2007, 8, 735-748.
-
(2007)
Nat. Rev. Genet
, vol.8
, pp. 735-748
-
-
Wang, W.1
-
48
-
-
84926505383
-
Biallelic mutations in BRCA1 cause a new Fanconi anemia subtype
-
Sawyer, S.L., Tian, L., Kahkonen, M., Schwartzentruber, J., Kircher, M., Majewski, J., Dyment, D.A., Innes, A.M., Boycott, K.M., Moreau, L.A., et al. Biallelic mutations in BRCA1 cause a new Fanconi anemia subtype. Cancer Discov. 2015, 5, 135-142.
-
(2015)
Cancer Discov
, vol.5
, pp. 135-142
-
-
Sawyer, S.L.1
Tian, L.2
Kahkonen, M.3
Schwartzentruber, J.4
Kircher, M.5
Majewski, J.6
Dyment, D.A.7
Innes, A.M.8
Boycott, K.M.9
Moreau, L.A.10
-
49
-
-
84868613789
-
Molecular pathogenesis and clinical management of Fanconi anemia
-
Kee, Y., D’Andrea, A.D. Molecular pathogenesis and clinical management of Fanconi anemia. J. Clin. Investig. 2012, 122, 3799-3806.
-
(2012)
J. Clin. Investig
, vol.122
, pp. 3799-3806
-
-
Kee, Y.1
D’Andrea, A.D.2
-
50
-
-
18444362122
-
Biallelic inactivation of BRCA2 in Fanconi anemia
-
Howlett, N.G., Taniguchi, T., Olson, S., Cox, B., Waisfisz, Q., De Die-Smulders, C., Persky, N., Grompe, M., Joenje, H., Pals, G., et al. Biallelic inactivation of BRCA2 in Fanconi anemia. Science 2002, 297, 606-609.
-
(2002)
Science
, vol.297
, pp. 606-609
-
-
Howlett, N.G.1
Taniguchi, T.2
Olson, S.3
Cox, B.4
Waisfisz, Q.5
De Die-Smulders, C.6
Persky, N.7
Grompe, M.8
Joenje, H.9
Pals, G.10
-
51
-
-
84947740589
-
The Fanconi anemia pathway maintains genome stability by coordinating replication and transcription
-
Schwab, R.A., Nieminuszczy, J., Shah, F., Langton, J., Lopez Martinez, D., Liang, C.C., Cohn, M.A., Gibbons, R.J., Deans, A.J., Niedzwiedz, W. The Fanconi anemia pathway maintains genome stability by coordinating replication and transcription. Mol. Cell 2015, 60, 351-361.
-
(2015)
Mol. Cell
, vol.60
, pp. 351-361
-
-
Schwab, R.A.1
Nieminuszczy, J.2
Shah, F.3
Langton, J.4
Lopez Martinez, D.5
Liang, C.C.6
Cohn, M.A.7
Gibbons, R.J.8
Deans, A.J.9
Niedzwiedz, W.10
-
52
-
-
84949256749
-
The Fanconi anemia pathway protects genome integrity from R-loops
-
Garcia-Rubio, M.L., Perez-Calero, C., Barroso, S.I., Tumini, E., Herrera-Moyano, E., Rosado, I.V., Aguilera, A. The Fanconi anemia pathway protects genome integrity from R-loops. PLoS Genet 2015, 11, e1005674.
-
(2015)
Plos Genet
, vol.11
-
-
Garcia-Rubio, M.L.1
Perez-Calero, C.2
Barroso, S.I.3
Tumini, E.4
Herrera-Moyano, E.5
Rosado, I.V.6
Aguilera, A.7
-
53
-
-
84898841862
-
The yeast and human fact chromatin-reorganizing complexes solve R-loop-mediated transcription-replication conflicts
-
Herrera-Moyano, E., Mergui, X., Garcia-Rubio, M.L., Barroso, S., Aguilera, A. The yeast and human fact chromatin-reorganizing complexes solve R-loop-mediated transcription-replication conflicts. Genes Dev. 2014, 28, 735-748.
-
(2014)
Genes Dev
, vol.28
, pp. 735-748
-
-
Herrera-Moyano, E.1
Mergui, X.2
Garcia-Rubio, M.L.3
Barroso, S.4
Aguilera, A.5
-
54
-
-
84871740379
-
Coordinated control of replication and transcription by a sapk protects genomic integrity
-
Duch, A., Felipe-Abrio, I., Barroso, S., Yaakov, G., Garcia-Rubio, M., Aguilera, A., de Nadal, E., Posas, F. Coordinated control of replication and transcription by a sapk protects genomic integrity. Nature 2013, 493, 116-119.
-
(2013)
Nature
, vol.493
, pp. 116-119
-
-
Duch, A.1
Felipe-Abrio, I.2
Barroso, S.3
Yaakov, G.4
Garcia-Rubio, M.5
Aguilera, A.6
De Nadal, E.7
Posas, F.8
-
55
-
-
79960802984
-
The replication checkpoint protects fork stability by releasing transcribed genes from nuclear pores
-
Bermejo, R., Capra, T., Jossen, R., Colosio, A., Frattini, C., Carotenuto, W., Cocito, A., Doksani, Y., Klein, H., Gomez-Gonzalez, B., et al. The replication checkpoint protects fork stability by releasing transcribed genes from nuclear pores. Cell 2011, 146, 233-246.
-
(2011)
Cell
, vol.146
, pp. 233-246
-
-
Bermejo, R.1
Capra, T.2
Jossen, R.3
Colosio, A.4
Frattini, C.5
Carotenuto, W.6
Cocito, A.7
Doksani, Y.8
Klein, H.9
Gomez-Gonzalez, B.10
-
56
-
-
84962385367
-
The core spliceosome as target and effector of non-canonical ATM signalling
-
Tresini, M., Warmerdam, D.O., Kolovos, P., Snijder, L., Vrouwe, M.G., Demmers, J.A., van IJcken, W.F.J., Grosveld, F.G., Medema, R.H., Hoeijmakers, J.H., et al. The core spliceosome as target and effector of non-canonical ATM signalling. Nature 2015, 523, 53-58.
-
(2015)
Nature
, vol.523
, pp. 53-58
-
-
Tresini, M.1
Warmerdam, D.O.2
Kolovos, P.3
Snijder, L.4
Vrouwe, M.G.5
Demmers, J.A.6
Van Ijcken, W.F.J.7
Grosveld, F.G.8
Medema, R.H.9
Hoeijmakers, J.H.10
-
57
-
-
84963588819
-
P53 maintains genomic stability by preventing interference between transcription and replication
-
Yeo, C.Q., Alexander, I., Lin, Z., Lim, S., Aning, O.A., Kumar, R., Sangthongpitag, K., Pendharkar, V., Ho, V.H., Cheok, C.F. P53 maintains genomic stability by preventing interference between transcription and replication. Cell Rep. 2016, 15, 132-146.
-
(2016)
Cell Rep
, vol.15
, pp. 132-146
-
-
Yeo, C.Q.1
Alexander, I.2
Lin, Z.3
Lim, S.4
Aning, O.A.5
Kumar, R.6
Sangthongpitag, K.7
Pendharkar, V.8
Ho, V.H.9
Cheok, C.F.10
-
58
-
-
49649099084
-
The human RecQ helicases, BLM and RECQ1, display distinct DNA substrate specificities
-
Popuri, V., Bachrati, C.Z., Muzzolini, L., Mosedale, G., Costantini, S., Giacomini, E., Hickson, I.D., Vindigni, A. The human RecQ helicases, BLM and RECQ1, display distinct DNA substrate specificities. J. Biol. Chem. 2008, 283, 17766-17776.
-
(2008)
J. Biol. Chem
, vol.283
, pp. 17766-17776
-
-
Popuri, V.1
Bachrati, C.Z.2
Muzzolini, L.3
Mosedale, G.4
Costantini, S.5
Giacomini, E.6
Hickson, I.D.7
Vindigni, A.8
-
59
-
-
84856966302
-
BLM helicase facilitates RNA polymerase I-mediated ribosomal RNA transcription
-
Grierson, P.M., Lillard, K., Behbehani, G.K., Combs, K.A., Bhattacharyya, S., Acharya, S., Groden, J. BLM helicase facilitates RNA polymerase I-mediated ribosomal RNA transcription. Hum. Mol. Genet. 2012, 21, 1172-1183.
-
(2012)
Hum. Mol. Genet
, vol.21
, pp. 1172-1183
-
-
Grierson, P.M.1
Lillard, K.2
Behbehani, G.K.3
Combs, K.A.4
Bhattacharyya, S.5
Acharya, S.6
Groden, J.7
-
60
-
-
72149090671
-
FANCM connects the genome instability disorders Bloom’s syndrome and Fanconi anemia
-
Deans, A.J., West, S.C. FANCM connects the genome instability disorders Bloom’s syndrome and Fanconi anemia. Mol. Cell 2009, 36, 943-953.
-
(2009)
Mol. Cell
, vol.36
, pp. 943-953
-
-
Deans, A.J.1
West, S.C.2
-
61
-
-
79955799175
-
Double-strand break repair-independent role for BRCA2 in blocking stalled replication fork degradation by mre11
-
Schlacher, K., Christ, N., Siaud, N., Egashira, A., Wu, H., Jasin, M. Double-strand break repair-independent role for BRCA2 in blocking stalled replication fork degradation by mre11. Cell 2011, 145, 529-542.
-
(2011)
Cell
, vol.145
, pp. 529-542
-
-
Schlacher, K.1
Christ, N.2
Siaud, N.3
Egashira, A.4
Wu, H.5
Jasin, M.6
-
62
-
-
77958499239
-
RAD18-mediated ubiquitination of PCNA activates the Fanconi anemia DNA repair network
-
Geng, L., Huntoon, C.J., Karnitz, L.M. RAD18-mediated ubiquitination of PCNA activates the Fanconi anemia DNA repair network. J. Cell Biol. 2010, 191, 249-257.
-
(2010)
J. Cell Biol
, vol.191
, pp. 249-257
-
-
Geng, L.1
Huntoon, C.J.2
Karnitz, L.M.3
-
63
-
-
84902187810
-
Human RECQ helicases in DNA repair, recombination, and replication
-
Croteau, D.L., Popuri, V., Opresko, P.L., Bohr, V.A. Human RECQ helicases in DNA repair, recombination, and replication. Annu. Rev. Biochem. 2014, 83, 519-552.
-
(2014)
Annu. Rev. Biochem.
, vol.83
, pp. 519-552
-
-
Croteau, D.L.1
Popuri, V.2
Opresko, P.L.3
Bohr, V.A.4
-
64
-
-
84949790002
-
Replication stress activates DNA repair synthesis in mitosis
-
Minocherhomji, S., Ying, S., Bjerregaard, V.A., Bursomanno, S., Aleliunaite, A., Wu, W., Mankouri, H.W., Shen, H., Liu, Y., Hickson, I.D. Replication stress activates DNA repair synthesis in mitosis. Nature 2015, 528, 286-290.
-
(2015)
Nature
, vol.528
, pp. 286-290
-
-
Minocherhomji, S.1
Ying, S.2
Bjerregaard, V.A.3
Bursomanno, S.4
Aleliunaite, A.5
Wu, W.6
Mankouri, H.W.7
Shen, H.8
Liu, Y.9
Hickson, I.D.10
-
65
-
-
84991510615
-
Increased global transcription activity as a mechanism of replication stress in cancer
-
Kotsantis, P., Silva, L.M., Irmscher, S., Jones, R.M., Folkes, L., Gromak, N., Petermann, E. Increased global transcription activity as a mechanism of replication stress in cancer. Nat. Commun. 2016.
-
(2016)
Nat. Commun
-
-
Kotsantis, P.1
Silva, L.M.2
Irmscher, S.3
Jones, R.M.4
Folkes, L.5
Gromak, N.6
Petermann, E.7
-
66
-
-
84979642998
-
DNA damage tolerance pathway involving DNA polymerase iota and the tumor suppressor p53 regulates DNA replication fork progression
-
Hampp, S., Kiessling, T., Buechle, K., Mansilla, S.F., Thomale, J., Rall, M., Ahn, J., Pospiech, H., Gottifredi, V., Wiesmuller, L. DNA damage tolerance pathway involving DNA polymerase iota and the tumor suppressor p53 regulates DNA replication fork progression. Proc. Natl. Acad. Sci. USA 2016, 113, E4311-E4319.
-
(2016)
Proc. Natl. Acad. Sci. USA
, vol.113
, pp. E4311-E4319
-
-
Hampp, S.1
Kiessling, T.2
Buechle, K.3
Mansilla, S.F.4
Thomale, J.5
Rall, M.6
Ahn, J.7
Pospiech, H.8
Gottifredi, V.9
Wiesmuller, L.10
-
67
-
-
84988470898
-
Co-transcriptional R-loops are the main cause of estrogen-induced DNA damage
-
Stork, C.T., Bocek, M., Crossley, M.P., Sollier, J., Sanz, L.A., Chedin, F., Swigut, T., Cimprich, K.A. Co-transcriptional R-loops are the main cause of estrogen-induced DNA damage. Elife 2016, 5, e17548.
-
(2016)
Elife
, vol.5
-
-
Stork, C.T.1
Bocek, M.2
Crossley, M.P.3
Sollier, J.4
Sanz, L.A.5
Chedin, F.6
Swigut, T.7
Cimprich, K.A.8
-
68
-
-
84907587725
-
Out of balance: R-loops in human disease
-
Groh, M., Gromak, N. Out of balance: R-loops in human disease. PLoS Genet. 2014, 10, e1004630.
-
(2014)
Plos Genet
, vol.10
-
-
Groh, M.1
Gromak, N.2
|